Items where Division is "05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Molecular and Systems Toxicology (Odermatt)"

2017

Araya, Selene and Kratschmar, Denise V. and Tsachaki, Maria and Stücheli, Simon and Beck, Katharina R. and Odermatt, Alex. (2017) DHRS7 (SDR34C1) - A new player in the regulation of androgen receptor function by inactivation of 5α-dihydrotestosterone? Journal of Steroid Biochemistry and Molecular Biology, 27. pp. 288-295.

Beck, Katharina R. and Bächler, Murielle and Vuorinen, Anna and Wagner, Sandra and Akram, Muhammad and Griesser, Ulrich and Temml, Veronika and Klusonova, Petra and Yamaguchi, Hideaki and Schuster, Daniela and Odermatt, Alex. (2017) Inhibition of 11β-hydroxysteroid dehydrogenase 2 by the fungicides itraconazole and posaconazole. Biochemical pharmacology, 130. pp. 93-103.

Beck, Katharina R. and Kaserer, Teresa and Schuster, Daniela and Odermatt, Alex. (2017) Virtual screening applications in short-chain dehydrogenase/reductase research. Journal of Steroid Biochemistry and Molecular Biology, 171. pp. 157-177.

Beck, Katharina Richarda. Small molecule-protein interactions exemplified on short-chain dehydrogenases/reductases. 2017, Doctoral Thesis, University of Basel, Faculty of Science.

Ben Rhouma, Bochra and Kallabi, Fakhri and Mahfoudh, Nadia and Ben Mahmoud, Afif and Engeli, Roger T. and Kamoun, Hassen and Keskes, Leila and Odermatt, Alex and Belguith, Neila. (2017) Novel cases of Tunisian patients with mutations in the gene encoding 17β-hydroxysteroid dehydrogenase type 3 and a founder effect. Journal of Steroid Biochemistry and Molecular Biology, 165 (A). pp. 86-94.

Bonifacio, Annalisa and Sanvee, Gerda M. and Brecht, Karin and Kratschmar, Denise V. and Odermatt, Alex and Bouitbir, Jamal and Krähenbühl, Stephan. (2017) IGF-1 prevents simvastatin-induced myotoxicity in C2C12 myotubes. Archives of Toxicology, 91 (5). pp. 2223-2234.

Boudon, Stéphanie M. and Vuorinen, Anna and Geotti-Bianchini, Piero and Wandeler, Eliane and Kratschmar, Denise V. and Heidl, Marc and Campiche, Remo and Jackson, Eileen and Odermatt, Alex. (2017) Novel 11β-hydroxysteroid dehydrogenase 1 inhibitors reduce cortisol levels in keratinocytes and improve dermal collagen content in human ex vivo skin after exposure to cortisone and UV. PLoS One, 12 (2). e0171079.

Engeli, Roger Thomas. Physiological and biochemical aspects of 17β-hydroxysteroid dehydrogenase type 2 and 3. 2017, Doctoral Thesis, University of Basel, Faculty of Science.

Strajhar, Petra. The effects of xenobiotics on steroidogenesis in human: "in vitro" and "in vivo" investigations. 2017, Doctoral Thesis, University of Basel, Faculty of Science.

Strajhar, Petra and Tonoli, David and Jeanneret, Fabienne and Imhof, Raphaella M. and Malagnino, Vanessa and Patt, Melanie and Kratschmar, Denise V. and Boccard, Julien and Rudaz, Serge and Odermatt, Alex. (2017) Steroid profiling in H295R cells to identify chemicals potentially disrupting the production of adrenal steroids. Toxicology, 381. pp. 51-63.

Tsachaki, Maria and Meyer, Arne and Weger, Benjamin and Kratschmar, Denise V. and Tokarz, Janina and Adamski, Jerzy and Belting, Heinz-Georg and Affolter, Markus and Dickmeis, Thomas and Odermatt, Alex. (2017) Absence of 11-keto reduction of cortisone and 11-ketotestosterone in the model organism zebrafish. Journal of Endocrinology, 232 (2). pp. 323-335.

