Items where Author is "Wittlin, S."
Number of items: 46. 2017Pavadai, E. and Kaur, G. and Wittlin, S. and Chibale, K.. (2017) Identification of steroid-like natural products as antiplasmodial agents by 2D and 3D similarity-based virtual screening. MedChemComm , 8 (6). pp. 1152-1157. 2015Kaur, G. and Singh, K. and Pavadai, E. and Njoroge, M. and Espinoza-Moraga, M. and de Kock, C. and Smith, P. J. and Wittlin, S. and Chibale, K.. (2015) Synthesis of fusidic acid bioisosteres as antiplasmodial agents and molecular docking studies in the binding site of elongation factor-G. MedChemComm, 6 (11). pp. 2023-2028. 2013Wang, X. and Dong, Y. and Wittlin, S. and Charman, S. A. and Chiu, F. C. and Chollet, J. and Katneni, K. and Mannila, J. and Morizzi, J. and Ryan, E. and Scheurer, C. and Steuten, J. and Santo, Tomas J. and Snyder, C. and Vennerstrom, J. L.. (2013) Comparative antimalarial activities and ADME profiles of ozonides (1,2,4-trioxolanes) OZ277, OZ439, and their 1,2-dioxolane, 1,2,4-trioxane, and 1,2,4,5-tetraoxane isosteres. Journal of medicinal chemistry, 56 (6). pp. 2547-2555. Moehrle, J. J. and Duparc, S. and Siethoff, C. and van Giersbergen, P. L. and Craft, J. C. and Arbe-Barnes, S. and Charman, S. A. and Gutierrez, M. and Wittlin, S. and Vennerstrom, J. L.. (2013) First-in-man safety and pharmacokinetics of synthetic ozonide OZ439 demonstrates an improved exposure profile relative to other peroxide antimalarials. British journal of clinical pharmacology, Vol. 75, H. 2. pp. 535-548. Ciana, C. L. and Siegrist, R. and Aissaoui, H. and Marx, L. and Racine, S. and Meyer, S. and Binkert, C. and de Kanter, R. and Fischli, C. and Wittlin, S. and Boss, C.. (2013) Novel in vivo active anti-malarials based on a hydroxy-ethyl-amine scaffold. Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 23, H. 3. pp. 658-662. Brunner, R. and Ng, C. L. and Aissaoui, H. and Akabas, M. H. and Boss, C. and Brun, R. and Callaghan, P. S. and Corminboeuf, O. and Fidock, D. A. and Frame, I. J. and Heidmann, B. and Le Bihan, A. and Jeno, P. and Mattheis, C. and Moes, S. and Muller, I. B. and Paguio, M. and Roepe, P. D. and Siegrist, R. and Voss, T. and Welford, R. W. and Wittlin, S. and Binkert, C.. (2013) UV-triggered affinity capture identifies interactions between the Plasmodium falciparum multidrug resistance protein 1 (PfMDR1) and antimalarial agents in live parasitized cells. Journal of biological chemistry, Vol. 288, H. 31. pp. 22576-22583. 2012Younis, Y. and Douelle, F. and Feng, T. S. and Cabrera, D. G. and Manach, C. L. and Nchinda, A. T. and Duffy, S. and White, K. L. and Shackleford, D. M. and Morizzi, J. and Mannila, J. and Katneni, K. and Bhamidipati, R. and Zabiulla, K. M. and Joseph, J. T. and Bashyam, S. and Waterson, D. and Witty, M. J. and Hardick, D. and Wittlin, S. and Avery, V. and Charman, S. A. and Chibale, K.. (2012) 3,5-Diaryl-2-aminopyridines as a novel class of orally active antimalarials demonstrating single dose cure in mice and clinical candidate potential. Journal of medicinal chemistry, 55 (7). pp. 3479-3487. Li, Y. and Wittlin, S. and Wu, Y.. (2012) Access to some UV chromophore-containing antimalarial trioxanes using hydrogen peroxide as source of the peroxy bonds. Heterocycles : an international journal for reviews and communications in heterocyclic chemistry, Vol. 84, H. 2. pp. 1217-1226. Mäser, P. and Wittlin, S. and Rottmann, M. and Wenzler, T. and Kaiser, M. and Brun, R.. (2012) Antiparasitic agents : new drugs on the horizon. Current opinion in pharmacology, Vol. 12, H. 5. pp. 