Gehring, W. J.. (1996) The master control gene for morphogenesis and evolution of the eye. Genes to cells, Vol. 1, H. 1. pp. 11-15.
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Official URL: http://edoc.unibas.ch/dok/A5257307
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Abstract
The human Aniridia, the murine Small eye, and the eyeless mutations of Drosophila affect homologous (Pax-6) genes that contain both a paired- and a homeobox. By ectopic expression of these genes, functional eyes can be induced on the legs, wings, and antennae of the fly, indicating that eyeless (Pax-6) is the master control gene for eye morphogenesis. The finding of Pax-6 from flatworms to humans suggests that eyeless is a universal master control gene and that the various types of eyes in the various animal phyla may have evolved from a single prototype.
Faculties and Departments: | 05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Cell Biology (Gehring) |
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UniBasel Contributors: | Gehring, Walter Jakob |
Item Type: | Article, refereed |
Article Subtype: | Research Article |
Publisher: | Blackwell Science |
ISSN: | 1356-9597 |
Note: | Publication type according to Uni Basel Research Database: Journal article |
Last Modified: | 22 Mar 2012 14:23 |
Deposited On: | 22 Mar 2012 13:32 |
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