Items where Division is "05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Pharmaceutical Technology (Huwyler)"

2017

Adler, Camille. New lipid-based formulation approaches and characterization tools for hot-melt extrusion. 2017, Doctoral Thesis, University of Basel, Faculty of Science.

Adler, Camille. New lipid-based formulation approaches and characterization tools for hot-melt extrusion. 2017, Doctoral Thesis, University of Basel, Faculty of Science.

Boll, Björn and Bessa, Juliana and Folzer, Emilien and RÍos Quiroz, Anacelia and Schmidt, Roland and Bulau, Patrick and Finkler, Christof and Mahler, Hanns-Christian and Huwyler, Jörg and Iglesias, Antonio and Koulov, Atanas V.. (2017) Extensive Chemical Modifications in the Primary Protein Structure of IgG1 Subvisible Particles Are Necessary for Breaking Immune Tolerance. Molecular Pharmaceutics, 14 (4). pp. 1292-1299.

Grossen, Philip. Nanomedicines in cancer therapy : from long-circulating drug carriers to novel therapeutic concepts. 2017, Doctoral Thesis, University of Basel, Faculty of Science.

Grossen, Philip and Witzigmann, Dominik and Sieber, Sandro and Huwyler, Jörg. (2017) PEG-PCL-based nanomedicines: A biodegradable drug delivery system and its application. Journal of Controlled Release, 260. pp. 46-60.

Kiene, Klara and Porta, Fabiola and Topacogullari, Buket and Detampel, Pascal and Huwyler, Jörg. (2017) Self-assembling chitosan hydrogel: A drug-delivery device enabling the sustained release of proteins. Journal of Applied Polymer Science, 135 (1). p. 45638.

Kiene, Klara and Schenk, Susanne H. and Porta, Fabiola and Ernst, Alexandra and Witzigmann, Dominik and Grossen, Philip and Huwyler, Jörg. (2017) PDMS-b-PMOXA polymersomes for hepatocyte targeting and assessment of toxicity. European Journal of Pharmaceutics and Biopharmaceutics, 119. pp. 322-332.

Moser, Wendelin and Coulibaly, Jean and Ali, Said M. and Ame, Shaali M. and Amour, Amour K. and Yapi, Richard B. and Albonico, Marco and Puchkov, Maxim and Huwyler, Jörg and Hattendorf, Jan and Keiser, Jennifer. (2017) Efficacy and safety of tribendimidine, tribendimidine plus ivermectin, tribendimidine plus oxantel pamoate, and albendazole plus oxantel pamoate against hookworm and concomitant soil-transmitted helminth infections in Tanzania and Côte d'Ivoire: a randomised, controlled, single-blinded, non-inferiority trial. Lancet Infectious Diseases. pp. 1-10.

Riede, Julia and Camenisch, Gian and Huwyler, Jörg and Poller, Birk. (2017) Current In Vitro Methods to Determine Hepatic Kpuu: A Comparison of Their Usefulness and Limitations. Journal of Pharmaceutical Sciences, 106 (9). pp. 2805-2814.

Riede, Julia and Poller, Birk and Huwyler, Jörg and Camenisch, Gian. (2017) Assessing the Risk of Drug-Induced Cholestasis Using Unbound Intrahepatic Concentrations. Drug Metabolism and Disposition, 45 (5). pp. 523-532.

Sieber, Sandro and Grossen, Philip and Detampel, Pascal and Siegfried, Salome and Witigmann, Dominik and Huwyler, Jörg. (2017) Zebrafish as an early stage screening tool to study the systemic circulation of nanoparticulate drug delivery systems in vivo. Journal of Controlled Release, 264. pp. 180-191.

Sieber, Sandro and Siegrist, Stefan and Schwarz, Stéphanie and Porta, Fabiola and Schenk, Susanne H. and Huwyler, Jörg. (2017) Immobilization of Enzymes on PLGA Sub-Micrometer Particles by Crosslinked Layer-by-Layer Deposition. Macromolecular Bioscience, 17 (8). p. 1700015.

Siegrist, Stefan and Kettiger, Helene and Fasler-Kan, E. and Huwyler, Jörg. (2017) Selective stimulation of the JAK/ ST AT signaling pathway by silica nanoparticles in human endothelial cells. Toxicology in Vitro, 42. pp. 308-318.

Uhl, Philipp and Pantze, Silvia and Storck, Philip and Parmentier, Johannes and Witzigmann, Dominik and Hofhaus, Götz and Huwyler, Jörg and Mier, Walter and Fricker, Gert. (2017) Oral delivery of vancomycin by tetraether lipid liposomes. European Journal of Pharmaceutical Sciences, 108. pp. 111-118.

Wagner-Hattler, Leonie and Schoelkopf, Joachim and Huwyler, Jörg and Puchkov, Maxim. (2017) Characterization of new Functionalized Calcium Carbonate-Polycaprolactone Composite Material for Application in Geometry-constrained Drug Release Formulation Development. Drug Development and Industrial Pharmacy, 43 (10). pp. 1669-1676.

Wagner-Hattler, Leonie and Wyss, Katharina and Schoelkopf, Joachim and Huwyler, Jörg and Puchkov, Maxim. (2017) In vitro characterization and mouthfeel study of functionalized calcium carbonate in orally disintegrating tablets. International Journal of Pharmaceutics, 534. pp. 50-59.

September 2016

Kettiger, Helene and Québatte, Gabriela and Perrone, Barbara and Huwyler, Jörg. (2016) Interactions between silica nanoparticles and phospholipid membranes. Biochimica et biophysica acta, 1858 (9). pp. 2163-2170.

August 2016

Buck, Jonas and Huwyler, Jörg and Kühl, Peter and Dischinger, Angela. (2016) Pediatric Dispersible Tablets: a Modular Approach for Rapid Prototyping. Pharmaceutical research, 33 (8). pp. 2043-2055.

Preisig, Daniel and Roth, Roger and Tognola, Sandy and Varum, Felipe J. O. and Bravo, Roberto and Cetinkaya, Yalcin and Huwyler, Jörg and Puchkov, Maxim. (2016) Mucoadhesive microparticles for local treatment of gastrointestinal diseases. European journal of pharmaceutics and biopharmaceutics, 105. pp. 156-165.

July 2016

Gliesche, Daniel G. and Hussner, Janine and Witzigmann, Dominik and Porta, Fabiola and Glatter, Timo and Schmidt, Alexander and Huwyler, Jörg and Meyer Zu Schwabedissen, Henriette E.. (2016) Secreted Matrix Metalloproteinase-9 of Proliferating Smooth Muscle Cells as a Trigger for Drug Release from Stent Surface Polymers in Coronary Arteries. Molecular Pharmaceutics, 13 (7). pp. 2290-2300.

