Items where Author is "Handschin, C."

Article

Summermatter, S. and Handschin, C.. (2012) PGC-1α and exercise in the control of body weight. International journal of obesity and related metabolic disorders, Vol. 36, H. 11. pp. 1428-1435.

Egger, A. and Samardzija, M. and Sothilingam, V. and Tanimoto, N. and Lange, C. and Salatino, S. and Fang, L. and Garcia-Garrido, M. and Beck, S. and Okoniewski, M. J. and Neutzner, A. and Seeliger, M. W. and Grimm, C. and Handschin, C.. (2012) PGC-1α determines light damage susceptibility of the murine retina. PloS one, Vol. 7, H. 2 , e31272.

Summermatter, S. and Troxler, H. and Santos, G. and Handschin, C.. (2011) Coordinated balancing of muscle oxidative metabolism through PGC-1α increases metabolic flexibility and preserves insulin sensitivity. Biochemical and biophysical research communications, Vol. 408, H. 1. pp. 180-185.

Arnold, A. -S. and Egger, A. and Handschin, C.. (2011) PGC-1α and Myokines in the aging muscle : a mini-review. Gerontology, Vol. 57, H. 1. pp. 37-43.

Handschin, C.. (2011) Peroxisome proliferator-activated receptor γ coactivator 1β (PGC-1β) improves skeletal muscle mitochondrial function and insulin sensitivity. Diabetologia, Vol. 54, no. 6. pp. 1270-1272.

Stein, S. and Lohmann, C. and Handschin, C. and Stenfeldt, E. and Boren, J. and Luscher, T. F. and Matter, C. M.. (2010) ApoE−/− PGC-1α−/− mice display reduced IL-18 levels and do not develop enhanced atherosclerosis. PLoS one, Vol. 5, H. 10 , e13539.

Burch, N. and Arnold, A. S. and Item, F. and Summermatter, S. and Brochmann Santana Santos, G. and Christe, M. and Boutellier, U. and Toigo, M. and Handschin, C.. (2010) Electric pulse stimulation of cultured murine muscle cells reproduces gene expression changes of trained mouse muscle. PLoS one, Vol. 5, H. 6 , e10970.

Summermatter, S. and Baum, O. and Santos, G. and Hoppeler, H. and Handschin, C.. (2010) Peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) promotes skeletal muscle lipid refueling in vivo by activating de novo lipogenesis and the pentose phosphate pathway. Journal of Biological Chemistry, 285 (43). pp. 32793-32800.

Handschin, C.. (2010) Regulation of skeletal muscle cell plasticity by the peroxisome proliferator-activated receptor gamma coactivator 1alpha. Journal of receptors and signal transduction, Vol. 30, H. 6. pp. 376-384.

Zenhaeusern, G. and Gubser, P. and Eisele, P. and Gasser, O. and Steinhuber, A. and Trampuz, A. and Handschin, C. and Luster, A. D. and Hess, C.. (2009) A high-mobility, low-cost phenotype defines human effector-memory CD8+ T cells. Blood, 113 (1). pp. 95-99.

Handschin, C.. (2009) PGC-1a in muscle links metabolism to inflammation. Proceedings of the Australian Physiological Society, Vol. 40. pp. 11-16.

Handschin, C.. (2009) Peroxisome proliferator-activated receptor-γ coactivator-1α in muscle links metabolism to inflammation. Clinical and experimental pharmacology and physiology, Vol. 36, H. 12. pp. 1139-1143.

Handschin, C.. (2009) The biology of PGC-1α and its therapeutic potential. Trends in Pharmacological Sciences, 30 (6). pp. 322-329.

Choi, C. S. and Befroy, D. E. and Codella, R. and Kim, S. and Reznick, R. M. and Hwang, Y. -J. and Liu, Z. -X. and Lee, H. -Y. and Distefano, A. and Samuel, V. T. and Zhang, D. and Cline, G. W. and Handschin, C. and Lin, J. and Petersen, K. F. and Spiegelman, B. M. and Shulman, G. I.. (2008) Paradoxical effects of increased expression of PGC-1α on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism. Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, H. 50. pp. 19926-19931.

Rohas, L. M. and St-Pierre, J. and Uldry, M. and Jager, S. and Handschin, C. and Spiegelman, B. M.. (2007) A fundamental system of cellular energy homeostasis regulated by PGC-1α. Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, H. 19. pp. 7933-7938.

Jager, S. and Handschin, C. and St-Pierre, J. and Spiegelman, B. M.. (2007) AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α. Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, H. 29. pp. 12017-12022.

Handschin, C. and Choi, C. S. and Chin, S. and Kim, S. and Kawamori, D. and Kurpad, A. J. and Neubauer, N. and Hu, J. and Mootha, V. K. and Kim, Y. -B. and Kulkarni, R. N. and Shulman, G. I. and Spiegelman, B. M.. (2007) Abnormal glucose homeostasis in skeletal muscle–specific PGC-1α knockout mice reveals skeletal muscle–pancreatic β cell crosstalk. Journal of Clinical Investigation, Vol. 117, H. 11. pp. 3463-3474.

