Browse by Basel Contributors ID
2018Farahat, Abdelbasset A. and Ismail, Mohamed A. and Kumar, Arvind and Wenzler, Tanja and Brun, Reto and Paul, Ananya and Wilson, W. David and Boykin, David W.. (2018) Indole and benzimidazole bichalcophenes: synthesis, DNA binding and antiparasitic activity. European journal of medicinal chemistry, 143. pp. 1590-1596. Schies, C. and Seupel, R. and Feineis, D. and Gehrold, A. and Schraut, M. and Kaiser, M. and Brun, R. and Bringmann, G.. (2018) Biomimetic total synthesis of mbandakamine A and further antiplasmodial naphthylisoquinoline dimers. ChemistrySelect, 3. pp. 940-945. 2017Farahat, A. A. and Kumar, A. and Say, M. and Wenzler, T. and Brun, R. and Paul, A. and Wilson, D. W. and Boykin, D. W.. (2017) Exploration of DAPI analogues : synthesis, antitrypanosomal activity, DNA binding and fluorescence properties. European journal of medicinal chemistry, 128. pp. 70-78. Li, Jun and Seupel, Raina and Feineis, Doris and Mudogo, Virima and Kaiser, Marcel and Brun, Reto and Brünnert, Daniela and Chatterjee, Manik and Seo, Ean-Jeong and Efferth, Thomas and Bringmann, Gerhard. (2017) Dioncophyllines C2, D2, and F and related naphthylisoquinoline alkaloids from the congolese liana Ancistrocladus ileboensis with potent activities against Plasmodium falciparum and against multiple myeloma and leukemia cell lines. Journal of natural products, 80 (2). pp. 443-458. Lombe, Blaise Kimbadi and Bruhn, Torsten and Feineis, Doris and Mudogo, Virima and Brun, Reto and Bringmann, Gerhard. (2017) Cyclombandakamines A1 and A2, oxygen-bridged naphthylisoquinoline dimers from a congolese Ancistrocladus liana. Organic letters, 19 (6). pp. 1342-1345. Kimani, Njogu M. and Matasyoh, Josphat C. and Kaiser, Marcel and Brun, Reto and Schmidt, Thomas J.. (2017) Anti-trypanosomatid elemanolide sesquiterpene lactones from Vernonia lasiopus O. Hoffm. Molecules, 22 (4). E597. Gillingwater, Kirsten and Kunz, Christina and Braghiroli, Christiane and Boykin, David W. and Tidwell, Richard R. and Brun, Reto. (2017) In vitro, ex vivo and in vivo activity of diamidines against Trypanosoma congolense and Trypanosoma vivax. Antimicrobial agents and chemotherapy, 61 (5). e02356-16. Tran, Huu-Anh and Zheng, Zhaoyan and Wen, Xianghui and Manivannan, Srinivasan and Pastor, Arnaud and Kaiser, Marcel and Brun, Reto and Snyder, Floyd F. and Back, Thomas G.. (2017) Synthesis and activity of nucleoside-based antiprotozoan compounds. Bioorganic & medicinal chemistry, 25 (7). pp. 2091-2104. Althaus, Julia B. and Malyszek, Claudine and Kaiser, Marcel and Brun, Reto and Schmidt, Thomas J.. (2017) Alkamides from Anacyclus pyrethrum L. and their in vitro antiprotozoal activity. Molecules, 22 (5). p. 796. Nnadi, Charles Okeke and Nwodo, Ngozi Justina and Kaiser, Marcel and Brun, Reto and Schmidt, Thomas J.. (2017) Steroid Alkaloids from Holarrhena africana with Strong Activity against Trypanosoma brucei rhodesiense. Molecules, 22 (7). E1129. Bringmann, Gerhard and Seupel, Raina and Feineis, Doris and Xu, Minjuan and Zhang, Guoliang and Kaiser, Marcel and Brun, Reto and Seo, Ean-Jeong and Efferth, Thomas. (2017) Antileukemic ancistrobenomine B and related 5,1'-coupled naphthylisoquinoline alkaloids from the Chinese liana Ancistrocladus tectorius. Fitoterapia, 121. pp. 76-85. Tshitenge, Dieudonné Tshitenge and Feineis, Doris and Mudogo, Virima and Kaiser, Marcel and Brun, Reto and Bringmann, Gerhard. (2017) Antiplasmodial ealapasamines A-C,'mixed' naphthylisoquinoline dimers from the Central African liana Ancistrocladus ealaensis. Scientific Reports, 7. p. 5767. Pagliero, Romina J. and Kaiser, Marcel and Brun, Reto and Nieto, Marcelo J. and Mazzieri, María R.. (2017) Lead selection of antiparasitic compounds from a focused library of benzenesulfonyl derivatives of heterocycles. Bioorganic & medicinal chemistry, 27 (17). pp. 3945-3949. Akama, T. and Zhang, Y. K. and Freund, Y. R. and Berry, P. and Lee, J. and Easom, E. E. and Jacobs, R. T. and Plattner, J. J. and Witty, M. J. and Peter, R. and Rowan, T. G. and Gillingwater, K. and Brun, R. and Nare, B. and Mercer, L. and Xu, M. and Wang, J. and Liang, H.. (2017) Identification of a 4-fluorobenzyl L-valinate amide benzoxaborole (AN11736) as a potential development candidate for the treatment of Animal African Trypanosomiasis (AAT). Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, 28. pp. 6-10. Greve, Hippolyt L. and Kaiser, Marcel and Brun, Reto and Schmidt, Thomas J.. (2017) Terpenoids from the oleo-gum-resin of Boswellia serrata and their antiplasmodial effects In Vitro. Planta medica, 83 (14-15). pp. 1214-1226. Lombe, Blaise Kimbadi and Bruhn, Torsten and Feineis, Doris and Mudogo, Virima and Brun, Reto and Bringmann, Gerhard. (2017) Antiprotozoal spirombandakamines A1 and A2, fused naphthylisoquinoline dimers from a congolese Ancistrocladus plant. Organic Letters, 19 (24). pp. 6740-6743. 2016Faist, J. and Seebacher, W. and Saf, R. and Brun, R. and Kaiser, M. and Weis, R.. (2016) New derivatives of bicyclic diamines with antiprotozoal activity. Monatshefte für Chemie, 147 (2). pp. 369-381. Wenzler, Tanja and Schumann Burkard, Gabriela and S. Schmidt, Remo and Mäser, Pascal and Bergner, Andreas and Roditi, Isabel and Brun, Reto. (2016) A new approach to chemotherapy : drug-induced differentiation kills African trypanosomes. Scientific Reports, 6. p. 22451. Tasdemir, D. and Sen, R. and Bergonzi, M. C. and Demirci, B. and Bilia, A. R. and Baser, K. H. C. and Brun, R. and Chatterjee, M.. (2016) Rapid chemical analysis and antiprotozoal effect of the solvent extracts and the essential oil of Artemisia indica. Planta medica, 81 (16). pp. 1547-1548. Patrick, Donald A. and Wenzler, Tanja and Yang, Sihyung and Weiser, Patrick T. and Wang, Michael Zhuo and Brun, Reto and Tidwell, Richard R.. (2016) Synthesis of novel amide and urea derivatives of thiazol-2-ethylamines and their activity against Trypanosoma brucei rhodesiense. Bioorganic & medicinal chemistry, 24 (11). pp. 2451-2465. Zheng, Zhaoyan and Tran, Huu-Anh and Manivannan, Srinivasan and Wen, Xianghui and Kaiser, Marcel and Brun, Reto and Snyder, Floyd F. and Back, Thomas G.. (2016) Novel nucleoside-based antimalarial compounds. Bioorganic & medicinal chemistry letters, 26 (12). pp. 2861-2865. Vanden Eynde, J. J. and Mayence, A. and Mottamal, M. and Bacchi, C. J. and Yarlett, N. and Kaiser, M. and Brun, R. and Huang, T. L.. (2016) Alkanediamide-linked bisbenzamidines are promising antiparasitic agents. Pharmaceuticals, 9 (2). pp. 1-11. Vahermo, M. and Krogerus, S. and Nasereddin, A. and Kaiser, M. and Brun, R. and Jaffe, C. L. and Yli-Kauhaluoma, J. and Moreira, V. M.. (2016) Antiprotozoal activity of dehydroabietic acid derivatives against Leishmania denovani and Trypanosoma cruzi. MedChemComm, 7 (3). pp. 457-463. Le Bihan, Amélie and de Kanter, Ruben and Angulo-Barturen, Iñigo and Binkert, Christoph and Boss, Christoph and Brun, Reto and Brunner, Ralf and Buchmann, Stephan and Burrows, Jeremy and Dechering, Koen J. and Delves, Michael and Ewerling, Sonja and Ferrer, Santiago and Fischli, Christoph and Gamo-Benito, Francisco Javier and Gnädig, Nina F. and Heidmann, Bibia and Jiménez-Díaz, María Belén and Leroy, Didier and Martínez, Maria Santos and Meyer, Solange and Moehrle, Joerg J. and Ng, Caroline L. and Noviyanti, Rintis and Ruecker, Andrea and Sanz, Laura María and Sauerwein, Robert W. and Scheurer, Christian and Schleiferboeck, Sarah and Sinden, Robert and Snyder, Christopher and Straimer, Judith and Wirjanata, Grennady and Marfurt, Jutta and Price, Ric N. and Weller, Thomas and Fischli, Walter and Fidock, David A. and Clozel, Martine and Wittlin, Sergio. (2016) Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose–Efficacy Modeling. PLoS medicine, 13 (10). e1002138. Nogueira, Mauro S. and Da Costa, Fernando B. and Brun, Reto and Kaiser, Marcel and Schmidt, Thomas J.. (2016) Ent-pimarane and ent-kaurane diterpenes from Aldama discolor (asteraceae) and their antiprotozoal activity. Molecules, 21 (9). p. 1237. Ahmad, Sarfraz and Seebacher, Werner and Faist, Johanna and Kaiser, Marcel and Brun, Reto and Saf, Robert and Weis, Robert. (2016) The antiprotozoal potencies of newly prepared 3-azabicyclo[3.2.2]nonanes. Archives of pharmacal research, 39 (10). pp. 1391-1403. Bringmann, Gerhard and Seupel, Raina and Feineis, Doris and Zhang, Guoliang and Xu, Minjuan and Wu, Jun and Kaiser, Marcel and Brun, Reto and Seo, Ean-Jeong and Efferth, Thomas. (2016) Ancistectorine D, a naphthylisoquinoline alkaloid with antiprotozoal and antileukemic activities, and further 5,8'- and 7,1'-linked metabolites from the Chinese liana Ancistrocladus tectorius. Fitoterapia, 115. pp. 1-8. Boss, Christoph and Aissaoui, Hamed and Amaral, Nathalie and Bauer, Aude and Bazire, Stephanie and Binkert, Christoph and Brun, Reto and Bürki, Cédric and Ciana, Claire-Lise and Corminboeuf, Olivier and Delahaye, Stephane and Dollinger, Claire and Fischli, Christoph and Fischli, Walter and Flock, Alexandre and Frantz, Marie-Céline and Girault, Malory and Grisostomi, Corinna and Friedli, Astrid and Heidmann, Bibia and Hinder, Claire and Jacob, Gael and Le Bihan, Amelie and Malrieu, Sophie and Mamzed, Saskia and Merot, Aurelien and Meyer, Solange and Peixoto, Sabrina and Petit, Nolwenn and Siegrist, Romain and Trollux, Julien and Weller, Thomas and Wittlin, Sergio. (2016) Discovery and characterization of ACT-451840 : an antimalarial drug with a novel mechanism of action. ChemMedChem, 11 (18). pp. 1995-2014. Karaaslan, Cigdem and Kaiser, Marcel and Brun, Reto and Göker, Hakan. (2016) Synthesis and potent antiprotozoal activity of mono/di amidino 2-anilinobenz-imidazoles versus Plasmodium falciparum and Trypanosoma brucei rhodesiense. Bioorganic and Medicinal Chemistry, 24 (18). pp. 4038-4044. Faist, Johanna and Seebacher, Werner and Saf, Robert and Brun, Reto and Kaiser, Marcel and Weis, Robert. (2016) Antiprotozoal activity of bicycles featuring a dimethylamino group at their bridgehead. Bioorganic & medicinal chemistry, 24 (16). pp. 3781-3789. Wolkinger, V. and Ahmad, S. and Seebacher, W. and Faist, J. and Saf, R. and Kaiser, M. and Brun, R. and Weis, R.. (2016) New diaryl-substituted azabicyclo[3.2.2]nonanes and their antiprotozoal potencies. Monatshefte für Chemie, 147 (10). pp. 1721-1735. Farahat, Abdelbasset A. and Bennett-Vaughn, Cheree and Mineva, Ekaterina M. and Kumar, Arvind and Wenzler, Tanja and Brun, Reto and Liu, Yang and Wilson, W. David and Boykin, David W.. (2016) Synthesis, DNA binding and antitrypanosomal activity of benzimidazole analogues of DAPI. Bioorganic & medicinal chemistry letters, 26 (24). pp. 5907-5910. Seupel, Raina and Hertlein-Amslinger, Barbara and Gulder, Tanja and Stawski, Philipp and Kaiser, Marcel and Brun, Reto and Bringmann, Gerhard. (2016) Directed synthesis of all four pure stereoisomers of the N,C-Coupled naphthylisoquinoline alkaloid ancistrocladinium A. Organic letters, 18 (24). pp. 6508-6511. 