Items where Author is "Hall, Michael N."

28 August 2017

Singer, Jochen and Ruscheweyh, Hans-Joachim and Hofmann, Ariane L. and Thurnherr, Thomas and Singer, Franziska and Toussaint, Nora C. and Ng, Charlotte K. Y. and Piscuoglio, Salvatore and Beisel, Christian and Christofori, Gerhard and Dummer, Reinhard and Hall, Michael N. and Krek, Wilhelm and Levesque, Mitchell and Manz, Markus G. and Moch, Holger and Papassotiropoulos, Andreas and Stekhoven, Daniel J. and Wild, Peter and Wüst, Thomas and Rinn, Bernd and Beerenwinkel, Niko. (2017) NGS-pipe: a flexible, easily extendable, and highly configurable framework for NGS analysis. Bioinformatics . pp. 1-2.

2017

Tang, Fei and Zhang, Peng and Ye, Peiying and Lazarski, Christopher A. and Wu, Qi and Bergin, Ingrid L. and Bender, Timothy P. and Hall, Michael N. and Cui, Ya and Zhang, Liguo and Jiang, Taijiao and Liu, Yang and Zheng, Pan. (2017) A population of innate myelolymphoblastoid effector cell expanded by inactivation of mTOR complex 1 in mice. eLife, 6. aheadofrint.

Hall, Michael N.. (2017) An Amazing Turn of Events. Cell, 171 (1). pp. 18-22.

Bozadjieva, Nadejda and Blandino-Rosano, Manuel and Chase, Jennifer and Dai, Xiao-Qing and Cummings, Kelsey and Gimeno, Jennifer and Dean, Danielle and Powers, Alvin C. and Gittes, George K. and Rüegg, Markus A. and Hall, Michael N. and MacDonald, Patrick E. and Bernal-Mizrachi, Ernesto. (2017) Loss of mTORC1 signaling alters pancreatic α cell mass and impairs glucagon secretion. Journal of Clinical Investigation. pp. 1-15.

Blandino-Rosano, Manuel and Barbaresso, Rebecca and Jimenez-Palomares, Margarita and Bozadjieva, Nadejda and Werneck-de-Castro, Joao Pedro and Hatanaka, Masayuki and Mirmira, Raghavendra G. and Sonenberg, Nahum and Liu, Ming and Rüegg, Markus A. and Hall, Michael N. and Bernal-Mizrachi, Ernesto. (2017) Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing. Nature Communications, 8. p. 16014.

González, Asier and Hall, Michael N.. (2017) Nutrient sensing and TOR signaling in yeast and mammals. The EMBO Journal, 36 (4). pp. 397-408.

Benjamin, Don and Hall, Michael N.. (2017) mTORC1 Controls Synthesis of Its Activator GTP. Cell Reports , 19 (13). pp. 2643-2644.

Fitter, Stephen and Matthews, Mary P. and Martin, Sally K. and Xie, Jianling and Ooi, Soo Siang and Walkley, Carl R. and Codrington, John D. and Ruegg, Markus A. and Hall, Michael N. and Proud, Christopher G. and Gronthos, Stan and Zannettino, Andrew C. W.. (2017) mTORC1 Plays an Important Role in Skeletal Development by Controlling Preosteoblast Differentiation. Molecular and Cellular Biology, 37 (7). e00668-16.

Fitter, Stephen and Matthews, Mary P. and Martin, Sally K. and Xie, Jianling and Ooi, Soo Siang and Walkley, Carl R. and Codrington, John D. and Ruegg, Markus A. and Hall, Michael N. and Proud, Christopher G. and Gronthos, Stan and Zannettino, Andrew C. W.. (2017) mTORC1 Plays an Important Role in Skeletal Development by Controlling pre-Osteoblast Differentiation. Molecular and Cellular Biology, 37 (7). e00668-16.

Guri, Yakir and Colombi, Marco and Dazert, Eva and Hindupur, Sravanth K. and Roszik, Jason and Moes, Suzette and Jenoe, Paul and Heim, Markus H. and Riezman, Isabelle and Riezman, Howard and Hall, Michael N.. (2017) mTORC2 Promotes Tumorigenesis via Lipid Synthesis. Cancer Cell, 32 (6). pp. 807-832.

