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Schwertz, Geoffrey and Witschel, Matthias C. and Rottmann, Matthias and Bonnert, Roger and Leartsakulpanich, Ubolsree and Chitnumsub, Penchit and Jaruwat, Aritsara and Ittarat, Wanwipa and Schäfer, Anja and Aponte, Raphael A. and Charman, Susan A. and White, Karen L. and Kundu, Abhijit and Sadhukhan, Surajit and Lloyd, Mel and Freiberg, Gail M. and Srikumaran, Myron and Siggel, Marc and Zwyssig, Adrian and Chaiyen, Pimchai and Diederich, François. (2017) Antimalarial inhibitors rargeting serine hydroxymethyltransferase (SHMT) with in vivo efficacy and analysis of their binding mode based on X-ray cocrystal structures. Journal of Medicinal Chemistry, 60 (12). pp. 4840-4860.

Najer, Adrian and Wu, Dalin and Nussbaumer, Martin G. and Schwertz, Geoffrey and Schwab, Anatol and Witschel, Matthias C. and Schafer, Anja and Diederich, Francois and Rottmann, Matthias and Palivan, Cornelia G. and Beck, Hans-Peter and Meier, Wolfgang. (2016) An amphiphilic graft copolymer-based nanoparticle platform for reduction-responsive anticancer and antimalarial drug delivery. Nanoscale, 8. pp. 14858-14869.

Lakshminarayana, Suresh B. and Freymond, Céline and Fischli, Christoph and Yu, Jing and Weber, Sebastian and Goh, Anne and Yeung, Bryan K. S. and Ho, Paul C. and Dartois, Véronique and Diagana, Thierry T. and Rottmann, Matthias and Blasco, Francesca. (2015) Pharmacokinetic-pharmacodynamic analysis of spiroindolone analogs and KAE609 in a murine malaria model. Antimicrobial agents and chemotherapy, Vol. 59, H. 2. pp. 1200-1210.

Witschel, Matthias C. and Rottmann, Matthias and Schwab, Anatol and Leartsakulpanich, Ubolsree and Chitnumsub, Penchit and Seet, Michael and Tonazzi, Sandro and Schwertz, Geoffrey and Stelzer, Frank and Mietzner, Thomas and McNamara, Case and Thater, Frank and Freymond, Céline and Jaruwat, Aritsara and Pinthong, Chatchadaporn and Riangrungroj, Pinpunya and Oufir, Mouhssin and Hamburger, Matthias and Mäser, Pascal and Sanz-Alonso, Laura M. and Charman, Susan and Wittlin, Sergio and Yuthavong, Yongyuth and Chaiyen, Pimchai and Diederich, François. (2015) Inhibitors of plasmodial serine hydroxymethyltransferase (SHMT) : co-crystal structures of pyrazolopyrans with potent blood-and liver-stage activities. Journal of Medicinal Chemistry, 58 (7). pp. 3117-3130.

Bürstner, Nathalie and Roggo, Silvio and Ostermann, Nils and Blank, Jutta and Delmas, Cecile and Freuler, Felix and Gerhartz, Bernd and Hinniger, Alexandra and Hoepfner, Dominic and Liechty, Brigitta and Mihalic, Manuel and Murphy, Jason and Pistorius, Dominik and Rottmann, Matthias and Thomas, Jason R. and Schirle, Markus and Schmitt, Esther K.. (2015) Gift from nature : cyclomarin s kills Mycobacteria and malaria parasites by distinct modes of action. ChemBioChem, 16 (17). pp. 2433-2436.

Urbán, Patricia and Valle-Delgado, Juan José and Mauro, Nicolò and Marques, Joana and Manfredi, Amedea and Rottmann, Matthias and Ranucci, Elisabetta and Ferruti, Paolo and Fernàndez-Busquets, Xavier. (2014) Use of poly(amidoamine) drug conjugates for the delivery of antimalarials to Plasmodium. Journal of controlled release : official journal of the Controlled Release Society, Vol. 177. pp. 84-95.

Kunfermann, Andrea and Witschel, Matthias and Illarionov, Boris and Martin, René and Rottmann, Matthias and Höffken, H. Wolfgang and Seet, Michael and Eisenreich, Wolfgang and Knölker, Hans-Joachim and Fischer, Markus and Bacher, Adelbert and Groll, Michael and Diederich, François. (2014) Pseudilins : halogenated, allosteric inhibitors of the non-mevalonate pathway enzyme IspD. Angewandte Chemie. International edition in English, Vol. 53, H. 8. pp. 2235-2239.

