Items where Author is "Avery, Vicky M."

2017

Leven, Michael and Knaab, Tanja C. and Held, Jana and Duffy, Sandra and Meister, Stephan and Fischli, Christoph and Meitzner, Diane and Lehmann, Ursula and Lungerich, Beate and Kuna, Krystina and Stahlke, Petra and Delves, Michael J. and Buchholz, Mirko and Winzeler, Elizabeth A. and Avery, Vicky M. and Mordmüller, Benjamin and Wittlin, Sergio and Kurz, Thomas. (2017) 3-hydroxy-N'-arylidenepropanehydrazonamides with halo-substituted phenanthrene scaffolds cure P. berghei infected mice when administered perorally. Journal of Medicinal Chemistry, 60 (14). pp. 6036-6044.

2016

Baragaña, Beatriz and Norcross, Neil R. and Wilson, Caroline and Porzelle, Achim and Hallyburton, Irene and Grimaldi, Raffaella and Osuna-Cabello, Maria and Norval, Suzanne and Riley, Jennifer and Stojanovski, Laste and Simeons, Frederick R. C. and Wyatt, Paul G. and Delves, Michael J. and Meister, Stephan and Duffy, Sandra and Avery, Vicky M. and Winzeler, Elizabeth A. and Sinden, Robert E. and Wittlin, Sergio and Frearson, Julie A. and Gray, David W. and Fairlamb, Alan H. and Waterson, David and Campbell, Simon F. and Willis, Paul and Read, Kevin D. and Gilbert, Ian H.. (2016) Discovery of a quinoline-4-carboxamide derivative with a novel mechanism of action, multistage antimalarial activity, and potent in vivo efficacy. Journal of medicinal chemistry, 59 (21). pp. 9672-9685.

Russell, Stephanie and Rahmani, Raphaël and Jones, Amy J. and Newson, Harriet L. and Neilde, Kevin and Cotillo, Ignacio and Rahmani Khajouei, Marzieh and Ferrins, Lori and Qureishi, Sana and Nguyen, Nghi and Martinez-Martinez, Maria S. and Weaver, Donald F. and Kaiser, Marcel and Riley, Jennifer and Thomas, John and De Rycker, Manu and Read, Kevin D. and Flematti, Gavin R. and Ryan, Eileen and Tanghe, Scott and Rodriguez, Ana and Charman, Susan A. and Kessler, Albane and Avery, Vicky M. and Baell, Jonathan B. and Piggott, Matthew J.. (2016) Hit-to-lead optimization of a novel class of potent, broad-spectrum trypanosomacides. Journal of Medicinal Chemistry, 59 (21). pp. 9686-9720.