May 2016

Canonica, Jérémie and Sergi, Chloé and Maillard, Marc and Klusonova, Petra and Odermatt, Alex and Koesters, Robert and Loffing-Cueni, Dominique and Loffing, Johannes and Rossier, Bernard and Frateschi, Simona and Hummler, Edith. (2016) Adult nephron-specific MR-deficient mice develop a severe renal PHA-1 phenotype. Pflügers Archiv : European journal of physiology, 468 (5). pp. 895-908.

Mani, Orlando and Nashev, Lyubomir G. and Livelo, Christopher and Baker, Michael E. and Odermatt, Alex. (2016) Role of Pro-637 and Gln-642 in human glucocorticoid receptors and Ser-843 and Leu-848 in mineralocorticoid receptors in their differential responses to cortisol and aldosterone. The Journal of steroid biochemistry and molecular biology, 159. pp. 31-40.

April 2016

Odermatt, Alex and Strajhar, Petra and Engeli, Roger T.. (2016) Disruption of steroidogenesis: Cell models for mechanistic investigations and as screening tools. The Journal of steroid biochemistry and molecular biology, 158. pp. 9-21.

Ramming, Thomas and Kanemura, Shingo and Okumura, Masaki and Inaba, Kenji and Appenzeller-Herzog, Christian. (2016) Cysteines 208 and 241 in Ero1α are required for maximal catalytic turnover. Redox biology, 7. pp. 14-20.

March 2016

Strajhar, Petra and Schmid, Y. and Liakoni, E. and Dolder, P. C. and Rentsch, K. M. and Kratschmar, Denise V. and Odermatt, Alex and Liechti, Matthias E.. (2016) Acute Effects of Lysergic Acid Diethylamide on Circulating Steroid Levels in Healthy Subjects. Journal of Neuroendocrinology, 28 (3). p. 12374.

February 2016

Rizner, Tea Lanisnik and Sasano, Hironobu and Choi, Man Ho and Odermatt, Alex and Adamski, Jerzy. (2016) Recommendations for description and validation for antibodies for research use. The journal of steroid biochemistry and molecular biology, 156. pp. 40-42.

January 2016

Engeli, Roger T. and Rhouma, Bochra Ben and Sager, Christoph P. and Tsachaki, Maria and Birk, Julia and Fakhfakh, Faiza and Keskes, Leila and Belguith, Neila and Odermatt, Alex. (2016) Biochemical analyses and molecular modeling explain the functional loss of 17β-hydroxysteroid dehydrogenase 3 mutant G133R in three Tunisian patients with 46, XY Disorders of Sex Development. The Journal of steroid biochemistry and molecular biology, 155. pp. 147-154.

2016

Beck, Katharina R. and Sommer, Tanja J. and Schuster, Daniela and Odermatt, Alex. (2016) Evaluation of tetrabromobisphenol A effects on human glucocorticoid and androgen receptors: A comparison of results from human- with yeast-based in vitro assays. Toxicology, 370. pp. 70-77.

Dubost, Valérie. Assessment of podocyte injury using two novel glomerular markers. 2016, Doctoral Thesis, University of Basel, Faculty of Science.

December 2015

Kaserer, Teresa and Beck, Katharina and Akram, Muhamad and Odermatt, Alex and Schuster, Daniela. (2015) Pharmacophore models and pharmacophore-based virtual screening: concepts and applications exemplified on hydroxysteroid dehydrogenases. Molecules, 20 (12). pp. 22799-22832.