2015Thuita, John K. and Wolf, Kristina K. and Murilla, Grace A. and Bridges, Arlene S. and Boykin, David W. and Mutuku, James N. and Liu, Qiang and Jones, Susan K. and Gem, Charles O. and Ching, Shelley and Tidwell, Richard R. and Wang, Michael Z. and Paine, Mary F. and Brun, Reto. (2015) Chemotherapy of second stage human African trypanosomiasis : comparison between the parenteral diamidine DB829 and its oral prodrug DB868 in vervet monkeys. PLoS neglected tropical diseases, Vol. 9, H. 2 , e3409. De Mieri, M. and Kaiser, M. and Brun, R. and Thormann, U. and Imanidis, G. and Hamburger, M.. (2015) Anti-trypanosomal cadinanes synthesized by transannular cyclization of the natural sesquiterpene lactone nobilin. Bioorganic & medicinal chemistry, 23 (7). pp. 1521-1529. Nwodo, Ngozi and Okoye, Festus and Lai, Daowan and Debbab, Abdesammed and Kaiser, Marcel and Brun, Reto and Proksch, Peter. (2015) Evaluation of the in vitro trypanocidal activity of methylated flavonoid constituents of Vitex simplicifolia leaves. BMC complementary and alternative medicine, Vol. 15 , 82. Seebacher, Werner and Wolkinger, Volker and Faist, Johanna and Kaiser, Marcel and Brun, Reto and Saf, Robert and Bucar, Franz and Gröblacher, Barbara and Brantner, Adelheid and Merino, Virginia and Kalia, Yogeshvar and Scapozza, Leonardo and Perozzo, Remo and Weis, Robert. (2015) Synthesis of 3-azabicyclo[3.2.2]nonanes and their antiprotozoal activities. Bioorganic & medicinal chemistry letters, Vol. 25, H. 7. pp. 1390-1393. Ellendorff, Therese and Brun, Reto and Kaiser, Marcel and Sendker, Jandirk and Schmidt, Thomas J.. (2015) PLS-prediction and confirmation of hydrojuglone glucoside as the antitrypanosomal constituent of "Juglans spp.". Molecules, Vol. 20, H. 6. pp. 10082-10094. Thao, Nguyen Phuong and Luyen, Bui Thi Thuy and Brun, Reto and Kaiser, Marcel and Van Kiem, Phan and Van Minh, Chau and Schmidt, Thomas J. and Kang, Jong Seong and Kim, Young Ho. (2015) Anti-protozoal activities of cembrane-type diterpenes from Vietnamese soft corals. Molecules, Vol. 20, H. 7. pp. 12459-12468. Kaiser, Marcel and Mäser, Pascal and Tadoori, Leela Pavan and Ioset, Jean-Robert and Brun, Reto. (2015) Antiprotozoal activity profiling of approved drugs : a starting point toward drug repositioning. PLoS one, Vol. 10, H. 8 , e0135556. Montesino, Núria Llurba and Kaiser, Marcel and Brun, Reto and Schmidt, Thomas J.. (2015) Search for antiprotozoal activity in herbal medicinal preparations : new natural leads against neglected tropical diseases. Molecules, Vol. 20, H. 8. pp. 14118-14138. Ahmad, Sarfraz and Seebacher, Werner and Wolkinger, Volker and Presser, Armin and Faist, Johanna and Kaiser, Marcel and Brun, Reto and Saf, Robert and Weis, Robert. (2015) Synthesis and antiprotozoal activities of new 3-azabicyclo[3.2.2]nonanes. Archives of pharmacal research, Vol. 38, H. 8. pp. 1455-1467. Herrmann, Fabian C. and Lenz, Mairin and Jose, Joachim and Kaiser, Marcel and Brun, Reto and Schmidt, Thomas J.. (2015) In silico identification and in vitro activity of novel natural inhibitors of Trypanosoma brucei glyceraldehyde-3-phosphate-dehydrogenase. Molecules, Vol. 20, H. 9. pp. 16154-16169. Hemberger, Yasmin and Zhang, Guoliang and Brun, Reto and Kaiser, Marcel and Bringmann, Gerhard. (2015) Highly antiplasmodial non-natural oxidative products of dioncophylline A: synthesis, absolute configuration, and conformational stability. Chemistry, a European journal, 21 (41). pp. 14507-14518. Woodland, Andrew and Thompson, Stephen and Cleghorn, Laura A. T. and Norcross, Neil and De Rycker, Manu and Grimaldi, Raffaella and Hallyburton, Irene and Rao, Bhavya and Norval, Suzanne and Stojanovski, Laste and Brun, Reto and Kaiser, Marcel and Frearson, Julie A. and Gray, David W. and Wyatt, Paul G. and Read, Kevin D. and Gilbert, Ian H.. (2015) Discovery of inhibitors of Trypanosoma brucei by phenotypic screening of a focused protein kinase library. ChemMedChem, 10 (11). pp. 1809-1820. Tasdemir, Deniz and Tierney, Michelle and Sen, Rupashree and Bergonzi, Maria Camilla and Demirci, Betül and Bilia, Anna Rita and Baser, Kemal Hüsnü Can and Brun, Reto and Chatterjee, Mitali. (2015) Antiprotozoal effect of Artemisia indica extracts and essential oil. Planta medica, 81 (12-13). pp. 1029-1037. Rodenko, Boris and Wanner, Martin J. and Alkhaldi, Abdulsalam A. M. and Ebiloma, Godwin U. and Barnes, Rebecca L. and Kaiser, Marcel and Brun, Reto and McCulloch, Richard and Koomen, Gerrit-Jan and de Koning, Harry P.. (2015) Targeting the parasite's DNA with methyltriazenyl purine analogs is a safe, selective, and efficacious antitrypanosomal strategy. Antimicrobial agents and chemotherapy, 59 (11). pp. 6708-6716. Prati, Federica and Bergamini, Christian and Molina, Maria Teresa and Falchi, Federico and Cavalli, Andrea and Kaiser, Marcel and Brun, Reto and Fato, Romana and Bolognesi, Maria Laura. (2015) 2-Phenoxy-1,4-naphthoquinones : from a multitarget antitrypanosomal to a potential antitumor profile. Journal of medicinal chemistry, 58 (16). pp. 6422-6434. 2014Mokoka, Tsholofelo A. and Peter, Xolani K. and Fouche, Gerda and Moodley, Nivan and Adams, Michael and Hamburger, Matthias and Kaiser, Marcel and Brun, Reto and Maharaj, Vinesh and Koorbanally, Neil. (2014) Antileishmanial activity of 12-methoxycarnosic acid from Salvia repens Buch. ex Benth. (Lamiaceae). South African journal of botany, Vol. 90. pp. 93-95. Hata, Yoshie and Ebrahimi, Samad Nejad and De Mieri, Maria and Zimmermann, Stefanie and Mokoka, Tsholofelo and Naidoo, Dashnie and Fouche, Gerda and Maharaj, Vinesh and Kaiser, Marcel and Brun, Reto and Potterat, Olivier and Hamburger, Matthias. (2014) Antitrypanosomal isoflavan quinones from Abrus precatorius. Fitoterapia, Vol. 93. pp. 81-87. Weis, R. and Seebacher, W. and Brun, R. and Kaiser, M. and Saf, R. and Faist, J.. (2014) 4-Aminobicyclo[2.2.2]octan-2-yl 4-aminobutanoates with antiprotozoal activity. Monatshefte für Chemie, Vol. 145, H. 2. pp. 311-317. D. A. Silva, Cristiane França and Batista, Denise DA Gama Jaen and Batista, Marcos Meuser and Lionel, Jessica and Hammer, Erica Ripoll and Brun, Reto and Soeiro, Maria DE Nazaré Correia. (2014) In vitro and in vivo activity of the chloroaryl-substituted imidazole viniconazole against Trypanosoma cruzi. Parasitology, Vol. 141, H. 3. pp. 367-373. Burri, C. and Chappuis, F. and Brun, R.. (2014) Human African trypanosomiasis. In: Manson's Tropical Diseases. - 23rd ed.. [Edinburgh], pp. 606-621. Usuki, Toyonobu and Sato, Makiko and Hara, Shihori and Yoshimoto, Yukiko and Kondo, Ryosuke and Zimmermann, Stefanie and Kaiser, Marcel and Brun, Reto and Hamburger, Matthias and Adams, Michael. (2014) Antitrypanosomal structure-activity-relationship study of synthetic cynaropicrin derivatives. Bioorganic & medicinal chemistry letters, Vol. 24, H. 3. pp. 794-798. Althaus, Julia B. and Jerz, Gerold and Winterhalter, Peter and Kaiser, Marcel and Brun, Reto and Schmidt, Thomas J.. (2014) Antiprotozoal activity of Buxus sempervirens and activity-guided isolation of O-tigloylcyclovirobuxeine-B as the main constituent active against Plasmodium falciparum. Molecules : a journal of synthetic chemistry and natural product chemistry, Vol. 19, H. 5. pp. 6184-6201. Schmidt, Thomas J. and Da Costa, Fernando B. and Lopes, Norberto P. and Kaiser, Marcel and Brun, Reto. (2014) In Silico prediction and experimental evaluation of furanoheliangolide sesquiterpene lactones as potent agents against Trypanosoma brucei rhodesiense. Antimicrobial agents and chemotherapy, Vol. 58, H. 1. pp. 325-332. Althaus, Julia B. and Kaiser, Marcel and Brun, Reto and Schmidt, Thomas J.. (2014) Antiprotozoal activity of achillea ptarmica (Asteraceae) and its main alkamide constituents. Molecules : a journal of synthetic chemistry and natural product chemistry, Vol. 19, H. 5. pp. 6428-6438. Orhan, Ilkay Erdogan and Sener, Bilge and Kaiser, Marcel and Brun, Reto and Tasdemir, Deniz. (2014) Antiprotozoal activity and cytotoxicity of Lycopodium clavatum and Lycopodium complanatum subsp. chamaecyparissus extracts. Turkish journal of biochemistry, Vol. 38, H. 4. pp. 403-408. Belluti, Federica and Uliassi, Elisa and Veronesi, Giacomo and Bergamini, Christian and Kaiser, Marcel and Brun, Reto and Viola, Angelo and Fato, Romana and Michels, Paul A. M. and Krauth-Siegel, R. Luise and Cavalli, Andrea and Bolognesi, Maria Laura. (2014) Toward the development of dual-targeted glyceraldehyde-3-phosphate dehydrogenase/trypanothione reductase inhibitors against Trypanosoma brucei and Trypanosoma cruzi. ChemMedChem : chemistry enabling drug discovery, Vol. 9, H. 2. pp. 371-382. Tatipaka, Hari Babu and Gillespie, J. Robert and Chatterjee, Arnab K. and Norcross, Neil R. and Hulverson, Matthew A. and Ranade, Ranae M. and Nagendar, Pendem and Creason, Sharon A. and McQueen, Joshua and Duster, Nicole A. and Nagle, Advait and Supek, Frantisek and Molteni, Valentina and Wenzler, Tanja and Brun, Reto and Glynne, Richard and Buckner, Frederick S. and Gelb, Michael H.. (2014) Substituted 2-phenylimidazopyridines : a new class of drug leads for human African trypanosomiasis. Journal of medicinal chemistry, 57 (3). pp. 828-835. Patrick, Donald A. and Bakunov, Stanislav A. and Bakunova, Svetlana M. and Wenzler, Tanja and Brun, Reto and Tidwell, Richard R.. (2014) Antiprotozoal activity of dicationic 3,5-diphenylisoxazoles, their prodrugs and aza-analogues. Bioorganic & medicinal chemistry, 22 (1). pp. 559-576. Julianti, Tasqiah and De Mieri, Maria and Zimmermann, Stefanie and Ebrahimi, Samad N. and Kaiser, Marcel and Neuburger, Markus and Raith, Melanie and Brun, Reto and Hamburger, Matthias. (2014) HPLC-based activity profiling for antiplasmodial compounds in the traditional Indonesian medicinal plant Carica papaya L. Journal of ethnopharmacology, Vol. 155, H. 1. pp. 426-434. Persch, Elke and Bryson, Steve and Todoroff, Nickolay K. and Eberle, Christian and Thelemann, Jonas and Dirdjaja, Natalie and Kaiser, Marcel and Weber, Maria and Derbani, Hassan and Brun, Reto and Schneider, Gisbert and Pai, Emil F. and Krauth-Siegel, R. Luise and Diederich, François. (2014) Binding to large enzyme pockets : small-molecule inhibitors of trypanothione reductase. ChemMedChem, Vol. 9, H. 8. pp. 1880-1891. Portmann, Cyril and Sieber, Simon and Wirthensohn, Silvan and Blom, Judith F. and Da Silva, Laeticia and Baudat, Emilie and Kaiser, Marcel and Brun, Reto and Gademann, Karl. (2014) Balgacyclamides, antiplasmodial heterocyclic peptides from Microcystis aeruguinosa EAWAG 251. Journal of natural products, Vol. 77, H. 3. pp. 557-562. Mizukawa, Yuki and Ge, Jian-Feng and Bakar Md, Abu and Itoh, Isamu and Scheurer, Christian and Wittlin, Sergio and Brun, Reto and Matsuoka, Hiroyuki and Ihara, Masataka. (2014) Novel synthetic route for antimalarial benzo[a]phenoxazine derivative SSJ-183 and two active metabolites. Bioorganic & medicinal chemistry, 22 (14). pp. 3749-3752. Liu, Zong-Ying and Wenzler, Tanja and Brun, Reto and Zhu, Xiaohua and Boykin, David W.. (2014) Synthesis and antiparasitic activity of new bis-arylimidamides : DB766 analogs modified in the terminal groups. European journal of medicinal chemistry, 83. pp. 167-173. Wenzler, Tanja and Yang, Sihyung and Patrick, Donald A. and Braissant, Olivier and Ismail, Mohamed A. and Tidwell, Richard R. and Boykin, David W. and Wang, Michael Zhuo and Brun, Reto. (2014) In vitro and In vivo evaluation of 28DAP010, a novel diamidine for treatment of second-stage African sleeping sickness. Antimicrobial agents and chemotherapy, Vol. 58, H. 8. pp. 4452-4463. Yang, Sihyung and Wenzler, Tanja and Miller, Patrik N. and Wu, Huali and Boykin, David W. and Brun, Reto and Wang, Michael Zhuo. (2014) Pharmacokinetic comparison to determine the mechanisms underlying the differential efficacies of cationic diamidines against first- and second-stage human African trypanosomiasis. Antimicrobial agents and chemotherapy, Vol. 58, H. 7. pp. 4064-4074. Giordani, Federica and Buschini, Annamaria and Baliani, Alessandro and Kaiser, Marcel and Brun, Reto and Barrett, Michael P. and Pellacani, Claudia and Poli, Paola and Gilbert, Ian H.. (2014) Characterization of a melamino nitroheterocycle