Handschin, C. and Kobayashi, Y. M. and Chin, S. and Seale, P. and Campbell, K. P. and Spiegelman, B. M.. (2007) PGC-1α regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy. Genes & development, Vol. 21, H. 7. pp. 770-783.

Matter, C. M. and Handschin, C.. (2007) RANTES (regulated on activation, normal T cell expressed and secreted), inflammation, obesity, and the metabolic syndrome. Circulation, 115 (8). pp. 946-948.

Handschin, C. and Chin, S. and Li, P. and Liu, F. and Maratos-Flier, E. and Lebrasseur, N. K. and Yan, Z. and Spiegelman, B. M.. (2007) Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1α muscle-specific knock-out animals. Journal of Biological Chemistry, 282 (41). pp. 30014-30021.

Sandri, M. and Lin, J. and Handschin, C. and Yang, W. and Arany, Z. P. and Lecker, S. H. and Goldberg, A. L. and Spiegelman, B. M.. (2006) PGC-1α protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription. Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, H. 44. pp. 16260-16265.

Rhee, J. and Ge, H. and Yang, W. and Fan, M. and Handschin, C. and Cooper, M. and Lin, J. and Li, C. and Spiegelman, B. M.. (2006) Partnership of PGC-1α and HNF4α in the regulation of lipoprotein metabolism. Journal of Biological Chemistry, 281 (21). pp. 14683-14690.

Handschin, C. and Spiegelman, B. M.. (2006) Peroxisome proliferator-activated receptor γ coactivator 1 coactivators, energy homeostasis, and metabolism. Endocrine reviews, Vol. 27, H. 7. pp. 728-735.

St-Pierre, J. and Drori, S. and Uldry, M. and Silvaggi, J. M. and Rhee, J. and Jager, S. and Handschin, C. and Zheng, K. and Lin, J. and Yang, W. and Simon, D. K. and Bachoo, R. and Spiegelman, B. M.. (2006) Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell, Vol. 127, H. 2. pp. 397-408.

Wu, Z. and Huang, X. and Feng, Y. and Handschin, C. and Gullicksen, P. S. and Bare, O. and Labow, M. and Spiegelman, B. and Stevenson, S. C.. (2006) Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1α transcription and mitochondrial biogenesis in muscle cells. Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, H. 39. pp. 14379-14384.

Handschin, C. and Mootha, V. K.. (2005) Estrogen-related receptor α (ERRα) : a novel target in type 2 diabetes. Drug Discovery Today. Therapeutic Strategies, 2 (2). pp. 151-156.

Lin, J. and Yang, R. and Tarr, P. T. and Wu, P. -H. and Handschin, C. and Li, S. and Yang, W. and Pei, L. and Uldry, M. and Tontonoz, P. and Newgard, C. B. and Spiegelman, B. M.. (2005) Hyperlipidemic effects of dietary saturated fats mediated through PGC-1β coactivation of SREBP. Cell, Vol. 120, H. 2. pp. 261-273.

Gnerre, C. and Schuster, G. U. and Roth, A. and Handschin, C. and Johansson, L. and Looser, R. and Parini, P. and Podvinec, M. and Robertsson, K. and Gustafsson, J. -A. and Meyer, U. A.. (2005) LXR deficiency and cholesterol feeding affect the expression and phenobarbital-mediated induction of cytochromes P450 in mouse liver. Journal of Lipid Research, 46 (8). pp. 1633-1642.

Lin, J. and Handschin, C. and Spiegelman, B. M.. (2005) Metabolic control through the PGC-1 family of transcription coactivators. Cell Metabolism, Vol. 1, H. 6. pp. 361-370.

Handschin, C. and Lin, J. and Rhee, J. and Peyer, A. -K. and Chin, S. and Wu, P. -H. and Meyer, U. A. and Spiegelman, B. M.. (2005) Nutritional Regulation of Hepatic Heme Biosynthesis and Porphyria through PGC-1α. Cell, Vol. 122, H. 4. pp. 505-515.

Handschin, C. and Meyer, U. A.. (2005) Regulatory network of lipid-sensing nuclear receptors: : roles for CAR, PXR, LXR, and FXR. Archives of Biochemistry and Biophysics, 433 (2). pp. 387-396.

Handschin, C. and Gnerre, C. and Fraser, D. J. and Martinez-Jimenez, C. and Jover, R. and Meyer, U. A.. (2005) Species-specific mechanisms for cholesterol 7alpha-hydroxylase (CYP7A1) regulation by drugs and bile acids. Archives of Biochemistry and Biophysics, 434 (1). pp. 75-85.

Arany, Z. and He, H. and Lin, J. and Hoyer, K. and Handschin, C. and Toka, O. and Ahmad, F. and Matsui, T. and Chin, S. and Wu, P. -H. and Rybkin, I. I. and Shelton, J. M. and Manieri, M. and Cinti, S. and Schoen, F. J. and Bassel-Duby, R. and Rosenzweig, A. and Ingwall, J. S. and Spiegelman, B. M.. (2005) Transcriptional coactivator PGC-1α controls the energy state and contractile function of cardiac muscle. Cell Metabolism, Vol. 1, H. 4. pp. 259-271.