June 2016

Witzigmann, Dominik and Quagliata, Luca and Schenk, Susanne H. and Quintavalle, Cristina and Terracciano, Luigi M. and Huwyler, Jörg. (2016) Variable asialoglycoprotein-receptor 1 expression in liver disease: Implications for therapeutic intervention. Hepatology research , 46 (7). pp. 686-696.

3 May 2016

Eberle, Veronika A. and Häring, Armella and Schoelkopf, Joachim and Gane, Patric A. C. and Huwyler, Jörg and Puchkov, Maxim. (2016) In silico and in vitro methods to optimize the performance of experimental gastroretentive floating mini-tablets. Drug development and industrial pharmacy, 42 (5). pp. 808-817.

30 April 2016

Riede, Julia and Poller, Birk and Umehara, Ken-ichi and Huwyler, Jörg and Camenisch, Gian. (2016) New IVIVE method for the prediction of total human clearance and relative elimination pathway contributions from in vitro hepatocyte and microsome data. European journal of pharmaceutical sciences, 86. pp. 96-102.

February 2016

Mathaes, Roman and Mahler, Hanns-Christian and Buettiker, Jean-Pierre and Roehl, Holger and Lam, Philippe and Brown, Helen and Luemkemann, Joerg and Adler, Michael and Huwyler, Jörg and Streubel, Alexander and Mohl, Silke. (2016) The pharmaceutical vial capping process; Container closure systems, capping equipment, regulatory framework, and seal quality tests. European journal of pharmaceutics and biopharmaceutics, 99. pp. 54-64.

Ríos Quiroz, Anacelia and Lamerz, Jens and De Cunha, Thierry and Boillon, Adeline and Adler, Michael and Finkler, Christof and Huwyler, Jörg and Schmidt, Roland and Mahler, Hanns-Christian and Koulov, Atanas V.. (2016) Factors Governing the Precision of Subvisible Particle Measurement Methods - A Case Study with a Low-Concentration Therapeutic Protein Product in a Prefilled Syringe. Pharmaceutical research, 33 (2). pp. 450-461.

2016

Camblin, Marine and Berger, Benjamin and Haschke, Manuel and Krähenbühl, Stephan and Huwyler, Jörg and Puchkov, Maxim. (2016) CombiCap: A novel drug formulation for the basel phenotyping cocktail. International Journal of Pharmaceutics, 512 (1). pp. 253-261.

Duthaler, Urs and Sayasone, Somphou and Vanobbergen, Fiona and Penny, Melissa A. and Odermatt, Peter and Huwyler, Jörg and Keiser, Jennifer. (2016) Single-ascending-Ddse pharmacokinetic study of tribendimidine in opisthorchis viverrini-infected patients. Antimicrobial Agents and Chemotherapy, 60 (10). pp. 5705-5715.

Grossen, Philip and Québatte, Gabriela and Witzigmann, Dominik and Prescianotto-Baschong, Cristina and Dieu, Le-Ha and Huwyler, Jörg. (2016) Functionalized Solid-Sphere PEG-b-PCL Nanoparticles to Target Brain Capillary Endothelial Cells In Vitro. Journal of Nanomaterials, 2016. p. 7818501.

Leonidova, Anna and Vargas, Mireille and Huwyler, Jörg and Keiser, Jennifer. (2016) Pharmacokinetics of the Antischistosomal Lead Ozonide OZ418 in Uninfected Mice Determined by Liquid Chromatography-Tandem Mass Spectrometry. Antimicrobial Agents and Chemotherapy, 60 (12). pp. 7364-7371.

Mathaes, Roman and Mahler, Hanns-Christian and Roggo, Yves and Huwyler, Jörg and Eder, Jürgen and Fritsch, Kamil and Posset, Tobias and Mohl, Silke and Streubel, Alexander. (2016) Influence of Different Container Closure Systems and Capping Process Parameters on Product Quality and Container Closure Integrity (CCI) in GMP Drug Product Manufacturing. PDA Journal of Pharmaceutical Science and Technology, 70 (2). pp. 109-119.

Mathaes, Roman and Mahler, Hanns-Christian and Roggo, Yves and Ovadia, Robert and Lam, Philippe and Stauch, Oliver and Vogt, Martin and Roehl, Holger and Huwyler, Joerg and Mohl, Silke and Streubel, Alexander. (2016) Impact of Vial Capping on Residual Seal Force and Container Closure Integrity. PDA Journal of Pharmaceutical Science and Technology, 70 (1). pp. 12-29.

Mathaes, Roman and Mahler, Hanns-Christian and Vorgrimler, Lothar and Steinberg, Henrik and Dreher, Sascha and Roggo, Yves and Nieto, Alejandra and Brwon, Helen and Roehl, Holger and Adler, Michael and Luemkemann, Joerg and Huwyler, Jörg and Lam, Philippe and Stauch, Oliver and Mohl, Silke and Streubel, Alexander. (2016) The Pharmaceutical Capping Process - Correlation between Residual Seal Force, Torque Moment, and Flip-off Removal Force. PDA Journal of Pharmaceutical Science and Technology, 70 (3). pp. 218-229.

Meister, Isabel and Kovac, Jana and Duthaler, Urs and Odermatt, Peter and Huwyler, Jörg and Vanobberghen, Fiona and Sayasone, Somphou and Keiser, Jennifer. (2016) Pharmacokinetic study of praziquantel enantiomers and its main metabolite R-trans-4-OH-PZQ in plasma, blood and dried blood spots in Opisthorchis viverrini-infected patients. PLoS Neglected Tropical Diseases, 10 (5). e0004700.

Meister, Isabel and Leonidova, Anna and Kovač, Jana and Duthaler, Urs and Keiser, Jennifer and Huwyler, Jörg. (2016) Development and validation of an enantioselective LC-MS/MS method for the analysis of the anthelmintic drug praziquantel and its main metabolite in human plasma, blood and dried blood spots. Journal of pharmaceutical and biomedical analysis, 118. pp. 81-88.

Werk, T. and Ludwig, I. S. and Luemkemann, J. and Huwyler, J. and Mahler, H. -C. and Haeuser, C. R. and Hafner, M.. (2016) New Processes for Freeze-Drying in Dual-Chamber Systems. PDA Journal of Pharmaceutical Science and Technology, 70 (3). pp. 191-207.

Werk, Tobias and Ludwig, Imke S. and Mahler, Hanns-Christian and Luemkemann, Joerg and Huwyler, Joerg and Hafner, Mathias. (2016) The Effect of Formulation, Process, and Method Variables on the Reconstitution Time in Dual Chamber Syringes. PDA Journal of Pharmaceutical Science and Technology, 70 (6). pp. 508-522.

Werk, Tobias and Mahler, Hanns-Christian and Ludwig, Imke Sonja and Luemkemann, Joerg and Huwyler, Joerg and Hafner, Mathias. (2016) A Method to Determine the Kinetics of Sulute Mixing in Liquid/Liquid Formulation Dual-Chamber Syringes. PDA Journal of Pharmaceutical Science and Technology, 71 (1). pp. 2-10.

