Möhler, H. and Fritschy, J. M. and Vogt, K. and Crestani, F. and Rudolph, U.. (2005) Pathophysiology and pharmacology of GABA(A) receptors. Handbook of Experimental Pharmacology, H. 169. pp. 225-247.
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Official URL: http://edoc.unibas.ch/dok/A5259784
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Abstract
By controlling spike timing and sculpting neuronal rhythms, inhibitory interneurons play a key role in brain function. GABAergic interneurons are highly diverse. The respective GABA(A) receptor subtypes, therefore, provide new opportunities not only for understanding GABA-dependent pathophysiologies but also for targeting of selective neuronal circuits by drugs. The pharmacological relevance of GABA(A) receptor subtypes is increasingly being recognized. A new central nervous system pharmacology is on the horizon. The development of anxiolytic drugs devoid of sedation and of agents that enhance hippocampus-dependent learning and memory has become a novel and highly selective therapeutic opportunity.
Faculties and Departments: | 05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Pharmacology/Neurobiology (Vogt) |
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UniBasel Contributors: | Vogt, Kaspar |
Item Type: | Article, refereed |
Article Subtype: | Research Article |
Publisher: | Springer |
Note: | Publication type according to Uni Basel Research Database: Journal article |
Last Modified: | 04 Sep 2015 14:31 |
Deposited On: | 22 Mar 2012 13:31 |
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