as a potential lead for the treatment of human african trypanosomiasis. Antimicrobial agents and chemotherapy, Vol. 58, H. 10. pp. 5747-5757. Hata, Y. and de Mieri, M. and Ebrahimi, S. N. and Mokoka, T. and Fouche, G. and Kaiser, M. and Brun, R. and Potterat, O. and Hamburger, M.. (2014) Identification of two new phenanthrenones and a saponin as antiprotozoal constituents of Drypetes gerrardii. Phytochemistry letters, Vol. 10. pp. 133-140. Usuki, T. and Sato, M. and Hara, S. and Yoshimoto, Y. and Kondo, R. and Zimmermann, S. and Kaiser, M. and Brun, R. and Hamburger, M. and Adams, M.. (2014) Antitrypanosomal structure-activity-relationship study of semisynthetic cynaropicrin derivatives. Bioorganic and Medicinal Chemistry Letters, 24 (3). pp. 794-798. Carvalho, Samir Aquino and Kaiser, Marcel and Brun, Reto and Silva, Edson Ferreira da and Fraga, Carlos Alberto Manssour. (2014) Antiprotozoal activity of (e)-cinnamic N-acylhydrazone derivatives. Molecules, Vol. 19, H. 12. pp. 20374-20381. Ayyari, Mahdi and Salehi, Peyman and Ebrahimi, Samad Nejad and Zimmermann, Stefanie and Portmann, Lena and Krauth-Siegel, R. Luise and Kaiser, Marcel and Brun, Reto and Rezadoost, Hassan and Rezazadeh, Shamsali and Hamburger, Matthias. (2014) Antitrypanosomal isothiocyanate and thiocarbamate glycosides from Moringa peregrina. Planta Medica, 80 (1). pp. 86-89. Nwodo, Ngozi Justina and Okoye, Festus Basden C. and Lai, Daowan and Debbab, Abdessamad and Brun, Reto and Proksch, Peter. (2014) Two trypanocidal dipeptides from the roots of Zapoteca portoricensis (Fabaceae). Molecules, Vol. 19, H. 5. pp. 5470-5477. Wube, Abraham and Hüfner, Antje and Seebacher, Werner and Kaiser, Marcel and Brun, Reto and Bauer, Rudolf and Bucar, Franz. (2014) 1,2-substituted 4-(1H)-quinolones : synthesis, antimalarial and antitrypanosomal activities in vitro. Molecules, Vol. 19, H. 9. pp. 14204-14220. Hata, Y. and De Mieri, M. and Ebrahimi, S. N. and Mokoka, T. and Fouche, G. and Kaiser, M. and Brun, R. and Potterat, O. and Hamburger, M.. (2014) Identification of two new phenathrenones and a saponin as antiprotozoal constituents of Drypetes gerrardii. Phytochemistry letters, Vol. 10. pp. 133-140. Mohsin, N. U. A. and Seebacher, W. and Faist, J. and Belaj, F. and Saf, R. and Kaiser, M. and Brun, R. and Weis, R.. (2014) Synthesis of antiprotozoal diamines by regioselective insertion of nitrogen into a bicyclic ring system. Monatshefte für Chemie, Vol. 145, H. 8. pp. 1319-1327. Hanna, J. N. and Ntie-Kang, F. and Kaiser, M. and Brun, R. and Efange, S. M. N.. (2014) 1-Aryl-1,2,3,4-tetrahydroisoquinolines as potential antimalarials : synthesis, in vitro antiplasmodial activity and in silico pharmacokinetics evaluation. RSC advances, Vol. 4, H. 44 ,22856-22865. 2013Ebrahimi, Samad N. and Zimmermann, Stefanie and Zaugg, Janine and Smiesko, Martin and Brun, Reto and Hamburger, Matthias. (2013) Abietane Diterpenoids from Salvia sahendica - Antiprotozoal Activity and Determination of Their Absolute Configurations. Planta medica, Vol. 79, H. 2. pp. 150-156. Moradi-Afrapoli, Fahimeh and Ebrahimi, Samad Nejad and Smiesko, Martin and Raith, Melanie and Zimmermann, Stefanie and Nadjafi, Farsad and Brun, Reto and Hamburger, Matthias. (2013) Bisabololoxide derivatives from Artemisia persica, and determination of their absolute configurations by ECD. Phytochemistry, Vol. 85. pp. 143-152. Hata, Yoshie and Raith, Melanie and Ebrahimi, Samad Nejad and Zimmermann, Stefanie and Mokoka, Tsholofelo and Naidoo, Dashnie and Fouche, Gerda and Maharaj, Vinesh and Kaiser, Marcel and Brun, Reto and Hamburger, Matthias. (2013) Antiprotozoal Isoflavan Quinones from Abrus precatorius ssp. africanus. Planta Medica, 79 (6). pp. 492-498. Obbo, C. J. D. and Makanga, B. and Mulholland, D. A. and Coombes, P. H. and Brun, R.. (2013) Antiprotozoal activity of Khaya anthotheca, (Welv.) C.D.C. A plant used by chimpanzees for self medication. Journal of ethnopharmacology : an interdisciplinary journal devoted to bioscientific research on indigenous drugs, Vol. 147, H. 1. pp. 220-223. Abiodun, Oyindamola O. and Brun, Reto and Wittlin, Sergio. (2013) In vitro interaction of artemisinin derivatives or the fully synthetic peroxidic anti-malarial OZ277 with thapsigargin in Plasmodium falciparum strains. Malaria journal, Vol. 12 , 43. Bringmann, G. and Zhang, G. and Büttner, T. and Bauckmann, G. and Kupfer, T. and Braunschweig, H. and Brun, R. and Mudogo, V.. (2013) Jozimine A2 : the first dimeric dioncophyllaceae-type naphthylisoquinoline alkaloid, with three chiral axes and high antiplasmodial activity. Chemistry : a European journal, Vol. 19, H. 3. pp. 916-923. Aureggi, V. and Ehmke, V. and Wieland, J. and Schweizer, W. B. and Bernet, B. and Bur, D. and Meyer, S. and Rottmann, M. and Freymond, C. and Brun, R. and Breit, B. and Diederich, F.. (2013) Potent inhibitors of malarial aspartic proteases, the plasmepsins, by hydroformylation of substituted 7-azanorbornenes. Chemistry : a European journal, Vol. 19, H. 1. pp. 155-164. Hwang, J. Y. and Smithson, S. C. and Zhu, F. and Holbrook, G. and Connelly, M. C. and Kaiser, M. and Brun, R. and Guy, R. K.. (2013) Optimization of chloronitrobenzamides (CNBs) as therapeutic leads for Human African Trypanosomiasis (HAT). Journal of medicinal chemistry, 56 (7). pp. 2850-2860. Endeshaw, Molla and Zhu, Xiaohua and He, Shanshan and Pandharkar, Trupti and Cason, Emily and Mahasenan, Kiran V. and Agarwal, Hitesh and Li, Chenglong and Munde, Manoj and Wilson, W. David and Bahar, Mark and Doskotch, Raymond W. and Kinghorn, A. Douglas and Kaiser, Marcel and Brun, Reto and Drew, Mark E. and Werbovetz, Karl A.. (2013) 8,8-dialkyldihydroberberines with potent antiprotozoal activity. Journal of natural products, Vol. 76, H. 3. pp. 311-315. Malebo, H. M. and Wenzler, T. and Cal, M. and Swaleh, S. M. and Omolo, M. O. and Hassanali, A. and Sequin, U. and Häussinger, D. and Dalsgaard, P. and Hamburger, M. and Brun, R. and Ndiege, I. O.. (2013) Anti-protozoal activity of aporphine and protoberberine alkaloids from Annickia kummeriae (Engl. & Diels) Setten & Maas (Annonaceae). BMC complementary and alternative medicine, Vol. 13 , 48. Patrick, Donald A. and Bakunov, Stanislav A. and Bakunova, Svetlana M. and Jones, Susan Kilgore and Wenzler, Tanja and Barszcz, Todd and Kumar, Arvind and Boykin, David W. and Werbovetz, Karl A. and Brun, Reto and Tidwell, Richard R.. (2013) Synthesis and antiprotozoal activities of benzyl phenyl ether diamidine derivatives. European journal of medicinal chemistry, 67. pp. 310-324. Graf, Fabrice E. and Ludin, Philipp and Wenzler, Tanja and Kaiser, Marcel and Brun, Reto and Pyana, Patient Pati and Büscher, Philippe and de Koning, Harry P. and Horn, David and Mäser, Pascal. (2013) Aquaporin 2 mutations in Trypanosoma brucei gambiense field isolates correlate with decreased susceptibility to pentamidine and melarsoprol. PLoS neglected tropical diseases, Vol. 7, H. 10 , e2475. Malebo, Hamisi M. and Wenzler, Tanja and Cal, Monical and Swaleh, Sauda M. and Hassanali, Ahmed and Sequin, Urs and Machocho, Alex K and Haeussinger, Daniel and Dalsgaard, Petur and Omolo, Maurice O. and Hamburger, Matthias and Brun, Reto and Ndiege, Isaiah O.. (2013) Anti-protozoal and structure-activity relationships of chemical constituents of Acridocarpus chloropterus Oliver (Malpighiaceae) from Tanzania. International Journal of Natural Products Research, 3 (4). pp. 74-81. Mokoka, Tsholofelo A. and Xolani, Peter K. and Zimmermann, S. and Hata, Y. and Adams, M. and Kaiser, M. and Moodley, N. and Maharaj, Y. and Koorbanally, Neil A. and Hamburger, M. and Brun, R. and Fouche, G.. (2013) Antiprotozoal Screening of 60 South African Plants, and the Identification of the Antitrypanosomal Germacranolides Schkuhrin I and II. Planta medica, Vol. 79, H. 14. pp. 1380-1384. Hu, Laixing and Patel, Alpa and Bondada, Lavanya and Yang, Sihyung and Wang, Michael Zhuo and Munde, Manoj and Wilson, W. David and Wenzler, Tanja and Brun, Reto and Boykin, David W.. (2013) Synthesis and antiprotozoal activity of dicationic 2,6-diphenylpyrazines and aza-analogues. Bioorganic & medicinal chemistry, 21 (21). pp. 6732-6741. Wenzler, Tanja and Yang, Sihyung and Braissant, Olivier and Boykin, David W. and Brun, Reto and Wang, Michael Zhuo. (2013) Pharmacokinetics, Trypanosoma brucei gambiense efficacy, and time of drug action of DB829, a preclinical candidate for treatment of second-stage human African trypanosomiasis. Antimicrobial agents and chemotherapy, Vol. 57, H. 11. pp. 5330-5343. Zimmermann, Stefanie and Oufir, Mouhssin and Leroux, Alejandro and Krauth-Siegel, R. Luise and Becker, Katja and Kaiser, Marcel and Brun, Reto and Hamburger, Matthias and Adams, Michael. (2013) Cynaropicrin targets the trypanothione redox system in Trypanosoma brucei. Bioorganic & Medicinal Chemistry, 21 (22). pp. 7202-7209. da Silva, Cristiane Franca and Batista, Denise da Gama Jaen and Siciliano, Julianna Araujo and Batista, Marcos Meuser and Lionel, Jessica and de Souza, Elen Mello and Hammer, Erica Ripoll and da Silva, Patricia Bernardino and De Mieri, Maria and Adams, Michael and Zimmermann, Stefanie and Hamburger, Matthias and Brun, Reto and Schühly, Wolfgang and de Nazare, Maria Correia Soeiro. (2013) Activities of psilostachyin A and cynaropicrin against trypanosoma cruzi in vitro and in vivo. Antimicrobial Agents and Chemotherapy, 57 (11). pp. 5307-5314. Harel, Dipak and Schepmann, Dirk and Prinz, Helge and Brun, Reto and Schmidt, Thomas J. and Wünsch, Bernhard. (2013) Natural product derived antiprotozoal agents : synthesis, biological evaluation, and structure-activity relationships of novel chromene and chromane derivatives. Journal of medicinal chemistry, 56 (18). pp. 7442-7448. Hwang, Jong Yeon and Smithson, David C. and Holbrook, Gloria and Zhu, Fangyi and Connelly, Michele C. and Kaiser, Marcel and Brun, Reto and Kiplin Guy, R.. (2013) Optimization of the electrophile of chloronitrobenzamide leads active against Trypanosoma brucei. Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 23, H. 14. pp. 4127-4131. Bringmann, Gerhard and Zhang, Guoliang and Olschläger, Tobias and Stich, August and Wu, Jun and Chatterjee, Manik and Brun, Reto. (2013) Highly selective antiplasmodial naphthylisoquinoline alkaloids from Ancistrocladus tectorius. Phytochemistry : an international journal of plant biochemistry, Vol. 91. pp. 220-228. Pieretti, Simone and Haanstra, Jurgen R. and Mazet, Muriel and Perozzo, Remo and Bergamini, Christian and Prati, Federica and Fato, Romana and Lenaz, Giorgio and Capranico, Giovanni and Brun, Reto and Bakker, Barbara M. and Michels, Paul A. M. and Scapozza, Leonardo and Bolognesi, Maria Laura and Cavalli, Andrea. (2013) Naphthoquinone derivatives exert their antitrypanosomal activity via a multi-target mechanism. PLoS neglected tropical diseases, Vol. 7 , e2012. Harel, Dipak and Schepmann, Dirk and Brun, Reto and Schmidt, Thomas J. and Wünsch, Bernhard. (2013) Enantioselective synthesis of encecaline-derived potent antimalarial agents. Organic & biomolecular chemistry : an international journal of synthetic, physical and biomolecular organic chemistry, Vol. 11, H. 42. pp. 7342-7349. Lödige, Melanie and Lewis, Matthew D. and Paulsen, Eleonora S. and Esch, Harald L. and Pradel, Gabriele and Lehmann, Leane and Brun, Reto and Bringmann, Gerhard and Mueller, Ann-Kristin. (2013) A primaquine-chloroquine hybrid with dual activity against Plasmodium liver and blood stages. International journal of medical microbiology, Vol. 303, H. 8. pp. 539-547. Thuita, John K. and Wolf, Kristina K. and Murilla, Grace A. and Liu, Qiang and Mutuku, James N. and Chen, Yao and Bridges, Arlene S. and Mdachi, Raymond E. and Ismail, Mohamed A. and Ching, Shelley and Boykin, David W. and Hall, James Edwin and Tidwell, Richard R. and Paine, Mary F. and Brun, Reto and Wang, Michael Zhuo. (2013) Safety, pharmacokinetic, and efficacy studies of oral DB868 in a first stage vervet monkey model of human African trypanosomiasis. PLoS neglected tropical diseases, Vol. 7, H. 6 , e2230. Munigunti, Ranjith and Becker, Katja and Brun, Reto and Calderón, Angela I.. (2013) Determination of antiplasmodial activity and binding affinity of selected natural products towards PfTrxR and PfGR. Natural product communications, Vol. 8, H. 8. pp. 1135-1136. Faist, Johanna and Seebacher, Werner and Kaiser, Marcel and Brun, Reto and Saf, Robert and Weis, Robert. (2013) Antiprotozoal activity of bicyclic diamines with a N-methylpiperazinyl group at the bridgehead atom. Bioorganic & medicinal chemistry : a Tetrahedron publication for the rapid dissemenination of full original research papers and critical reviews on biomolecular chemistry, medicinal chemistry and related disciplines, 21 (17). pp. 4988-4996. von Bargen, Katharina Walburga and Niehaus, Eva-Maria and Bergander, Klaus and Brun, Reto and Tudzynski, Bettina and Humpf, Hans-Ulrich. (2013) Structure elucidation and antimalarial activity of apicidin F : an apicidin-like compound produced by Fusarium fujikuroi. Journal of natural products, Vol. 76, H. 11. pp. 2136-2140. Brunner, R. and Ng, C. L. and Aissaoui, H. and Akabas, M. H. and Boss, C. and Brun, R. and Callaghan, P. S. and Corminboeuf, O. and Fidock, D. A. and Frame, I. J. and Heidmann, B. and Le Bihan, A. and Jeno, P. and Mattheis, C. and Moes, S. and Muller, I. B. and Paguio, M. and Roepe, P. D. and Siegrist, R. and Voss, T. and Welford, R. W. and Wittlin, S. and Binkert, C.. (2013) UV-triggered affinity capture identifies interactions between the Plasmodium falciparum multidrug resistance protein 1 (PfMDR1) and antimalarial agents in live parasitized cells. Journal of biological chemistry, Vol. 288, H. 31. pp. 22576-22583. Molette, J. and Routier, J. and Abla, N. and Besson, D. and Bombrun, A. and Brun, R. and Burt, H. and Georgi, K. and Kaiser, M. and Nwaka, S. and Muzerelle, M. and Scheer, A.. (2013) Identification and optimization of an aminoalcohol-carbazole series with antimalarial properties. ACS medicinal chemistry letters, Vol. 4, H. 11. pp. 1037-1041. Bringmann, Gerhard and Lombe, Blaise Kimbadi and Steinert, Claudia and Ioset, Karine Ndjoko and Brun, Reto and Turini, Florian and Heubl, Günther and Mudogo, Virima. (2013) Mbandakamines A and B, unsymmetrically coupled dimeric naphthylisoquinoline alkaloids, from a Congolese ancistrocladus species. Organic letters, Vol. 15, H. 11. pp. 2590-2593. Belluti, Federica and Perozzo, Remo and Lauciello, Leonardo and Colizzi, Francesco and Kostrewa, Dirk and Bisi, Alessandra and Gobbi, Silvia and Rampa, Angela and Bolognesi, Maria Laura and Recanatini, Maurizio and Brun, Reto and Scapozza, Leonardo and Cavalli, Andrea. (2013) Design, synthesis, and biological and crystallographic evaluation of novel inhibitors of Plasmodium falciparum enoyl-ACP-reductase (PfFabI). Journal of medicinal chemistry, 56 (19). pp. 7516-7526. Patrick, Donald A. and Ismail, Mohamed A. and Arafa, Reem K. and Wenzler, Tanja and Zhu, Xiaohua and Pandharkar, Trupti and Jones, Susan Kilgore and Werbovetz, Karl A. and Brun, Reto and Boykin, David W. and Tidwell, Richard R.. (2013) Synthesis and antiprotozoal activity of dicationic m-terphenyl and 1,3-dipyridylbenzene derivatives. Journal of medicinal chemistry, 56 (13). pp. 5473-5494. Friggeri, L. and Scipione, L. and Costi, R. and Kaiser, M. and Moraca, F. and Zamperini, C. and Botta, B. and Di Santo, R. and De Vita, D. and Brun, R. and Tortorella, S.. (2013) New promising compounds with in vitro nanomolar activity against Trypanosoma cruzi. ACS medicinal chemistry letters, Vol. 4, H. 6. pp. 538-541. Schleiferböck, Sarah and Scheurer, Christian and Ihara, Masataka and Itoh, Isamu and Bathurst, Ian and Burrows, Jeremy N. and Fantauzzi, Pascal and Lotharius, Julie and Charman, Susan A. and Morizzi, Julia and Shackleford, David M. and White, Karen L. and Brun, Reto and Wittlin, Sergio. (2013) In vitro and in vivo characterization of the antimalarial lead compound SSJ-183 in Plasmodium models. Drug design, development and therapy, Vol. 7. pp. 1377-1384. 2012Farimani, M. M. and Taheri, S. and Ebrahimi, S. N. and Bahadori, M. B. and Khavasi, H. R. and Zimmermann, S. and Brun, R. and Hamburger, M.. (2012) Hydrangenone, a new Isoprenoid with an unprecedented skeleton from Salvia hydrangea. Organic Letters, 14 (1). pp. 166-169. Zimmermann, S. and Kaiser, M. and Brun, R. and Hamburger, M. and Adams, M.. (2012) Cynaropicrin : the first natural product with in vivo activity against Trypanosoma bruce rhodesiense. Planta medica, Vol. 78, H. 6. pp. 553-556. Ahmad, S. and Weis, R. and Faist, J. and Wolkinger, V. and Saf, R. and Belaj, F. and Brun, R. and Kaiser, M. and Seebacher, W.. (2012) Diarylcyclohexanones : synthons for new bicyclic compounds. Monatshefte für Chemie, Vol. 143, H. 1. pp. 145-152. Witschel, M. and Rottmann, M. and Kaiser, M. and Brun, R.. (2012) Agrochemicals against malaria, sleeping sickness, leishmaniasis and Chagas disease. PLoS neglected tropical diseases, Vol. 6, H. 10 , e1805. Carvalho, S. A. and Feitosa, L. O. and Soares, M. and Costa, T. E. and Henriques, M. G. and Salomao, K. and de Castro, S. L. and Kaiser, M. and Brun, R. and Wardell, J. L. and Wardell, S. M. and Trossini, G. H. and Andricopulo, A. D. and da Silva, E. F. and Fraga, C. A.. (2012) Design and synthesis of new (E)-cinnamic N-acylhydrazones as potent antitrypanosomal agents. European journal of medicinal chemistry, 54. pp. 512-521. Thuita, J. K. and Wang, M. Z. and Kagira, J. M. and Denton, C. L. and Paine, M. F. and Mdachi, R. E. and Murilla, G. A. and Ching, S. and Boykin, D. W. and Tidwell, R. R. and Hall, J. E. and Brun, R.. (2012) Pharmacology of DB844, an orally active aza analogue of pafuramidine, in a monkey model of second stage human African trypanosomiasis. PLoS neglected tropical diseases, Vol. 6, H. 7 , e1734. Nagle, A. and Wu, T. and Kuhen, K. and Gagaring, K. and Borboa, R. and Francek, C. and Chen, Z. and Plouffe, D. and Lin, X. and Caldwell, C. and Ek, J. and Skolnik, S. and Liu, F. and Wang, J. and Chang, J. and Li, C. and Liu, B. and Hollenbeck, T. and Tuntland, T. and Isbell, J. and Chuan, T. and Alper, P. B. and Fischli, C. and Brun, R. and Lakshminarayana, S. B. and Rottmann, M. and Diagana, T. T. and Winzeler, E. A. and Glynne, R. and Tully, D. C. and Chatterjee, A. K.. (2012) Imidazolopiperazines: lead optimization of the second-generation antimalarial agents. Journal of medicinal chemistry, 55 (9). pp. 4244-4273. Schmidt, T. J. and Rzeppa, S. and Kaiser, M. and Brun, R.. (2012) Larrea tridentata - absolute configuration of its epoxylignans and investigations on its antiprotozoal activity. Phytochemistry letters, Vol. 5, H. 3. pp. 632-637. Schmidt, T. J. and Khalid, S. A. and Romanha, A. J. and Alves, T. Ma and Biavatti, M. W. and Brun, R. and Da Costa, F. B. and de Castro, S. L. and Ferreira, V. F. and de Lacerda, M. V. G. and Lago, J. H. G. and Leon, L. L. and Lopes, N. P. and das Neves Amorim, R. C. and Niehues, M. and Ogungbe, I. V. and Pohlit, A. M. and Scotti, M. T. and Setzer, W. N. and de N. C. Soeiro, M. and Steindel, M. and Tempone, A. G.. (2012) The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases : part I. Current medicinal chemistry, Vol. 19, H. 14. pp. 2128-2175. Schmidt, T. J. and Khalid, S. A. and Romanha, A. J. and Alves, T. Ma and Biavatti, M. W. and Brun, R. and Da Costa, F. B. and de Castro, S. L. and Ferreira, V. F. and de Lacerda, M. V. G. and Lago, J. H. G. and Leon, L. L. and Lopes, N. P. and das Neves Amorim, R. C. and Niehues, M. and Ogungbe, I. V. and Pohlit, A. M. and Scotti, M. T. and Setzer, W. N. and de N. C. Soeiro, M. and Steindel, M. and Tempone, A. G.. (2012) The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases : part II. Current medicinal chemistry, Vol. 19, H. 14. pp. 2176-2228. Faist, J. and Seebacher, W. and Saf, R. and Brun, R. and Kaiser, M. and Weis, R.. (2012) New N-methylpiperazinyl derivatives of bicyclic antiprotozoal compounds. European journal of medicinal chemistry, 47 (1). pp. 510-519. Ehmke, V. and Quinsaat, J. E. and Rivera-Fuentes, P. and Heindl, C. and Freymond, C. and Rottmann, M. and Brun, R. and Schirmeister, T. and Diederich, F.. (2012) Tuning and predicting biological affinity : aryl nitriles as cysteine protease inhibitors. Organic & biomolecular chemistry, Vol. 10, H. 30. pp. 5764-5768. Brun, R. and Blum, J.. (2012) Human African trypanosomiasis. Infectious disease clinics of North America, Vol. 26, H. 2. pp. 261-273. Wenzler, T. and Steinhuber, A. and Wittlin, S. and Scheurer, C. and Brun, R. and Trampuz, A.. (2012) Isothermal microcalorimetry, a new tool to monitor drug action against Trypanosoma brucei and Plasmodium falciparum. PLoS neglected tropical diseases, Vol. 6, H. 6 , e1668. Ge, J. F. and Zhang, Q. Q. and Lu, J. M. and Kaiser, M. and Brun, R. and Ihara, M.. (2012) Synthesis of cyanine dyes and investigation of their in vitro antiprotozoal activities. MedChemComm, Vol. 3, H. 11. pp. 1435-1442. Banerjee, M. and Farahat, A. A. and Kumar, A. and Wenzler, T. and Brun, R. and Munde, M. M. and Wilson, W. D. and Zhu, X. and Werbovetz, K. A. and Boykin, D. W.. (2012) Synthesis, DNA binding and antileishmanial activity of low molecular weight bis-arylimidamides. European journal of medicinal chemistry, 55. pp. 449-454. Stec, J. and Huang, Q. and Pieroni, M. and Kaiser, M. and Fomovska, A. and Mui, E. and Witola, W. H. and Bettis, S. and McLeod, R. and Brun, R. and Kozikowski, A. P.. (2012) Synthesis, biological evaluation and structure-activity relationships of N-benzoyl-2-hydroxybenzamides as agents active against P. falciparum (K1 strain), Trypanosomes, and Leishmania. Journal of medicinal chemistry, 55 (7). pp. 3088-3100. Mombelli, P. and Witschel, M. C. and van Zijl, A. W. and Geist, J. G. and Rottmann, M. and Freymond, C. and Röhl, F. and Kaiser, M. and Illarionova, V. and Fischer, M. and Siepe, I. and Schweizer, W. B. and Brun, R. and Diederich, F.. (2012) Identification of 1,3-diiminoisoindoline carbohydrazides as potential antimalarial candidates. ChemMedChem, Vol. 7, H. 1. pp. 151-158. Mäser, P. and Wittlin, S. and Rottmann, M. and Wenzler, T. and Kaiser, M. and Brun, R.. (2012) Antiparasitic agents : new drugs on the horizon. Current opinion in pharmacology, Vol. 12, H. 5. pp. 562-566. Gökbulut, A. and Kaiser, M. and Brun, R. and Sarer, E. and Schmidt, T. J.. (2012) 9β-hydroxyparthenolide esters from Inula montbretiana and their antiprotozoal activity. Planta medica, Vol. 78, H. 3. pp. 225-229. Abiodun, O. O. and Gbotosho, G. O. and Ajaiyeoba, E. O. and Brun, R. and Oduola, A. M.. (2012) Antitrypanosomal activity of some medicinal plants from Nigerian ethnomedicine. Parasitology research, Vol. 110, H. 2. pp. 521-526. Brunner, R. and Aissaoui, H. and Boss, C. and Bozdech, Z. and Brun, R. and Corminboeuf, O. and Delahaye, S. and Fischli, C. and Heidmann, B. and Kaiser, M. and Kamber, J. and Meyer, S. and Papastogiannidis, P. and Siegrist, R. and Voss, T. and Welford, R. and Wittlin, S. and Binkert, C.. (2012) Identification of a new chemical class of antimalarials. The Journal of Infectious Diseases, Vol. 206, no. 5. pp. 735-743. Lizzi, F. and Veronesi, G. and Belluti, F. and Bergamini, C. and Lopez-Sanchez, A. and Kaiser, M. and Brun, R. and Krauth-Siegel, R. L. and Hall, D. and Rivas, L. and Bolognesi, M. L.. (2012) Conjugation of quinones with natural polyamines : towards an expanded anti-trypanosomatid profile. Journal of medicinal chemistry, 55 (23). pp. 10490-10500. 