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Article

Assmus, Frauke and Ross, Alfred and Fischer, Holger and Seelig, Joachim and Seelig, Anna. (2017) (31)P and (1)H NMR Studies of the Molecular Organization of Lipids in the Parallel Artificial Membrane Permeability Assay. Molecular Pharmaceutics, 14 (1). pp. 284-295.

Xu, Yanyan and Seelig, Anna and Bernèche, Simon. (2017) Unidirectional Transport Mechanism in an ATP Dependent Exporter. ACS Central Science, 3 (3). pp. 250-258.

Zwick, Matthias and Esposito, Cinzia and Hellstern, Manuel and Seelig, Anna. (2016) Interplay between CFTR Phosphorylation, CFTR-ATPase Activity, and Anion Flux. Journal of Biological Chemistry, 291 (28). pp. 14483-14498.

Assmus, Frauke and Seelig, Anna and Gobbi, Luca and Borroni, Edilio and Glaentzlin, Patricia and Fischer, Holger. (2015) Label-free assay for the assessment of nonspecific binding of positron emission tomography tracer candidates. European journal of pharmaceutical sciences, 79. pp. 27-35.

Egido, Estefanía and Müller, Rita and Li-Blatter, Xiaochun and Merino, Gracia and Seelig, Anna. (2015) Predicting Activators and Inhibitors of the Breast Cancer Resistance Protein (ABCG2) and P-Glycoprotein (ABCB1) Based on Mechanistic Considerations. Molecular pharmaceutics, 12 (11). pp. 4026-4037.

Wagner, Bjoern and Fischer, Holger and Kansy, Manfred and Seelig, Anna and Assmus, Frauke. (2015) Carrier Mediated Distribution System (CAMDIS): a new approach for the measurement of octanol/water distribution coefficients. European journal of pharmaceutical sciences, 68. pp. 68-77.

Zolnerciks, Joseph K. and Akkaya, Begum G. and Snippe, Marjolein and Chiba, Peter and Seelig, Anna and Linton, Kenneth J.. (2014) The Q loops of the human multidrug resistance transporter ABCB1 are necessary to couple drug binding to the ATP catalytic cycle. FASEB Journal, 28 (10). pp. 4335-4346.

Marzolini, Catia and Mueller, Rita and Li-Blatter, Xiaochun and Battegay, Manuel and Seelig, Anna. (2013) The Brain Entry of HIV-1 Protease Inhibitors Is Facilitated When Used in Combination. Molecular pharmaceutics, Vol. 10, H. 6 , S. 2340–2349.

Beck, Andreas and Aanismaa, Paivi and Li-Blatter, Xiaochun and Dawson, Roger and Locher, Kaspar P. and Seelig, Anna. (2013) SAV1866 from Staphylococcus aureus and P-Glycoprotein – Similarities and Differences in ATPase Activity Assessed with Detergents as Allocrites. Biochemistry, Vol. 52, H. 19 , S. 3297–3309.

Li-Blatter, Xiaochun and Beck, Andreas and Seelig, Anna. (2012) P-glycoprotein-ATPase modulation: the molecular mechanisms. Biophysical journal, Vol. 102, H. 6. pp. 1383-1393.

Barrera, Borja and Otero, Jon A. and Egido, Estefanía and Prieto, Julio G. and Seelig, Anna and Alvarez, Ana I. and Merino, Gracia. (2012) The Anthelmintic Triclabendazole and Its Metabolites Inhibit the Membrane Transporter ABCG2/BCRP. Antimicrobial Agents and Chemotherapy, 56 (7). pp. 3535-3543.

Beck, A. and Li-Blatter, X. and Seelig, A. and Seelig, J.. (2010) On the Interaction of Ionic Detergents with Lipid Membranes : Thermodynamic Comparison of n-Alkyl-+N(CH3)3 and n-Alkyl-SO4-. Journal of Physical Chemistry B, 114 (48). pp. 15862-15871.

Nervi, P. and Li-Blatter, X. and Aanismaa, P. and Seelig, A.. (2010) P-glycoprotein substrate transport assessed by comparing cellular and vesicular ATPase activity. Biochimica et biophysica acta, Vol. 1798. pp. 515-525.

