Items where contributor is "Rüegg, Markus A."
2017Brockhoff, Marielle and Rion, Nathalie and Chojnowska, Kathrin and Wiktorowicz, Tatiana and Eickhorst, Christopher and Erne, Beat and Frank, Stephan and Angelini, Corrado and Furling, Denis and Rüegg, Markus A. and Sinnreich, Michael and Castets, Perrine. (2017) Targeting deregulated AMPK/mTORC1 pathways improves muscle function in myotonic dystrophy type I. Journal of Clinical Investigation, 127 (2). pp. 549-563. McKee, Karen K. and Crosson, Stephanie C. and Meinen, Sarina and Reinhard, Judith R. and Rüegg, Markus A. and Yurchenco, Peter D.. (2017) Chimeric protein repair of laminin polymerization ameliorates muscular dystrophy phenotype. Journal of Clinical Investigation, 127 (3). pp. 1075-1089. Rion, Nathalie and Rüegg, Markus A.. (2017) LncRNA-encoded peptides: More than translational noise? Cell Research, 27 (5). pp. 604-605. Willmann, Raffaella and Gordish-Dressman, Heather and Meinen, Sarina and Rüegg, Markus A. and Yu, Qing and Nagaraju, Kanneboyina and Kumar, Ayar and Girgenrath, Mahasweta and Coffey, Caroline B. M. and Cruz, Vivian and Van Ry, Pam M. and Bogdanik, Laurent and Lutz, Cathleen and Rutkowski, Anne and Burkin, Dean J.. (2017) Improving Reproducibility of Phenotypic Assessments in the DyW Mouse Model of Laminin-α2 Related Congenital Muscular Dystrophy. Journal of Neuromuscular Diseases, 4 (2). pp. 115-126. Fitter, Stephen and Matthews, Mary P. and Martin, Sally K. and Xie, Jianling and Ooi, Soo Siang and Walkley, Carl R. and Codrington, John D. and Ruegg, Markus A. and Hall, Michael N. and Proud, Christopher G. and Gronthos, Stan and Zannettino, Andrew C. W.. (2017) mTORC1 Plays an Important Role in Skeletal Development by Controlling Preosteoblast Differentiation. Molecular and Cellular Biology, 37 (7). e00668-16. Reinhard, Judith R. and Lin, Shuo and McKee, Karen K. and Meinen, Sarina and Crosson, Stephanie C. and Sury, Maurizio and Hobbs, Samantha and Maier, Geraldine and Yurchenco, Peter D. and Rüegg, Markus A.. (2017) Linker proteins restore basement membrane and correct LAMA2-related muscular dystrophy in mice. Science Translational Medicine, 9 (396). eaal4649. Kleinert, Maximilian and Parker, Benjamin L. and Fritzen, Andreas M. and Knudsen, Jonas R. and Jensen, Thomas E. and Kjøbsted, Rasmus and Sylow, Lykke and Ruegg, Markus and James, David E. and Richter, Erik A.. (2017) Mammalian target of rapamycin complex 2 regulates muscle glucose uptake during exercise in mice. Journal of Physiology, 595 (14). pp. 4845-4855. 2016Reinhard, Judith R. and Kriz, Alexander and Galic, Milos and Angliker, Nico and Rajalu, Mathieu and Vogt, Kaspar E. and Rüegg, Markus A.. (2016) The calcium sensor Copine-6 regulates spine structural plasticity and learning and memory. Nature Communications, 7. p. 11613. Guridi, Maitea and Kupr, Barbara and Romanino, Klaas and Lin, Shuo and Falcetta, Denis and Tintignac, Lionel and Rüegg, Markus A.. (2016) Alterations to mTORC1 signaling in the skeletal muscle differentially affect whole-body metabolism. Skeletal Muscle, 6 (13). pp. 1-14. Schell, Christoph and Kretz, Oliver and Liang, Wei and Kiefer, Betina and Schneider, Simon and Sellung, Dominik and Bork, Tillmann and Leiber, Christian and Rüegg, Markus A. and Mallidis, Con and Schlatt, Stefan and Mayerhofer, Artur and Huber, Tobias B. and Grahammer, Florian. (2016) The Rapamycin-Sensitive Complex of Mammalian Target of Rapamycin Is Essential to Maintain Male Fertility. American Journal of Pathology, 