562-566. Marfurt, J. and Chalfein, F. and Prayoga, P. and Wabiser, F. and Wirjanata, G. and Sebayang, B. and Piera, K. A. and Wittlin, S. and Haynes, R. K. and Mohrle, J. J. and Anstey, N. M. and Kenangalem, E. and Price, R. N.. (2012) Comparative ex vivo activity of novel endoperoxides in multidrug-resistant Plasmodium falciparum and P. vivax. Antimicrobial agents and chemotherapy : AAC, Vol. 56, H. 10. pp. 5258-5263. Edlin, C. D. and Morgans, G. and Winks, S. and Duffy, S. and Avery, V. M. and Wittlin, S. and Waterson, D. and Burrows, J. and Bryans, J.. (2012) Identification and in-vitro ADME assessment of a series of novel anti-malarial agents suitable for hit-to-lead chemistry. ACS medicinal chemistry letters, Vol. 3, H. 7. pp. 570-573. Brunner, R. and Aissaoui, H. and Boss, C. and Bozdech, Z. and Brun, R. and Corminboeuf, O. and Delahaye, S. and Fischli, C. and Heidmann, B. and Kaiser, M. and Kamber, J. and Meyer, S. and Papastogiannidis, P. and Siegrist, R. and Voss, T. and Welford, R. and Wittlin, S. and Binkert, C.. (2012) Identification of a new chemical class of antimalarials. The Journal of Infectious Diseases, Vol. 206, no. 5. pp. 735-743. Wittlin, S. and Ekland, E. and Craft, J. C. and Lotharius, J. and Bathurst, I. and Fidock, D. A. and Fernandes, P.. (2012) In vitro and in vivo activity of Solithromycin (CEM-101) against Plasmodium species. Antimicrobial agents and chemotherapy : AAC, Vol. 56, H. 2. pp. 703-707. Wenzler, T. and Steinhuber, A. and Wittlin, S. and Scheurer, C. and Brun, R. and Trampuz, A.. (2012) Isothermal microcalorimetry, a new tool to monitor drug action against Trypanosoma brucei and Plasmodium falciparum. PLoS neglected tropical diseases, Vol. 6, H. 6 , e1668. Dreyer, A. M. and Matile, H. and Papastogiannidis, P. and Kamber, J. and Favuzza, P. and Voss, T. S. and Wittlin, S. and Pluschke, G.. (2012) Passive immunoprotection of Plasmodium falciparum-infected mice designates the CyRPA as candidate malaria vaccine antigen. Journal of immunology : official journal of the American Association of Immunologists, Vol. 188, H. 12. pp. 6225-6237. Li, Y. and Hao, H. D. and Wittlin, S. and Wu, Y.. (2012) Simple analogues of Qinghaosu (Artemisinin). Chemistry : an Asian journal / an ACES journal, Vol. 7, H. 8. pp. 1881-1886. González, Cabrera and Douelle, F. and Younis, Y. E. and Feng, T. S. and Lemanach, C. and Nchinda, A. T. and Street, L. J. and Scheurer, C. and Kamber, J. and White, K. L. and Montagnat, O. D. and Ryan, E. and Katneni, K. and Zabiulla, K. M. and Joseph, J. T. and Bashyam, S. and Waterson, D. and Witty, M. J. and Charman, S. A. and Wittlin, S. and Chibale, K.. (2012) Structure-activity relationship studies of orally active antimalarial 3,5-substituted 2-aminopyridines. Journal of medicinal chemistry, 55 (24). pp. 11022-11030. Delves, M. and Plouffe, D. and Scheurer, C. and Meister, S. and Wittlin, S. and Winzeler, E. A. and Sinden, R. E. and Leroy, D.. (2012) The activities of current antimalarial drugs on the life cycle stages of Plasmodium : a comparative study with human and rodent parasites. PLoS medicine, Vol. 9, H. 2 , e1001169. 