Li-Blatter, Xiaochun and Seelig, Anna. (2010) Exploring the p-glycoprotein binding cavity with polyoxyethylene alkyl ethers. Biophysical Journal, 99 (11). pp. 3589-3598.

Li-Blatter, X. and Nervi, P. and Seelig, A.. (2009) Detergents as intrinsic P-glycoprotein substrates and inhibitors. Biochimica et biophysica acta, Vol. 1788, H. 10. pp. 2335-2344.

Turunen, B. J. and Ge, H. and Oyetunji, J. and Desino, K. E. and Vasandani, V. and Guthe, S. and Himes, R. H. and Audus, K. L. and Seelig, A. and Georg, G. I.. (2008) Paclitaxel succinate analogs : anionic and amide introduction as a strategy to impart blood-brain barrier permeability. Bioorganic & medicinal chemistry letters, Vol. 18. pp. 5971-5974.

Aanismaa, P. and Gatlik-Landwojtowicz, E. and Seelig, A.. (2008) P-glycoprotein senses its substrates and the lateral membrane packing density : consequences for the catalytic cycle. Biochemistry, Vol. 47, H. 38. pp. 10197-10207.

Seelig, A.. (2007) The role of size and charge for blood-brain barrier permeation of drugs and fatty acids. Journal of Molecular Neuroscience, 33 (1). pp. 32-41.

Aanismaa, P. and Seelig, A.. (2007) P-Glycoprotein kinetics measured in plasma membrane vesicles and living cells. Biochemistry, Vol. 46, H. 11. pp. 3394-3404.

Ge, H. and Vasandani, V. and Huff, J. K. and Audus, K. L. and Himes, R. H. and Seelig, A. and Georg, G. I.. (2006) Synthesis and interactions of 7-deoxy-, 10-deacetoxy, and 10-deacetoxy-7-deoxypaclitaxel with NCI/ADR-RES cancer cells and bovine brain microvessel endothelial cells. Bioorganic & medicinal chemistry letters, Vol. 16, H. 2. pp. 433-436.

Spletstoser, J. T. and Turunen, B. J. and Desino, K. and Rice, A. and Datta, A. and Dutta, D. and Huff, J. K. and Himes, R. H. and Audus, K. L. and Seelig, A. and Georg, G. I.. (2006) Single-site chemical modification at C10 of the baccatin III core of paclitaxel and Taxol C reduces P-glycoprotein interactions in bovine brain microvessel endothelial cells. Bioorganic & medicinal chemistry letters, Vol. 16, H. 3. pp. 495-498.

Meier, M. and Blatter, X. L. and Seelig, A. and Seelig, J.. (2006) Interaction of verapamil with lipid membranes and P-glycoprotein : connecting thermodynamics and membrane structure with functional activity. Biophysical journal, Vol. 91, H. 8. pp. 2943-2955.

Seelig, A.. (2006) Unraveling membrane-mediated substrate-transporter interactions. Biophysical journal, Vol. 90, H. 11. pp. 3825-3826.

Seelig, A. and Gerebtzoff, G.. (2006) Enhancement of drug absorption by noncharged detergents through membrane and P-glycoprotein binding. Expert Opinion on Drug Metabolism & Toxicology, Vol. 2, H. 5. pp. 733-752.

Gerebtzoff, G. and Seelig, A.. (2006) In silico prediction of blood-brain barrier permeation using the calculated molecular cross-sectional area as main parameter. Journal of Chemical Information and Modeling, Vol. 46, H. 6. pp. 2638-2650.

Gatlik-Landwojtowicz, E. and Aanismaa, P. and Seelig, A.. (2006) Quantification and characterization of P-glycoprotein-substrate interactions. Biochemistry, Vol. 45, H. 9. pp. 3020-3032.

Seelig, A. and Gatlik-Landwojtowicz, E.. (2005) Inhibitors of multidrug efflux transporters : their membrane and protein interactions. Mini Reviews in Medicinal Chemistry, 5 (2). pp. 135-151.

Gatlik-Landwojtowicz, E. and Aanismaa, P. and Seelig, A.. (2004) The rate of P-glycoprotein activation depends on the metabolic state of the cell. Biochemistry, Vol. 43, H. 46. pp. 14840-14851.