186 (2). pp. 324-336. Ruegsegger, Céline and Stucki, David M. and Steiner, Silvio and Angliker, Nico and Radecke, Julika and Keller, Eva and Zuber, Benoît and Rüegg, Markus A. and Saxena, Smita. (2016) Impaired mTORC1-Dependent Expression of Homer-3 Influences SCA1 Pathophysiology. Neuron, 89 (1). pp. 129-146. Shende, Pankaj and Xu, Lifen and Morandi, Christian and Pentassuglia, Laura and Heim, Philippe and Lebboukh, Sonia and Berthonneche, Corinne and Pedrazzini, Thierry and Kaufmann, Beat A. and Hall, Michael N. and Rüegg, Markus A. and Brink, Marijke. (2016) Cardiac mTOR complex 2 preserves ventricular function in pressure-overload hypertrophy. Cardiovascular Research, 109 (1). pp. 103-114. Kleinert, Maximilian and Parker, Benjamin L. and Chaudhuri, Rima and Fazakerley, Daniel J. and Serup, Annette and Thomas, Kristen C. and Krycer, James R. and Sylow, Lykke and Fritzen, Andreas M. and Hoffman, Nolan J. and Jeppesen, Jacob and Schjerling, Peter and Rüegg, Markus A. and Kiens, Bente and James, David E. and Richter, Erik A.. (2016) mTORC2 and AMPK differentially regulate muscle triglyceride content via Perilipin 3. Molecular Metabolism, 5 (8). pp. 646-655. Ding, Xiaolei and Bloch, Wilhelm and Iden, Sandra and Rüegg, Markus A. and Hall, Michael N. and Leptin, Maria and Partridge, Linda and Eming, Sabine A.. (2016) mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation. Nature Communications, 7. p. 13226. Castets, Perrine and Frank, Stephan and Sinnreich, Michael and Rüegg, Markus A.. (2016) "Get the Balance Right": Pathological Significance of Autophagy Perturbation in Neuromuscular Disorders. Journal of Neuromuscular Diseases, 3 (2). pp. 127-155. 2015Aimi, Fabio and Georgiopoulou, Stavroula and Kalus, Ina and Lehner, Fabienne and Hegglin, Alica and Limani, Përparim and Gomes de Lima, Vinicius and Rüegg, Markus A. and Hall, Michael N. and Lindenblatt, Nicole and Haas, Elvira and Battegay, Edouard J. and Humar, Rok. (2015) Endothelial Rictor is crucial for midgestational development and sustained and extensive FGF2-induced neovascularization in the adult. Scientific Reports, 5. p. 17705. Guridi, Maitea and Tintignac, Lionel A. and Lin, Shuo and Kupr, Barbara and Castets, Perrine and Rüegg, Markus A.. (2015) Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21. Science Signaling, 8 (402). ra113. Angliker, Nico and Burri, Michael and Zaichuk, Mariana and Fritschy, Jean-Marc and Rüegg, Markus A.. (2015) mTORC1 and mTORC2 have largely distinct functions in Purkinje cells. European Journal of Neuroscience, 42 (8). pp. 2595-2612. Zhang, Yina and Lin, Shuo and Karakatsani, Andromachi and Rüegg, Markus A. and Kröger, Stephan. (2015) Differential regulation of AChR clustering in the polar and equatorial region of murine muscle spindles. European Journal of Neuroscience, 41 (1). pp. 69-78. Lopez, Rubén J. and Mosca, Barbara and Treves, Susan and Maj, Marcin and Bergamelli, Leda and Calderon, Juan C. and Bentzinger, C. Florian and Romanino, Klaas and Hall, Michael N. and Rüegg, Markus A. and Delbono, Osvaldo and Caputo, Carlo and Zorzato, Francesco. (2015) Raptor ablation in skeletal muscle decreases Cav1.1 expression and affects the function of the excitation-contraction coupling supramolecular complex. Biochemical Journal, 466 (1). pp. 123-135. Venkatesh, A. and Ma, S. and Le, Y. Z. and Hall, M. N. and Rüegg, M. A. and Punzo, C.. (2015) Activated mTORC1 promotes long-term cone survival in retinitis pigmentosa mice. Journal of Clinical Investigation, 