2011Schiaffo, C. E. and Rottmann, M. and Wittlin, S. and Dussault, P. H.. (2011) 3-alkoxy-1,2-dioxolanes : synthesis and evaluation as potential antimalarial agents. ACS medicinal chemistry letters, Vol. 2, H. 4. pp. 316-319. Barker, R. H. Jr. and Urgaonkar, S. and Mazitschek, R. and Celatka, C. and Skerlj, R. and Cortese, J. F. and Tyndall, E. and Liu, H. and Cromwell, M. and Sidhu, A. B. and Guerrero-Bravo, J. E. and Crespo-Llado, K. N. and Serrano, A. E. and Lin, J. W. and Janse, C. J. and Khan, S. M. and Duraisingh, M. and Coleman, B. I. and Angulo-Barturen, I. and Jimenez-Diaz, M. B. and Magan, N. and Gomez, V. and Ferrer, S. and Martinez, M. S. and Wittlin, S. and Papastogiannidis, P. and O'Shea, T. and Klinger, J. D. and Bree, M. and Lee, E. and Levine, M. and Wiegand, R. C. and Munoz, B. and Wirth, D. F. and Clardy, J. and Bathurst, I. and Sybertz, E.. (2011) Aminoindoles, a novel scaffold with potent activity against Plasmodium falciparum. Antimicrobial agents and chemotherapy, 55 (6). pp. 2612-2622. Chadwick, J. and Amewu, R. K. and Marti, F. and Bousejra-El Garah F., and Sharma, R. and Berry, N. G. and Stocks, P. A. and Burrell-Saward H., and Wittlin, S. and Rottmann, M. and Brun, R. and Taramelli, D. and Parapini, S. and Ward, S. A. and O'Neill P. M., . (2011) Antimalarial mannoxanes : hybrid antimalarial drugs with outstanding oral activity profiles and a potential dual mechanism of action. ChemMedChem : chemistry enabling drug discovery, Vol. 6, H. 8. pp. 1357-1361. González Cabrera D., and Douelle, F. and Feng, T. S. and Nchinda, A. T. and Younis, Y. and White, K. L. and Wu, Q. and Ryan, E. and Burrows, J. N. and Waterson, D. and Witty, M. J. and Wittlin, S. and Charman, S. A. and Chibale, K.. (2011) Novel orally active antimalarial thiazoles. Journal of medicinal chemistry, 54 (21). pp. 7713-7719. Skerlj, R. T. and Bastos, C. M. and Booker, M. L. and Kramer, M. L. and Barker, R. H. and Celatka, C. A. and O'Shea T. J., and Munoz, B. and Sidhu, A. B. and Cortese, J. F. and Wittlin, S. and Papastogiannidis, P. and Angulo-Barturen I., and Jimenez-Diaz M. B., and Sybertz, E.. (2011) Optimization of potent inhibitors of P. falciparum dihydroorotate dehydrogenase for the treatment of malaria. ACS medicinal chemistry letters, Vol. 2, H. 9. pp. 708-713. Vargas, S. and Ndjoko Ioset K., and Hay, A. E. and Ioset, J. R. and Wittlin, S. and Hostettmann, K.. (2011) Screening medicinal plants for the detection of novel antimalarial products applying the inhibition of beta-hematin formation. Journal of pharmaceutical and biomedical analysis, Vol. 56, H. 5. pp. 880-886. Shi, X. L. and Ge, J. F. and Liu, B. Q. and Kaiser, M. and Wittlin, S. and Brun, R. and Ihara, M.. (2011) Synthesis and in vitro antiprotozoal activities of 5-phenyliminobenzo[a]phenoxazine derivatives. Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 21, H. 19. pp. 5804-5807. Lu, Y. T. and Arai, C. and Ge, J. F. and Ren, W. S. and Kaiser, M. and Wittlin, S. and Brun, R. and Lu, J. M. and Ihara, M.. (2011) Synthesis and in vitro antiprotozoal activities of water-soluble, inexpensive phenothiazinium chlorides. Dyes and pigments : an international journal, Vol. 89, H. 1. pp. 44-48. Charman, S. A. and Arbe-Barnes S., and Bathurst, I. C. and Brun, R. and Campbell, M. and Charman, W. N. and Chiu, F. C. and Chollet, J. and Craft, J. C. and Creek, D. J. and Dong, Y. and Matile, H. and Maurer, M. and Morizzi, J. and Nguyen, T. and Papastogiannidis, P. and Scheurer, C. and Shackleford, D. M. and Sriraghavan, K. and Stingelin, L. and Tang, Y. and Urwyler, H. and Wang, X. and White, K. L. and Wittlin, S. and Zhou, L. and Vennerstrom, J. L.. (2011) Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria. Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, H. 11. pp. 4400-4405. 