Brancucci, Nicolas M. B. and Bertschi, Nicole L. and Zhu, Lei and Niederwieser, Igor and Chin, Wai Hoe and Wampfler, Rahel and Freymond, Céline and Rottmann, Matthias and Felger, Ingrid and Bozdech, Zbynek and Voss, Till S.. (2014) Heterochromatin protein 1 secures survival and transmission of malaria parasites. Cell host & microbe, Vol. 16, H. 2. pp. 165-176.

Kuhen, Kelli L. and Chatterjee, Arnab K. and Rottmann, Matthias and Gagaring, Kerstin and Borboa, Rachel and Buenviaje, Jennifer and Chen, Zhong and Francek, Carolyn and Wu, Tao and Nagle, Advait and Barnes, S. Whitney and Plouffe, David and Lee, Marcus C. S. and Fidock, David A. and Graumans, Wouter and van de Vegte-Bolmer, Marga and van Gemert, Geert J. and Wirjanata, Grennady and Sebayang, Boni and Marfurt, Jutta and Russell, Bruce and Suwanarusk, Rossarin and Price, Ric N. and Nosten, Francois and Tungtaeng, Anchalee and Gettayacamin, Montip and Sattabongkot, Jetsumon and Taylor, Jennifer and Walker, John R. and Tully, David and Patra, Kailash P. and Flannery, Erika L. and Vinetz, Joseph M. and Renia, Laurent and Sauerwein, Robert W. and Winzeler, Elizabeth A. and Glynne, Richard J. and Diagana, Thierry T.. (2014) KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment, and prevention of disease transmission. Antimicrobial agents and chemotherapy, Vol. 58, H. 9. pp. 5060-5067.

Reker, Daniel and Seet, Michael and Pillong, Max and Koch, Christian P. and Schneider, Petra and Witschel, Matthias C. and Rottmann, Matthias and Freymond, Céline and Brun, Reto and Schweizer, Bernd and Illarionov, Boris and Bacher, Adelbert and Fischer, Markus and Diederich, François and Schneider, Gisbert. (2014) Deorphaning pyrrolopyrazines as potent multi-target antimalarial agents. Angewandte Chemie, Jg. 53, Nr. 27. pp. 7079-7084.

Aureggi, V. and Ehmke, V. and Wieland, J. and Schweizer, W. B. and Bernet, B. and Bur, D. and Meyer, S. and Rottmann, M. and Freymond, C. and Brun, R. and Breit, B. and Diederich, F.. (2013) Potent inhibitors of malarial aspartic proteases, the plasmepsins, by hydroformylation of substituted 7-azanorbornenes. Chemistry : a European journal, Vol. 19, H. 1. pp. 155-164.

Kemp, Louise E. and Rusch, Marion and Adibekian, Alexander and Bullen, Hayley E. and Graindorge, Arnault and Freymond, Céline and Rottmann, Matthias and Braun-Breton, Catherine and Baumeister, Stefan and Porfetye, Arthur T. and Vetter, Ingrid R. and Hedberg, Christian and Soldati-Favre, Dominique. (2013) Characterization of a serine hydrolase targeted by acyl-protein thioesterase inhibitors in toxoplasma gondii. Journal of biological chemistry, Vol. 288, H. 38. pp. 27002-27018.

McNamara, Case W. and Lee, Marcus C. S. and Lim, Chek Shik and Lim, Siau Hoi and Roland, Jason and Nagle, Advait and Simon, Oliver and Yeung, Bryan K. S. and Chatterjee, Arnab K. and McCormack, Susan L. and Manary, Micah J. and Zeeman, Anne-Marie and Dechering, Koen J. and Kumar, T. R. Santha and Henrich, Philipp P. and Gagaring, Kerstin and Ibanez, Maureen and Kato, Nobutaka and Kuhen, Kelli L. and Fischli, Christoph and Rottmann, Matthias and Plouffe, David M. and Bursulaya, Badry and Meister, Stephan and Rameh, Lucia and Trappe, Joerg and Haasen, Dorothea and Timmerman, Martijn and Sauerwein, Robert W. and Suwanarusk, Rossarin and Russell, Bruce and Renia, Laurent and Nosten, Francois and Tully, David C. and Kocken, Clemens H. M. and Glynne, Richard J. and Bodenreider, Christophe and Fidock, David A. and Diagana, Thierry T. and Winzeler, Elizabeth A.. (2013) Targeting Plasmodium PI(4)K to eliminate malaria. Nature, Vol. 504, H. 7479. pp. 248-253.