Witzigmann, Dominik. Hepatocyte-specific drug delivery using active targeted nanomedicines - evaluation of targeting strategies in vitro and in vivo. 2016, Doctoral Thesis, University of Basel, Faculty of Science.

Witzigmann, Dominik and Detampel, Pascal and Porta, Fabiola and Huwyler, Jörg. (2016) Isolation of Multiantennary N-Glycans from Glycoproteins for Hepatocyte Specific Targeting via the Asialoglycoprotein Receptor. RSC Advances, 6. pp. 97636-97640.

25 December 2015

Kettiger, Helene and Karaman, Didem Sen and Schiesser, Laura and Rosenholm, Jessica M. and Huwyler, Jörg. (2015) Comparative safety evaluation of silica-based particles. Toxicology in vitro, 30 (1). pp. 355-363.

December 2015

Boll, Björn and Folzer, Emilien and Finkler, Christof and Huwyler, Jörg and Mahler, Hanns-Christian and Schmidt, Roland and Koulov, Atanas V.. (2015) Comparative Evaluation of Two Methods for Preparative Fractionation of Proteinaceous Subvisible Particles-Differential Centrifugation and FACS. Pharmaceutical research, 32 (12). pp. 3952-3964.

Folzer, Emilien and Khan, Tarik and Schmidt, Roland and Finkler, Christof and Huwyler, Jörg and Mahler, Hanns-Christian and Koulov, Atanas V.. (2015) Determination of the Density of Protein Particles Using a Suspended Microchannel Resonator. Journal of pharmaceutical sciences, 104 (12). pp. 4034-4040.

October 2015

Allmendinger, Andrea and Mueller, Robert and Huwyler, Jörg and Mahler, Hans-Christian and Fischer, Stefan. (2015) Sterile Filtration of Highly Concentrated Protein Formulations: Impact of Protein Concentration, Formulation Composition, and Filter Material. Journal of pharmaceutical sciences, 104 (10). pp. 3319-3329.

September 2015

Folzer, Emilien and Diepold, Katharina and Bomans, Katrin and Finkler, Christof and Schmidt, Roland and Bulau, Patrick and Huwyler, Jörg and Mahler, Hanns-Christian and Koulov, Atanas V.. (2015) Selective Oxidation of Methionine and Tryptophan Residues in a Therapeutic IgG1 Molecule. Journal of pharmaceutical sciences, 104 (9). pp. 2824-2831.

Kunze, Annett and Poller, Birk and Huwyler, Jörg and Camenisch, Gian. (2015) Application of the extended clearance concept classification system (ECCCS) to predict the victim drug-drug interaction potential of statins. Drug Metabolism and Personalized Therapy, 30 (3). pp. 175-188.

Werk, Tobias and Huwyler, Jörg and Hafner, Mathias and Luemkemann, Jörg and Mahler, Hanns-Christian. (2015) An Impedance-Based Method to Determine Reconstitution Time for Freeze-Dried Pharmaceuticals. Journal of pharmaceutical sciences, 104 (9). pp. 2948-2955.

July 2015

Allmendinger, Andrea and Mueller, Robert and Schwarb, Edward and Chipperfield, Mark and Huwyler, Jörg and Mahler, Hanns-Christian and Fischer, Stefan. (2015) Measuring Tissue Back-Pressure - In Vivo Injection Forces During Subcutaneous Injection. Pharmaceutical research, 32 (7). pp. 2229-2240.

20 June 2015

Preisig, Daniel and Weingartner, Michael and Varum, Felipe J. O. and Bravo, Roberto and Alles, Rainer and Huwyler, Jörg and Puchkov, Maxim. (2015) Marker-ion analysis for quantification of mucoadhesivity of microparticles in particle-retention assays. International journal of pharmaceutics, 487 (1-2). pp. 157-166.

March 2015

Camenisch, Gian and Riede, Julia and Kunze, Annett and Huwyler, Jörg and Poller, Birk and Umehara, Kanichi. (2015) The extended clearance model and its use for the interpretation of hepatobiliary elimination data. ADMET & DMPK, 3 (1). pp. 1-14.

Seeland, Swen and Kettiger, Helene and Murphy, Mark and Treiber, Alexander and Giller, Jasmin and Kiss, Andrea and Sube, Romain and Krähenbühl, Stephan and Hafner, Mathias and Huwyler, Jörg. (2015) ATP-induced cellular stress and mitochondrial toxicity in cells expressing purinergic P2X7 receptor. Pharmacology Research & Perspecitves, 3 (2). e00123.

28 February 2015

Wicki, Andreas and Witzigmann, Dominik and Balasubramanian, Vimalkumar and Huwyler, Jörg. (2015) Nanomedicine in cancer therapy : challenges, opportunities, and clinical applications. Journal of controlled release, 200. pp. 138-157.

12 February 2015

Jaeschke, Georg and Kolczewski, Sabine and Spooren, Will and Vieira, Eric and Bitter-Stoll, Nadia and Boissin, Patrick and Borroni, Edilio and Büttelmann, Bernd and Ceccarelli, Simona and Clemann, Nicole and David, Beatrice and Funk, Christoph and Guba, Wolfgang and Harrison, Anthony and Hartung, Thomas and Honer, Michael and Huwyler, Jörg and Kuratli, Martin and Niederhauser, Urs and Pähler, Axel and Peters, Jens-Uwe and Petersen, Ann and Prinssen, Eric and Ricci, Antonio and Rueher, Daniel and Rueher, Marianne and Schneider, Manfred and Spurr, Paul and Stoll, Theodor and Tännler, Daniel and Wichmann, Jürgen and Porter, Richard H. and Wettstein, Joseph G. and Lindemann, Lothar. (2015) Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators: Discovery of 2-Chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (Basimglurant, RO4917523), a Promising Novel Medicine for Psychiatric Diseases. Journal of medicinal chemistry, 58 (3). pp. 1358-1371.

2015

Eberle, Veronika Anna. Floating gastroretentive drug delivery systems based on functionalized calcium carbonate. 2015, Doctoral Thesis, University of Basel, Faculty of Science.

Folzer, Emilien. Techniques for fractionation, isolation and characterization of subvisible and submicron particles in biopharmaceutical preparations. 2015, Doctoral Thesis, University of Basel, Faculty of Science.

Keiser, Jenifer and [et al.], . (2015) Efficacy and safety of albendazole plus ivermectin, albendazole plus mebendazole, albendazole plus oxantel pamoate, and mebendazole alone against Trichuris trichiura and concomitant soil-transmitted helminth infection : a four-arm, randomised controlled trial. The Lancet infectious diseases, Vol. 15, H. 3. pp. 277-284.