Shelton, Luke M. and Lister, Adam and Walsh, Joanne and Jenkins, Rosalind E. and Wong, Michael H. L. and Rowe, Cliff and Ricci, Emanuele and Ressel, Lorenzo and Fang, Yongxiang and Demougin, Philippe and Vukojevic, Vanja and O'Neill, Paul M. and Goldring, Christopher E. and Kitteringham, Neil R. and Park, B. Kevin and Odermatt, Alex and Copple, Ian M.. (2015) Integrated transcriptomic and proteomic analyses uncover regulatory roles of Nrf2 in the kidney. Kidney international, 88 (6). pp. 1261-1273.

1 November 2015

Di Chiara, Marianna and Glaudemans, Bob and Loffing-Cueni, Dominique and Odermatt, Alex and Al-Hasani, Hadi and Devuyst, Olivier and Faresse, Nourdine and Loffing, Johannes. (2015) Rab-GAP TBC1D4 (AS160) is dispensable for the renal control of sodium and water homeostasis but regulates GLUT4 in mouse kidney. American journal of physiology. Gastrointestinal and liver physiology, 309 (9). F779-F790.

November 2015

Seibert, Julia K. and Quagliata, Luca and Quintavalle, Cristina and Hammond, Thomas G. and Terracciano, Luigi and Odermatt, Alex. (2015) A role for the dehydrogenase DHRS7 (SDR34C1) in prostate cancer. Cancer medicine, 4 (11). pp. 1717-1729.

July 2015

Odermatt, Alex and Klusonova, Petra. (2015) 11β-Hydroxysteroid dehydrogenase 1: Regeneration of active glucocorticoids is only part of the story. The journal of steroid biochemistry and molecular biology, 151. pp. 85-92.

Tsachaki, Maria and Birk, Julia and Egert, Aurélie and Odermatt, Alex. (2015) Determination of the topology of endoplasmic reticulum membrane proteins using redox-sensitive green-fluorescence protein fusions. Biochimica et biophysica acta. Molecular cell research, 1853 (7). pp. 1672-1682.

June 2015

Delaunay-Moisan, Agnès and Appenzeller-Herzog, Christian. (2015) The antioxidant machinery of the endoplasmic reticulum: Protection and signaling. Free radical biology & medicine, 83. pp. 341-351.

Ramming, Thomas and Okumura, Masaki and Kanemura, Shingo and Baday, Sefer and Birk, Julia and Moes, Suzette and Spiess, Martin and Jenö, Paul and Bernèche, Simon and Inaba, Kenji and Appenzeller-Herzog, Christian. (2015) A PDI-catalyzed thiol-disulfide switch regulates the production of hydrogen peroxide by human Ero1. Free radical biology & medicine, 83. pp. 361-372.

May 2015

Tonoli, David and Fürstenberger, Cornelia and Boccard, Julien and Hochstrasser, Denis and Jeanneret, Fabienne and Odermatt, Alex and Rudaz, Serge. (2015) Steroidomic Footprinting Based on Ultra-High Performance Liquid Chromatography Coupled with Qualitative and Quantitative High-Resolution Mass Spectrometry for the Evaluation of Endocrine Disrupting Chemicals in H295R Cells. Chemical research in toxicology, 28 (5). pp. 955-966.

April 2015

Vuorinen, Anna and Seibert, Julia and Papageorgiou, Vassilios P. and Rollinger, Judith M. and Odermatt, Alex and Schuster, Daniela and Assimopoulou, Andreana N.. (2015) Pistacia lentiscus Oleoresin: Virtual Screening and Identification of Masticadienonic and Isomasticadienonic Acids as Inhibitors of 11β-Hydroxysteroid Dehydrogenase 1. Planta medica, 81 (6). pp. 525-532.

2015

Seibert, Julia Katharina. Characterization of the 11β-hydroxysteroid dehydrogenase 1-related short-chain dehydrogenase/reductase DHRS7. 2015, Doctoral Thesis, University of Basel, Faculty of Science.

Vuorinen, Anna and Odermatt, Alex and Schuster, Daniela. (2015) Reprint of "In silico methods in the discovery of endocrine disrupting chemicals". The Journal of steroid biochemistry and molecular biology, 153 (September 2015). pp. 93-101.