2010Wright, C. W. and Linley, P. A. and Brun, R. and Wittlin, S. and Hsu, E.. (2010) Ancient Chinese methods are remarkably effective for the preparation of artemisinin-rich extracts of Qing Hao with potent antimalarial activity. Molecules, Vol. 15, H. 2. pp. 804-812. Abiodun, O. O. and Gbotosho, G. O. and Ajaiyeoba, E. O. and Happi, C. T. and Hofer, S. and Wittlin, S. and Sowunmi, A. and Brun, R. and Oduola, A. M. J.. (2010) Comparison of SYBR Green I-, PicoGreen-, and [H-3]-hypoxanthine-based assays for in vitro antimalarial screening of plants from Nigerian ethnomedicine. Parasitology research : Organ der Deutschen Gesellschaft für Parasitologie, Vol. 106, H. 4. pp. 933-939. Ge, J. F. and Arai, C. and Yang, M. and Bakar, M. A. and Lu, J. and Ismail, N. S. M. and Wittlin, S. and Kaiser, M. and Brun, R. and Charman, S. A. and Nguyen, T. and Morizzi, J. and Itoh, I. and Ihara, M.. (2010) Discovery of novel benzo[a]phenoxazine SSJ-183 as a drug candidate for malaria. ACS medicinal chemistry letters, Vol. 1, H. 7. pp. 360-364. O'Neill P. M., and Amewu, R. K. and Nixon, G. L. and Bousejra, E. F. and Mungthin, M. and Chadwick, J. and Shone, A. E. and Vivas, L. and Lander, H. and Barton, V. and Muangnoicharoen, S. and Bray, P. G. and Davies, J. and Park, B. K. and Wittlin, S. and Brun, R. and Preschel, M. and Zhang, K. and Ward, S. A.. (2010) Identification of a 1,2,4,5-tetraoxane antimalarial drug-development candidate (RKA 182) with superior properties to the semisynthetic artemisinins. Angewandte Chemie. International edition in English, Vol. 49, H. 33. pp. 5693-5697. Booker, M. L. and Bastos, C. M. and Kramer, M. L. and Barker, R. H. and Skerlj, R. and Sidhu, A. B. and Deng, X. and Celatka, C. and Cortese, J. F. and Guerrero Bravo J. E., and Crespo Llado K. N., and Serrano, A. E. and Angulo-Barturen I., and Jimenez-Diaz M. B., and Viera, S. and Garuti, H. and Wittlin, S. and Papastogiannidis, P. and Lin, J. W. and Janse, C. J. and Khan, S. M. and Duraisingh, M. and Coleman, B. and Goldsmith, E. J. and Phillips, M. A. and Munoz, B. and Wirth, D. F. and Klinger, J. D. and Wiegand, R. and Sybertz, E.. (2010) Novel inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with anti-malarial activity in the mouse model. Journal of Biological Chemistry, Vol. 285, H. 43. pp. 33054-33064. Nzila, A. and Rottmann, M. and Chitnumsub, P. and Kiara, S. M. and Kamchonwongpaisan, S. and Maneeruttanarungroj, C. and Taweechai, S. and Yeung, B. K. and Goh, A. and Lakshminarayana, S. B. and Zou, B. and Wong, J. and Ma, N. L. and Weaver, M. and Keller, T. H. and Dartois, V. and Wittlin, S. and Brun, R. and Yuthavong, Y. and Diagana, T. T.. (2010) Preclinical evaluation of the antifolate QN254, 5-chloro- N'6'-(2,5-dimethoxy-benzyl)-quinazoline-2,4,6-triamine, as an antimalarial drug candidate. Antimicrobial agents and chemotherapy : AAC, Vol. 54, H. 6. pp. 2603-2610. Burgess, S. J. and Kelly, J. X. and Shomloo, S. and Wittlin, S. and Brun, R. and Liebmann, K. and Peyton, D. H.. (2010) Synthesis, structure-activity relationship, and mode-of-action studies of antimalarial reversed chloroquine compounds. Journal of medicinal chemistry, 53 (17). pp. 6477-6489. Tang, Y. and Wittlin, S. and Charman, S. A. and Chollet, J. and Chiu, F. C. and Morizzi, J. and Johnson, L. M. and Tomas, J. S. and Scheurer, C. and Snyder, C. and Zhou, L. and Dong, Y. and Charman, W. N. and Matile, H. and Urwyler, H. and Dorn, A. and Vennerstrom, J. L.. (2010) The comparative antimalarial properties of weak base and neutral synthetic ozonides. Bioorganic and Medicinal Chemistry Letters, Vol. 20, H. 2. pp. 563-566. Dong, Y. and McCullough, K. J. and Wittlin, S. and Chollet, J. and Vennerstrom, J. L.. (2010) The structure and antimalarial activity