Ehmke, Veronika and Winkler, Edwin and Banner, David W. and Haap, Wolfgang and Schweizer, W. Bernd and Rottmann, Matthias and Kaiser, Marcel and Freymond, Céline and Schirmeister, Tanja and Diederich, François. (2013) Optimization of triazine nitriles as rhodesain inhibitors : structure-activity relationships, bioisosteric imidazopyridine nitriles, and X-ray crystal structure analysis with human cathepsin L. ChemMedChem : chemistry enabling drug discovery, Vol. 8, H. 6. pp. 967-975.

Mugasa, J. and Qi, W. and Rusch, S. and Rottmann, M. and Beck, H. P.. (2012) Genetic diversity of expressed Plasmodium falciparum var genes from Tanzanian children with severe malaria. Malaria journal, Vol. 11 , 230.

Witschel, M. and Rottmann, M. and Kaiser, M. and Brun, R.. (2012) Agrochemicals against malaria, sleeping sickness, leishmaniasis and Chagas disease. PLoS neglected tropical diseases, Vol. 6, H. 10 , e1805.

Nagle, A. and Wu, T. and Kuhen, K. and Gagaring, K. and Borboa, R. and Francek, C. and Chen, Z. and Plouffe, D. and Lin, X. and Caldwell, C. and Ek, J. and Skolnik, S. and Liu, F. and Wang, J. and Chang, J. and Li, C. and Liu, B. and Hollenbeck, T. and Tuntland, T. and Isbell, J. and Chuan, T. and Alper, P. B. and Fischli, C. and Brun, R. and Lakshminarayana, S. B. and Rottmann, M. and Diagana, T. T. and Winzeler, E. A. and Glynne, R. and Tully, D. C. and Chatterjee, A. K.. (2012) Imidazolopiperazines: lead optimization of the second-generation antimalarial agents. Journal of medicinal chemistry, 55 (9). pp. 4244-4273.

Ehmke, V. and Quinsaat, J. E. and Rivera-Fuentes, P. and Heindl, C. and Freymond, C. and Rottmann, M. and Brun, R. and Schirmeister, T. and Diederich, F.. (2012) Tuning and predicting biological affinity : aryl nitriles as cysteine protease inhibitors. Organic & biomolecular chemistry, Vol. 10, H. 30. pp. 5764-5768.

Mombelli, P. and Witschel, M. C. and van Zijl, A. W. and Geist, J. G. and Rottmann, M. and Freymond, C. and Röhl, F. and Kaiser, M. and Illarionova, V. and Fischer, M. and Siepe, I. and Schweizer, W. B. and Brun, R. and Diederich, F.. (2012) Identification of 1,3-diiminoisoindoline carbohydrazides as potential antimalarial candidates. ChemMedChem, Vol. 7, H. 1. pp. 151-158.

Mäser, P. and Wittlin, S. and Rottmann, M. and Wenzler, T. and Kaiser, M. and Brun, R.. (2012) Antiparasitic agents : new drugs on the horizon. Current opinion in pharmacology, Vol. 12, H. 5. pp. 562-566.

van Pelt-Koops, J. C. and Pett, H. E. and Graumans, W. and Vegte-Bolmer, Mv and van Gemert, G. J. and Rottmann, M. and Yeung, B. K. and Diagana, T. T. and Sauerwein, R. W.. (2012) The spiroindolone drug candidate NITD609 potently inhibits gametocytogenesis and blocks Plasmodium falciparum transmission to Anopheles mosquito vector. Antimicrobial agents and chemotherapy, Vol. 56, H. 7. pp. 3544-3548.

