Cretton, Sylvian and Oyarzún, Alejandra and Righi, Davide and Sahib, Lamia and Kaiser, Marcel and Christen, Philippe and Fajardo, Victor. (2018) A new antifungal and antiprotozoal bibenzyl derivative from Gavilea lutea. Natural Product Research, 32 (6). pp. 695-701.
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Official URL: http://edoc.unibas.ch/58375/
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Abstract
A new bibenzyl derivative (4), together with two glycosylated flavonoids (1 and 2), batatasin III (3) and the phenanthrene isohircinol (5) were isolated from the aerial parts of Gavilea lutea. Their structures were elucidated on the basis of spectroscopic studies including 1D and 2D NMR, UV, IR and HRESIMS. All isolated compounds were evaluated for their antifungal activity towards Candida albicans. The new compound 4 showed inhibitory activity with a MIQ of 50 μg. In addition, compound 4 exhibited a selective activity (IC50 = 2.3 μg/mL) against Leishmania donovani.
| Faculties and Departments: | 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Parasite Chemotherapy (Mäser) |
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| UniBasel Contributors: | Kaiser, Marcel |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Taylor & Francis |
| ISSN: | 1478-6419 |
| e-ISSN: | 1478-6427 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Identification Number: |
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| Last Modified: | 02 Feb 2018 13:51 |
| Deposited On: | 02 Feb 2018 13:51 |
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