125 (4). pp. 1446-1458. Carr, T. D. and Feehan, R. P. and Hall, M. N. and Rüegg, M. A. and Shantz, L. M.. (2015) Conditional disruption of rictor demonstrates a direct requirement for mTORC2 in skin tumor development and continued growth of established tumors. Carcinogenesis, 36 (4). pp. 487-497. Martin, Sally K. and Fitter, Stephen and Dutta, Ankit K. and Matthews, Mary P. and Walkley, Carl R. and Hall, Michael N. and Ruegg, Markus A. and Gronthos, Stan and Zannettino, Andrew C. W.. (2015) Brief Report: The Differential Roles of mTORC1 and mTORC2 in Mesenchymal Stem Cell Differentiation. Stem cells, Vol. 33, H. 4. pp. 1359-1365. Ma, S. and Venkatesh, A. and Langellotto, F. and Le, Y. Z. and Hall, M. N. and Rüegg, M. A. and Punzo, C.. (2015) Loss of mTOR signaling affects cone function, cone structure and expression of cone specific proteins without affecting cone survival. Experimental Eye Research, 135. pp. 1-13. Tintignac, Lionel A. and Brenner, Hans-Rudolf and Rüegg, Markus A.. (2015) Mechanisms Regulating Neuromuscular Junction Development and Function and Causes of Muscle Wasting. Physiological Reviews, 95 (3). pp. 809-852. Domi, Teuta and Porrello, Emanuela and Velardo, Daniele and Capotondo, Alessia and Biffi, Alessandra and Tonlorenzi, Rossana and Amadio, Stefano and Ambrosi, Alessandro and Miyagoe-Suzuki, Yuko and Takeda, Shin'ichi and Ruegg, Markus A. and Previtali, Stefano Carlo. (2015) Mesoangioblast delivery of miniagrin ameliorates murine model of merosin-deficient congenital muscular dystrophy type 1A. Skeletal Muscle, 5 (30). pp. 1-17. Raffaella Willmann, Annamaria De Luca and Kanneboyina Nagaraju, and Markus A. Ruegg, . (2015) Best Practices and Standard Protocols as a Tool to Enhance Translation for Neuromuscular Disorders. Journal of Neuromuscular Diseases, 2 (2). pp. 113-117. 2014Chen, J. and Tu, X. and Esen, E. and Joeng, K. S. and Lin, C. and Arbeit, J. M. and Rüegg, M. A. and Hall, M. N. and Ma, L. and Long, F.. (2014) WNT7B promotes bone formation in part through mTORC1. PLoS Genetics, 10 (1). e1004145. Lebrun-Julien, F. and Bachmann, L. and Norrmén, C. and Trötzmüller, M. and Köfeler, H. and Rüegg, M. A. and Hall, M. N. and Suter, U.. (2014) Balanced mTORC1 activity in oligodendrocytes is required for accurate CNS myelination. Journal of Neuroscience, 34 (25). pp. 8432-8448. Grahammer, F. and Haenisch, N. and Steinhardt, F. and Sander, L. and Roerden, M. and Arnold, F. and Cordts, T. and Wanner, N. and Reichardt, W. and Kerjaschki, D. and Ruegg, M. A. and Hall, M. N. and Moulin, P. and Busch, H. and Boerries, M. and Walz, G. and Artunc, F. and Huber, T. B.. (2014) mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress. Proceedings of the National Academy of Sciences of the United States of America, 111 (27). E2817-E2826. Zhang, Lianjun and Tschumi, Benjamin O. and Corgnac, Stéphanie and Rüegg, Markus A. and Hall, Michael N. and Mach, Jean-Pierre and Romero, Pedro and Donda, Alena. (2014) Mammalian target of rapamycin complex 1 orchestrates invariant NKT cell differentiation and effector function. Journal of Immunology, 193 (4). pp. 1759-1765. Chou, Po-Chien and Oh, Won Jun and Wu, Chang-Chih and Moloughney, Joseph and Rüegg, Markus A. and Hall, Michael N. and Jacinto, Estela and Werlen, Guy. (2014) Mammalian target of rapamycin complex 2 modulates αβTCR processing and surface expression during thymocyte development. Journal of Immunology, 193 (3). pp. 1162-1170. Norrmén, C. and Figlia, G. and Lebrun-Julien, F. and