Gemma, S. and Camodeca, C. and Sanna, Coccone and Joshi, B. P. and Bernetti, M. and Moretti, V. and Brogi, S. and Bonache, M. C. and Savini, L. and Taramelli, D. and Basilico, N. and Parapini, S. and Rottmann, M. and Brun, R. and Lamponi, S. and Caccia, S. and Guiso, G. and Summer, R. and Martin, R. and Saponara, S. and Gorelli, B. and Novellino, E. and Campiani, G. and Butini, S.. (2012) Optimization of 4-aminoquinoline/clotrimazole-based hybrid antimalarials : further structure-activity relationships, in vivo studies, and preliminary toxicity profiling. Journal of medicinal chemistry, 55 (15). pp. 6948-6967.

Chadwick, J. and Amewu, R. K. and Marti, F. and Bousejra-El Garah F., and Sharma, R. and Berry, N. G. and Stocks, P. A. and Burrell-Saward H., and Wittlin, S. and Rottmann, M. and Brun, R. and Taramelli, D. and Parapini, S. and Ward, S. A. and O'Neill P. M., . (2011) Antimalarial mannoxanes : hybrid antimalarial drugs with outstanding oral activity profiles and a potential dual mechanism of action. ChemMedChem : chemistry enabling drug discovery, Vol. 6, H. 8. pp. 1357-1361.

Wu, T. and Nagle, A. and Kuhen, K. and Gagaring, K. and Borboa, R. and Francek, C. and Chen, Z. and Plouffe, D. and Goh, A. and Lakshminarayana, S. B. and Wu, J. and Ang, H. Q. and Zeng, P. and Kang, M. L. and Tan, W. and Tan, M. and Ye, N. and Lin, X. and Caldwell, C. and Ek, J. and Skolnik, S. and Liu, F. and Wang, J. and Chang, J. and Li, C. and Hollenbeck, T. and Tuntland, T. and Isbell, J. and Fischli, C. and Brun, R. and Rottmann, M. and Dartois, V. and Keller, T. and Diagana, T. and Winzeler, E. and Glynne, R. and Tully, D. C. and Chatterjee, A. K.. (2011) Imidazolopiperazines: hit to lead optimization of new antimalarial agents. Journal of medicinal chemistry, 54 (14). pp. 5116-5130.

Schiaffo, C. E. and Rottmann, M. and Wittlin, S. and Dussault, P. H.. (2011) 3-alkoxy-1,2-dioxolanes : synthesis and evaluation as potential antimalarial agents. ACS medicinal chemistry letters, Vol. 2, H. 4. pp. 316-319.

Ehmke, V. and Heindl, C. and Rottmann, M. and Freymond, C. and Schweizer, W. B. and Brun, R. and Stich, A. and Schirmeister, T. and Diederich, F.. (2011) Potent and selective inhibition of cysteine proteases from Plasmodium falciparum and Trypanosoma brucei. ChemMedChem : chemistry enabling drug discovery, Vol. 6, H. 2. pp. 273-278.

Tripathi, A. and Puddick, J. and Prinsep, M. R. and Rottmann, M. and Chan, K. P. and Chen, D. Y. and Tan, L. T.. (2011) Lagunamide C, a cytotoxic cyclodepsipeptide from the marine cyanobacterium Lyngbya majuscula. Phytochemistry : an international journal of plant biochemistry, Vol. 72, H. 18. pp. 2369-2375.

Meister, S. and Plouffe, D. M. and Kuhen, K. L. and Bonamy, G. M. and Wu, T. and Barnes, S. W. and Bopp, S. E. and Borboa, R. and Bright, A. T. and Che, J. and Cohen, S. and Dharia, N. V. and Gagaring, K. and Gettayacamin, M. and Gordon, P. and Groessl, T. and Kato, N. and Lee, M. C. and McNamara, C. W. and Fidock, D. A. and Nagle, A. and Nam, T. G. and Richmond, W. and Roland, J. and Rottmann, M. and Zhou, B. and Froissard, P. and Glynne, R. J. and Mazier, D. and Sattabongkot, J. and Schultz, P. G. and Tuntland, T. and Walker, J. R. and Zhou, Y. and Chatterjee, A. and Diagana, T. T. and Winzeler, E. A.. (2011) Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery. Science, Vol. 334, H. 6061. pp. 1372-1377.

Tripathi, A. and Puddick, J. and Prinsep, M. R. and Rottmann, M. and Tan, L. T.. (2010) Lagunamides A and B : cytotoxic and antimalarial cyclodepsipeptides from the marine cyanobacterium Lyngbya majuscula. Journal of natural products, Vol. 73, H. 11. pp. 1810-1814.