17 May 2016

Swierczynska, Marta M. and Hall, Michael N.. (2016) eIF4A moonlights as an off switch for TORC1. The EMBO Journal, 35 (10). pp. 1013-1014.

May 2016

Grahammer, Florian and Nesterov, Viatcheslav and Ahmed, Azaz and Steinhardt, Frederic and Sandner, Lukas and Arnold, Frederic and Cordts, Tomke and Negrea, Silvio and Bertog, Marko and Ruegg, Marcus A. and Hall, Michael N. and Walz, Gerd and Korbmacher, Christoph and Artunc, Ferruh and Huber, Tobias B.. (2016) mTORC2 critically regulates renal potassium handling. Journal of Clinical Investigation, 126 (5). pp. 1773-1782.

22 April 2016

Drägert, Katja and Bhattacharya, Indranil and Hall, Michael N. and Humar, Rok and Battegay, Edouard and Haas, Elvira. (2016) Basal mTORC2 activity and expression of its components display diurnal variation in mouse perivascular adipose tissue. Biochemical and Biophysical Research Communications, 473 (1). pp. 317-322.

9 February 2016

Zhang, Lianjun and Tschumi, Benjamin O. and Lopez-Mejia, Isabel C. and Oberle, Susanne G. and Meyer, Marten and Samson, Guerric and Rüegg, Markus A. and Hall, Michael N. and Fajas, Lluis and Zehn, Dietmar and Mach, Jean-Pierre and Donda, Alena and Romero, Pedro. (2016) Mammalian Target of Rapamycin Complex 2 Controls CD8 T Cell Memory Differentiation in a Foxo1-Dependent Manner. Cell Reports , 14 (5). pp. 1206-1217.

2 February 2016

Dazert, Eva and Colombi, Marco and Boldanova, Tujana and Moes, Suzette and Adametz, David and Quagliata, Luca and Roth, Volker and Terracciano, Luigi and Heim, Markus H. and Jenoe, Paul and Hall, Michael N.. (2016) Quantitative proteomics and phosphoproteomics on serial tumor biopsies from a sorafenib-treated HCC patient. Proceedings of the National Academy of Sciences of the United States of America, 113 (5). pp. 1381-1386.

1 January 2016

Aylett, Christopher H. S. and Sauer, Evelyn and Imseng, Stefan and Boehringer, Daniel and Hall, Michael N. and Ban, Nenad and Maier, Timm. (2016) Architecture of human mTOR complex 1. Science, 351 (6268). pp. 48-52.

January 2016

Shimobayashi, Mitsugu and Hall, Michael N.. (2016) Multiple amino acid sensing inputs to mTORC1. Cell research, 26 (1). pp. 7-20.

2016

Shende, Pankaj and Xu, Lifen and Morandi, Christian and Pentassuglia, Laura and Heim, Philippe and Lebboukh, Sonia and Berthonneche, Corinne and Pedrazzini, Thierry and Kaufmann, Beat A. and Hall, Michael N. and Rüegg, Markus A. and Brink, Marijke. (2016) Cardiac mTOR complex 2 preserves ventricular function in pressure-overload hypertrophy. Cardiovascular Research, 109 (1). pp. 103-114.

Fonseca, Bruno D. and Graber, Tyson E. and Hoang, Huy-Dung and González, Asier and Soukas, Alexandre A. and Hernández, Greco and Alain, Tommy and Swift, Stephanie L. and Weisman, Ronit and Meyer, Christian and Robaglia, Christophe and Avruch, Joseph and Hall, Michael N.. (2016) Evolution of TOR and Translation Control. In: Evolution of the Protein Synthesis Machinery and Its Regulation. Cham, pp. 327-412.

