Müller, Ivan and Beyleveld, Lindsey and Gerber, Markus and Pühse, Uwe and du Randt, Rosa and Utzinger, Jürg and Zondie, Leyli and Walter, Cheryl and Steinmann, Peter. (2016) Low efficacy of albendazole against Trichuris trichiura infection in schoolchildren from Port Elizabeth, South Africa. Transactions of the Royal Society of Tropical Medicine and Hygiene, 110 (11). pp. 676-678.
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Abstract
Albendazole is one of two standard drugs for the control of soil-transmitted helminthiasis.; A total of 149 schoolchildren from Port Elizabeth, South Africa, were examined for soil-transmitted helminth infections using duplicate Kato-Katz thick smears before and 2 weeks after administration of albendazole (400 mg).; Trichuris trichiura was the predominant soil-transmitted helminth species (prevalence 60.4%), followed by Ascaris lumbricoides (47.7%). While albendazole was highly efficacious against A. lumbricoides (cure rate [CR] 97.2%; egg reduction rate [ERR] 94.3%), it lacked efficacy against T. trichiura (CR 1.1%; ERR 46.0%).; Our study confirms low efficacy of single dose albendazole against T. trichiura. There is a need for safe and efficacious drugs against T. trichiura.
| Faculties and Departments: | 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Former Units within Swiss TPH > Health Impact Assessment (Utzinger) |
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| UniBasel Contributors: | Müller, Ivan and Utzinger, Jürg and Steinmann, Peter |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Elsevier |
| ISSN: | 0035-9203 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Identification Number: |
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| Last Modified: | 20 Apr 2017 13:50 |
| Deposited On: | 20 Apr 2017 13:50 |
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