2014

Blüthgen, Nancy. Effects of UV filters (benzophenones and octocrylene) and mifepristone on different life stages of zebrafish (Danio rerio). 2014, Doctoral Thesis, University of Basel, Faculty of Science.

Blüthgen, Nancy and Meili, Nicole and Chew, Geraldine and Odermatt, Alex and Fent, Karl. (2014) Accumulation and effects of the UV-filter octocrylene in adult and embryonic zebrafish (Danio rerio). Science of the Total Environment, 476-477. pp. 207-217.

Boudon, Stéphanie Marie and Morandi, Grégory and Prideaux, Brendan and Staab, Dieter and Junker, Ursula and Odermatt, Alex and Stoeckli, Markus and Bauer, Daniel. (2014) Evaluation of sparfloxacin distribution by mass spectrometry imaging in a phototoxicity model. Journal of the American Society for Mass Spectrometry, 25 (10). pp. 1803-1809.

Boudon, Stéphanie Marie and Plappert-Helbig, Ulla and Odermatt, Alex and Bauer, Daniel. (2014) Characterization of vemurafenib phototoxicity in a mouse model. Toxicological Sciences, 137 (1). pp. 259-267.

Chantong, Boonrat. Regulation of microglial cell function by corticosteroids and disruption by organotins. 2014, Doctoral Thesis, University of Basel, Faculty of Science.

Chantong, Boonrat and Kratschmar, Denise V. and Lister, Adam and Odermatt, Alex. (2014) Dibutyltin promotes oxidative stress and increases inflammatory mediators in BV-2 microglia cells. Toxicology letters, Vol. 230, H. 2. pp. 177-187.

Chantong, Boonrat and Kratschmar, Denise V. and Lister, Adam and Odermatt, Alex. (2014) Inhibition of metabotropic glutamate receptor 5 induces cellular stress through pertussis toxin-sensitive G i -proteins in murine BV-2 microglia cells. Journal of neuroinflammation, Vol. 11, H. 1. p. 190.

Copple, Ian M. and Shelton, Luke M. and Walsh, Joanne and Kratschmar, Denise V. and Lister, Adam and Odermatt, Alex and Goldring, Christopher E. and Dinkova-Kostova, Albena T. and Honda, Tadashi and Park, B. Kevin. (2014) Chemical tuning enhances both potency toward nrf2 and in vitro therapeutic index of triterpenoids. Toxicological Sciences, 140 (2). pp. 462-469.

Felser, Andrea and Lindinger, Peter W. and Schnell, Dominik and Kratschmar, Denise V. and Odermatt, Alex and Mies, Suzette and Jenö, Paul and Krähenbühl, Stephan. (2014) Hepatocellular toxicity of benzbromarone : Effects on mitochondrial function and structure. Toxicology, Vol. 324. pp. 136-146.

Fürstenberger, Cornelia. Disruption of androgen metabolism, regulation and effects : involvement of steroidogenic enzymes. 2014, Doctoral Thesis, University of Basel, Faculty of Science.

Gai, Zhibo and Chu, Lei and Hiller, Christian and Arsenijevic, Denis and Penno, Carlos A. and Montani, Jean-Pierre and Odermatt, Alex and Kullak-Ublick, Gerd A.. (2014) Effect of chronic renal failure on the hepatic, intestinal, and renal expression of bile acid transporters. American Journal of Physiology - Renal Physiology, 306 (1). F130-137.

Legeza, Balázs and Balázs, Zoltán and Odermatt, Alex. (2014) Fructose promotes the differentiation of 3T3-L1 adipocytes and accelerates lipid metabolism. FEBS letters, Vol. 588, H. 3. pp. 490-496.

Penno, Carlos A. and Morgan, Stuart A. and Rose, Adam J. and Herzig, Stephan and Lavery, Gareth G. and Odermatt, Alex. (2014) 11β-Hydroxysteroid dehydrogenase-1 is involved in bile acid homeostasis by modulating fatty acid transport protein-5 in the liver of mice. Molecular metabolism, Vol. 3, H. 5. pp. 554-564.