Pereira, J. A. and Trötzmüller, M. and Köfeler, H. C. and Rantanen, V. and Wessig, C. and van Deijk, A. F. and Smit, A. B. and Verheijen, M. G. and Rüegg, M. A. and Hall, M. N. and Suter, U.. (2014) mTORC1 Controls PNS Myelination along the mTORC1-RXRγ-SREBP-Lipid Biosynthesis Axis in Schwann Cells. Cell Reports , 9 (2). pp. 646-660. Hettwer, Stefan and Lin, Shuo and Kucsera, Stefan and Haubitz, Monika and Oliveri, Filippo and Fariello, Ruggero G. and Ruegg, Markus A. and Vrijbloed, Jan W.. (2014) Injection of a soluble fragment of neural agrin (NT-1654) considerably improves the muscle pathology caused by the disassembly of the neuromuscular junction. PLoS ONE, 9 (2). e88739. Miloslavski, Rachel and Cohen, Elad and Avraham, Adam and Iluz, Yifat and Hayouka, Zvi and Kasir, Judith and Mudhasani, Rajini and Jones, Stephen N. and Cybulski, Nadine and Rüegg, Markus A. and Larsson, Ola and Gandin, Valentina and Rajakumar, Arjuna and Topisirovic, Ivan and Meyuhas, Oded. (2014) Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner. Journal of Molecular Cell Biology, 6 (3). pp. 255-266. Kleinert, Maximilian and Sylow, Lykke and Fazakerley, Daniel J. and Krycer, James R. and Thomas, Kristen C. and Oxbøll, Anne-Julie and Jordy, Andreas B. and Jensen, Thomas E. and Yang, Guang and Schjerling, Peter and Kiens, Bente and James, David E. and Ruegg, Markus A. and Richter, Erik A.. (2014) Acute mTOR inhibition induces insulin resistance and alters substrate utilization in vivo. Molecular Metabolism, 3 (6). pp. 630-641. Steiner, Esther and Enzmann, Gaby U. and Lyck, Ruth and Lin, Shuo and Rüegg, Markus A. and Kröger, Stephan and Engelhardt, Britta. (2014) The heparan sulfate proteoglycan agrin contributes to barrier properties of mouse brain endothelial cells by stabilizing adherens junctions. Cell and Tissue Research, 358 (2). pp. 465-479. 2013Bentzinger, C. Florian and Lin, Shuo and Romanino, Klaas and Castets, Perrine and Guridi, Maitea and Summermatter, Serge and Handschin, Christoph and Tintignac, Lionel A. and Hall, Michael N. and Rüegg, Markus A.. (2013) Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy. Skeletal muscle, Vol. 3, H. 1 , 6. Thomanetz, Venus and Angliker, Nico and Cloëtta, Dimitri and Lustenberger, Regula M. and Schweighauser, Manuel and Oliveri, Filippo and Suzuki, Noboru and Rüegg, Markus A.. (2013) Ablation of the mTORC2 component rictor in brain or Purkinje cells affects size and neuron morphology. The journal of cell biology, Vol. 201, H. 2. pp. 293-308. Cloëtta, Dimitri and Thomanetz, Venus and Baranek, Constanze and Lustenberger, Regula M. and Lin, Shuo and Oliveri, Filippo and Atanasoski, Suzana and Rüegg, Markus A.. (2013) Inactivation of mTORC1 in the Developing Brain Causes Microcephaly and Affects Gliogenesis. Journal of neuroscience, Vol. 33, H. 18. pp. 7799-7810. Castets, P. and Lin, S. and Rion, N. and Di Fulvio, S. and Romanino, K. and Guridi, M. and Frank, S. and Tintignac, L. A. and Sinnreich, M. and Ruegg, M. A.. (2013) Sustained activation of mTORC1 in skeletal muscle inhibits constitutive and starvation-induced autophagy and causes a severe, late-onset myopathy. Cell metabolism, Vol. 17, H. 5. pp. 731-744. Song, Jian and Lokmic, Zerina and Lämmermann, Tim and Rolf, Julia and Wu, Chuan and Zhang, Xueli and Hallmann, Rupert and Hannocks, Melanie-Jane and Horn, Nathalie and Ruegg, Markus A. and Sonnenberg, Arnoud and Georges-Labouesse, Elisabeth and Winkler, Thomas H. and Kearney, John F. and Cardell, Susanna and Sorokin, Lydia. (2013) Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survival. Proceedings of the National Academy of Sciences of the United States of America, 110 (31). pp. 2915-E2924. Castets, Perrine and Rüegg, Markus A.. (2013) MTORC1 determines autophagy through ULK1 regulation in skeletal muscle. Autophagy, 9 (9). pp. 1435-1437. Angliker, Nico and Rüegg, Markus A.. (2013) In vivo evidence for mTORC2-mediated actin cytoskeleton rearrangement in neurons. Bioarchitecture, 3 (4). pp. 113-118. 