Van Voorhis, Wesley C. and Adams, John H. and Adelfio, Roberto and Ahyong, Vida and Akabas, Myles H. and Alano, Pietro and Alday, Aintzane and Alemán Resto, Yesmalie and Alsibaee, Aishah and Alzualde, Ainhoa and Andrews, Katherine T. and Avery, Simon V. and Avery, Vicky M. and Ayong, Lawrence and Baker, Mark and Baker, Stephen and Ben Mamoun, Choukri and Bhatia, Sangeeta and Bickle, Quentin and Bounaadja, Lotfi and Bowling, Tana and Bosch, Jürgen and Boucher, Lauren E. and Boyom, Fabrice F. and Brea, Jose and Brennan, Marian and Burton, Audrey and Caffrey, Conor R. and Camarda, Grazia and Carrasquilla, Manuela and Carter, Dee and Belen Cassera, Maria and Chih-Chien Cheng, Ken and Chindaudomsate, Worathad and Chubb, Anthony and Colon, Beatrice L. and Colón-López, Daisy D. and Corbett, Yolanda and Crowther, Gregory J. and Cowan, Noemi and D'Alessandro, Sarah and Le Dang, Na and Delves, Michael and DeRisi, Joseph L. and Du, Alan Y. and Duffy, Sandra and Abd El-Salam El-Sayed, Shimaa and Ferdig, Michael T. and Fernández Robledo, José A. and Fidock, David A. and Florent, Isabelle and Fokou, Patrick V. T. and Galstian, Ani and Gamo, Francisco Javier and Gokool, Suzanne and Gold, Ben and Golub, Todd and Goldgof, Gregory M. and Guha, Rajarshi and Guiguemde, W. Armand and Gural, Nil and Guy, R. Kiplin and Hansen, Michael A. E. and Hanson, Kirsten K. and Hemphill, Andrew and Hooft van Huijsduijnen, Rob and Horii, Takaaki and Horrocks, Paul and Hughes, Tyler B. and Huston, Christopher and Igarashi, Ikuo and Ingram-Sieber, Katrin and Itoe, Maurice A. and Jadhav, Ajit and Naranuntarat Jensen, Amornrat and Jensen, Laran T. and Jiang, Rays H. Y. and Kaiser, Annette and Keiser, Jennifer and Ketas, Thomas and Kicka, Sebastien and Kim, Sunyoung and Kirk, Kiaran and Kumar, Vidya P. and Kyle, Dennis E. and Lafuente, Maria Jose and Landfear, Scott and Lee, Nathan and Lee, Sukjun and Lehane, Adele M. and Li, Fengwu and Little, David and Liu, Liqiong and Llinás, Manuel and Loza, Maria I. and Lubar, Aristea and Lucantoni, Leonardo and Lucet, Isabelle and Maes, Louis and Mancama, Dalu and Mansour, Nuha R. and March, Sandra and McGowan, Sheena and Medina Vera, Iset and Meister, Stephan and Mercer, Luke and Mestres, Jordi and Mfopa, Alvine N. and Misra, Raj N. and Moon, Seunghyun and Moore, John P. and Morais Rodrigues da Costa, Francielly and Müller, Joachim and Muriana, Arantza and Nakazawa Hewitt, Stephen and Nare, Bakela and Nathan, Carl and Narraidoo, Nathalie and Nawaratna, Sujeevi and Ojo, Kayode K. and Ortiz, Diana and Panic, Gordana and Papadatos, George and Parapini, Silvia and Patra, Kailash and Pham, Ngoc and Prats, Sarah and Plouffe, David M. and Poulsen, Sally-Ann and Pradhan, Anupam and Quevedo, Celia and Quinn, Ronald J. and Rice, Christopher A. and Abdo Rizk, Mohamed and Ruecker, Andrea and St Onge, Robert and Salgado Ferreira, Rafaela and Samra, Jasmeet and Robinett, Natalie G. and Schlecht, Ulrich and Schmitt, Marjorie and Silva Villela, Filipe and Silvestrini, Francesco and Sinden, Robert and Smith, Dennis A. and Soldati, Thierry and Spitzmüller, Andreas and Stamm, Serge Maximilian and Sullivan, David J. and Sullivan, William and Suresh, Sundari and Suzuki, Brian M. and Suzuki, Yo and Swamidass, S. Joshua and Taramelli, Donatella and Tchokouaha, Lauve R. Y. and Theron, Anjo and Thomas, David and Tonissen, Kathryn F. and Townson, Simon and Tripathi, Abhai K. and Trofimov, Valentin and Udenze, Kenneth O. and Ullah, Imran and Vallieres, Cindy and Vigil, Edgar and Vinetz, Joseph M. and Voong Vinh, Phat and Vu, Hoan and Watanabe, Nao-Aki and Weatherby, Kate and White, Pamela M. and Wilks, Andrew F. and Winzeler, Elizabeth A. and Wojcik, Edward and Wree, Melanie and Wu, Wesley and Yokoyama, Naoaki and Zollo, Paul H. A. and Abla, Nada and Blasco, Benjamin and Burrows, Jeremy and Laleu, Benoît and Leroy, Didier and Spangenberg, Thomas and Wells, Timothy and Willis, Paul A.. (2016) Open source drug discovery with the malaria box compound collection for neglected diseases and beyond. PLoS Pathogens, 12 (7). e1005763.

Norcross, Neil R. and Baragaña, Beatriz and Wilson, Caroline and Hallyburton, Irene and Osuna-Cabello, Maria and Norval, Suzanne and Riley, Jennifer and Stojanovski, Laste and Simeons, Frederick R. C. and Porzelle, Achim and Grimaldi, Raffaella and Wittlin, Sergio and Duffy, Sandra and Avery, Vicky M. and Meister, Stephan and Sanz, Laura and Jiménez-Díaz, Belén and Angulo-Barturen, Iñigo and Ferrer, Santiago and Martínez, María Santos and Gamo, Francisco Javier and Frearson, Julie A. and Gray, David W. and Fairlamb, Alan H. and Winzeler, Elizabeth A. and Waterson, David and Campbell, Simon F. and Willis, Paul and Read, Kevin D. and Gilbert, Ian H.. (2016) Trisubstituted Pyrimidines as Efficacious and Fast-Acting Antimalarials. Journal of Medicinal Chemistry, 59 (13). pp. 6101-6120.