Herkert, Barbara and Kauffmann, Audrey and Mollé, Sandra and Schnell, Christian and Ferrat, Thomas and Voshol, Hans and Juengert, Janina and Erasimus, Hélène and Marszalek, Grégory and Kazic-Legueux, Malika and Billy, Eric and Ruddy, David and Stump, Mark and Guthy, Daniel and Ristov, Mitko and Calkins, Keith and Maira, Sauveur-Michel and Sellers, William R. and Hofmann, Francesco and Hall, Michael N. and Brachmann, Saskia M.. (2016) Maximizing the Efficacy of MAPK-Targeted Treatment in PTENLOF/BRAFMUT Melanoma through PI3K and IGF1R Inhibition. Cancer Research, 76 (2). pp. 390-402.

Benjamin, Don and Colombi, Marco and Hindupur, Sravanth K. and Betz, Charles and Lane, Heidi A. and El-Shemerly, Mahmoud Y. M. and Lu, Min and Quagliata, Luca and Terracciano, Luigi and Moes, Suzette and Sharpe, Timothy and Wodnar-Filipowicz, Aleksandra and Moroni, Christoph and Hall, Michael N.. (2016) Syrosingopine sensitizes cancer cells to killing by metformin. Science Advances, 2 (12). e1601756.

Hall, Michael N.. (2016) TOR and paradigm change: cell growth is controlled. Molecular Biology of the Cell, 27 (18). pp. 2804-2806.

Guri, Yakir and Hall, Michael N.. (2016) mTOR Signaling Confers Resistance to Targeted Cancer Drugs. Trends in Cancer, 2 (11). pp. 688-697.

Swierczynska, Marta M. and Hall, Michael N.. (2016) mTOR in Metabolic and Endocrine Disorders. In: Molecules to Medicine with mTOR. Translating Critical Pathways into Novel Therapeutic Strategies. London, pp. 347-364.

Ding, Xiaolei and Bloch, Wilhelm and Iden, Sandra and Rüegg, Markus A. and Hall, Michael N. and Leptin, Maria and Partridge, Linda and Eming, Sabine A.. (2016) mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation. Nature Communications, 7. p. 13226.

Driscoll, David R. and Karim, Saadia A. and Sano, Makoto and Gay, David M. and Jacob, Wright and Yu, Jun and Mizukami, Yusuke and Gopinathan, Aarthi and Jodrell, Duncan I. and Evans, T. R. Jeffry and Bardeesy, Nabeel and Hall, Michael N. and Quattrochi, Brian J. and Klimstra, David S. and Barry, Simon T. and Sansom, Owen J. and Lewis, Brian C. and Morton, Jennifer P.. (2016) mTORC2 signaling drives the development and progression of pancreatic cancer. Cancer Research, 76 (23). pp. 6911-6923.

Albert, Verena and Svensson, Kristoffer and Shimobayashi, Mitsugu and Colombi, Marco and Muñoz, Sergio and Jimenez, Veronica and Handschin, Christoph and Bosch, Fatima and Hall, Michael N.. (2016) mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue. EMBO Molecular Medicine, 8 (3). pp. 232-246.

4 December 2015

Aimi, Fabio and Georgiopoulou, Stavroula and Kalus, Ina and Lehner, Fabienne and Hegglin, Alica and Limani, Përparim and Gomes de Lima, Vinicius and Rüegg, Markus A. and Hall, Michael N. and Lindenblatt, Nicole and Haas, Elvira and Battegay, Edouard J. and Humar, Rok. (2015) Endothelial Rictor is crucial for midgestational development and sustained and extensive FGF2-induced neovascularization in the adult. Scientific Reports, 5. p. 17705.

October 2015

Liko, Dritan and Hall, Michael N.. (2015) mTOR in health and in sickness. Journal of Molecular Medicine, 93 (10). pp. 1061-1073.

2015

Martin, Sally K. and Fitter, Stephen and Dutta, Ankit K. and Matthews, Mary P. and Walkley, Carl R. and Hall, Michael N. and Ruegg, Markus A. and Gronthos, Stan and Zannettino, Andrew C. W.. (2015) Brief Report: The Differential Roles of mTORC1 and mTORC2 in Mesenchymal Stem Cell Differentiation. Stem cells, Vol. 33, H. 4. pp. 1359-1365.