Ramming, Thomas and Hansen, Henning Gram and Nagata, Kazuhiro and Ellgaard, Lars and Appenzeller-Herzog, Christian. (2014) GPx8 peroxidase prevents leakage of H2O2 from the endoplasmic reticulum. Free radical biology & medicine, Vol. 70 , S. 106–116.

Seibert, Julia and Hysek, Cédric M. and Penno, Carlos A. and Schmid, Yasmin and Kratschmar, Denise V. and Liechti, Matthias E. and Odermatt, Alex. (2014) Acute Effects of 3,4-Methylenedioxymethamphetamine and Methylphenidate on Circulating Steroid Levels in Healthy Subjects. Neuroendocrinology, 100 (1). pp. 17-25.

Vuorinen, Anna and Engeli, Roger and Meyer, Arne and Bachmann, Fabio and Griesser, Ulrich J. and Schuster, Daniela and Odermatt, Alex. (2014) Ligand-based pharmacophore modeling and virtual screening for the discovery of novel 17β-hydroxysteroid dehydrogenase 2 inhibitors. Journal of medicinal chemistry, Vol. 57, H. 14. pp. 5995-6007.

Vuorinen, Anna and Nashev, Lyubomir G. and Odermatt, Alex and Rollinger, Judith M. and Schuster, Daniela. (2014) Pharmacophore model refinement for 11β-hydroxysteroid dehydrogenase inhibitors: Search for modulators of intracellular glucocorticoid concentrations. Molecular Informatics, 33. pp. 15-25.

2013

Appenzeller-Herzog, Christian and Birk, Julia. (2013) Erratum: Green fluorescent protein-based monitoring of endoplasmic reticulum redox poise. Frontiers in genetics, Vol. 4, art. 255 , 1 S..

Birk, Julia and Meyer, Mariangela and Aller, Isabel and Hansen, Henning G. and Odermatt, Alex and Dick, Tobias P. and Meyer, Andreas J. and Appenzeller-Herzog, Christian. (2013) Endoplasmic reticulum : reduced and oxidized glutathione revisited. Journal of Cell Science, 126 (7). pp. 1604-1617.

Birk, Julia and Ramming, Thomas and Odermatt, Alex and Appenzeller-Herzog, Christian. (2013) Green fluorescent protein-based monitoring of endoplasmic reticulum redox poise. Frontiers in genetics, Vol. 4, art. 108 , 10 S.. p. 108.

Blüthgen, Nancy and Sumpter, John P. and Odermatt, Alex and Fent, Karl. (2013) Effects of low concentrations of the antiprogestin mifepristone (RU486) in adults and embryos of zebrafish (Danio rerio): 2. Gene expression analysis and in vitro activity. Aquatic Toxicology, 144-145. pp. 96-104.

Boudon, Stéphanie. Characterization of phototoxicity reactions in human and animal skin models. 2013, Doctoral Thesis, University of Basel, Faculty of Science.

Hofer, Sandra and Kratschmar, Denise V. and Schernthanner, Brigitte and Vuorinen, Anna and Schuster, Daniela and Odermatt, Alex and Easmon, Johnny. (2013) Synthesis and biological analysis of benzazol-2-yl piperazine sulfonamides as 11β-hydroxysteroid dehydrogenase 1 inhibitors. Bioorganic and Medicinal Chemistry Letters, 23 (19). pp. 5397-5400.

Legeza, Balazs. Generation and utilization of NADPH in the endoplasmic reticulum : novel insight into the role of luminal NADPH in pathophysiological processes. 2013, Doctoral Thesis, University of Basel, Faculty of Science.