Seelig, A.. (2004) Screening for multidrug resistance. Screening, Vol. 4. pp. 20-21.

Green, J. D. and Kreplak, L. and Goldsbury, C. and Li Blatter, X. and Stolz, M. and Cooper, G. S. and Seelig, A. and Kistler, J. and Aebi, U.. (2004) Atomic force microscopy reveals defects within mica supported lipid bilayers induced by the amyloidogenic human amylin peptide. Journal of molecular biology, Vol. 342, H. 3. pp. 877-887.

Gerebtzoff, G. and Li-Blatter, X. and Fischer, H. and Frentzel, A. and Seelig, A.. (2004) Halogenation of drugs enhances membrane binding and permeation. ChemBioChem, Vol. 5, H. 5. pp. 676-684.

Ziegler, A. and Blatter, X. L. and Seelig, A. and Seelig, J.. (2003) Protein transduction domains of HIV-1 and SIV TAT interact with charged lipid vesicles : binding mechanism and thermodynamic analysis. Biochemistry, Vol. 42, H. 30. pp. 9185-9194.

Landwojtowicz, E. and Nervi, P. and Seelig, A.. (2002) Real-time monitoring of P-glycoprotein activation in living cells. Biochemistry, Vol. 41, H. 25. pp. 8050-8057.

Seelig, A. and Blatter, X. L. and Frentzel, A. and Isenberg, G.. (2000) Phospholipid binding of synthetic talin peptides provides evidence for an intrinsic membrane anchor of talin. Journal of Biological Chemistry, 275 (24). pp. 17954-17961.

Seelig, A. and Landwojtowicz, E.. (2000) Structure-activity relationship of P-glycoprotein substrates and modifiers. European journal of pharmaceutical sciences, Vol. 12, H. 1. pp. 31-40.

Zurbriggen, R. and Novak-Hofer, I. and Seelig, A. and Gluck, R.. (2000) IRIV-adjuvanted hepatitis A vaccine : in vivo absorption and biophysical characterization. Progress in Lipid Research, 39 (1). pp. 3-18.

Seelig, A. and Blatter, X. L. and Wohnsland, F.. (2000) Substrate recognition by P-glycoprotein and the multidrug resistance-associated protein MRP1 : a comparison. International Journal of Clinical Pharmacology and Therapeutics, 38 (3). pp. 111-121.

Fischer, H. and Seelig, A. and Beier, N. and Raddatz, P. and Seelig, J.. (1999) New drugs for the Na+/H+ exchanger : Influence of Na+ concentration and determination of inhibition constants with a microphysiometer. The Journal of Membrane Biology, 168 (1). pp. 39-45.

Seitz, H. R. and Heck, M. and Hofmann, K. P. and Alt, T. and Pellaud, J. and Seelig, A.. (1999) Molecular determinants of the reversible membrane anchorage of the G-protein transducin. Biochemistry, Vol. 38, H. 25. pp. 7950-7960.

Andre, J. P. and Toth, E. and Fischer, H. and Seelig, A. and Macke, H. R. and Merbach, A. E.. (1999) High relaxivity for monomeric Gd(DOTA)-based MRI contrast agents, thanks to micellar self-organization. Chemistry, Vol. 5, no. 10. pp. 2977-2983.

Fischer, H. and Gottschlich, R. and Seelig, A.. (1998) Blood-brain barrier permeation : molecular parameters governing passive diffusion. The Journal of Membrane Biology, 165 (3). pp. 201-211.

Seelig, A.. (1998) A general pattern for substrate recognition by P-glycoprotein. European journal of biochemistry, Vol. 251, H. 1/2. pp. 252-261.

Seelig, A.. (1998) How does P-glycoprotein recognize its substrates? International Journal of Clinical Pharmacology and Therapeutics, 36 (1). pp. 50-54.

Wenk, M. R. and Alt, T. and Seelig, A. and Seelig, J.. (1997) Octyl-beta-D-glucopyranoside partitioning into lipid bilayers: thermodynamics of binding and structural changes of the bilayer. Biophysical Journal, 72 (4). pp. 1719-1731.