Meister, Isabel and Leonidova, Anna and Kovac, Jana and Duthaler, Urs and Keiser, Jennifer and Huwyler, Jörg. (2015) Development and validation of an enantioselective LC-MS/MS method for the analysis of the anthelmintic drug parziquantel and its main metabolite in human plasma, blood and dried blood spots. Journal of Pharmaceutical and Biomedical Analysis, 118. pp. 81-88.

Moser, Wendelin and Ali, Said M. and Ame, Shaali M. and Speich, Benjamin and Puchkov, Maxim and Huwyler, Jörg and Albonico, Marco and Hattendorf, Jan and Keiser, Jennifer. (2015) Efficacy and safety of oxantel pamoate in school-aged children infected with Trichuris trichiura on Pemba Island, Tanzania: a parallel, randomised, controlled, dose-ranging study. The Lancet infectious diseases, 16 (1). pp. 53-60.

Müller, Bert and Zumbuehl, Andreas and Walter, Martin A. and Pfohl, Thomas and Cattin, Philippe C. and Huwyler, Jörg and Hieber, Simone E.. (2015) Translational Medicine: Nanoscience and Nanotechnology to Improve Patient Care. In: The Nano-Micro Interface: Bridging the Micro and Nano Worlds, 2. Weinheim, pp. 291-309.

Preisig, Daniel. Development of a mucoadhesive and multiparticulate colon drug delivery system. 2015, Doctoral Thesis, University of Basel, Faculty of Science.

Ríos Quiroz, Anacelia. Application of novel techniques for characterization of subvisible and sub-micron particles in biopharmaceutical preparations. 2015, Doctoral Thesis, University of Basel, Faculty of Science.

Ríos Quiroz, Anacelia and Québatte, Gabriela and Stump, Fabian and Finkler, Christof and Huwyler, Joerg and Schmidt, Roland and Mahler, Hanns-Christian and Koulov, Atanas V. and Adler, Michael. (2015) Measuring Subvisible Particles in Protein Formulations Using a Modified Light Obscuration Sensor with Improved Detection Capabilities. Analytical chemistry, Vol. 87, H. 12. pp. 6119-6124.

Sohn, Myriam. In vitro biorelevant and in silico sunscreen performance evaluation on the basis of film Thickness frequency distribution of formulations and UV filter repartition. 2015, Doctoral Thesis, University of Basel, Faculty of Science.

Witzigmann, Dominik and Camblin, Marine and Huwyler, Jürg and Balasubramaniana, Vimalkumar. (2015) Nanomaterials: Therapeutic Applications. In: Encyclopedia of Biomedical Polymers and Polymer Biomaterials. New York, pp. 5364-5378.

Witzigmann, Dominik and Sieber, Sandro and Porta, Fabiola and Grossen, Philip and Bieri, Andrej and Strelnikova, Natalja and Pfohl, Thomas and Prescianotto-Baschong, Cristina and Huwyler, Jörg. (2015) Formation of lipid and polymer based gold nanohybrids using a nanoreactor approach. RSC Advances, 5 (91). pp. 74320-74328.

Witzigmann, Dominik and Wu, Dalin and Schenk, Susanne H. and Balasubramanian, Vimalkumar and Meier, Wolfgang and Huwyler, Jörg. (2015) Biocompatible Polymer-Peptide Hybrid-Based DNA Nanoparticles for Gene Delivery. ACS applied materials & interfaces, 7 (19). pp. 10446-10456.

2014

Allmendinger, A. and Dieu, L. H. and Fischer, S. and Mueller, R. and Mahler, H. C. and Huwyler, J.. (2014) High-throughput viscosity measurement using capillary electrophoresis instrumentation and its application to protein formulation. Journal of pharmaceutical and biomedical analysis, Vol. 99. pp. 51-58.

Allmendinger, A. and Fischer, S. and Huwyler, J. and Mahler, H. C. and Schwarb, E. and Zarraga, I. E. and Mueller, R.. (2014) Rheological characterization and injection forces of concentrated protein formulations : an alternative predictive model for non-Newtonian solutions. European journal of pharmaceutics and biopharmaceutics, Vol. 87, H. 2. pp. 318-328.

Allmendinger, Andrea Martina. Rheological investigation of manufacturability and injectability of highly concentrated monoclonal antibody formulations. 2014, Doctoral Thesis, University of Basel, Faculty of Science.

Camblin, M. and Detampel, P. and Kettiger, H. and Wu, D. and Balasubramanian, V. and Huwyler, J.. (2014) Polymersomes containing quantum dots for cellular imaging. International journal of nanomedicine, Vol. 9. pp. 2287-2298.

Detampel, Pascal and Witzigmann, Dominik and Krähenbühl, Stephan and Huwyler, Jörg. (2014) Hepatocyte targeting using pegylated asialofetuin-conjugated liposomes. Journal of drug targeting, Vol. 22, No. 3. pp. 232-241.

Dieu, Le-Ha. "In vitro" evaluation of blood-brain barrier transport. 2014, Doctoral Thesis, University of Basel, Faculty of Science.

Dieu, Le-Ha and Wu, Dalin and Palivan, Cornelia G. and Balasubramanian, Vimalkumar and Huwyler, Jörg. (2014) Polymersomes conjugated to 83-14 monoclonal antibodies : in vitro targeting of brain capillary endothelial cells. European journal of pharmaceutics and biopharmaceutics, 88 (2). pp. 316-324.

Eberle, V. A. and Schoelkopf, J. and Gane, P. A. and Alles, R. and Huwyler, J. and Puchkov, M.. (2014) Floating gastroretentive drug delivery systems : comparison of experimental and simulated dissolution profiles and floatation behavior. European journal of pharmaceutical sciences, Vol. 58. pp. 34-43.

Kettiger, Hélène Emilie. Silica nanoparticles and their interaction with cells : a multidisciplinary approach. 2014, Doctoral Thesis, University of Basel, Faculty of Science.

Kunze, A. and Huwyler, J. and Camenisch, G. and Poller, B.. (2014) Prediction of OATP1B1 and OATP1B3 Mediated Hepatic Uptake of Statins Based on Transporter Protein Expression and Activity Data. Drug metabolism and disposition, Vol. 42, H. 9. pp. 1514-1521.

Kunze, A. and Huwyler, J. and Poller, B. and Gutmann, H. and Camenisch, G.. (2014) In vitro-in vivo extrapolation method to predict human renal clearance of drugs. Journal of pharmaceutical sciences, Vol. 103, H. 3. pp. 994-1001.

Kunze, Annett. Prediction of human drug clearance and anticipation of clinical drug-drug interaction potential from in vitro drug transport studies. 2014, Doctoral Thesis, University of Basel, Faculty of Science.

Mueller, B. and Hieber, S. E. and Zumbuehl, A. and Walter, M. A. and Huwyler, J. and Pfohl, T. and Cattin, Ph. C.. (2014) Translational medicine : nanoscience and nanotechnology to improve patient care. In: The nano-micro interface. Weinheim, pp. 291-309.

