Cattori, V. and Hagenbuch, B. and Hagenbuch, N. and Stieger, B. and Ha, R. and Winterhalter, K. E. and Meier, P. J.. (2000) Identification of organic anion transporting polypeptide 4 (Oatp4) as a major full-length isoform of the liver-specific transporter-1 (rlst-1) in rat liver. FEBS letters, Vol. 474, H. 2-3. pp. 242-245.
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Official URL: http://edoc.unibas.ch/dok/A5261676
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Abstract
A novel organic anion transporting polypeptide (Oatp)4(1) was isolated from rat liver that is 35 amino acids longer than the reported rat liver specific organic anion transporter (rlst)-1 and exhibits a 64% amino acid sequence identity with the human OATP-C (LST-1/OATP2; gene symbol SLC21A6). When expressed in Xenopus laevis oocytes, Oatp4 (Slc21a10) mediated polyspecific uptake of a variety of organic anions including taurocholate (K(m) approximately 27 microM), bromosulfophthalein (K(m) approximately 1.1 microM) and steroid conjugates. Based on nuclease protection analysis Oatp4 appears to be the predominant transcript in rat liver indicating that rlst-1 plays a minor role in overall hepatic organic anion uptake.
| Faculties and Departments: | 11 Rektorat und Verwaltung > Vizerektorat Forschung |
|---|---|
| UniBasel Contributors: | Meier-Abt, Peter J. |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Elsevier Science |
| ISSN: | 0014-5793 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
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| Last Modified: | 22 Mar 2012 14:23 |
| Deposited On: | 22 Mar 2012 13:35 |
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