Podvinec, M. and Handschin, C. and Looser, R. and Meyer, U. A.. (2004) Identification of the xenosensors regulating human 5-aminolevulinate synthase. Proceedings of the National Academy of Sciences of the United States of America, 101 (24). pp. 9127-9132.

Fan, M. and Rhee, J. and St-Pierre, J. and Handschin, C. and Puigserver, P. and Lin, J. and Jaeger, S. and Erdjument-Bromage, H. and Tempst, P. and Spiegelman, B. M.. (2004) Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1α : modulation by p38 MAPK. Genes & development, Vol. 18, H. 3. pp. 278-289.

Handschin, C. and Blattler, S. and Roth, A. and Looser, R. and Oscarson, M. and Kaufmann, M. R. and Podvinec, M. and Gnerre, C. and Meyer, U. A.. (2004) The evolution of drug-activated nuclear receptors : one ancestral gene diverged into two xenosensor genes in mammals. Nuclear Receptor, Vol. 2, H. 1. p. 7.

Handschin, C. and Rhee, J. and Lin, J. and Tarr, P. T. and Spiegelman, B. M.. (2003) An An autoregulatory loop controls peroxisome proliferator-activated receptor γ coactivator 1α expression in muscle. Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, H. 12. pp. 7111-7116.

Handschin, C. and Meyer, U. A.. (2003) Induction of drug metabolism: the role of nuclear receptors. Pharmacological reviews, 55 (4). pp. 649-673.

Sanyal, S. and Handschin, C. and Podvinec, M. and Song, K. -H. and Kim, H. -J. and Kim, J. -Y. and Seo, Y. -W. and Kim, S. -A. and Kwon, H. -B. and Lee, K. and Kim, W. -S. and Meyer, U. A. and Choi, H. -S.. (2003) Molecular cloning and characterization of chicken orphan nuclear receptor cTR2. General and Comparative Endocrinology, 132 (3). pp. 474-484.

Ourlin, J. -C. and Handschin, C. and Kaufmann, M. and Meyer, U. A.. (2002) A Link between cholesterol levels and phenobarbital induction of cytochromes P450. Biochemical and Biophysical Research Communications, 291 (2). pp. 378-384.

Handschin, C. and Podvinec, M. and Amherd, R. and Looser, R. and Ourlin, J. -C. and Meyer, U. A.. (2002) Cholesterol and bile acids regulate xenosensor signaling in drug-mediated induction of cytochromes P450. Journal of Biological Chemistry, 277 (33). pp. 29561-29567.

Podvinec, M. and Kaufmann, M. R. and Handschin, C. and Meyer, U. A.. (2002) NUBIScan, an in silico approach for prediction of nuclear receptor response elements. Molecular endocrinology, Vol. 16, H. 6. pp. 1269-1279.

Handschin, C. and Podvinec, M. and Stockli, J. and Hoffmann, K. and Meyer, U. A.. (2001) Conservation of signaling pathways of xenobiotic-sensing orphan nuclear receptors, chicken xenobiotic receptor, constitutive androstane receptor, and pregnane X receptor, from birds to humans. Molecular endocrinology, Vol. 15, H. 9. pp. 1571-1585.

Handschin, C. and Podvinec, M. and Looser, R. and Amherd, R. and Meyer, U. A.. (2001) Multiple enhancer units mediate drug induction of CYP2H1 by xenobiotic-sensing orphan nuclear receptor chicken xenobiotic receptor. Molecular pharmacology, 60 (4). pp. 681-689.

Handschin, C. and Meyer, U. A.. (2000) A conserved nuclear receptor consensus sequence (DR-4) mediates transcriptional activation of the chicken CYP2H1 gene by phenobarbital in a hepatoma cell line. Journal of Biological Chemistry, 275 (18). pp. 13362-13369.

Handschin, C. and Podvinec, M. and Meyer, U. A.. (2000) CXR, a chicken xenobiotic-sensing orphan nuclear receptor, is related to both mammalian pregnane X receptor (PXR) and constitutive androstane receptor (CAR). Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, No. 20. pp. 10769-10774.

Spiess, M. and Handschin, C. and Baker, K. P.. (1989) Stop-transfer activity of hydrophobic sequences depends on the translation system. Journal of biological chemistry, Vol. 264. pp. 19117-19124.

Book Section

Handschin, C.. (2008) Induction of drug metabolism : role for nuclear receptors. In: Nuclear Receptors as Drug Targets (Methods and Principles in Medicinal Chemistry, Vol. 39). Weinheim, pp. 453-468.

Handschin, C. and Meyer, U. A.. (2005) PXR and CAR: more than meets the eye. In: Proceedings of the 15th Int. symposium on microsomes and drug oxidation. Bologna, pp. 17-21.

Handschin, C. and Meyer, U. A.. (2003) The molecular mechanism of induction of cytochromes P450 by drugs and other xenobiotics. In: Molecular Investigation of Metabolism and Transport of Drugs - from Animal to Human Tissue, 87. Halle (Saale), pp. 205-211.