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Self-assembling chitosan hydrogel: A drug-delivery device enabling the sustained release of proteins

Kiene, Klara and Porta, Fabiola and Topacogullari, Buket and Detampel, Pascal and Huwyler, Jörg. (2017) Self-assembling chitosan hydrogel: A drug-delivery device enabling the sustained release of proteins. Journal of Applied Polymer Science, 135 (1). p. 45638.

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Official URL: http://edoc.unibas.ch/55900/

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Abstract

The development of a self-assembling hydrogel, prepared from maleimide-modified and thiolated chitosan (CS), is described. Under mild reaction conditions, the natural CS polymer was coupled with either maleimide or sulfhydryl moieties in a one-step synthesis. Subsequently, these CS polymers spontaneously formed a covalently crosslinked CS hydrogel when mixed. The three-dimensional network structure was visualized with scanning electron microscopy. The swelling and degradation behavior was evaluated, and viscosity measurements were conducted. The gel was loaded with the model protein albumin, and prolonged release was achieved. These properties were preserved after lyophilization and rehydration. This makes the hydrogel a promising scaffold for biological wound dressings for the treatment of chronic wounds.
Faculties and Departments:05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Pharmaceutical Technology (Huwyler)
UniBasel Contributors:Huwyler, Jörg and Kiene, Klara and Porta, Fabiola and Detampel, Pascal
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Wiley
ISSN:0021-8995
e-ISSN:1097-4628
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:23 Oct 2017 10:25
Deposited On:23 Oct 2017 10:25

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