2012Hagiwara, Asami and Cornu, Marion and Cybulski, Nadine and Polak, Pazit and Betz, Charles and Trapani, Francesca and Terracciano, Luigi and Heim, Markus H. and Rüegg, Markus A. and Hall, Michael N.. (2012) Hepatic mTORC2 activates glycolysis and lipogenesis through akt, glucokinase, and SREBP1c. Cell Metabolism, 15 (5). pp. 725-738. Punga, Anna Rostedt and Ruegg, Markus A.. (2012) Signaling and aging at the neuromuscular synapse : lessons learnt from neuromuscular diseases. Current Opinion in Pharmacology, 12 (3). pp. 340-346. Blättler, Sharon M. and Cunningham, John T. and Verdeguer, Francisco and Chim, Helen and Haas, Wilhelm and Liu, Huifei and Romanino, Klaas and Rüegg, Markus A. and Gygi, Steven P. and Shi, Yang and Puigserver, Pere. (2012) Yin yang 1 deficiency in skeletal muscle protects against rapamycin-induced diabetic-like symptoms through activation of insulin/IGF signaling. Cell Metabolism, 15 (4). pp. 505-517. Meinen, Sarina and Lin, Shuo and Rüegg, Markus A. and Punga, Anna Rostedt. (2012) Fatigue and Muscle Atrophy in a Mouse Model of Myasthenia Gravis Is Paralleled by Loss of Sarcolemmal nNOS. PLoS one, Vol. 7, H. 8 , e44148. Blättler, Sharon M. and Verdeguer, Francisco and Liesa, Marc and Cunningham, John T. and Vogel, Rutger O. and Chim, Helen and Liu, Huifei and Romanino, Klaas and Shirihai, Orian S. and Vazquez, Francisca and Rüegg, Markus A. and Shi, Yang and Puigserver, Pere. (2012) Defective mitochondrial morphology and bioenergetic function in mice lacking the transcription factor Yin Yang 1 in skeletal muscle. Molecular and cellular biology, 32 (16). pp. 3333-3346. Meinen, Sarina and Lin, Shuo and Ruegg, Markus A.. (2012) Angiotensin II type 1 receptor antagonists alleviate muscle pathology in the mouse model for laminin-alpha2-deficient congenital muscular dystrophy (MDC1A). Skeletal muscle, Vol. 2, H. 1. p. 18. Steiner, Esther and Enzmann, Gaby U. and Lin, Shuo and Ghavampour, Sharang and Hannocks, Melanie-Jane and Zuber, Benoît and Rüegg, Markus A. and Sorokin, Lydia and Engelhardt, Britta. (2012) Loss of astrocyte polarization upon transient focal brain ischemia as a possible mechanism to counteract early edema formation. Glia, 60 (11). pp. 1646-1659. 2011Inoki, K. and Mori, H. and Wang, J. and Suzuki, T. and Hong, S. and Yoshida, S. and Blattner, S. M. and Ikenoue, T. and Ruegg, M. A. and Hall, M. N. and Kwiatkowski, D. J. and Rastaldi, M. P. and Huber, T. B. and Kretzler, M. and Holzman, L. B. and Wiggins, R. C. and Guan, K. -L.. (2011) mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice. Journal of Clinical Investigation, 121 (6). pp. 2181-2196. Godel, M. and Hartleben, B. and Herbach, N. and Liu, S. and Zschiedrich, S. and Lu, S. and Debreczeni-Mor, A. and Lindenmeyer, M. T. and Rastaldi, M. -P. and Hartleben, G. and Wiech, T. and Fornoni, A. and Nelson, R. G. and Kretzler, M. and Wanke, R. and Pavenstadt, H. and Kerjaschki, D. and Cohen, C. D. and Hall, M. N. and Ruegg, M. A. and Inoki, K. and