Items where Author is "Jiang, Xiaohua"

2016

Kleeb, Simon and Jiang, Xiaohua and Frei, Priska and Sigl, Anja and Bezençon, Jacqueline and Bamberger, Karen and Schwardt, Oliver and Ernst, Beat. (2016) FimH Antagonists: Phosphate Prodrugs Improve Oral Bioavailability. Journal of Medicinal Chemistry, 59 (7). pp. 3163-3182.

Eris, Deniz and Preston, Roland C. and Scharenberg, Meike and Hulliger, Fabian and Abgottspon, Daniela and Pang, Lijuan and Jiang, Xiaohua and Schwardt, Oliver and Ernst, Beat. (2016) The Conformational Variability of FimH: Which Conformation Represents the Therapeutic Target? ChemBioChem, 17 (11). pp. 1012-1020.

2015

Kleeb, Simon and Pang, Lijuan and Mayer, Katharina and Eris, Deniz and Sigl, Anja and Preston, Roland C. and Zihlmann, Pascal and Sharpe, Timothy and Jakob, Roman P. and Abgottspon, Daniela and Hutter, Aline S. and Scharenberg, Meike and Jiang, Xiaohua and Navarra, Giulio and Rabbani, Said and Smiesko, Martin and Lüdin, Nathalie and Bezençon, Jacqueline and Schwardt, Oliver and Maier, Timm and Ernst, Beat. (2015) FimH Antagonists: Bioisosteres To Improve the in Vitro and in Vivo PK/PD Profile. Journal of Medicinal Chemistry, 58 (5). pp. 2221-2239.

Fiege, Brigitte and Rabbani, Said and Preston, Roland C. and Jakob, Roman P. and Zihlmann, Pascal and Schwardt, Oliver and Jiang, Xiaohua and Maier, Timm and Ernst, Beat. (2015) The Tyrosine Gate of the Bacterial Lectin FimH : a Conformational Analysis by NMR Spectroscopy and X-ray Crystallography. ChemBioChem, 16 (8). pp. 1235-1246.

2013

Scharenberg, Meike and Jiang, Xiaohua and Pang, Lijuan and Navarra, Giulio and Rabbani, Said and Binder, Florian and Schwardt, Oliver and Ernst, Beat. (2013) Kinetic properties of carbohydrate–lectin interactions: FimH antagonists. ChemMedChem, 9 (1). pp. 78-83.

2012

Jiang, Xiaohua and Abgottspon, Daniela and Kleeb, Simon and Rabbani, Said and Scharenberg, Meike and Wittwer, Matthias and Haug, Martina and Schwardt, Oliver and Ernst, Beat. (2012) Anti-adhesion therapy for urinary tract infections - a balanced PK/PD-profile proved to be key for success. Journal of Medicinal Chemistry, 55 (10). pp. 4700-4713.

2011

Scharenberg, Meike and Abgottspon, Daniela and Cicek, Evelin and Jiang, Xiaohua and Schwardt, Oliver and Rabbani, Said and Ernst, Beat. (2011) A Flow Cytometry-based Assay for Screening FimH Antagonists. Assay and Drug Development Technologies, 9 (5). pp. 455-464.

2010

Shelke, Sachin V. and Cutting, Brian and Jiang, Xiaohua and Koliwer-Brandl, Hendrik and Strasser, Daniel S. and Schwardt, Oliver and Kelm, Soerge and Ernst Beat, . (2010) A Fragment-Based In Situ Combinatorial Approach To Identify High-Affinity Ligands for Unknown Binding Sites. Angewandte Chemie. International edition in English, Vol. 49. pp. 5721-5725.

Abgottspon, Daniela and Rölli, Gina and Hosch, Lucie and Steinhuber, Andrea and Jiang, Xiaohua and Schwardt, Oliver and Cutting, Brian and Smiesko, Martin and Jenal, Urs and Ernst, Beat and Trampuz, Andrej. (2010) Development of an aggregation assay to screen FimH antagonists. Journal of Microbiological Methods, 82 (3). pp. 249-255.

Rabbani, Said and Jiang, Xiaohua and Schwardt, Oliver and Ernst, Beat. (2010) Expression of the Carbohydrate Recognition Domain of FimH and Development of a Competitive Binding Assay. Analytical Biochemistry , 407. pp. 188-195.

Klein, Tobias and Abgottspon, Daniela and Wittwer, Matthias and Rabbani, Said and Herold, Janno and Jiang, Xiaohua and Kleeb, Simon and Lüthi, Christine and Scharenberg, Meike and Bezençcon, Jacqueline and Gubler, Erich and Pang, Lijuan and Smiesko, Martin and Cutting, Brian and Schwardt, Oliver and Ernst, Beat. (2010) FimH Antagonists for the Oral Treatment of Urinary Tract Infections : From Design and Synthesis to In Vitro and In Vivo Evaluation. Journal of Medicinal Chemistry, 53 (24). pp. 8627-8641.