2011Moridi Farimani M., and Bahadori, M. B. and Taheri, S. and Ebrahimi, S. N. and Zimmermann, S. and Brun, R. and Amin, G. and Hamburger, M.. (2011) Triterpenoids with rare carbon skeletons from Salvia hydrangea : antiprotozoal activity and absolute configurations. Journal of Natural Products, Vol. 74, H. 10. pp. 2200-2205. Mokoka, Tsholofelo A. and Zimmermann, Stefanie and Julianti, Tasqiah and Hata, Yoshie and Moodley, Nivan and Cal, Monica and Adams, Michael and Kaiser, Marcel and Brun, Reto and Koorbanally, Neil and Hamburger, Matthias. (2011) In vitro Screening of Traditional South African Malaria Remedies against Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Leishmania donovani, and Plasmodium falciparum. Planta medica, Vol. 77, H. 14. pp. 1663-1667. Gillingwater, K. and Gutierrez, C. and Bridges, A. and Wu, H. and Deborggraeve, S. and Ali Ekangu R., and Kumar, A. and Ismail, M. and Boykin, D. and Brun, R.. (2011) Efficacy study of novel diamidine compounds in a Trypanosoma evansi goat model. PLoS one, Vol. 6, H. 6 , e20836. Jacobs, R. T. and Naré, B. and Wring, S. A. and Orr, M. D. and Chen, D. and Sligar, J. M. and Jenks, M. X. and Noe, R. A. and Bowling, T. S. and Mercer, L. T. and Rewerts, C. and Gaukel, E. and Owens, J. and Parham, R. and Randolph, R. and Beaudet, B. and Bacchi, C. J. and Yarlett, N. and Plattner, J. J. and Freund, Y. and Ding, C. and Akama, T. and Zhang, Y. K. and Brun, R. and Kaiser, M. and Scandale, I. and Don, R.. (2011) SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 Human African trypanosomiasis. PLoS neglected tropical diseases, Vol. 5, H. 6 , e1151. Chadwick, J. and Amewu, R. K. and Marti, F. and Bousejra-El Garah F., and Sharma, R. and Berry, N. G. and Stocks, P. A. and Burrell-Saward H., and Wittlin, S. and Rottmann, M. and Brun, R. and Taramelli, D. and Parapini, S. and Ward, S. A. and O'Neill P. M., . (2011) Antimalarial mannoxanes : hybrid antimalarial drugs with outstanding oral activity profiles and a potential dual mechanism of action. ChemMedChem : chemistry enabling drug discovery, Vol. 6, H. 8. pp. 1357-1361. Maas, M. and Hensel, A. and Batista da Costa F., and Brun, R. and Kaiser, M. and Schmidt, T. J.. (2011) An unusual dimeric guaianolide with antiprotozoal activity and further sesquiterpene lactones from Eupatorium perfoliatum. Phytochemistry : an international journal of plant biochemistry, Vol. 72, H. 7. pp. 635-644. Bouchikhi, F. and Anizon, F. and Brun, R. and Moreau, P.. (2011) Biological evaluation of glycosyl-isoindigo derivatives against the pathogenic agents of tropical diseases (malaria, Chagas disease, leishmaniasis and human African trypanosomiasis). Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 21, H. 21. pp. 6319-6321. Ismail, M. A. and Bialy, S. A. and Brun, R. and Wenzler, T. and Nanjunda, R. and Wilson, W. D. and Boykin, D. W.. (2011) Dicationic phenyl-2,2'-bichalcophenes and analogues as antiprotozoal agents. Bioorganic & medicinal chemistry : a Tetrahedron publication for the rapid dissemenination of full original research papers and critical reviews on biomolecular chemistry, medicinal chemistry and related disciplines, 19 (2). pp. 978-984. Shi, X. L. and Ge, J. F. and Liu, B. Q. and Kaiser, M. and Wittlin, S. and Brun, R. and Ihara, M.. (2011) Synthesis and in vitro antiprotozoal activities of 5-phenyliminobenzo[a]phenoxazine derivatives. Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 21, H. 19. pp. 5804-5807. Brun, R. and Don, R. and Jacobs, R. T. and Wang, M. Z. and Barrett, M. P.. (2011) Development of novel drugs for human African trypanosomiasis. Future microbiology, Vol. 6. pp. 677-691. Lu, Y. T. and Arai, C. and Ge, J. F. and Ren, W. S. and Kaiser, M. and Wittlin, S. and Brun, R. and Lu, J. M. and Ihara, M.. (2011) Synthesis and in vitro antiprotozoal activities of water-soluble, inexpensive phenothiazinium chlorides. Dyes and pigments : an international journal, Vol. 89, H. 1. pp. 44-48. Bourdin Trunz B., and Jedrysiak, R. and Tweats, D. and Brun, R. and Kaiser, M. and Suwinski, J. and Torreele, E.. (2011) 1-aryl-4-nitro-1H-imidazoles, a new promising series for the treatment of human African trypanosomiasis. European journal of medicinal chemistry, 46 (5). pp. 1524-1535. Charman, S. A. and Arbe-Barnes S., and Bathurst, I. C. and Brun, R. and Campbell, M. and Charman, W. N. and Chiu, F. C. and Chollet, J. and Craft, J. C. and Creek, D. J. and Dong, Y. and Matile, H. and Maurer, M. and Morizzi, J. and Nguyen, T. and Papastogiannidis, P. and Scheurer, C. and Shackleford, D. M. and Sriraghavan, K. and Stingelin, L. and Tang, Y. and Urwyler, H. and Wang, X. and White, K. L. and Wittlin, S. and Zhou, L. and Vennerstrom, J. L.. (2011) Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria. Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, H. 11. pp. 4400-4405. Bringmann, G. and Hertlein-Amslinger B., and Kajahn, I. and Dreyer, M. and Brun, R. and Moll, H. and Stich, A. and Ioset, K. N. and Schmitz, W. and Ngoc, L. H.. (2011) Phenolic analogs of the N,C-coupled naphthylisoquinoline alkaloid ancistrocladinium A, from Ancistrocladus cochinchinensis (Ancistrocladaceae), with improved antiprotozoal activities. Phytochemistry : an international journal of plant biochemistry, Vol. 72, H. 1. pp. 89-93. Wu, T. and Nagle, A. and Kuhen, K. and Gagaring, K. and Borboa, R. and Francek, C. and Chen, Z. and Plouffe, D. and Goh, A. and Lakshminarayana, S. B. and Wu, J. and Ang, H. Q. and Zeng, P. and Kang, M. L. and Tan, W. and Tan, M. and Ye, N. and Lin, X. and Caldwell, C. and Ek, J. and Skolnik, S. and Liu, F. and Wang, J. and Chang, J. and Li, C. and Hollenbeck, T. and Tuntland, T. and Isbell, J. and Fischli, C. and Brun, R. and Rottmann, M. and Dartois, V. and Keller, T. and Diagana, T. and Winzeler, E. and Glynne, R. and Tully, D. C. and Chatterjee, A. K.. (2011) Imidazolopiperazines: hit to lead optimization of new antimalarial agents. Journal of medicinal chemistry, 54 (14). pp. 5116-5130. Liu, L. and Bruhn, T. and Guo, L. and Gotz, D. C. and Brun, R. and Stich, A. and Che, Y. and Bringmann, G.. (2011) Chloropupukeanolides C-E : cytotoxic pupukeanane chlorides with a spiroketal skeleton from Pestalotiopsis fici. Chemistry : an Asian journal / an ACES journal, Vol. 17, H. 9. pp. 2604-2613. Nehrbass-Stuedli A., and Boykin, D. and Tidwell, R. R. and Brun, R.. (2011) Novel diamidines with activity against Babesia divergens in Vitro and Babesia microti in Vivo. Antimicrobial agents and chemotherapy : AAC, Vol. 55, H. 7. pp. 3439-3445. Munigunti, R. and Nelson, N. and Mulabagal, V. and Gupta, M. P. and Brun, R. and Calderón, A. I.. (2011) Identification of oleamide in Guatteria recurvisepala by LC/MS-Based Plasmodium falciparum thioredoxin reductase ligand binding method. Planta medica : Zeitschrift für Arzneipflanzenforschung : official organ of the Society for Medicinal Plant Research, Vol. 77, H. 15. pp. 1749-1753. Papadopoulou, M. V. and Bourdin, B. and Bloomer, W. D. and McKenzie, C. and Wilkinson, S. R. and Prasittichai, C. and Brun, R. and Kaiser, M. and Torreele, E.. (2011) Novel 3-nitro-1H-1,2,4-triazole-based aliphatic and aromatic amines as anti-chagasic agents. Journal of medicinal chemistry, 54 (23). pp. 8214-8223. Harel, D. and Khalid, S. A. and Kaiser, M. and Brun, R. and Wunsch, B. and Schmidt, T. J.. (2011) Encecalol angelate, an unstable chromene from Ageratum conyzoides L. : total synthesis and investigation of its antiprotozoal activity. Journal of ethnopharmacology : an interdisciplinary journal devoted to bioscientific research on indigenous drugs, Vol. 137, H. 1. pp. 620-650. Gachet, M. S. and Kunert, O. and Kaiser, M. and Brun, R. and Zehl, M. and Keller, W. and Munoz, R. A. and Bauer, R. and Schuehly, W.. (2011) Antiparasitic compounds from Cupania cinerea with activities against Plasmodium falciparum and Trypanosoma brucei rhodesiense. Journal of Natural Products, 74 (4). pp. 559-566. Nieto, L. and Mascaraque, A. and Miller, F. and Glacial, F. and Rios Martinez C., and Kaiser, M. and Brun, R. and Dardonville, C.. (2011) Synthesis and antiprotozoal activity of N-alkoxy analogues of the trypanocidal lead compound 4,4'-bis(imidazolinylamino)diphenylamine with improved human blood-brain barrier permeability. Journal of medicinal chemistry, 54 (2). pp. 485-494. Dua, V. K. and Verma, G. and Agarwal, D. D. and Kaiser, M. and Brun, R.. (2011) Antiprotozoal activities of traditional medicinal plants from the Garhwal region of North West Himalaya, India. Journal of ethnopharmacology : an interdisciplinary journal devoted to bioscientific research on indigenous drugs, Vol. 136, H. 1. pp. 123-128. Kirmizibekmez, H. and Atay, I. and Kaiser, M. and Brun, R. and Cartagena, M. M. and Carballeira, N. M. and Yesilada, E. and Tasdemir, D.. (2011) Antiprotozoal activity of Melampyrum arvense and its metabolites. Phytotherapy research : an international journal devoted to pharmacological and toxocological evaluation of natural product derivatives, Vol. 25, H. 1. pp. 142-146. Ruda, G. F. and Nguyen, C. and Ziemkowski, P. and Felczak, K. and Kasinathan, G. and Musso-Buendia A., and Sund, C. and Zhou, X. X. and Kaiser, M. and Ruiz-Perez L. M., and Brun, R. and Kulikowski, T. and Johansson, N. G. and Gonzalez-Pacanowska D., and Gilbert, I. H.. (2011) Modified 5'-trityl nucleosides as inhibitors of Plasmodium falciparum dUTPase. ChemMedChem : chemistry enabling drug discovery, Vol. 6, H. 2. pp. 309-320. Eberle, C. and Lauber, B. S. and Fankhauser, D. and Kaiser, M. and Brun, R. and Krauth-Siegel R. L., and Diederich, F.. (2011) Improved inhibitors of trypanothione reductase by combination of motifs : synthesis, inhibitory potency, binding mode, and antiprotozoal activities. ChemMedChem : chemistry enabling drug discovery, Vol. 6, H. 2. pp. 292-301. Hampton, S. E. and Baragana, B. and Schipani, A. and Bosch-Navarrete C., and Musso-Buendia J. A., and Recio, E. and Kaiser, M. and Whittingham, J. L. and Roberts, S. M. and Shevtsov, M. and Brannigan, J. A. and Kahnberg, P. and Brun, R. and Wilson, K. S. and Gonzalez-Pacanowska D., and Johansson, N. G. and Gilbert, I. H.. (2011) Design, synthesis, and evaluation of 5'-diphenyl nucleoside analogues as inhibitors of the Plasmodium falciparum dUTPase. ChemMedChem : chemistry enabling drug discovery, Vol. 6, H. 10. pp. 1816-1831. Mayence, A. and Vanden Eynde J. J., and Kaiser, M. and Brun, R. and Yarlett, N. and Huang, T. L.. (2011) Bis(oxyphenylene)benzimidazoles: a novel class of anti-Plasmodium falciparum agents. Bioorganic & medicinal chemistry : a Tetrahedron publication for the rapid dissemenination of full original research papers and critical reviews on biomolecular chemistry, medicinal chemistry and related disciplines, 19 (24). pp. 7493-7500. Baragana, B. and McCarthy, O. and Sanchez, P. and Bosch-Navarrete C., and Kaiser, M. and Brun, R. and Whittingham, J. L. and Roberts, S. M. and Zhou, X. X. and Wilson, K. S. and Johansson, N. G. and Gonzalez-Pacanowska D., and Gilbert, I. H.. (2011) Beta-Branched acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase. Bioorganic & medicinal chemistry : a Tetrahedron publication for the rapid dissemenination of full original research papers and critical reviews