Items where contributor is "Schwardt, Oliver"
2017Mayer, Katharina and Eris, Deniz and Schwardt, Oliver and Sager, Christoph P. and Rabbani, Said and Kleeb, Simon and Ernst, Beat. (2017) Urinary Tract Infection: Which Conformation of the Bacterial Lectin FimH Is Therapeutically Relevant? Journal of Medicinal Chemistry, 60 (13). pp. 5646-5662. Frei, Priska and Pang, Lijuan and Silbermann, Marleen and Eriş, Deniz and Mühlethaler, Tobias and Schwardt, Oliver and Ernst, Beat. (2017) Target-directed Dynamic Combinatorial Chemistry: A Study on Potentials and Pitfalls as Exemplified on a Bacterial Target. Chemistry - A European Journal, 23 (48). pp. 11570-11577. 2016Kleeb, Simon and Jiang, Xiaohua and Frei, Priska and Sigl, Anja and Bezençon, Jacqueline and Bamberger, Karen and Schwardt, Oliver and Ernst, Beat. (2016) FimH Antagonists: Phosphate Prodrugs Improve Oral Bioavailability. Journal of Medicinal Chemistry, 59 (7). pp. 3163-3182. Eris, Deniz and Preston, Roland C. and Scharenberg, Meike and Hulliger, Fabian and Abgottspon, Daniela and Pang, Lijuan and Jiang, Xiaohua and Schwardt, Oliver and Ernst, Beat. (2016) The Conformational Variability of FimH: Which Conformation Represents the Therapeutic Target? ChemBioChem, 17 (11). pp. 1012-1020. Schönemann, Wojciech and Kleeb, Simon and Dätwyler, Philipp and Schwardt, Oliver and Ernst, Beat. (2016) Prodruggability of Carbohydrates - Oral FimH Antagonists. Canadian Journal of Chemistry, 94 (11). pp. 909-919. 2015Kleeb, Simon and Pang, Lijuan and Mayer, Katharina and Eris, Deniz and Sigl, Anja and Preston, Roland C. and Zihlmann, Pascal and Sharpe, Timothy and Jakob, Roman P. and Abgottspon, Daniela and Hutter, Aline S. and Scharenberg, Meike and Jiang, Xiaohua and Navarra, Giulio and Rabbani, Said and Smiesko, Martin and Lüdin, Nathalie and Bezençon, Jacqueline and Schwardt, Oliver and Maier, Timm and Ernst, Beat. (2015) FimH Antagonists: Bioisosteres To Improve the in Vitro and in Vivo PK/PD Profile. Journal of Medicinal Chemistry, 58 (5). pp. 2221-2239. Fiege, Brigitte and Rabbani, Said and Preston, Roland C. and Jakob, Roman P. and Zihlmann, Pascal and Schwardt, Oliver and Jiang, Xiaohua and Maier, Timm and Ernst, Beat. (2015) The Tyrosine Gate of the Bacterial Lectin FimH : a Conformational Analysis by NMR Spectroscopy and X-ray Crystallography. ChemBioChem, 16 (8). pp. 1235-1246. Schwardt, Oliver and Kelm, Soerge and Ernst, Beat. (2015) SIGLEC-4 (MAG) Antagonists: From the Natural Carbohydrate Epitope to Glycomimetics. Topics in Current Chemistry, 367. pp. 151-200. 2013Egger, Jonas and Weckerle, Céline and Cutting, Brian and Schwardt, Oliver and Rabbani, Said and Lemme, Katrin and Ernst, Beat. (2013) Nanomolar E-selectin antagonists with prolonged half-lives by a fragment-based approach. Journal of the American Chemical Society, 135 (26). pp. 9820-9828. Scharenberg, Meike and Jiang, Xiaohua and Pang, Lijuan and Navarra, Giulio and Rabbani, Said and Binder, Florian and Schwardt, Oliver and Ernst, Beat. (2013) Kinetic properties of carbohydrate–lectin interactions: FimH antagonists. ChemMedChem, 9 (1). pp. 78-83. 2012Mesch, Stefanie and Lemme, Katrin and Wittwer, Matthias and Koliwer-Brandl, Hendrik and Schwardt, Oliver and Kelm, Sorge and Ernst, Beat. (2012) From a Library of MAG Antagonists to Nanomolar CD22 Ligands. ChemMedChem, 7 (1). pp. 134-143. Schwizer, Daniel and Patton, John T. and Cutting, Brian and Smiesko, Martin and Wagner, Beatrice and Kato, Ako and Weckerle, Céline and Binder, Florian P. C. and Rabbani, Said and Schwardt, Oliver and Magnani, John L. and Ernst, Beat. (2012) Pre-organization of the core structure of E-selectin antagonists. Chemistry - A European Journal, 18 (5). pp. 1342-1351. Pang, Lijuan and Kleeb, Simon and Lemme, Katrin and Rabbani, Said and Scharenberg, Meike and Zalewski, Adam and Schädler, Florentina and Schwardt, Oliver and Ernst, Beat. (2012) FimH Antagonists: Structure-Activity and Structure-Property Relationships for Biphenyl α-D-Mannopyranosides. ChemMedChem, 7 (8). pp. 1404-1422. Jiang, Xiaohua and Abgottspon, Daniela and Kleeb, Simon and Rabbani, Said and Scharenberg, Meike and Wittwer, Matthias and Haug, Martina and Schwardt, Oliver and Ernst, Beat. (2012) Anti-adhesion therapy for urinary tract infections - a balanced PK/PD-profile proved to be key for success. Journal of Medicinal Chemistry, 55 (10). pp. 4700-4713. 