Walz, G. and Huber, T. B.. (2011) Role of mTOR in podocyte function and diabetic nephropathy in humans and mice. Journal of Clinical Investigation, 121 (6). pp. 2197-2209. Shende, P. and Plaisance, I. and Morandi, C. and Pellieux, C. and Berthonneche, C. and Zorzato, F. and Krishnan, J. and Lerch, R. and Hall, M. N. and Ruegg, M. A. and Pedrazzini, T. and Brink, M.. (2011) Cardiac raptor ablation impairs adaptive hypertrophy, alters metabolic gene expression, and causes heart failure in mice. Circulation, 123 (10). pp. 1073-1082. Punga, A. R. and Lin, S. and Oliveri, F. and Meinen, S. and Ruegg, M. A.. (2011) Muscle-selective synaptic disassembly and reorganization in MuSK antibody positive MG mice. Experimental Neurology, 230 (2). pp. 207-217. Punga, A. R. and Maj, M. and Lin, S. and Meinen, S. and Ruegg, M. A.. (2011) MuSK levels differ between adult skeletal muscles and influence postsynaptic plasticity. The European journal of neuroscience, Vol. 33, H. 5. pp. 890-898. Meinen, Sarina and Lin, Shuo and Thurnherr, Raphael and Erb, Michael and Meier, Thomas and Rüegg, Markus A.. (2011) Apoptosis inhibitors and mini-agrin have additive benefits in congenital muscular dystrophy mice. EMBO Molecular Medicine, 3 (8). pp. 465-479. Rieker, Claus and Dev, Kumlesh K. and Lehnhoff, Katja and Barbieri, Samuel and Ksiazek, Iwona and Kauffmann, Sabine and Danner, Simone and Schell, Heinrich and Boden, Cindy and Ruegg, Markus A. and Kahle, Philipp J. and van der Putten, Herman and Shimshek, Derya R.. (2011) Neuropathology in mice expressing mouse alpha-synuclein. PLoS one, Vol. 6, H. 9 , e24834. Romanino, Klaas and Mazelin, Laetitia and Albert, Verena and Conjard-Duplany, Agnès and Lin, Shuo and Bentzinger, C. Florian and Handschin, Christoph and Puigserver, Pere and Zorzato, Francesco and Schaeffer, Laurent and Gangloff, Yann-Gaël and Rüegg, Markus A.. (2011) Myopathy caused by mammalian target of rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial function. Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, H. 51. pp. 20808-20813. 2010Rüegg, Markus A. and Glass, David J.. (2010) Molecular mechanisms and treatment options for muscle wasting eiseases. Annual Review of Pharmacology and Toxicology, 51. pp. 373-395. Escher, Claudia and Lochmüller, Hanns and Fischer, Dirk and Frank, Stephan and Reimann, Jens and Walter, Maggie C. and Ehrat, Markus and Ruegg, Markus A. and Gygax, Daniel. (2010) Reverse protein arrays as novel approach for protein quantification in muscular dystrophies. Neuromuscular disorders, 20. pp. 302-309. 2009Cybulski, N. and Polak, P. and Auwerx, J. and Ruegg, M. A. and Hall, M. N.. (2009) mTOR complex 2 in adipose tissue negatively controls whole-body growth. Proceedings of the National Academy of Sciences of the United States of America, 106 (24). pp. 9902-9907. Patursky-Polischuk, I. and Stolovich-Rain, M. and Hausner-Hanochi, M. and Kasir, J. and Cybulski, N. and Avruch, J. and Ruegg, M. A. and Hall, M. N. and Meyuhas, O.. (2009) The TSC-mTOR pathway mediates translational activation of TOP mRNAs by insulin largely in a raptor- or rictor-independent manner. Molecular and cellular biology, Vol. 29, H. 3. pp. 640-649. Huze, C. and Bauche, S. and Richard, P. and Chevessier, F. and Goillot, E. and Gaudon, K. and Ben Ammar, A. and Chaboud, A. and Grosjean, I. and Lecuyer, H. -A. and Bernard, V. and Rouche, A. and Alexandri, N. and Kuntzer, T. and Fardeau, M. and Fournier, E. and Brancaccio, A. and Ruegg, M. A. and Koenig, J. and