Hanakam, F. and Gerisch, G. and Lotz, S. and Alt, T. and Seelig, A.. (1996) Binding of hisactophilin I and II to lipid membranes is controlled by a pH-dependent myristoyl-histidine switch. Biochemistry, Vol. 35, H. 34. pp. 11036-11044.

Seelig, A. and Alt, T. and Lotz, S. and Holzemann, G.. (1996) Binding of substance P agonists to lipid membranes and to the neurokinin-1 receptor. Biochemistry, Vol. 35, H. 14. pp. 4365-4374.

Dathe, M. and Wieprecht, T. and Seelig, A. and Matsuzaki, K. and Bienert, M.. (1996) Antimikrobiell wirksame Peptide : zur Rolle der Primär- und Sekundärstruktur für die Peptid-Membran-Interaktion. Nova acta Leopoldina. [Neue Folge]. Supplementum, Nr. 14. pp. 33-45.

Seelig, A. and Gottschlich, R. and Devant, R. M.. (1994) A method to determine the ability of drugs to diffuse through the blood-brain barrier. Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, H. 1. pp. 68-72.

Holzemann, G. and Greiner, H. E. and Harting, J. and Barnickel, G. and Seelig, A.. (1993) Do substance P agonists insert into the lipid membrane? Regulatory Peptides, Vol. 46, H. 1-2. pp. 453-454.

Seelig, A.. (1992) Interaction of a substance P agonist and of substance P antagonists with lipid membranes : a thermodynamic analysis. Biochemistry, Vol. 31, H. 11. pp. 2897-2904.

Seelig, A. and Doelz, R.. (1991) Substance P and antagonists : Surface activity, conformations, and lipid binding. Annals of the New York Academy of Sciences, Vol. 632. pp. 468-470.

Seelig, A.. (1990) The use of monolayers for simple and quantitative analysis of lipid-drug interactions exemplified with dibucaine and substance P. Cell Biology International Reports, Vol. 14, H. 4. pp. 369-380.

Seelig, A.. (1990) Substance P and antagonists : surface activity and molecular shapes. Biochimica et biophysica acta, Vol. 1030, H. 1. pp. 111-118.

Seelig, A. and Macdonald, P. M.. (1989) Binding of a neuropeptide, substance P, to neutral and negatively charged lipids. Biochemistry, Vol. 28, H. 6. pp. 2490-2496.

Seelig, A. and Allegrini, P. R. and Seelig, J.. (1988) Partitioning of local anesthetics into membranes : surface charge effects monitored by the phospholipid head-group. Biochimica et biophysica acta, Vol. 939, H. 2. pp. 267-276.

Seelig, A.. (1987) Local anesthetics and pressure : a comparison of dibucaine binding to lipid monolayers and bilayers. Biochimica et biophysica acta, Vol. 899, H. 2. pp. 196-204.

Seelig, A. and Seelig, J.. (1985) Phospholipid composition and organization of cytochrome c oxidase preparations as determined by 31P-nuclear magnetic resonance. Biochimica et biophysica acta, Vol. 815, H. 2. pp. 153-158.

Seelig, A. and Ludwig, B. and Seelig, J. and Schatz, G.. (1981) Copper and manganese electron spin resonance studies of cytochrome c oxidase from Paracoccus denitrificans. Biochimica et biophysica acta, Vol. 636, H. 2. pp. 162-167.

Seelig, J. and Seelig, A.. (1980) Lipid conformation in model membranes and biological membranes. Quarterly Reviews of Biophysics, 13 (1). pp. 19-61.

Zaccai, G. and Buldt, G. and Seelig, A. and Seelig, J.. (1979) Neutron diffraction studies on phosphatidylcholine model membranes : II. Chain conformation and segmental disorder. Journal of molecular biology, Vol. 134, H. 4. pp. 693-706.

Seelig, A. and Seelig, J.. (1978) Lipid-protein interaction in reconstituted cytochrome c oxidase/phospholipid membranes. Hoppe-Seyler's Zeitschrift für physiologische Chemie, Vol. 359, H. 12. pp. 1747-1756.

Buldt, G. and Gally, H. U. and Seelig, A. and Seelig, J. and Zaccai, G.. (1978) Neutron diffraction studies on selectively deuterated phospholipid bilayers. Nature, Vol. 271. pp. 182-184.