2011Schwardt, Oliver and Rabbani, Said and Hartmann, Margrit and Abgottspon, Daniela and Wittwer, Matthias and Kleeb, Simon and Zalewski, Adam and Smiesko, Martin and Cutting, Brian and Ernst, Beat. (2011) Design, Synthesis and Biological Evaluation of Mannosyl Triazoles as FimH Antagonists. Bioorganic & Medicinal Chemistry, 19 (21). pp. 6454-6473. Scharenberg, Meike and Abgottspon, Daniela and Cicek, Evelin and Jiang, Xiaohua and Schwardt, Oliver and Rabbani, Said and Ernst, Beat. (2011) A Flow Cytometry-based Assay for Screening FimH Antagonists. Assay and Drug Development Technologies, 9 (5). pp. 455-464. 2010Ernst, Beat and Schwardt, Oliver and Mesch, Stefanie and Wittwer, Matthias and Rossato, Gianluca and Vedani, Angelo. (2010) From the ganglioside GQ1ba to glycomimetic antagonists of the myelin-associated glycoprotein (MAG). Chimia, 64 (1-2). pp. 17-22. Mesch, Stefanie and Moser, D. and Strasser, Daniel and Kelm, A. and Cutting, Brian and Rossato, Gianluca and Vedani, Angelo and Koliwer-Brandl, H. and Wittwer, Matthias and Rabbani, Said and Schwardt, Oliver and Kelm, S. and Ernst Beat, . (2010) Low Molecular Weight Antagonists of the Myelin-associated Glycoprotein : Synthesis, Docking and Biological Evaluation. Journal of Medicinal Chemistry, Vol. 53, no. 4. pp. 1597-1615. Titz, Alexander and Patton, John and Smiesko, Martin and Radic, Zorana and Schwardt, Oliver and Magnani, John L. and Ernst, Beat. (2010) Probing the Carbohydrate Recognition Domain of E-Selectin : The Importance of the Acid Orientation in sLex Mimetics. Bioorganic & Medicinal Chemistry, 18 (1). pp. 19-27. Shelke, Sachin V. and Cutting, Brian and Jiang, Xiaohua and Koliwer-Brandl, Hendrik and Strasser, Daniel S. and Schwardt, Oliver and Kelm, Soerge and Ernst Beat, . (2010) A Fragment-Based In Situ Combinatorial Approach To Identify High-Affinity Ligands for Unknown Binding Sites. Angewandte Chemie. International edition in English, Vol. 49. pp. 5721-5725. Abgottspon, Daniela and Rölli, Gina and Hosch, Lucie and Steinhuber, Andrea and Jiang, Xiaohua and Schwardt, Oliver and Cutting, Brian and Smiesko, Martin and Jenal, Urs and Ernst, Beat and Trampuz, Andrej. (2010) Development of an aggregation assay to screen FimH antagonists. Journal of Microbiological Methods, 82 (3). pp. 249-255. Schwardt, Oliver and Koliwer-Brandl, Hendrik and Zimmerli, Raphael and Mesch, Stefanie and Rossato, Gianluca and Spreafico, Morena and Vedani, Angelo and Kelm, Sorge and Ernst, Beat. (2010) Design, synthesis, biological evaluation and modeling of a non-carbohydrate antagonist of the myelin-associated glycoprotein. Bioorganic & Medicinal Chemistry, 18 (20). pp. 7239-7251. Mesch, Stefanie and Lemme, Katrin and Koliwer-Brandl, Hendrik and Strasser, Daniel and Schwardt, Oliver and Kelm, Sorge and Ernst, Beat. (2010) Kinetic and thermodynamic properties of MAG antagonists. Carbohydrate Research, 345 (10). pp. 1348-1359. Rabbani, Said and Jiang, Xiaohua and Schwardt, Oliver and Ernst, Beat. (2010) Expression of the Carbohydrate Recognition Domain of FimH and Development of a Competitive Binding Assay. Analytical Biochemistry , 407. pp. 188-195. Klein, Tobias and Abgottspon, Daniela and Wittwer, Matthias and Rabbani, Said and Herold, Janno and Jiang, Xiaohua and Kleeb, Simon and Lüthi, Christine and Scharenberg, Meike and Bezençcon, Jacqueline and Gubler, Erich and Pang, Lijuan and Smiesko, Martin and Cutting, Brian and Schwardt, Oliver and Ernst, Beat. (2010) FimH Antagonists for the Oral Treatment of Urinary Tract Infections : From Design and Synthesis to In Vitro and In Vivo Evaluation. Journal of Medicinal Chemistry, 53 (24). pp. 8627-8641. 2009Schwardt, Oliver and Gäthje, H. and Gao, G. -P. and Mesch, Stefanie and von Orelli, J. and Spreafico, Morena and Vedani, Angelo and Kelm, S. and Ernst Beat, . (2009) Examination of the biological role of the a(2-6)-linked sialic acid in gangliosides binding to the myelin-associated glycoprotein (MAG). Journal of Medicinal Chemistry, Vol. 52, no. 4. pp. 989-1004. Stokmaier, Daniela and Khorev, Oleg and Böni, F. and Gentner, M. and Cutting, Brian and Born, Rita and Schwingruber, K. and Ernst, T. O. G. and Wittwer, Matthias and Ricklin, Daniel and Spreafico, Morena and Vedani, Angelo and Rabbani, Said and Schwardt, Oliver and Ernst, Beat. (2009) Design, synthesis and evaluation of monovalent ligands for the asialoglycoprotein receptor (ASGP-R). Bioorganic & Medicinal Chemistry, 17 (20). pp. 7254-7264. |