Eymard, B. and Schaeffer, L. and Hantai, D.. (2009) Identification of an agrin mutation that causes congenital myasthenia and affects synapse function. American Journal of Human Genetics, 85 (2). pp. 155-167. Erb, M. and Meinen, S. and Barzaghi, P. and Sumanovski, L. T. and Courdier-Fruh, I. and Ruegg, M. A. and Meier, T.. (2009) Omigapil ameliorates the pathology of muscle dystrophy caused by laminin-α2 deficiency. Journal of pharmacology and experimental therapeutics, 331 (3). pp. 787-795. Willmann, Raffaella and Possekel, Stefanie and Dubach-Powell, Judith and Meier, Thomas and Rüegg, Markus A.. (2009) Mammalian animal models for Duchenne muscular dystrophy. Neuromuscular Disorders, 19 (4). pp. 241-249. Risson, Valérie and Mazelin, Laetitia and Roceri, Mila and Sanchez, Hervé and Moncollin, Vincent and Corneloup, Claudine and Richard-Bulteau, Hélène and Vignaud, Alban and Baas, Dominique and Defour, Aurélia and Freyssenet, Damien and Tanti, Jean-François and Le-Marchand-Brustel, Yannick and Ferrier, Bernard and Conjard-Duplany, Agnès and Romanino, Klaas and Bauché, Stéphanie and Hantaï, Daniel and Mueller, Matthias and Kozma, Sara C. and Thomas, George and Rüegg, Markus A. and Ferry, Arnaud and Pende, Mario and Bigard, Xavier and Koulmann, Nathalie and Schaeffer, Laurent and Gangloff, Yann-Gaël. (2009) Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy. The Journal of cell biology, Vol. 187, H. 6. pp. 859-874. 2008Reiterer, V. and Maier, S. and Sitte, H. H. and Kriz, A. and Ruegg, M. A. and Hauri, H. P. and Freissmuth, M. and Farhan, H.. (2008) Sec24- and ARFGAP1-dependent trafficking of GABA transporter-1 is a prerequisite for correct axonal targeting. Journal of Neuroscience, 28 (47). pp. 12453-12464. Lin, S. and Maj, M. and Bezakova, G. and Magyar, J. P. and Brenner, H. R. and Ruegg, M. A.. (2008) Muscle-wide secretion of a miniaturized form of neural agrin rescues focal neuromuscular innervation in agrin mutant mice. Proceedings of the National Academy of Sciences of the United States of America, 105 (32). pp. 11406-11411. Lin, S. and Landmann, L. and Ruegg, M. A. and Brenner, H. R.. (2008) The role of nerve- versus muscle-derived factors in mammalian neuromuscular junction formation. Journal of neuroscience, Vol. 28, H. 13. pp. 3333-3340. Polak, P. and Cybulski, N. and Feige, J. N. and Auwerx, J. and Ruegg, M. A. and Hall, M. N.. (2008) Adipose-Specific Knockout of raptor Results in Lean Mice with Enhanced Mitochondrial Respiration. Cell Metabolism, Vol. 8, H. 5. pp. 399-410. Bentzinger, C. F. and Romanino, K. and Cloetta, D. and Lin, S. and Mascarenhas, J. B. and Oliveri, F. and Xia, J. and Casanova, E. and Costa, C. F. and Brink, M. and Zorzato, F. and Hall, M. N. and Ruegg, M. A.. (2008) Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy. Cell Metabolism, Vol. 8, H. 5. pp. 411-424. 2007Hausser, H. -J. and Ruegg, M. A. and Brenner, R. E. and Ksiazek, I.. (2007) Agrin is highly expressed by chondrocytes and is required for normal growth. Histochemistry and Cell Biology, 127 (4). pp. 363-374. Plachta, N. and Annaheim, C. and Bissiere, S. and Lin, S. and Ruegg, M. and Hoving, S. and Muller, D. and Poirier, F. and Bibel, M. and Barde, Y. -A.. (2007) Identification of a lectin causing the degeneration of neuronal processes using engineered embryonic stem cells. Nature neuroscience, Vol. 10, H. 6. pp. 712-719. Meinen, S. and Barzaghi, P. and Lin, S. and Lochmuller, H. and Ruegg, M. A.. 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