Preisig, D. and Haid, D. and Varum, F. J. and Bravo, R. and Huwyler, J. and Puchkov, M.. (2014) Drug loading into porous calcium carbonate microparticles by solvent evaporation. European journal of pharmaceutics and biopharmaceutics, Vol. 87, H. 3. pp. 548-558.

Speich, Benjamin and Ame, Shaali M. and Ali, Said M. and Alles, Rainer and Huwyler, Jörg and Hattendorf, Jan and Utzinger, Jürg and Albonico, Marco and Keiser, Jennifer. (2014) Oxantel pamoate-albendazole for Trichuris trichiura infection. The New England journal of medicine, Vol. 370, H. 7. pp. 610-620.

Stirnimann, T. and Atria, S. and Schoelkopf, J. and Gane, P. A. and Alles, R. and Huwyler, J. and Puchkov, M.. (2014) Compaction of functionalized calcium carbonate, a porous and crystalline microparticulate material with a lamellar surface. International journal of pharmaceutics, Vol. 466, H. 1-2 , S. 266–275.

Stirnimann, Tanja. Characterization of functionalized calcium carbonate as a new pharmaceutical excipient. 2014, Doctoral Thesis, University of Basel, Faculty of Science.

2013

Detampel, Pascal. Targeting of hepatocytes using vector-conjugated liposomes : evaluation of targeting strategies. 2013, Doctoral Thesis, University of Basel, Faculty of Science.

Fasler-Kan, E. and Barteneva, N. S. and Ketterer, S. and Wunderlich, K. and Reschner, A. and Nurzhanova, A. and Flammer, J. and Huwyler, J. and Meyer, P.. (2013) Human cytokines activate JAK-STAT signaling pathway in porcine ocular tissue. Xenotransplantation, Vol. 20, H. 6. pp. 469-480.

Kettiger, H. and Schipanski, A. and Wick, P. and Huwyler, J.. (2013) Engineered nanomaterial uptake and tissue distribution : from cell to organism. International journal of nanomedicine, Vol. 8. pp. 3255-3269.

Khanicheh, Elham. Cardiovascular molecular imaging. 2013, Doctoral Thesis, University of Basel, Faculty of Science.

Kimura, Go and Puchkov, Maxim and Leuenberger, Hans. (2013) An attempt to calculate in silico disintegration time of tablets containing mefenamic acid, a low water-soluble drug. Journal of pharmaceutical sciences, Vol. 102, H. 7. pp. 2166-2178.

Martínez Heredia, Lizbeth Araceli. Batch and continuous blending of particulate material studied by near-infrared spectroscopy. 2013, Doctoral Thesis, University of Basel, Faculty of Science.

Meister, Isabel and Duthaler, Urs and Huwyler, Jörg and Rinaldi, Laura and Bosco, Antonio and Cringoli, Giuseppe and Keiser, Jennifer. (2013) Efficacy and pharmacokinetics of OZ78 and MT04 against a natural infection with Fasciola hepatica in sheep. Veterinary parasitology, Vol. 198, H. 1-2. pp. 102-110.

Nalluri, Venkateshwar Rao and Puchkov, Maxim and Kuentz, Martin. (2013) Toward better understanding of powder avalanching and shear cell parameters of drug-excipient blends to design minimal weight variability into pharmaceutical capsules. International journal of pharmaceutics, Vol. 442, H. 1-2. pp. 49-56.

Québatte, Gabriela and Kitas, Eric and Seelig, Joachim. (2013) riDOM, a cell-penetrating peptide. Interaction with DNA and heparan sulfate. Journal of Physical Chemistry B, 117 (37). pp. 10807-10817.

Schoenbaechler, A. and Olfa, G. and Huwyler, J. and Frenz, M. and Pieles, U.. (2013) Indocyanine green loaded biocompatible nanoparticles: Stabilization of indocyanine green (ICG) using biocompatible silica-poly(; e; -caprolactone) grafted nanocomposites. Journal of photochemistry and photobiology. A, Chemistry, Vol. 261. pp. 12-19.

Seeland, S. and Torok, M. and Kettiger, H. and Treiber, A. and Hafner, M. and Huwyler, J.. (2013) A cell-based, multiparametric sensor approach characterises drug-induced cytotoxicity in human liver HepG2 cells. Toxicology in vitro, Vol. 27, H. 3. pp. 1109-1120.

Simmler, Linda. Pharmacology of amphetamine-type designer drugs. 2013, Doctoral Thesis, University of Basel, Faculty of Science.

Stirnimann, Tanja and Di Maiuta, Nicola and Gerard, Daniel E. and Alles, Rainer and Huwyler, Jörg and Puchkov, Maxim. (2013) Functionalized Calcium Carbonate as a Novel Pharmaceutical Excipient for the Preparation of Orally Dispersible Tablets. Pharmaceutical research, Vol. 30, H. 7. pp. 1915-1925.

2012

Duthaler, U. and Huwyler, J. and Rinaldi, L. and Cringoli, G. and Keiser, J.. (2012) Evaluation of the pharmacokinetic profile of artesunate, artemether and their metabolites in sheep naturally infected with Fasciola hepatica. Veterinary parasitology, Vol. 186, H. 3-4. pp. 270-280.

Hysek, C. M. and Simmler, L. D. and Nicola, V. G. and Vischer, N. and Donzelli, M. and Krahenbuhl, S. and Grouzmann, E. and Huwyler, J. and Hoener, M. C. and Liechti, M. E.. (2012) Duloxetine inhibits effects of MDMA ("ecstasy") in vitro and in humans in a randomized placebo-controlled laboratory study. PLoS one, Vol. 7, H. 5 , e36476.

Kirchhofer, C. and Vargas, M. and Huwyler, J. and Keiser, J.. (2012) Pharmacokinetics of the fasciocidal drug candidates MT04 and OZ78 in uninfected rats and in vitro pharmacodynamic studies. International journal for parasitology: drugs and drug resistance, Vol. 2. pp. 121-125.

Kunze, A. and Huwyler, J. and Camenisch, G. and Gutmann, H.. (2012) Interaction of the antiviral drug telaprevir with renal and hepatic drug transporters. Biochemical pharmacology, Vol. 84, Issue 8. pp. 1096-1102.

Sano, Y. and Kashiwamura, Y. and Abe, M. and Dieu, L. H. and Huwyler, J. and Shimizu, F. and Haruki, H. and Maeda, T. and Saito, K. and Tasaki, A. and Kanda, T.. (2012) A stable human brain microvascular endothelial cell line retaining its barrier-specific nature, independent of the passage number. Clinical and experimental neuroimmunology, Vol. 3. pp. 1-12.