Drägert, Katja and Bhattacharya, Indranil and Pellegrini, Giovanni and Seebeck, Petra and Azzi, Abdelhalim and Brown, Steven A. and Georgiopoulou, Stavroula and Held, Ulrike and Blyszczuk, Przemyslaw and Arras, Margarete and Humar, Rok and Hall, Michael N. and Battegay, Edouard and Haas, Elvira. (2015) Deletion of Rictor in Brain and Fat Alters Peripheral Clock Gene Expression and Increases Blood Pressure. Hypertension, 66 (2). pp. 332-339.

Lopez, Rubén J. and Mosca, Barbara and Treves, Susan and Maj, Marcin and Bergamelli, Leda and Calderon, Juan C. and Bentzinger, C. Florian and Romanino, Klaas and Hall, Michael N. and Rüegg, Markus A. and Delbono, Osvaldo and Caputo, Carlo and Zorzato, Francesco. (2015) Raptor ablation in skeletal muscle decreases Cav1.1 expression and affects the function of the excitation-contraction coupling supramolecular complex. Biochemical Journal, 466 (1). pp. 123-135.

Albert, Verena and Hall, Michael N.. (2015) Reduced C/EBPβ-LIP translation improves metabolic health. EMBO reports, Vol. 16, H. 8. pp. 881-882.

Hindupur, Sravanth K. and González, Asier and Hall, Michael N.. (2015) The Opposing Actions of Target of Rapamycin and AMP-Activated Protein Kinase in Cell Growth Control. Cold Spring Harbor Perspectives in Biology, 7 (8). pp. 1-21.

Hindupur, Sravanth K. and González, Asier and Hall, Michael N.. (2015) The Opposing Actions of Target of Rapamycin and AMP-Activated Protein Kinase in Cell Growth Control. In: Size Control in Biology: From Organelles to Organisms. New York, pp. 221-240.

Cornu, Marion and de Caudron de Coquereaumont, Grégoire and Hall, Michael N.. (2015) mTOR signaling in liver disease. In: Signaling Pathways in Liver Diseases. West Sussex, pp. 314-325.

Albert, Verena and Cornu, Marion and Hall, Michael N.. (2015) mTORC1 signaling in Agrp neurons mediates circadian expression of Agrp and NPY but is dispensable for regulation of feeding behavior. Biochemical and Biophysical Research Communications, 464 (2). pp. 480-486.

2014

Zhang, Lianjun and Tschumi, Benjamin O. and Corgnac, Stéphanie and Rüegg, Markus A. and Hall, Michael N. and Mach, Jean-Pierre and Romero, Pedro and Donda, Alena. (2014) Mammalian target of rapamycin complex 1 orchestrates invariant NKT cell differentiation and effector function. Journal of Immunology, 193 (4). pp. 1759-1765.

Chou, Po-Chien and Oh, Won Jun and Wu, Chang-Chih and Moloughney, Joseph and Rüegg, Markus A. and Hall, Michael N. and Jacinto, Estela and Werlen, Guy. (2014) Mammalian target of rapamycin complex 2 modulates αβTCR processing and surface expression during thymocyte development. Journal of Immunology, 193 (3). pp. 1162-1170.

Stracka, Daniele and Jozefczuk, Szymon and Rudroff, Florian and Sauer, Uwe and Hall, Michael N.. (2014) Nitrogen Source Activates TOR (Target of Rapamycin) Complex 1 via Glutamine and Independently of Gtr/Rag Proteins. Journal of Biological Chemistry, 289 (36). pp. 25010-25020.

2013

Bentzinger, C. Florian and Lin, Shuo and Romanino, Klaas and Castets, Perrine and Guridi, Maitea and Summermatter, Serge and Handschin, Christoph and Tintignac, Lionel A. and Hall, Michael N. and Rüegg, Markus A.. (2013) Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy. Skeletal muscle, Vol. 3, H. 1 , 6.

Cornu, Marion and Albert, Verena and Hall, Michael N.. (2013) mTOR in aging, metabolism, and cancer. Current Opinion in Genetics & Development, 23 (1). pp. 53-62.

2012

Appenzeller-Herzog, Christian and Hall, Michael N.. (2012) Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling. Trends in Cell Biology, 22 (5). pp. 272-282.