2015

Rahmani, Raphaël and Ban, Kung and Jones, Amy J. and Ferrins, Lori and Ganame, Danny and Sykes, Melissa L. and Avery, Vicky M. and White, Karen L. and Ryan, Eileen and Kaiser, Marcel and Charman, Susan A. and Baell, Jonathan B.. (2015) 6-Arylpyrazine-2-carboxamides : a new core for Trypanosoma brucei inhibitors. Journal of medicinal chemistry, 58 (17). pp. 6753-6765.

Phillips, Margaret A. and Lotharius, Julie and Marsh, Kennan and White, John and Dayan, Anthony and White, Karen L. and Njoroge, Jacqueline W. and El Mazouni, Farah and Lao, Yanbin and Kokkonda, Sreekanth and Tomchick, Diana R. and Deng, Xiaoyi and Laird, Trevor and Bhatia, Sangeeta N. and March, Sandra and Ng, Caroline L. and Fidock, David A. and Wittlin, Sergio and Lafuente-Monasterio, Maria and Benito, Francisco Javier Gamo and Alonso, Laura Maria Sanz and Martinez, Maria Santos and Jimenez-Diaz, Maria Belen and Bazaga, Santiago Ferrer and Angulo-Barturen, Iñigo and Haselden, John N. and Louttit, James and Cui, Yi and Sridhar, Arun and Zeeman, Anna-Marie and Kocken, Clemens and Sauerwein, Robert and Dechering, Koen and Avery, Vicky M. and Duffy, Sandra and Delves, Michael and Sinden, Robert and Ruecker, Andrea and Wickham, Kristina S. and Rochford, Rosemary and Gahagen, Janet and Iyer, Lalitha and Riccio, Ed and Mirsalis, Jon and Bathhurst, Ian and Rueckle, Thomas and Ding, Xavier and Campo, Brice and Leroy, Didier and Rogers, M. John and Rathod, Pradipsinh K. and Burrows, Jeremy N. and Charman, Susan A.. (2015) A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria. Science translational medicine, Vol. 7, H. 296 , 296ra111.

Baragaña, Beatriz and Hallyburton, Irene and Lee, Marcus C. S. and Norcross, Neil R. and Grimaldi, Raffaella and Otto, Thomas D. and Proto, William R. and Blagborough, Andrew M. and Meister, Stephan and Wirjanata, Grennady and Ruecker, Andrea and Upton, Leanna M. and Abraham, Tara S. and Almeida, Mariana J. and Pradhan, Anupam and Porzelle, Achim and Martínez, María Santos and Bolscher, Judith M. and Woodland, Andrew and Norval, Suzanne and Zuccotto, Fabio and Thomas, John and Simeons, Frederick and Stojanovski, Laste and Osuna-Cabello, Maria and Brock, Paddy M. and Churcher, Tom S. and Sala, Katarzyna A. and Zakutansky, Sara E. and Jiménez-Díaz, María Belén and Sanz, Laura Maria and Riley, Jennifer and Basak, Rajshekhar and Campbell, Michael and Avery, Vicky M. and Sauerwein, Robert W. and Dechering, Koen J. and Noviyanti, Rintis and Campo, Brice and Frearson, Julie A. and Angulo-Barturen, Iñigo and Ferrer-Bazaga, Santiago and Gamo, Francisco Javier and Wyatt, Paul G. and Leroy, Didier and Siegl, Peter and Delves, Michael J. and Kyle, Dennis E. and Wittlin, Sergio and Marfurt, Jutta and Price, Ric N. and Sinden, Robert E. and Winzeler, Elizabeth A. and Charman, Susan A. and Bebrevska, Lidiya and Gray, David W. and Campbell, Simon and Fairlamb, Alan H. and Willis, Paul A. and Rayner, Julian C. and Fidock, David A. and Read, Kevin D. and Gilbert, Ian H.. (2015) A novel multiple-stage antimalarial agent that inhibits protein synthesis. Nature, Vol. 522, H. 7556. pp. 315-320.