of dispiro-1,2,4,5-tetraoxanes derived from (+)-dihydrocarvone. Bioorganic and Medicinal Chemistry Letters, Vol. 20, H. 22. pp. 6359-6361. Dong, Y. and Wittlin, S. and Sriraghavan, K. and Chollet, J. and Charman, S. A. and Charman, W. N. and Scheurer, C. and Urwyler, H. and Santo, T. J. and Snyder, C. and Creek, D. J. and Morizzi, J. and Koltun, M. and Matile, H. and Wang, X. and Padmanilayam, M. and Tang, Y. and Dorn, A. and Brun, R. and Vennerstrom, J. L.. (2010) The structure-activity relationship of the antimalarial ozonide arterolane (OZ277). Journal of Medicinal Chemistry, 53 (1). pp. 481-491. 2009Tritten, L. and Matile, H. and Brun, R. and Wittlin, S.. (2009) A new double-antibody sandwich ELISA targeting Plasmodium falciparum aldolase to evaluate anti-malarial drug sensitivity. Malaria Journal, Vol. 8 , 226. Sturm, N. and Hu, Y. and Zimmermann, H. and Fritz-Wolf K., and Wittlin, S. and Rahlfs, S. and Becker, K.. (2009) Compounds structurally related to ellagic acid show improved antiplasmodial activity. Antimicrobial agents and chemotherapy : AAC, Vol. 53, H. 2. pp. 622-630. Kelly, J. X. and Smilkstein, M. J. and Brun, R. and Wittlin, S. and Cooper, R. A. and Lane, K. D. and Janowsky, A. and Johnson, R. A. and Dodean, R. A. and Winter, R. and Hinrichs, D. J. and Riscoe, M. K.. (2009) Discovery of dual function acridones as a new antimalarial chemotype. Nature, Vol. 459, H. 7244. pp. 270-273. Irungu, B. and Kiboi, D. and Langat, B. and Rukunga, G. and Wittlin, S. and Nzila, A.. (2009) Methotrexate and aminopterin lack in vivo antimalarial activity against murine malaria species. Experimental parasitology : EP, Vol. 123, H. 2. pp. 118-121. Efange, S. M. and Brun, R. and Wittlin, S. and Connolly, J. D. and Hoye, T. R. and McAkam, T. and Makolo, F. L. and Mbah, J. A. and Nelson, D. P. and Nyongbela, K. D. and Wirmum, C. K.. (2009) Okundoperoxide, a bicyclic cyclofarnesylsesquiterpene endoperoxide from Scleria striatinux with antiplasmodial activity. Journal of Natural Products, Vol. 72, H. 2. pp. 280-283. Kiboi, D. M. and Irungu, B. N. and Langat, B. and Wittlin, S. and Brun, R. and Chollet, J. and Abiodun, O. and Nganga, J. K. and Nyambati, V. C. and Rukunga, G. M. and Bell, A. and Nzila, A.. (2009) Plasmodium berghei ANKA: selection of resistance to piperaquine and lumefantrine in a mouse model. Experimental parasitology : EP, Vol. 122, H. 3. pp. 196-202. Wang, X. and Creek, D. J. and Schiaffo, C. E. and Dong, Y. and Chollet, J. and Scheurer, C. and Wittlin, S. and Charman, S. A. and Dussault, P. H. and Wood, J. K. and Vennerstrom, J. L.. (2009) Spiroadamantyl 1,2,4-trioxolane, 1,2,4-trioxane, and 1,2,4-trioxepane pairs : relationship between peroxide bond iron(II) reactivity, heme alkylation efficiency, and antimalarial activity. Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 19, H. 16. pp. 4542-4545. Pudhom, K. and Ge, M. F. and Arai, C. and Yang, M. and Kaiser, M. and Wittlin, S. and Brun, R. and Itoh, I. and Ihara, M.. (2009) Synthesis and biological properties of a rhodacyanine derivative, Ssj-127, having high efficacy against malaria protozoa. Heterocycles : an international journal for reviews and communications in heterocyclic chemistry, Vol. 77, H. 1. pp. 207-210. 2008Li, J. V. and Wang, Y. and Saric, J. and Nicholson, J. K. and Dirnhofer, S. and Singer, B. H. and Tanner, M. and Wittlin, S. and Holmes, E. and Utzinger, J.. (2008) Global metabolic responses of NMRI mice to an experimental Plasmodium berghei infection. Journal of Proteome Research, Vol. 7, H. 9. pp. 3948-3956. |