Durán, Raúl V. and Hall, Michael N.. (2012) Glutaminolysis feeds mTORC1. Cell Cycle, 11 (22). pp. 4107-4108.

Hagiwara, Asami and Cornu, Marion and Cybulski, Nadine and Polak, Pazit and Betz, Charles and Trapani, Francesca and Terracciano, Luigi and Heim, Markus H. and Rüegg, Markus A. and Hall, Michael N.. (2012) Hepatic mTORC2 activates glycolysis and lipogenesis through akt, glucokinase, and SREBP1c. Cell Metabolism, 15 (5). pp. 725-738.

Cybulski, Nadine and Zinzalla, Vittoria and Hall, Michael N.. (2012) Inducible raptor and rictor Knockout Mouse Embryonic Fibroblasts. Methods in Molecular Biology, 821. pp. 267-278.

2011

Benjamin, Don and Colombi, Marco and Moroni, Christoph and Hall, Michael N.. (2011) Rapamycin passes the torch: a new generation of mTOR inhibitors. Nature Reviews. Drug Discovery, 10 (11). pp. 868-880.

2010

Blagosklonny, Mikhail V. and Campisi, Judy and Sinclair, David A. and Bartke, Andrzej and Blasco, Maria A. and Bonner, William M. and Bohr, Vilhelm A. and Brosh, Robert M. and Brunet, Anne and Depinho, Ronald A. and Donehower, Lawrence A. and Finch, Caleb E. and Finkel, Toren and Gorospe, Myriam and Gudkov, Andrei V. and Hall, Michael N. and Hekimi, Siegfried and Helfand, Stephen L. and Karlseder, Jan and Kenyon, Cynthia and Kroemer, Guido and Longo, Valter and Nussenzweig, Andre and Osiewacz, Heinz D. and Peeper, Daniel S. and Rando, Thomas A. and Rudolph, K. Lenhard and Sassone-Corsi, Paolo and Serrano, Manuel and Sharpless, Norman E. and Skulachev, Vladimir P. and Tilly, Jonathan L. and Tower, John and Verdin, Eric and Vijg, Jan. (2010) Impact papers on aging in 2009. Aging, 2 (3). pp. 111-121.

2009

Blagosklonny, Mikhail V. and Hall, Michael N.. (2009) Growth and aging : a common molecular mechanism. Aging, Vol. 1, H. 4. pp. 357-362.

2007

Li, Weimin and Petrimpol, Marco and Molle, Klaus D. and Hall, Michael N. and Battegay, Edouard J. and Humar, Rok. (2007) Hypoxia-induced endothelial proliferation requires both mTORC1 and mTORC2. Circulation Research, 100 (1). pp. 79-87.

2006

Wahl, Patricia R. and Serra, Andreas L. and Le Hir, Michel and Molle, Klaus D. and Hall, Michael N. and Wüthrich, Rudolf P.. (2006) Inhibition of mTOR with sirolimus slows disease progression in Han:SPRD rats with autosomal dominant polycystic kidney disease (ADPKD). Nephrology Dialysis Transplantation, 21 (3). pp. 598-604.

Honma, Yoshimi and Kitamura, Aiko and Shioda, Ryo and Maruyama, Hironori and Ozaki, Kanako and Oda, Yoko and Mini, Thierry and Jenö, Paul and Maki, Yasushi and Yonezawa, Kazuyoshi and Hurt, Ed and Ueno, Masaru and Uritani, Masahiro and Hall, Michael N. and Ushimaru, Takashi. (2006) TOR regulates late steps of ribosome maturation in the nucleoplasm via Nog1 in response to nutrients. The EMBO Journal, 25 (16). pp. 3832-3842.

2004

Audhya, Anjon and Loewith, Robbie and Parsons, Ainslie B. and Gao, Lu and Tabuchi, Mitsuaki and Zhou, Huilin and Boone, Charles and Hall, Michael N. and Emr, Scott D.. (2004) Genome-wide lethality screen identifies new PI4,5P2 effectors that regulate the actin cytoskeleton. The EMBO Journal, 23 (19). pp. 3747-3757.