Simmler, L. D. and Buser, T. A. and Donzelli, M. and Schramm, Y. and Dieu, L. H. and Huwyler, J. and Chaboz, S. and Hoener, M. C. and Liechti, M. E.. (2012) Pharmacological characterization of designer cathinones in vitro. British journal of pharmacology, Vol. 168, no. 2. pp. 458-470.

Suenderhauf, C. and Hammann, F. and Huwyler, J.. (2012) Computational Prediction of Blood-Brain Barrier Permeability Using Decision Tree Induction. Molecules, Vol. 17, H. 9. pp. 10429-10445.

2011

Duthaler, Urs and Keiser, Jennifer and Huwyler, Jörg. (2011) Development and validation of a liquid chromatography and ion spray tandem mass spectrometry method for the quantification of artesunate, artemether, and their major metabolites dihydroartemisinin and dihydroartemisininglucuronide in sheep plasma. Journal of Mass Spectrometry, 46 (2). pp. 172-181.

Hammann, F. and Suenderhauf, C. and Huwyler, J.. (2011) A Binary Ant Colony Optimization Classifier for Molecular Activities. Journal of Chemical Information and Modeling, Vol. 51. pp. 2690-2696.

Hysek, C. M. and Simmler, L. D. and Ineichen, M. and Grouzmann, E. and Hoener, M. C. and Brenneisen, R. and Huwyler, J. and Liechti, M. E.. (2011) The Norepinephrine Transporter Inhibitor Reboxetine Reduces Stimulant Effects of MDMA ("Ecstasy") in Humans. Clinical pharmacology and therapeutics, Vol. 90, H. 2. pp. 246-255.

Leuenberger, Hans and Leuenberger, Michael and Puchkov, Maxim. (2011) Virtual scale-up of manufacturing solid dosage forms. In: Pharmaceutical process scale-up. New York, p. 490.

Schmutz, Hans-Rudolf and Detampel, Pascal and Bühler, Theo and Büttler, André and Gygax, Benjamin and Huwyler, Jörg. (2011) In Vitro Assessment of the Formation of Ceftriaxone-Calcium Precipitates in Human Plasma. Journal of pharmaceutical sciences, Vol. 100, H. 6. pp. 2300-2310.

Schroeder, K. and Bremm, K. D. and Alepee, N. and Bessems, J. G. and Blaauboer, B. and Boehn, S. N. and Burek, C. and Coecke, S. and Gombau, L. and Hewitt, N. J. and Heylings, J. and Huwyler, J. and Jaeger, M. and Jagelavicius, M. and Jarrett, N. and Ketelslegers, H. and Kocina, I. and Koester, J. and Kreysa, J. and Note, R. and Poth, A. and Radtke, M. and Rogiers, V. and Scheel, J. and Schulz, T. and Steinkellner, H. and Toeroek, M. and Whelan, M. and Winkler, P. and Diembeck, W.. (2011) Report from the EPAA workshop : in vitro ADME in safety testing used by EPAA industry sectors. Toxicology in vitro, Vol. 25, H. 3. pp. 589-604.

Seeland, S. and Treiber, A. and Hafner, M. and Huwyler, J.. (2011) On-line identification of P-glycoprotein substrates by monitoring of extracellular acidification and respiration rates in living cells. Biochimica et biophysica acta, Vol. 1808, H. 7. pp. 1827-1831.

Suenderhauf, Claudia. "In silico" prediction of drug transport across physiological barriers. 2011, Doctoral Thesis, University of Basel, Faculty of Science.

Suenderhauf, Claudia and Hammann, Felix and Maunz, Andreas and Helma, Christoph and Huwyler, Jörg. (2011) Combinatorial QSAR Modeling of human Intestinal Absorption. Molecular pharmaceutics, Vol. 8, H. 1. pp. 213-224.

2010

Boehringer, M. and Fischer, H. and Hennig, M. and Hunziker, D. and Huwyler, J. and Kuhn, B. and Loeffler, B. M. and Luebbers, T. and Mattei, P. and Narquizian, R. and Sebokova, E. and Sprecher, U. and Wessel, H. P.. (2010) Aryl- and heteroaryl-substituted aminobenzo[a]quinolizines as dipeptidyl peptidase IV inhibitors. Bioorganic & medicinal chemistry letters, Vol. 20, H. 3. pp. 1106-1108.

Fasler-Kan, E. and Barteneva, N. and Ketterer, S. and Wunderlich, K. and Huwyler, J. and Gygax, D. and Flammer, J. and Meyer, P.. (2010) Activation of the JAK?STAT intracellular pathway in human retinal pigment epithelialcell line ARPE-19. International Journal of Interferon, Cytokine and Mediator Research, Vol. 2. pp. 127-136.

Fasler-Kan, Elizaveta and Suenderhauf, Claudia and Barteneva, Natasha and Poller, Birk and Gygax, Daniel and Huwyler, Jörg. (2010) Cytokine signaling in the human brain capillary endothelial cell line hCMEC/D3. Brain research, Vol. 1354. pp. 15-22.

Keiser, Jennifer and Kirchhofer, Carla and Haschke, Manuel and Huwyler, Jörg and Dong, Yuxiang and Vennerstrom, Jonathan L. and Vanhoff, Kathleen and Kaminsky, Ronald and Malikides, Nick. (2010) Efficacy, safety and pharmacokinetics of 1,2,4-trioxolane OZ78 against an experimental infection with Fasciola hepatica in sheep. Veterinary parasitology, Vol. 173, H. 3-4. pp. 228-235.

Kirchhofer, C. and Keiser, J. and Huwyler, J.. (2010) Development and validation of a liquid chromatography/mass spectrometry method for pharmacokinetic studies of OZ78, a fasciocidal drug candidate. Journal of chromatography B, Vol. 878, H. 28. pp. 2770-2774.

Mattei, P. and Boehringer, M. and Di Giorgio, P. and Fischer, H. and Hennig, M. and Huwyler, J. and Kocer, B. and Kuhn, B. and Loeffler, B. M. and Macdonald, A. and Narquizian, R. and Rauber, E. and Sebokova, E. and Sprecher, U.. (2010) Discovery of carmegliptin : a potent and long-acting dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. Bioorganic & medicinal chemistry letters, Vol. 20, H. 3. pp. 1109-1113.

Poller, Birk and Drewe, Jürgen and Krähenbühl, Stephan and Huwyler, Jörg and Gutmann, Heike. (2010) Regulation of BCRP (ABCG2) and P-glycoprotein (ABCB1) by cytokines in a model of the human blood-brain barrier. Cellular and Molecular Neurobiology, Vol. 30, No. 1. pp. 63-70.

Richter, H. G. and Freichel, C. and Huwyler, J. and Nakagawa, T. and Nettekoven, M. and Plancher, J. M. and Raab, S. and Roche, O. and Schuler, F. and Taylor, S. and Ullmer, C. and Wiegand, R.. (2010) Discovery of potent and selective histamine H3 receptor inverse agonists based on the 3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one scaffold. Bioorganic & medicinal chemistry letters, Vol. 20, H. 19. pp. 5713-5717.

