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PEG-PCL-based nanomedicines: A biodegradable drug delivery system and its application

Grossen, Philip and Witzigmann, Dominik and Sieber, Sandro and Huwyler, Jörg. (2017) PEG-PCL-based nanomedicines: A biodegradable drug delivery system and its application. Journal of Controlled Release, 260. pp. 46-60.

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Official URL: http://edoc.unibas.ch/55314/

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Abstract

The lack of efficient therapeutic options for many severe disorders including cancer spurs demand for improved drug delivery technologies. Nanoscale drug delivery systems based on poly(ethylene glycol)-poly(ε-caprolactone) copolymers (PEG-PCL) represent a strategy to implement therapies with enhanced drug accumulation at the site of action and decreased off-target effects. In this review, we discuss state-of-the-art nanomedicines based on PEG-PCL that have been investigated in a preclinical setting. We summarize the various synthesis routes and different preparation methods used for the production of PEG-PCL nanoparticles. Additionally, we review physico-chemical properties including biodegradability, biocompatibility, and drug loading. Finally, we highlight recent therapeutic applications investigated in vitro and in vivo using advanced systems such as triggered release, multi-component therapies, theranostics, or gene delivery systems.
Faculties and Departments:05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Pharmaceutical Technology (Huwyler)
UniBasel Contributors:Huwyler, Jörg and Grossen, Philip and Witzigmann, Dominik and Sieber, Sandro
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:0168-3659
e-ISSN:1873-4995
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:24 Oct 2017 07:32
Deposited On:24 Oct 2017 07:32

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