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The hypothalamic-pituitary-adrenal axis in critical illness

Schuetz, P. and Muller, B.. (2006) The hypothalamic-pituitary-adrenal axis in critical illness. Endocrinology and Metabolism Clinics of North America, 35 (4). pp. 823-838.

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Official URL: http://edoc.unibas.ch/56705/

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Abstract

The hypothalamic-pituitary-adrenal response to stress is a dynamic process. The homeostatic corrections that have emerged in the course of human evolution to cope with the catastrophic events during critical illness involve a complex multisystem endeavor. Although the repertoire of endocrine changes has been probed in some detail, discerning the vulnerabilities and failures of this system is far more challenging. One of the most controversially debated topics in the current literature is the characterization and optimal treatment of allegedly inadequate adaptations of the hypothalamic-pituitary-adrenal axis during critical illness. This outline attempts to touch briefly some of the debated issues, stir the discussion, and thereby contribute to resolving the dispute.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Allgemeine innere Medizin AG > Argovia Professur für Medizin (Müller)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Allgemeine innere Medizin AG > Argovia Professur für Medizin (Müller)
UniBasel Contributors:Müller, Beat
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Publisher:Saunders
ISSN:0889-8529
e-ISSN:1558-4410
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:27 Nov 2017 12:56
Deposited On:27 Nov 2017 12:56

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