Woltering, Thomas J. and Wichmann, Jürgen and Goetschi, Erwin and Knoflach, Frédéric and Ballard, Theresa M. and Huwyler, Jörg and Gatti, Silvia. (2010) Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives : Part 4. In vivo active potent and selective non-competitive metabotropic glutamate receptor 2/3 antagonists. Bioorganic & medicinal chemistry letters, Vol. 20, H. 23. pp. 6969-6974.

2009

Pierson, Pascale David and Fettes, Alec and Freichel, Christian and Gatti-McArthur, Silvia and Hertel, Cornelia and Huwyler, Jörg and Mohr, Peter and Nakagawa, Toshito and Nettekoven, Matthias and Plancher, Jean-Marc and Raab, Susanne and Richter, Hans and Roche, Olivier and Rodríguez Sarmiento, Rosa María and Schmitt, Monique and Schuler, Franz and Takahashi, Tadakatsu and Taylor, Sven and Ullmer, Christoph and Wiegand, Ruby. (2009) 5-hydroxyindole-2-carboxylic acid amides: novel histamine-3 receptor inverse agonists for the treatment of obesity. Journal of Medicinal Chemistry, 52 (13). pp. 3855-3868.

Rumman, Murad. Understanding the functionality of MCC Rapid as an excipient for DC - Moving towards QbD. 2009, Doctoral Thesis, University of Basel, Faculty of Science.

Vieira, Eric and Huwyler, Jörg and Jolidon, Synèse and Knoflach, Frédéric and Mutel, Vincent and Wichmann, Jürgen. (2009) Fluorinated 9H-xanthene-9-carboxylic acid oxazol-2-yl-amides as potent, orally available mGlu1 receptor enhancers. Bioorganic and Medicinal Chemistry Letters, 19 (6). pp. 1666-1669.

2008

Bausch, Ursula J.. Impact of filling processes on protein solutions. 2008, Doctoral Thesis, University of Basel, Faculty of Science.

Bendels, Stefanie and Kansy, Manfred and Wagner, Björn and Huwyler, Jörg. (2008) In silico prediction of brain and CSF permeation of small molecules using PLS regression models. European Journal of Medicinal Chemistry, 43 (8). pp. 1581-1592.

Du-Cuny, Lei and Huwyler, Jörg and Wiese, Michael and Kansy, Manfred. (2008) Computational aqueous solubility prediction for drug-like compounds in congeneric series. European Journal of Medicinal Chemistry, 43 (3). pp. 501-512.

Guntermann, Anja Maria. Untersuchung der Tablettiersimulation mit dem PressterTM in Abhängigkeit von der Formulierung, Chargengrösse und der Tablettenpresse. 2008, Doctoral Thesis, University of Basel, Faculty of Science.

Hadzovic, Ervina. Roller compaction of theophylline. 2008, Doctoral Thesis, University of Basel, Faculty of Science.

Krausbauer, Etienne and Puchkov, Maxim and Betz, Gabriele and Leuenberger, Hans. (2008) Rational estimation of the optimum amount of non-fibrous disintegrant applying percolation theory for binary fast disintegrating formulation. Journal of pharmaceutical sciences, Vol. 97, H. 1. pp. 529-541.

Maurer, Lene. Near infrared spectroscopy/imaging and terahertz pulsed spectroscopy/imaging for the analysis of solid dosage forms. 2008, Doctoral Thesis, University of Basel, Faculty of Science.

Meyer, Thomas Alexander. Novel determination of powder mixing qualities and study of dry coated particles. 2008, Doctoral Thesis, University of Basel, Faculty of Science.

Müller, Franziska Simone. Modified celluloses as multifunctional excipients in rapidly dissolving immediate release tablets. 2008, Doctoral Thesis, University of Basel, Faculty of Science.

Oppel, Katrin. Taste masking of an active pharmaceutical ingredient for veterinary application. 2008, Doctoral Thesis, University of Basel, Faculty of Science.

Pasic, Maja. Study to design stable lansoprazole pellets. 2008, Doctoral Thesis, University of Basel, Faculty of Science.

Reiser, Miriam Regina Luise. Effect of continuous phase drug concentration, evaporation and partitioning on transdermal drug permeation kinetics with lipophilic vehicles. 2008, Doctoral Thesis, University of Basel, Faculty of Science.

Schneider, Marcel. Investigation of the transport of lipophilic drugs in structurally diverse lipid formulations through caco-2 cell monolayer using mathematical modeling. 2008, Doctoral Thesis, University of Basel, Faculty of Science.

Sehic, Selma. Investigation of variability of primary materials on the intrinsic dissolution behavior of carbamazepine. 2008, Doctoral Thesis, University of Basel, Faculty of Science.

Tuffin, Gérald and Huwyler, Jörg and Waelti, Ernst and Hammer, Caroline and Marti, Hans-Peter. (2008) Drug targeting using OX7-immunoliposomes: Correlation between Thy1.1 antigen expression and tissue distribution in the rat. Journal of Drug Targeting, 16 (2). pp. 156-166.

Woltering, Thomas J. and Wichmann, Jürgen and Goetschi, Erwin and Adam, Geo and Kew, James N. C. and Knoflach, Frédéric and Ballard, Theresa M. and Huwyler, Jörg and Mutel, Vincent and Gatti, Silvia. (2008) Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 3. New potent non-competitive metabotropic glutamate receptor 2/3 antagonists. Bioorganic and Medicinal Chemistry Letters, 18 (8). pp. 2725-2729.

Zimmermann, Esther. In vitro-/ ex vivo-Hautmodelle zur Erfassung der Reaktion auf externe Reize sowie der Wirkung einer antiinflammatorischen Behandlung. 2008, Doctoral Thesis, University of Basel, Faculty of Science.

2007

Blaser, David Werner. Determination of drug absorption parameters in Caco-2 cell monolayers with a mathematical model encompassing passive diffusion, carrier-mediated efflux, non-specific binding and phase II metabolism. 2007, Doctoral Thesis, University of Basel, Faculty of Science.

Ceccarelli, Simona M. and Jaeschke, Georg and Buettelmann, Bernd and Huwyler, Jörg and Kolczewski, Sabine and Peters, Jens-Uwe and Prinssen, Eric and Porter, Richard and Spooren, Will and Vieira, Eric. (2007) Rational design, synthesis, and structure-activity relationship of benzoxazolones: new potent mglu5 receptor antagonists based on the fenobam structure. Bioorganic and Medicinal Chemistry Letters, 17 (5). pp. 1302-1306.

Daneshvari, Dana. Investigation of binary polar solvent mixtures, solubilized ferroelectric salts and paraffin-based derivatives using dielectric spectroscopy. 2007, Doctoral Thesis, University of Basel, Faculty of Science.

