Grossen, Philip and Witzigmann, Dominik and Sieber, Sandro and Huwyler, Jörg. (2017) PEG-PCL-based nanomedicines: A biodegradable drug delivery system and its application. Journal of Controlled Release, 260. pp. 46-60.
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Official URL: http://edoc.unibas.ch/55314/
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Abstract
The lack of efficient therapeutic options for many severe disorders including cancer spurs demand for improved drug delivery technologies. Nanoscale drug delivery systems based on poly(ethylene glycol)-poly(ε-caprolactone) copolymers (PEG-PCL) represent a strategy to implement therapies with enhanced drug accumulation at the site of action and decreased off-target effects. In this review, we discuss state-of-the-art nanomedicines based on PEG-PCL that have been investigated in a preclinical setting. We summarize the various synthesis routes and different preparation methods used for the production of PEG-PCL nanoparticles. Additionally, we review physico-chemical properties including biodegradability, biocompatibility, and drug loading. Finally, we highlight recent therapeutic applications investigated in vitro and in vivo using advanced systems such as triggered release, multi-component therapies, theranostics, or gene delivery systems.
| Faculties and Departments: | 05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Pharmaceutical Technology (Huwyler) |
|---|---|
| UniBasel Contributors: | Huwyler, Jörg and Grossen, Philip and Witzigmann, Dominik and Sieber, Sandro |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Elsevier |
| ISSN: | 0168-3659 |
| e-ISSN: | 1873-4995 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Identification Number: |
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| Last Modified: | 24 Oct 2017 07:32 |
| Deposited On: | 24 Oct 2017 07:32 |
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