Legeza, Balázs and Balázs, Zoltán and Nashev, Lyubomir G. and Odermatt, Alex. (2013) The microsomal enzyme 17β-hydroxysteroid dehydrogenase 3 faces the cytoplasm and uses NADPH generated by glucose-6-phosphate dehydrogenase. Endocrinology, Vol. 154, H. 1. pp. 205-213.

Leunig, M. and Jüni, P. and Werlen, S. and Limacher, A. and Nüesch, E. and Pfirrmann, C. W. and Trelle, S. and Odermatt, A. and Hofstetter, W. and Ganz, R. and Reichenbach, S.. (2013) Prevalence of cam and pincer-type deformities on hip MRI in an asymptomatic young Swiss female population: a cross-sectional study. Osteoarthritis and Cartilage , 21 (4). pp. 544-550.

Marchais-Oberwinkler, Sandrine and Xu, Kuiying and Wetzel, Marie and Perspicace, Enrico and Negri, Matthias and Meyer, Arne and Odermatt, Alex and Möller, Gabriele and Adamski, Jerzy and Hartmann, Rolf W.. (2013) Structural Optimization of 2,5-Thiophene Amides as Highly Potent and Selective 17β-Hydroxysteroid Dehydrogenase Type 2 Inhibitors for the Treatment of Osteoporosis. Journal of Medicinal Chemistry, Vol. 56, H. 1. pp. 167-181.

Meyer, Arne. The role of the endoplasmic reticulum in the metabolism of "xenobiotica". 2013, Doctoral Thesis, University of Basel, Faculty of Science.

Meyer, Arne and Vuorinen, Anna and Zielinska, Agnieszka E. and Da Cunha, Thierry and Strajhar, Petra and Lavery, Gareth G. and Schuster, Daniela and Odermatt, Alex. (2013) Carbonyl reduction of triadimefon by human and rodent 11β-hydroxysteroid dehydrogenase 1. Biochemical pharmacology, Vol. 85, H. 9. pp. 1370-1378.

Meyer, Arne and Vuorinen, Anna and Zielinska, Agnieszka E. and Strajhar, Petra and Lavery, Gareth G. and Schuster, Daniela and Odermatt, Alex. (2013) Formation of threohydrobupropion from bupropion is dependent on 11β-hydroxysteroid dehydrogenase 1. Drug metabolism and disposition, Vol. 41, H. 9. pp. 1671-1678.

Montero, Davide and Tachibana, Christine and Rahr Winther, Jakob and Appenzeller-Herzog, Christian. (2013) Intracellular glutathione pools are heterogeneously concentrated. Redox biology, Vol. 1, H. 1. pp. 508-513.

Nashev, Lyubomir G. and Atanasov, Atanas G. and Baker, Michael E. and Odermatt, Alex. (2013) Cysteine-10 on 17 β-Hydroxysteroid dehydrogenase 1 has stabilizing interactions in the cofactor binding region and renders sensitivity to sulfhydryl modifying chemicals. International journal of cell biology, Vol. 2013 , art. 769536.

Pandya, Keyur and Dietrich, David and Seibert, Julia and Vederas, John C. and Odermatt, Alex. (2013) Synthesis of sterically encumbered 11β-aminoprogesterone derivatives and evaluation as 11β-hydroxysteroid dehydrogenase inhibitors and mineralocorticoid receptor antagonists. Bioorganic & medicinal chemistry letters, Vol. 21, H. 21. pp. 6274-6281.

Penno, C. A. and Arsenijevic, D: Da Cunha and Kullak-Ublick, G. A. and Montani, J.-P. and Odermatt, A.. (2013) Quantification of multiple bile acids in uninephrectomized rats using ultra-performance liquid chromatography-tandem mass spectrometry. Analytical methods, Vol. 5. pp. 1155-1164.

Penno, Carlos A. and Morgan, Stuart A. and Vuorinen, Anna and Schuster, Daniela and Lavery, Gareth G. and Odermatt, Alex. (2013) Impaired oxidoreduction by 11β-hydroxysteroid dehydrogenase 1 results in the accumulation of 7-oxolithocholic acid. Journal of Lipid Research, 54 (10). pp. 2874-2883.