Du-Cuny, Lei and Huwyler, Jörg and Fischer, Holger and Kansy, Manfred. (2007) A potentiometric titration method for the crystallization of drug-like organic molecules. International Journal of Pharmaceutics, 342 (1-2). pp. 161-167.

Faatz, Mariam Susan. "Ländervergleich Irland-Schweiz betreffend der bildungspolitischen Rahmenbedingungen für die globale pharmazeutische Industrie". 2007, Doctoral Thesis, University of Basel, Faculty of Science.

Jaeschke, Georg and Porter, Richard and Büttelmann, Bernd and Ceccarelli, Simona M. and Guba, Wolfgang and Kuhn, Bernd and Kolczewski, Sabine and Huwyler, Jörg and Mutel, Vincent and Peters, Jens-Uwe and Ballard, Theresa and Prinssen, Eric and Vieira, Eric and Wichmann, Jürgen and Spooren, Will. (2007) Synthesis and biological evaluation of fenobam analogs as mGlu5 receptor antagonists. Bioorganic and Medicinal Chemistry Letters, 17 (5). pp. 1307-1311.

2006

Büttelmann, Bernd and Peters, Jens-Uwe and Ceccarelli, Simona and Kolczewski, Sabine and Vieira, Eric and Prinssen, Eric P. and Spooren, Will and Schuler, Franz and Huwyler, Jörg and Porter, Richard H. P. and Jaeschke, Georg. (2006) Arylmethoxypyridines as novel, potent and orally active mGlu5 receptor antagonists. Bioorganic and Medicinal Chemistry Letters, 16 (7). pp. 1892-1897.

Fässler Tassopoulos, Tatiana. Evaluation of topical bioavailability in human stratum corneum in vivo by tape stripping using a direct sprectroscopic method. 2006, Doctoral Thesis, University of Basel, Faculty of Science.

Huwyler, Jörg and Wright, Matthew B. and Gutmann, Heike and Drewe, Juergen. (2006) Induction of Cytochrome P450 3A4 and P-Glycoprotein by the Isoxazolyl-Penicillin Antibiotic Flucloxacillin. Current Drug Metabolism, 7 (2). pp. 119-126.

Lanz, Michael. Pharmaceutical powder technology : towards a science based understanding of the behavior of powder systems. 2006, Doctoral Thesis, University of Basel, Faculty of Science.

Leuenberger, H. and Plitzko, M. and Puchkov, M.. (2006) Spray freeze drying in a fluidized bed at normal and low pressure. Drying technology, Vol. 24, H. 6. pp. 711-719.

Marti, Sébastien Jérôme Georges. Towards the synthesis of a macrocyclic E-selectin antagonist. 2006, Doctoral Thesis, University of Basel, Faculty of Science.

Nalenz, Heiko. Dependence of skin drug permeation on microstructure and time dependent alterations following application of more-phasic dermatological formulations studied by the continuous phase drug concentration concept. 2006, Doctoral Thesis, University of Basel, Faculty of Science.

Plitzko, Matthias. Gefriertrocknung in der Wirbelschicht : Möglichkeiten und Grenzen für die Anwendung in der Pharmazie. 2006, Doctoral Thesis, University of Basel, Faculty of Science.

Rehorik-Valer Farfan, Lars. Ganzheitliche systemische Qualitätsbetrachtung in der Produktion fester Arzneiformen : ein praxisorientiertes Vorgehensmodell anhand einer Synthese der Methoden Prozesssimulation und multivariate Datenanalyse. 2006, Doctoral Thesis, University of Basel, Faculty of Science.

Sautter, Caroline Anne Françoise. Sustained release injectables formed "in-situ" for veterinary use. 2006, Doctoral Thesis, University of Basel, Faculty of Science.

Valþórsson, Héðinn. PAT implementation in pharmaceutical manufacturing and its economical impact. 2006, Doctoral Thesis, University of Basel, Faculty of Science.

Walter, Marijke. Integration und Evaluation neuer Medien angewandt in der Lehre der pharmazeutischen Technologie an der Universität Basel : Erfahrungen bei der Entwicklung und Umsetzung. 2006, Doctoral Thesis, University of Basel, Faculty of Science.

2005

Altenbach, Melanie Pamela. Cutaneous metabolism, tissue binding, lipophilicity and electroosmosis : relevance for iontophoretic enhancement. 2005, Doctoral Thesis, University of Basel, Faculty of Science.

Egger-Heigold, Barbara. The effect of excipients on pharmacokinetic parameters of parenteral drugs. 2005, Doctoral Thesis, University of Basel, Faculty of Science.

Orelli, Johannes Caspar von. Search for technological reasons to develop a capsule or a tablet formulation. 2005, Doctoral Thesis, University of Basel, Faculty of Science.

Reitbauer, Susanne. Einfluss pharmazeutischer Hilfsstoffe auf die Plamasmembran von Caco-2 Zellmonolayern ermittelt durch Fluoreszenzdepolarisation. 2005, Doctoral Thesis, University of Basel, Faculty of Science.

Schiffmann, Axel Ullrich. Modellierung und Formulierung von WIP (Washing In Place) - und CIP (Cleaning In Place) - Konzepten für Wirbelschichtanlagen. 2005, Doctoral Thesis, University of Basel, Faculty of Science.

Schnyder, Anita. "In vitro" and "in vivo" drug targeting using biotinylated immunoliposomes. 2005, Doctoral Thesis, University of Basel, Faculty of Science.

Schnyder, Anita and Krähenbühl, Stephan and Drewe, Jürgen and Huwyler, Jörg. (2005) Targeting of daunomycin using biotinylated immunoliposomes: Pharmacokinetics, tissue distribution and in vitro pharmacological effects. Journal of Drug Targeting, 13 (5). pp. 325-335.

Tuffin, Gérald and Waelti, Ernst and Huwyler, Jörg and Hammer, Caroline and Marti, Hans-Peter. (2005) Immunoliposome Targeting to Mesangial Cells: A Promising Strategy for Specific Drug Delivery to the Kidney. Journal of the American Society of Nephrology, 16 (11). pp. 3295-3305.

2004

Gräflein, Claudia. Parenterale Ernährung mit stabilitätsgeprüften, modularen Standardnährlösungen in der Neonatologie. 2004, Doctoral Thesis, University of Basel, Faculty of Science.

Hernandez Perni, Maria Engracia. A contribution to the understanding of percolation phenomena in binary liquids. 2004, Doctoral Thesis, University of Basel, Faculty of Science.

Kuny, Tanja Tamara. Compression behavior of the enzyme ß-galactosidase. 2004, Doctoral Thesis, University of Basel, Faculty of Science.

2003

Sukowski, Lars. NIR based process analytical technology: in-line residual moisture determination for a complete batch inspection of lyophilized end-products. 2003, Doctoral Thesis, University of Basel, Faculty of Science.