on biomolecular chemistry, medicinal chemistry and related disciplines, 19 (7). pp. 2378-2391. Hobbie, S. N. and Kaiser, M. and Schmidt, S. and Shcherbakov, D. and Janusic, T. and Brun, R. and Böttger, E. C.. (2011) Genetic reconstruction of protozoan rRNA decoding sites provides a rationale for paromomycin activity against Leishmania and Trypanosoma. PLoS neglected tropical diseases, Vol. 5, H. 5 , e1161. Kaiser, M. and Bray, M. A. and Cal, M. and Trunz, B. B. and Torreele, E. and Brun, R.. (2011) Anti-trypanosomal activity of Fexinidazole: a new oral nitroimidazole drug candidate for the treatment of sleeping sickness. Antimicrobial agents and chemotherapy : AAC, Vol. 55, H. 12. pp. 5602-5608. Ehmke, V. and Heindl, C. and Rottmann, M. and Freymond, C. and Schweizer, W. B. and Brun, R. and Stich, A. and Schirmeister, T. and Diederich, F.. (2011) Potent and selective inhibition of cysteine proteases from Plasmodium falciparum and Trypanosoma brucei. ChemMedChem : chemistry enabling drug discovery, Vol. 6, H. 2. pp. 273-278. Reid, C. S. and Patrick, D. A. and He, S. and Fotie, J. and Premalatha, K. and Tidwell, R. R. and Wang, M. Z. and Liu, Q. and Gershkovich, P. and Wasan, K. M. and Wenzler, T. and Brun, R. and Werbovetz, K. A.. (2011) Synthesis and antitrypanosomal evaluation of derivatives of N-benzyl-1,2-dihydroquinolin-6-ols : effect of core substitutions and salt formation. Bioorganic & medicinal chemistry : a Tetrahedron publication for the rapid dissemenination of full original research papers and critical reviews on biomolecular chemistry, medicinal chemistry and related disciplines, 19 (1). pp. 513-523. Farahat, A. A. and Paliakov, E. and Kumar, A. and Barghash, A. E. and Goda, F. E. and Eisa, H. M. and Wenzler, T. and Brun, R. and Liu, Y. and Wilson, W. D. and Boykin, D. W.. (2011) Exploration of larger central ring linkers in furamidine analogues : synthesis and evaluation of their DNA binding, antiparasitic and fluorescence properties. Bioorganic & medicinal chemistry : a Tetrahedron publication for the rapid dissemenination of full original research papers and critical reviews on biomolecular chemistry, medicinal chemistry and related disciplines, 19 (7). pp. 2156-2167. Arafa, R. K. and Wenzler, T. and Brun, R. and Chai, Y. and Wilson, D.. (2011) Molecular modeling study and synthesis of novel dicationic flexible triaryl guanidines and imidamides as antiprotozoal agents. European journal of medicinal chemistry, 46 (12). pp. 5852-5860. Baschong, Werner and Wittlin, Sergio and Inglis, Kirstine A. and Fairlamb, Alan H. and Croft, Simon L. and Kumar, T. R. Santha and Fidock, David A. and Brun, Reto. (2011) Triclosan is minimally effective in rodent malaria models. Nature medicine, Vol. 17. pp. 33-34. Bakunov, S. A. and Bakunova, S. M. and Wenzler, T. and Ghebru, M. and Werbovetz, K. A. and Brun, R. and Tidwell, R. R.. (2011) Correction to synthesis and antiprotozoal activity of cationic1,4-diphenyl-1H-1,2,3-triazoles. Journal of medicinal chemistry, 54 (12). p. 4281. Schmidt, T. J. and Kaiser, M. and Brun, R.. (2011) Complete structural assignment of serratol, a cembrane-type diterpene from Boswellia serrata and evaluation of its antiprotozoal activity. Planta medica, 77 (8). pp. 849-850. 2010O'Neill P. M., and Amewu, R. K. and Nixon, G. L. and Bousejra, E. F. and Mungthin, M. and Chadwick, J. and Shone, A. E. and Vivas, L. and Lander, H. and Barton, V. and Muangnoicharoen, S. and Bray, P. G. and Davies, J. and Park, B. K. and Wittlin, S. and Brun, R. and Preschel, M. and Zhang, K. and Ward, S. A.. (2010) Identification of a 1,2,4,5-tetraoxane antimalarial drug-development candidate (RKA 182) with superior properties to the semisynthetic artemisinins. Angewandte Chemie. International edition in English, Vol. 49, H. 33. pp. 5693-5697. Brun, R. and Blum, J. and Chappuis, F. and Burri, C.. (2010) Human African trypanosomiasis. Lancet, Vol. 375, no. 9709. pp. 148-159. Gachet, M. S. and Kunert, O. and Kaiser, M. and Brun, R. and Munoz, R. A. and Bauer, R. and Schuhly, W.. (2010) Jacaranone-derived glucosidic esters from Jacaranda glabra and their activity against Plasmodium falciparum. Journal of Natural Products, Vol. 73, H. 4. pp. 553-556. Nour, A. M. and Khalid, S. A. and Kaiser, M. and Brun, R. and Abdalla, W. E. and Schmidt, T. J.. (2010) The antiprotozoal activity of methylated flavonoids from Ageratum conyzoides L. Journal of Ethnopharmacology, Vol. 129, H. 1. pp. 127-130. Faist, J. and Seebacher, W. and Kaiser, M. and Brun, R. and Saf, R. and Weis, R.. (2010) Alkyl and dialkylaminoethyl derivatives of 5-amino-2-azabicyclo[3.2.2]nonanes and their antiplasmodial and antitrypanosomal activities. European Journal of Medicinal Chemistry, 45 (1). pp. 179-185. Bakunov, S. A. and Bakunova, S. M. and Wenzler, T. and Ghebru, M. and Werbovetz, K. A. and Brun, R. and Tidwell, R. R.. (2010) Synthesis and antiprotozoal activity of cationic 1,4-diphenyl-1H-1,2,3-triazoles. Journal of Medicinal Chemistry, 53 (1). pp. 254-272. Tasdemir, D. and Sanabria, D. and Lauinger, I. L. and Tarun, A. and Herman, R. and Perozzo, R. and Zloh, M. and Kappe, S. H. and Brun, R. and Carballeira, N. M.. (2010) 2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage Plasmodium infections. Bioorganic and Medicinal Chemistry, 18 (21). pp. 7475-7485. Wright, C. W. and Linley, P. A. and Brun, R. and Wittlin, S. and Hsu, E.. (2010) Ancient Chinese methods are remarkably effective for the preparation of artemisinin-rich extracts of Qing Hao with potent antimalarial activity. Molecules, Vol. 15, H. 2. pp. 804-812. Yeung, B. K. and Zou, B. and Rottmann, M. and Lakshminarayana, S. B. and Ang, S. H. and Leong, S. Y. and Tan, J. and Wong, J. and Keller-Maerki S., and Fischli, C. and Goh, A. and Schmitt, E. K. and Krastel, P. and Francotte, E. and Kuhen, K. and Plouffe, D. and Henson, K. and Wagner, T. and Winzeler, E. A. and Petersen, F. and Brun, R. and Dartois, V. and Diagana, T. T. and Keller, T. H.. (2010) Spirotetrahydro beta-carbolines (spiroindolones) : a new class of potent and orally efficacious compounds for the treatment of malaria. Journal of Medicinal Chemistry, 53 (14). pp. 5155-5164. Rottmann, M. and McNamara, C. and Yeung, B. K. and Lee, M. C. and Zou, B. and Russell, B. and Seitz, P. and Plouffe, D. M. and Dharia, N. V. and Tan, J. and Cohen, S. B. and Spencer, K. R. and Gonzalez-Paez G. E., and Lakshminarayana, S. B. and Goh, A. and Suwanarusk, R. and Jegla, T. and Schmitt, E. K. and Beck, H. P. and Brun, R. and Nosten, F. and Renia, L. and Dartois, V. and Keller, T. H. and Fidock, D. A. and Winzeler, E. A. and Diagana, T. T.. (2010) Spiroindolones, a potent compound class for the treatment of malaria. Science, Vol. 329, no. 5996. pp. 1175-1180. Wenzel, N. I. and Chavain, N. and Wang, Y. and Friebolin, W. and Maes, L. and Pradines, B. and Lanzer, M. and Yardley, V. and Brun, R. and Herold-Mende C., and Biot, C. and Toth, K. and Davioud-Charvet E., . (2010) Antimalarial versus cytotoxic properties of dual drugs derived from 4-aminoquinolines and Mannich bases: interaction with DNA. Journal of Medicinal Chemistry, 53 (8). pp. 3214-3226. Bonazzi, S. and Barbaras, D. and Patiny, L. and Scopelliti, R. and Schneider, P. and Cole, S. T. and Kaiser, M. and Brun, R. and Gademann, K.. (2010) Antimalarial and antitubercular nostocarboline and eudistomin derivatives: Synthesis, in vitro and in vivo biological evaluation. Bioorganic and Medicinal Chemistry, 18 (4). pp. 1464-1476. Dong, Y. and Wittlin, S. and Sriraghavan, K. and Chollet, J. and Charman, S. A. and Charman, W. N. and Scheurer, C. and Urwyler, H. and Santo, T. J. and Snyder, C. and Creek, D. J. and Morizzi, J. and Koltun, M. and Matile, H. and Wang, X. and Padmanilayam, M. and Tang, Y. and Dorn, A. and Brun, R. and Vennerstrom, J. L.. (2010) The structure-activity relationship of the antimalarial ozonide arterolane (OZ277). Journal of Medicinal Chemistry, 53 (1). pp. 481-491. Pagliero, R. J. and Lusvarghi, S. and Pierini, A. B. and Brun, R. and Mazzieri, M. R.. (2010) Synthesis, stereoelectronic characterization and antiparasitic activity of new 1-benzenesulfonyl-2-methyl-1,2,3,4-tetrahydroquinolines. Bioorganic & Medicinal Chemistry, 18 (1). pp. 142-150. Farahat, A. A. and Kumar, A. and Say, M. and Barghash Aedm, and Goda, F. E. and Eisa, H. M. and Wenzler, T. and Brun, R. and Liu, Y. and Mickelson, L. and Wilson, W. D. and Boykin, D. W.. (2010) Synthesis, DNA binding, fluorescence measurements and antiparasitic activity of DAPI related diamidines. Bioorganic & Medicinal Chemistry, 18 (2). pp. 557-566. Branowska, D. and Farahat, A. A. and Kumar, A. and Wenzler, T. and Brun, R. and Liu, Y. and Wilson, W. D. and Boykin, D. W.. (2010) Synthesis and antiprotozoal activity of 2,5-bis[amidinoaryl]thiazoles. Bioorganic & Medicinal Chemistry, 18 (10). pp. 3551-3558. Adams, M. and Christen, M. and Plitzko, I. and Zimmermann, S. and Brun, R. and Hamburger, M.. (2010) Antiplasmodial lanostanes from the Ganoderma lucidum mushroom. Journal of Natural Products, Vol. 73, H. 5. pp. 897-900. Yang, M. and Arai, C. and Bakar, M. A. and Lu, J. and Ge, J. F. and Pudhom, K. and Takasu, K. and Kasai, K. and Kaiser, M. and Brun, R. and Yardley, V. and Itoh, I. and Ihara, M.. (2010) Fluorinated rhodacyanine (SJL-01) possessing high efficacy for visceral leishmaniasis (VL). Journal of medicinal chemistry, 53 (1). pp. 368-373. Link, Andreas and Heidler, Philipp and Kaiser, Marcel and Brun, Reto. (2010) Parallel synthesis of a series of non-functional ATP/NAD analogs with activity against trypanosomatid parasites. Molecular Diversity, 14 (2). pp. 215-224. Bringmann, G. and Bischof, S. K. and Müller, S. and Gulder, T. and Winter, C. and Stich, A. and Moll, H. and Kaiser, M. and Brun, R. and Dreher, J. and Baumann, K.. (2010) QSAR guided synthesis of simplified antiplasmodial analogs of naphthylisoquinoline alkaloids. European journal of medicinal chemistry, 45 (11). pp. 5370-5383. Xu, M. and Bruhn, T. and Hertlein, B. and Brun, R. and Stich, A. and Wu, J. and Bringmann, G.. (2010) Shuangancistrotectorines A-E, dimeric naphthylisoquinoline alkaloids with three chiral biaryl axes from the Chinese plant Ancistrocladus tectorius. Chemistry : a European journal, Vol. 16, H. 14. pp. 4206-4216. Gachet, M. S. and Lecaro, J. S. and Kaiser, M. and Brun, R. and Navarrete, H. and Munoz, R. A. and Bauer, R. and Schuhly, W.. (2010) Assessment of anti-protozoal activity of plants traditionally used in Ecuador in the treatment of leishmaniasis. Journal of ethnopharmacology : an interdisciplinary journal devoted to bioscientific research on indigenous drugs, Vol. 128, H. 1. pp. 184-197. Mallari, J. P. and Zhu, F. and Lemoff, A. and Kaiser, M. and Lu, M. and Brun, R. and Guy, R. K.. (2010) Optimization of purine-nitrile TbcatB inhibitors for use in vivo and evaluation of efficacy in murine models. Bioorganic & medicinal chemistry : a Tetrahedron publication for the rapid dissemenination of full original research papers and critical reviews on biomolecular chemistry, medicinal chemistry and related disciplines, 18 (23). pp. 8302-8309. Oberle, M. and Balmer, O. and Brun, R. and Roditi, I.. (2010) Bottlenecks and the maintenance of minor genotypes during the life cycle of Trypanosoma brucei. PLoS Pathogens, Vol. 6, H. 7 , e1001023. Nzila, A. and Rottmann, M. and Chitnumsub, P. and Kiara, S. M. and Kamchonwongpaisan, S. and Maneeruttanarungroj, C. and Taweechai, S. and Yeung, B. K. and Goh, A. and Lakshminarayana, S. B. and Zou, B. and Wong, J. and Ma, N. L. and Weaver, M. and Keller, T. H. and