Seelig, A. and Seelig, J.. (1977) Effect of a single cis double bond on the structures of a phospholipid bilayer. Biochemistry, Vol. 16, H. 1. pp. 45-50.

Gally, H. U. and Seelig, A. and Seelig, J.. (1976) Cholesterol-induced rod-like motion of fatty acyl chains in lipid bilayers a deuterium magnetic resonance study. Hoppe-Seyler's Zeitschrift für physiologische Chemie, Vol. 357, H. 10. pp. 1447-1450.

Schwarz, G. and Seelig-Loffler, A.. (1975) Aggregation of linear biopolymers induced by cooperative binding of ligands. Biochimica et biophysica acta, Vol. 379, H. 1. pp. 125-138.

Robinson, B. H. and Seelig-Loffler, A. and Schwarz, G.. (1975) Kinetic and amplitude measurements for process of association of acridine-orange studied by temperature-jump relaxation spectroscopy. Journal of the Chemical Society, Vol. 71, H. 4. pp. 815-830.

Seelig, A. and Seelig, J.. (1975) Bilayers of dipalmitoyl-3-sn-phosphatidylcholine : conformational differences between the fatty acyl chains. Biochimica et biophysica acta, Vol. 406, H. 1. pp. 1-5.

Seelig, A. and Seelig, J.. (1974) The dynamic structure of fatty acyl chains in a phospholipid bilayer measured by deuterium magnetic resonance. Biochemistry, Vol. 13, H. 23. pp. 4839-4845.

Seelig, J. and Seelig, A.. (1974) Deuterium magnetic resonance studies of phospholipid bilayers. Biochemical and biophysical research communications, Vol. 57, H. 2. pp. 406-411.

Robinson, B. H. and Loffler, A. and Schwarz, G.. (1973) Thermodynamic behavior of acridine-orange in solution : Model system for studying stacking and charge-effects on self-aggregation. Journal of the Chemical Society, Vol. 69, H. 1. pp. 56-69.

Book Section

Seelig, A.. (2009) Toward understanding P-glycoprotein structure-activity relationships. In: Drug bioavailability. Weinheim, pp. 497-519.

Seelig, A. and Gatlik, E. and Fischer, H. and Li-Blatter, X.. (2003) Towards P-glycoprotein structure-activity relationships. In: Drug bioavailability. Weinheim, pp. 461-492.

Seelig, A. and Seelig, J.. (2002) Membrane structure. In: Encyclopedia of physical science and technology, Vol. 9. San Diego, pp. 355-367.

Seelig, A. and Alt, T. and Kuerz, L. and Mutter, M.. (1993) The Gibbs Adsorption isotherm provides information on the secondary structure formation of amphiphilic peptides. In: Peptides 1992. Leiden, pp. 113-114.

Seelig, J. and Seelig, A. and Tamm, L.. (1982) Nuclear magnetic resonance and lipid-protein interactions : a review. In: Lipid-Protein Interactions, Vol. 2. New York, pp. 127-148.

Robinson, B. H. and Seelig-Loffler, A. and Schwarz, G.. (1975) The thermodynamics and kinetics of association of acridine dyes in aqueous media : a model system for the study of stacking and charge effects on self-aggregation. In: Chemical and biological applications of relaxation spectrometry. Dordrecht, pp. 481-485.

Conference or Workshop Item

Seelig, A. and Seelig, J.. (1996) Interaction of drugs and peptides with the lipid membrane. In: Structure and Function of 7TM Receptors. Copenhagen, pp. 184-191.

Holzemann, G. and Gotsmann, W. and Greiner, H. and Seelig, A.. (1994) Surface activity measurements of NK-2 antagonists. In: Proceedings of the 5th Akabori Conference. München, pp. 116-119.

Mutter, M. and Altmann, K. -H. and Buttkus, U. and Gassmann, R. and Kuerz, L. and Seelig, A.. (1991) Switch peptides : medium induced alpha-helix to beta-sheet transitions of bis-amphiphilic secondary structures and their membrane activity. In: Peptides, 1991. Leiden, pp. 344-345.