Malmquist, Nicholas A. and Sundriyal, Sandeep and Caron, Joachim and Chen, Patty and Witkowski, Benoit and Menard, Didier and Suwanarusk, Rossarin and Renia, Laurent and Nosten, Francois and Jiménez-Díaz, María Belén and Angulo-Barturen, Iñigo and Martínez, María Santos and Ferrer, Santiago and Sanz, Laura M. and Gamo, Francisco-Javier and Wittlin, Sergio and Duffy, Sandra and Avery, Vicky M. and Ruecker, Andrea and Delves, Michael J. and Sinden, Robert E. and Fuchter, Matthew J. and Scherf, Artur. (2015) Histone methyltransferase inhibitors are orally bioavailable, fast-acting molecules with activity against different species causing malaria in humans. Antimicrobial agents and chemotherapy, Vol. 59, H. 2. pp. 950-959.

Jones, Amy J. and Kaiser, Marcel and Avery, Vicky M.. (2015) Identification and characterization of FTY720 for the treatment of human African trypanosomiasis. Antimicrobial agents and chemotherapy, 60 (3). pp. 1859-1861.

2014

González Cabrera, Diego and Le Manach, Claire and Douelle, Frederic and Younis, Yassir and Feng, Tzu-Shean and Paquet, Tanya and Nchinda, Aloysius T. and Street, Leslie J. and Taylor, Dale and de Kock, Carmen and Wiesner, Lubbe and Duffy, Sandra and White, Karen L. and Zabiulla, K. Mohammed and Sambandan, Yuvaraj and Bashyam, Sridevi and Waterson, David and Witty, Michael J. and Charman, Susan A. and Avery, Vicky M. and Wittlin, Sergio and Chibale, Kelly. (2014) 2,4-diaminothienopyrimidines as orally active antimalarial agents. Journal of medicinal chemistry, 57 (3). pp. 1014-1022.

Leven, Michael and Held, Jana and Duffy, Sandra and Tschan, Serena and Sax, Sibylle and Kamber, Jolanda and Frank, Walter and Kuna, Krystina and Geffken, Detlef and Siethoff, Christoph and Barth, Stéphane and Avery, Vicky M. and Wittlin, Sergio and Mordmüller, Benjamin and Kurz, Thomas. (2014) Blood schizontocidal and gametocytocidal activity of 3-hydroxy-N'-arylidenepropanehydrazonamides. Journal of medicinal chemistry, 57 (19). pp. 7971-7976.

Le Manach, Claire and Gonzàlez Cabrera, Diego and Douelle, Frederic and Nchinda, Aloysius T. and Younis, Yassir and Taylor, Dale and Wiesner, Lubbe and White, Karen L. and Ryan, Eileen and March, Corinne and Duffy, Sandra and Avery, Vicky M. and Waterson, David and Witty, Michael J. and Wittlin, Sergio and Charman, Susan A. and Street, Leslie J. and Chibale, Kelly. (2014) Medicinal chemistry optimization of antiplasmodial imidazopyridazine hits from high throughput screening of a SoftFocus kinase library : part 1. Journal of medicinal chemistry, 57 (6). pp. 2789-2798.

Ferrins, Lori and Gazdik, Michelle and Rahmani, Raphaël and Varghese, Swapna and Sykes, Melissa L. and Jones, Amy J. and Avery, Vicky M. and White, Karen L. and Ryan, Eileen and Charman, Susan A. and Kaiser, Marcel and Bergström, Christel A. S. and Baell, Jonathan B.. (2014) Pyridyl benzamides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei. Journal of medicinal chemistry, 57 (15). pp. 6393-6402.

2013

Ferrins, Lori and Rahmani, Raphaël and Sykes, Melissa L. and Jones, Amy J. and Avery, Vicky M. and Teston, Eliott and Almohaywi, Basmah and Yin, Jiexiang and Smith, Jason and Hyland, Chris and White, Karen L. and Ryan, Eileen and Campbell, Michael and Charman, Susan A. and Kaiser, Marcel and Baell, Jonathan B.. (2013) 3-(Oxazolo[4,5-b]pyridin-2-yl)anilides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei, the causative agent for human African trypanosomiasis. European journal of medicinal chemistry, 66. pp. 450-465.