Dartois, V. and Wittlin, S. and Brun, R. and Yuthavong, Y. and Diagana, T. T.. (2010) Preclinical evaluation of the antifolate QN254, 5-chloro- N'6'-(2,5-dimethoxy-benzyl)-quinazoline-2,4,6-triamine, as an antimalarial drug candidate. Antimicrobial agents and chemotherapy : AAC, Vol. 54, H. 6. pp. 2603-2610. Burgess, S. J. and Kelly, J. X. and Shomloo, S. and Wittlin, S. and Brun, R. and Liebmann, K. and Peyton, D. H.. (2010) Synthesis, structure-activity relationship, and mode-of-action studies of antimalarial reversed chloroquine compounds. Journal of medicinal chemistry, 53 (17). pp. 6477-6489. Abiodun, O. O. and Gbotosho, G. O. and Ajaiyeoba, E. O. and Happi, C. T. and Hofer, S. and Wittlin, S. and Sowunmi, A. and Brun, R. and Oduola, A. M. J.. (2010) Comparison of SYBR Green I-, PicoGreen-, and [H-3]-hypoxanthine-based assays for in vitro antimalarial screening of plants from Nigerian ethnomedicine. Parasitology research : Organ der Deutschen Gesellschaft für Parasitologie, Vol. 106, H. 4. pp. 933-939. Pacorel, B. and Leung, S. C. and Stachulski, A. V. and Davies, J. and Vivas, L. and Lander, H. and Ward, S. A. and Kaiser, M. and Brun, R. and O'Neill P. M., . (2010) Modular synthesis and in vitro and in vivo antimalarial assessment of C-10 pyrrole mannich base derivatives of artemisinin. Journal of medicinal chemistry, 53 (2). pp. 633-640. Nare, B. and Wring, S. and Bacchi, C. and Beaudet, B. and Bowling, T. and Brun, R. and Chen, D. and Ding, C. and Freund, Y. and Gaukel, E. and Hussain, A. and Jarnagin, K. and Jenks, M. and Kaiser, M. and Mercer, L. and Mejia, E. and Noe, A. and Orr, M. and Parham, R. and Plattner, J. and Randolph, R. and Rattendi, D. and Rewerts, C. and Sligar, J. and Yarlett, N. and Don, R. and Jacobs, R.. (2010) Discovery of novel orally bioavailable oxaborole 6-carboxamides that demonstrate cure in a murine model of late stage central nervous system African Trypanosomiasis. Antimicrobial agents and chemotherapy : AAC, Vol. 54, H. 10. pp. 4379-4388. Ge, J. F. and Arai, C. and Yang, M. and Bakar, M. A. and Lu, J. and Ismail, N. S. M. and Wittlin, S. and Kaiser, M. and Brun, R. and Charman, S. A. and Nguyen, T. and Morizzi, J. and Itoh, I. and Ihara, M.. (2010) Discovery of novel benzo[a]phenoxazine SSJ-183 as a drug candidate for malaria. ACS medicinal chemistry letters, Vol. 1, H. 7. pp. 360-364. Paine, M. F. and Wang, M. Z. and Generaux, C. N. and Boykin, D. W. and Wilson, W. D. and de Koning H. P., and Olson, C. A. and Pohlig, G. and Burri, C. and Brun, R. and Murilla, G. A. and Thuita, J. K. and Barrett, M. P. and Tidwell, R. R.. (2010) Diamidines for human African trypanosomiasis. Current opinion in investigational drugs, Vol. 11, H. 8. pp. 876-883. Faist, J. and Seebacher, W. and Kaiser, M. and Brun, R. and Saf, R. and Weis, R.. (2010) Dialkylaminoalkyl derivatives of bicyclic compounds with antiplasmodial activity. Bioorganic & medicinal chemistry : a Tetrahedron publication for the rapid dissemenination of full original research papers and critical reviews on biomolecular chemistry, medicinal chemistry and related disciplines, 18 (18). pp. 6796-6804. Gigante, F. and Kaiser, M. and Brun, R. and Gilbert, I. H.. (2010) Design and preparation of sterol mimetics as potential antiparasitics. Bioorganic & medicinal chemistry : a Tetrahedron publication for the rapid dissemenination of full original research papers and critical reviews on biomolecular chemistry, medicinal chemistry and related disciplines, 18 (20). pp. 7291-7301. Orhan, Ilkay and Sener, Bilge and Kaiser, Marcel and Brun, Reto and Tasdemir, Deniz. (2010) Inhibitory activity of marine sponge-derived natural products against parasitic protozoa. Marine drugs, Vol. 8, H. 1. pp. 47-58. Zohrabi-Kalantari, V. and Heidler, P. and Kaiser, M. and Brun, R. and Kamper, C. and Link, A.. (2010) Inhibitors of adenosine consuming parasites through polymer-assisted N-acylation of N6-substituted 5'-amino-5'-deoxyadenosines. Molecular Diversity, 14 (2). pp. 307-320. Torreele, E. and BourdinTrunz, B. and Tweats, D. and Kaiser, M. and Brun, R. and Mazue, G. and Bray, M. A. and Pecoul, B.. (2010) Fexinidazole: a new oral nitroimidazole drug candidate entering clinical development for the treatment of sleeping sickness. PLoS neglected tropical diseases, Vol. 4, H. 12 , e923. Gillingwater, K. and Kumar, A. and Ismail, M. A. and Arafa, R. K. and Stephens, C. E. and Boykin, D. W. and Tidwell, R. R. and Brun, R.. (2010) In vitro activity and preliminary toxicity of various diamidine compounds against Trypanosoma evansi. Veterinary parasitology : an international scientific journal, Vol. 169. pp. 264-272. Brun, R. and Stich, A.. (2010) Afrikanische Trypanosomiasis oder Schlafkrankheit. In: Tropenmedizin in Klinik und Praxis : mit Reise- und Migrationsmedizin. Stuttgart, pp. 617-629. Zohrabi-Kalantari, V. and Heidler, P. and Kaiser, M. and Brun, R. and Kamper, C. and Link, A.. (2010) Inhibitors of adenosine consuming parasites through polymer-assisted N-acylation of N(6)-substituted 5 (`)-amino-5 (`)-deoxyadenosines. Molecular Diversity, 14 (2). pp. 307-320. 2009Adams, M. and Zimmermann, S. and Kaiser, M. and Brun, R. and Hamburger, M.. (2009) A protocol for HPLC-based activity profiling for natural products with activities against tropical parasites. Natural Product Communications, 4 (10). pp. 1377-1381. Tritten, L. and Matile, H. and Brun, R. and Wittlin, S.. (2009) A new double-antibody sandwich ELISA targeting Plasmodium falciparum aldolase to evaluate anti-malarial drug sensitivity. Malaria Journal, Vol. 8 , 226. Faist, J. and Seebacher, W. and Schlapper, C. and Kaiser, M. and Brun, R. and Saf, R. and Weis, R.. (2009) Antiplasmodial and antitrypanosomal activity of bicyclic amides and esters of dialkylamino acids. Bioorganic & medicinal chemistry : a Tetrahedron publication for the rapid dissemenination of full original research papers and critical reviews on biomolecular chemistry, medicinal chemistry and related disciplines, 17 (10). pp. 3595-3603. Malebo, H. M. and Wenzler, T. and Cal, M. and Swaleh, S. A. and Omolo, M. O. and Hassanali, A. and Sequin, U. and Hamburger, M. and Brun, R. and Ndiege, I. O.. (2009) Antiplasmodial, anti-trypanosomal, anti-leishmanial and cytotoxicity activity of selected Tanzanian medicinal plants. Tanzania journal of health research, Vol. 11, H. 4. pp. 226-234. Dardonville, C. and Fernandez-Fernandez C., and Gibbons, S. L. and Jagerovic, N. and Nieto, L. and Ryan, G. and Kaiser, M. and Brun, R.. (2009) Antiprotozoal activity of 1-phenethyl-4-aminopiperidine derivatives. Antimicrobial agents and chemotherapy : AAC, Vol. 53, H. 9. pp. 3815-3821. Chavain, N. and Davioud-Charvet E., and Trivelli, X. and Mbeki, L. and Rottmann, M. and Brun, R. and Biot, C.. (2009) Antimalarial activities of ferroquine conjugates with either glutathione reductase inhibitors or glutathione depletors via a hydrolyzable amide linker. Bioorganic & medicinal chemistry : a Tetrahedron publication for the rapid dissemenination of full original research papers and critical reviews on biomolecular chemistry, medicinal chemistry and related disciplines, 17 (23). pp. 8048-8059. Schlapper, C. and Seebacher, W. and Faist, J. and Kaiser, M. and Brun, R. and Saf, R. and Weis, R.. (2009) Antiplasmodial and antitrypanosomal activities of aminobicyclo[2.2.2]octyl omega-aminoalkanoates. European journal of medicinal chemistry, 44 (2). pp. 736-744. McCarthy, O. and Musso-Buendia A., and Kaiser, M. and Brun, R. and Ruiz-Perez L. M., and Johansson, N. G. and Pacanowska, D. G. and Gilbert, I. H.. (2009) Design, synthesis and evaluation of novel uracil acetamide derivatives as potential inhibitors of Plasmodium falciparum dUTP nucleotidohydrolase. European journal of medicinal chemistry, 44 (2). pp. 678-688. Holloway, G. A. and Charman, W. N. and Fairlamb, A. H. and Brun, R. and Kaiser, M. and Kostewicz, E. and Novello, P. M. and Parisot, J. P. and Richardson, J. and Street, I. P. and Watson, K. G. and Baell, J. B.. (2009) Trypanothione reductase high-throughput screening campaign identifies novel classes of inhibitors with anti-parasitic activity. Antimicrobial agents and chemotherapy : AAC, Vol. 53, H. 7. pp. 2824-2833. Kelly, J. X. and Smilkstein, M. J. and Brun, R. and Wittlin, S. and Cooper, R. A. and Lane, K. D. and Janowsky, A. and Johnson, R. A. and Dodean, R. A. and Winter, R. and Hinrichs, D. J. and Riscoe, M. K.. (2009) Discovery of dual function acridones as a new antimalarial chemotype. Nature, Vol. 459, H. 7244. pp. 270-273. Mdachi, R. E. and Thuita, J. K. and Kagira, J. M. and Ngotho, J. M. and Murilla, G. A. and Ndung'u J. M., and Tidwell, R. R. and Hall, J. E. and Brun, R.. (2009) Efficacy of the novel diamidine compound 2,5-Bis(4-amidinophenyl)- furan-bis-O-Methlylamidoxime (Pafuramidine, DB289) against Trypanosoma brucei rhodesiense infection in vervet monkeys after oral administration. Antimicrobial agents and chemotherapy : AAC, Vol. 53, H. 3. pp. 953-957. Christen, M. and Adams, M. and Zimmermann, S. and Brun, R. and Hamburger, M.. (2009) HPLC based activity profiling of Ganoderma lucidum extract for antiplasmodial activity and isolation of new active lanostane triterpenoids. Planta medica : Zeitschrift für Arzneipflanzenforschung : official organ of the Society for Medicinal Plant Research, Vol. 75, H. 9. p. 948. Adams, M. and Plitzko, I. and Kaiser, M. and Brun, R. and Hamburger, M.. (2009) HPLC-profiling for antiplasmodial compounds-3-methoxycarpachromene from Pistacia atlantica. Planta medica : Zeitschrift für Arzneipflanzenforschung : official organ of the Society for Medicinal Plant Research, Vol. 75, H. 9. p. 948. Nwodo, N. J. and Omeje, E. O. and Brun, R.. (2009) In vitro-in vivo studies on anti-trypanosomal potentials of Zapoteca portoricensis. Asian pacific journal of tropical medicine, Vol. 2, H. 1. pp. 25-29. Kiboi, D. M. and Irungu, B. N. and Langat, B. and Wittlin, S. and Brun, R. and Chollet, J. and Abiodun, O. and Nganga, J. K. and Nyambati, V. C. and Rukunga, G. M. and Bell, A. and Nzila, A.. (2009) Plasmodium berghei ANKA: selection of resistance to piperaquine and lumefantrine in a mouse model. Experimental parasitology : EP, Vol. 122, H. 3. pp. 196-202. Cavalli, A. and Lizzi, F. and Bongarzone, S. and Brun, R. and Luise Krauth-Siegel R., and Bolognesi, M. L.. (2009) Privileged structure-guided synthesis of quinazoline derivatives as inhibitors of trypanothione reductase. Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 19, H. 11. pp. 3031-3035. Schmidt, T. J. and Nour, A. M. and Khalid, S. A. and Kaiser, M. and Brun, R.. (2009) Quantitative structure--antiprotozoal activity relationships of sesquiterpene lactones. Molecules : a journal of synthetic chemistry and natural product chemistry, Vol. 14, H. 6. pp. 2062-2076. Baliani, A. and Peal, V. and Gros, L. and Brun, R. and Kaiser, M. and Barrett, M. P. and Gilbert, I. H.. (2009) Novel functionalized melamine-based nitroheterocycles: synthesis and activity against trypanosomatid parasites. Organic & biomolecular chemistry : an international journal of synthetic, physical and biomolecular organic chemistry, Vol. 7, H. 6. pp. 1154-1166. Van Baelen G., and Hostyn, S. and Dhooghe, L. and Tapolcsanyi, P. and Matyus, P. and Lemiere, G. and Dommisse, R. and Kaiser, M. and Brun, R. and Cos, P. and Maes, L. and Hajos, G. and Riedl, Z. and Nagy, I. and Maes, B. U. and Pieters, L.. (2009) Structure-activity relationship of antiparasitic and cytotoxic indoloquinoline alkaloids, and their tricyclic and bicyclic analogues. Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 17, H. 20. pp. 7209-7217. Bakunova, S. M. and Bakunov, S. A. and Patrick, D. A. and Kumar, E. V. and Ohemeng, K. A. and Bridges, A. S. and Wenzler, T. and Barszcz, T. and Jones, S. K. and Werbovetz, K. A. and Brun, R. and Tidwell, R. R.. (2009) Structure-activity study of pentamidine analogues as antiprotozoal agents. Journal of Medicinal Chemistry, 52 (7). pp. 2016-2035. Hu, L. and Arafa, R. K. and Ismail, M. A. and Patel, A. and Munde, M. and Wilson, W. D. and Wenzler, T. and Brun, R. and Boykin, D. W.. (2009) Synthesis and activity of azaterphenyl diamidines against Trypanosoma brucei rhodesiense and Plasmodium falciparum. Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 17, H. 18. pp. 6651-6658. Alp, M. and Göker, H. and Brun, R. and Yildiz, S.. (2009) Synthesis and antiparasitic and antifungal evaluation of 2'-arylsubstituted-1H,1'H-[2,5']bisbenzimidazolyl-5-carboxamidines. European Journal of Medicinal Chemistry, 44 (5). pp. 2002-2008. Bakunova, S. M. and Bakunov, S. A. and Wenzler, T. and Barszcz, T. and Werbovetz, K. A. and Brun, R. and Tidwell, R. R.. (2009) Synthesis and antiprotozoal activity of pyridyl analogues of pentamidine. Journal of Medicinal Chemistry, 52 (15). pp. 4657-4667. Patrick, D. A. and Bakunov, S. A. and Bakunova, S. M. and Suresh Kumar E. V., and Chen, H. and Jones, S. K. and Wenzler, T. and Barzcz, T. and Werbovetz, K. A. and Brun, R. and Tidwell, R. R.. (2009) Synthesis and antiprotozoal activities of dicationic bis(phenoxymethyl)benzenes, bis(phenoxymethyl)naphthalenes, and bis(benzyloxy)naphthalenes. European Journal of Medicinal Chemistry, 44 (9). pp. 3543-3551. Bakunov, S. A. and Bakunova, S. M. and Bridges, A. S. and Wenzler, T. and Barszcz, T. and Werbovetz, K. A. and Brun, R. and Tidwell, R. R.. (2009) Synthesis and antiprotozoal properties of pentamidine congeners bearing the benzofuran motif. Journal of Medicinal Chemistry, 52 (18). pp. 5763-5767. Pudhom, K. and Ge, M. F. and Arai, C. and Yang, M. and Kaiser, M. and Wittlin, S. and Brun, R. and Itoh, I. and Ihara, M.. (2009) Synthesis and biological properties of a rhodacyanine derivative, Ssj-127, having high efficacy against malaria protozoa. Heterocycles : an international journal for reviews and communications in heterocyclic chemistry, Vol. 77, H. 1. pp. 207-210. Musonda, C. C. and Whitlock, G. A. and Witty, M. J. and Brun, R. and Kaiser, M.. (2009) Synthesis and evaluation of 2-pyridyl pyrimidines with in vitro antiplasmodial and antileishmanial activity. Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 19, H. 2. pp. 401-405. Kuettel, S. and Mosimann, M. and Mäser, P. and Kaiser, M. and Brun, R. and Scapozza, L. and Perozzo, R.. (2009) Adenosine kinase of T. b. Rhodesiense identified as the putative target of 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine using chemical proteomics. PLoS Neglected Tropical Diseases, Vol. 3, H. 8 , e506. Nwaka, S. and Ramirez, B. and Brun, R. and Maes, L. and Douglas, F. and Ridley, R.. (2009) Advancing drug innovation for neglected diseases-criteria for lead progression. PLoS Neglected Tropical Diseases, Vol. 3, H. 8 , e440. Faist, J. and Seebacher, W. and Kaiser, M. and Brun, R. and Saf, R. and Weis, R.. (2009) Bicyclic amido compounds with antiprotozoal activity. Monatshefte für Chemie = Chemical monthly : an international journal of chemistry, Vol. 140, H. 10. pp. 1261-1268. Musonda, C. C. and Whitlock, G. A. and Witty, M. J. and Brun, R. and Kaiser, M.. (2009) Chloroquine-astemizole hybrids with potent in vitro and in vivo antiplasmodial activity. Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 19, H. 2. pp. 481-484. Gachet, M. S. and Schuhly, W. and Kunert, O. and Kaiser, M. and Brun, R. and Munoz, R. A. and Bauer, R.. (2009) Jacaranone derived glucosidic esters from Jacaranda glabra. Planta medica : Zeitschrift für Arzneipflanzenforschung : official organ of the Society for Medicinal Plant Research, Vol. 75, H. 9. pp. 901-902. Stump, B. and Eberle, C. and Schweizer, W. B. and Kaiser, M. and Brun, R. and Krauth-Siegel R. L., and Lentz, D. and Diederich, F.. (2009) Pentafluorosulfanyl as a novel building block for enzyme inhibitors: trypanothione reductase inhibition and antiprotozoal activities of diarylamines. ChemBioChem : a European journal of chemical biology, Vol. 10, H. 1. pp. 79-83. Gigante, F. and Kaiser, M. and Brun, R. and Gilbert, I. H.. (2009) SAR studies on azasterols as potential anti-trypanosomal and anti-leishmanial agents. Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 17, H. 16. pp. 5950-5961. Berger, H. and Seebacher, W. and Kaiser, M. and Brun, R. and Saf, R. and Weis, R.. (2009) SARs of the antiprotozoal action of 6,7-diaryl-bicyclo[2.2.2]octan-2-ols. Monatshefte für Chemie = Chemical monthly : an international journal of chemistry, Vol. 140, H. 5. pp. 495-502. Huang, Q. and Mao, J. and Wan, B. and Wang, Y. and Brun, R. and Franzblau, S. G. and Kozikowski, A. P.. (2009) Searching for new cures for tuberculosis: design, synthesis, and biological evaluation of 2-methylbenzothiazoles. Journal of Medicinal Chemistry, 52 (21). pp. 6757-6767. Link, A. and Heidler, P. and Kaiser, M. and Brun, R.. (2009) Synthesis of a series of N(6)-substituted adenosines with activity against trypanosomatid parasites. European Journal of Medicinal Chemistry, 44 (9). pp. 3665-3671. Nour, A. M. and Khalid, S. A. and Kaiser, M. and Brun, R. and Abdallah, W. E. and Schmidt, T. J.. (2009) The antiprotozoal activity of sixteen asteraceae species native to Sudan and bioactivity-guided isolation of xanthanolides from Xanthium brasilicum. Planta medica : Zeitschrift für Arzneipflanzenforschung : official organ of the Society for Medicinal Plant Research, Vol. 75, H. 2. pp. 1363-1368. Gemma, S. and Campiani, G. and Butini, S. and Joshi, B. P. and Kukreja, G. and Coccone, S. S. and Bernetti, M. and Persico, M. and Nacci, V. and Fiorini, I. and Novellino, E. and Taramelli, D. and Basilico, N. and Parapini, S. and Yardley, V. and Croft, S. and Keller-Maerki S., and Rottmann, M. and Brun, R. and Coletta, M. and Marini, S. and Guiso, G. and Caccia, S. and Fattorusso, C.. (2009) Combining 4-aminoquinoline- and clotrimazole-based pharmacophores toward innovative and potent hybrid antimalarials. Journal of Medicinal Chemistry, 52 (2). pp. 502-513. Ganapaty, S. and Srilakshmi, G. V. and Pannakal, S. T. and Rahman, H. and Laatsch, H. and Brun, R.. (2009) Cytotoxic benzil and coumestan derivatives from Tephrosia calophylla. Phytochemistry : an international journal of plant biochemistry, Vol. 70, H. 1. pp. 95-99. Gillingwater, K. and Kumar, A. and Anbazhagan, M. and Boykin, D. W. and Tidwell, R. R. and Brun, R.. (2009) In vivo investigations of selected diamidine compounds against Trypanosoma evansi using a mouse model. Antimicrobial agents and chemotherapy : AAC, Vol. 53, H. 12. pp. 5074-5079. Heidler, P. and Zohrabi-Kalantari V., and Kaiser, M. and Brun, R. and Emmrich, T. and Link, A.. (2009) Inhibitors of adenosine consuming parasites through polymer-assisted solution phase synthesis of lipophilic 5'-amido-5'-deoxyadenosine derivatives. Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 17, H. 4. pp. 1428-1436. Balmer, O. and Stearns, S. C. and Schotzau, A. and Brun, R.. (2009) Intraspecific competition between co-infecting parasite strains enhances host survival in African trypanosomes. Ecology : a publication of the Ecological Society of America, Vol. 90, Nr. 12. pp. 3367-3378. Riente, R. R. and Souza, V. P. and Carvalho, S. A. and Kaiser, M. and Brun, R. and da Silva E. F., . (2009) Leishmanicidal activity of new megazol derivatives. Medicinal chemistry, Vol. 5, H. 4. pp. 392-397. Vassella, E. and Oberle, M. and Urwyler, S. and Renggli, C. K. and Studer, E. and Hemphill, A. and Fragoso, C. and Butikofer, P. and Brun, R. and Roditi, I.. (2009) Major surface glycoproteins of insect forms of Trypanosoma brucei are not essential for cyclical transmission by tsetse. PLoS One, Vol. 4, H. 2 , e4493. Portmann, C. and Blom, J. F. and Kaiser, M. and Brun, R. and Juttner, F. and Gademann, K.. (2009) New antiplasmodial natural products from cyanobacteria: linking their ecological role to their therapeutic potential. Planta medica : Zeitschrift für Arzneipflanzenforschung : official organ of the Society for Medicinal Plant Research, Vol. 75, H. 9. p. 886. Wenzler, T. and Boykin, D. W. and Ismail, M. A. and Hall, J. E. and Tidwell, R. R. and Brun, R.. (2009) New treatment option for second stage African sleeping sickness: In vitro and in vivo efficacy of aza analogs of DB289. Antimicrobial agents and chemotherapy : AAC, Vol. 53, H. 10. pp. 4185-4192. Efange, S. M. and Brun, R. and Wittlin, S. and Connolly, J. D. and Hoye, T. R. and McAkam, T. and Makolo, F. L. and Mbah, J. A. and Nelson, D. P. and Nyongbela, K. D. and Wirmum, C. K.. (2009) Okundoperoxide, a bicyclic cyclofarnesylsesquiterpene endoperoxide from Scleria striatinux with antiplasmodial activity. Journal of Natural Products, Vol. 72, H. 2. pp. 280-283. Wolkinger, V. and Weis, R. and Belaj, F. and Kaiser, M. and Brun, R. and Saf, R. and Seebacher, W.. (2009) Synthesis of novel diazabicycles and their antiprotozoal activities. Australian journal of chemistry, Vol. 62, H. 9. pp. 1166-1172. Ma, X. and Zhou, W. and Brun, R.. (2009) Synthesis, in vitro antitrypanosomal and antibacterial activity of phenoxy, phenylthio or benzyloxy substituted quinolones. Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 19, H. 3. pp. 986-989. Eberle, C. and Burkhard, J. A. and Stump, B. and Kaiser, M. and Brun, R. and Krauth-Siegel R. L., and Diederich, F.. (2009) Synthesis, inhibition potency, binding mode, and antiprotozoal activities of fluorescent inhibitors of trypanothione reductase based on mepacrine-conjugated diaryl sulfide scaffolds. ChemMedChem : chemistry enabling drug discovery, Vol. 4, H. 12. pp. 2034-2044. Adams, Michael and Zimmermann, Stefanie and Kaiser, Marcel and Brun, Reto and Hamburger, Matthias. (2009) A protocol for HPLC-based activity profiling for natural products with activities against tropical parasites. Natural Product Communications, 4 (10). pp. 1377-1381. Nyongbela, Kennedy and Ndjoko, Karine Ioset and Brun, Reto and Wittlin, Sergio and Mbah, James and Makolo, Felix and Akam, Marc and Wirmum, Claire and Efange, Simon and Hostettmann, Kurt. (2009) Occurrence of sesquiterpene derivatives in Scleria striatonux de wild (Cyperaceae). Natural product communications : NPC, Vol. 4, H. 1. pp. 5-8. 2008Portmann, C. and Blom, J. F. and Kaiser, M. and Brun, R. and Juttner, F. and Gademann, K.. (2008) Isolation of aerucyclamides C and D and structure revision of microcyclamide 7806A: heterocyclic ribosomal peptides from Microcystis aeruginosa PCC 7806 and their antiparasite evaluation. Journal of natural products, Vol. 71, H. 11. pp. 1891-1896. 2007Maina, Naomi and Maina, Kagira Joseph and Mäser, Pascal and Brun, Reto. (2007) Genotypic and phenotypic characterization of Trypanosoma brucei gambiense isolates from Ibba, South Sudan, an area of high melarsoprol treatment failure rate. Acta tropica : Zeitschrift für Tropenwissenschaften und Tropenmedizin = revue des sciences tropicales et de médecine tropicale = review of tropical science and tropical medicine, 104 (2-3). pp. 84-90. 2002Mäser, Pascal and Grether-Bühler, Yvonne and Kaminsky, Ronald and Brun, Reto. (2002) An anti-contamination cocktail for the in vitro isolation and cultivation of parasitic protozoa. Parasitology research : Organ der Deutschen Gesellschaft für Parasitologie, Vol. 88, H. 2. pp. 172-174. |