Penno, Carlos Alberto. The role of 11β-hydroxysteroid dehydrogenase type 1 in bile acid homeostasis. 2013, Doctoral Thesis, University of Basel, Faculty of Science.

Ramming, Thomas and Appenzeller-Herzog, Christian. (2013) Destroy and exploit: catalyzed removal of hydroperoxides from the endoplasmic reticulum. International journal of cell biology, Vol. 2013 , 180906.

Sorensen, Mads V. and Grossmann, Solveig and Roesinger, Marian and Gresko, Nikolay and Todkar, Abhijeet P. and Barmettler, Gery and Ziegler, Urs and Odermatt, Alex and Loffing-Cueni, Dominique and Loffing, Johannes. (2013) Rapid dephosphorylation of the renal sodium chloride cotransporter in response to oral potassium intake in mice. Kidney International, 83 (5). pp. 811-824.

Vuorinen, Anna and Odermatt, Alex and Schuster, Daniela. (2013) In silico methods in the discovery of endocrine disrupting chemicals. Journal of Steroid Biochemistry and Molecular Biology, 137. pp. 18-26.

Wright, Jordan and Birk, Julia and Haataja, Leena and Liu, Ming and Ramming, Thomas and Weiss, Michael A. and Appenzeller-Herzog, Christian and Arvan, Peter. (2013) Endoplasmic reticulum oxidoreductin-1α (Ero1α) improves folding and secretion of mutant proinsulin and limits mutant proinsulin-induced endoplasmic reticulum stress. Journal of biological chemistry, 288 (43). pp. 31010-31018.

2012

Appenzeller-Herzog, Christian. (2012) Updates on "Endoplasmic Reticulum Redox". Antioxidants & redox signaling, Vol. 16, No. 8. pp. 760-762.

Chantong, Boonrat and Kratschmar, Denise V. and Nashev, Lyubomir G. and Balazs, Zoltan and Odermatt, Alex. (2012) Mineralocorticoid and glucocorticoid receptors differentially regulate NF-kappaB activity and pro-inflammatory cytokine production in murine BV-2 microglial cells. Journal of neuroinflammation, Vol. 9. p. 260.

Fürstenberger, Cornelia and Vuorinen, Anna and Da Cunha, Thierry and Kratschmar, Denise V. and Saugy, Martial and Schuster, Daniela and Odermatt, Alex. (2012) The anabolic androgenic steroid fluoxymesterone inhibits 11β-hydroxysteroid dehydrogenase 2-dependent glucocorticoid inactivation. Toxicological Sciences, Vol. 126, H. 2. pp. 353-361.

Hansen, Henning Gram and Schmidt, Jonas Damgård and Søltoft, Cecilie Lützen and Ramming, Thomas and Geertz-Hansen, Henrik Marcus and Christensen, Brian and Sørensen, Esben Skipper and Juncker, Agnieszka Sierakowska and Appenzeller-Herzog, Christian and Ellgaard, Lars. (2012) Hyperactivity of the ero1α oxidase elicits endoplasmic reticulum stress but no broad antioxidant response. Journal of biological chemistry, Vol. 287, H. 47. pp. 39513-39523.

Kratschmar, Denise V. and Calabrese, Diego and Walsh, Jo and Lister, Adam and Birk, Julia and Appenzeller-Herzog, Christian and Moulin, Pierre and Goldring, Chris E. and Odermatt, Alex. (2012) Suppression of the Nrf2-dependent antioxidant response by glucocorticoids and 11β-HSD1-mediated glucocorticoid activation in hepatic cells. PLoS one, Vol. 7, H. 5 , e36774.

Meyer, Arne and Strajhar, Petra and Murer, Céline and Da Cunha, Thierry and Odermatt, Alex. (2012) Species-specific differences in the inhibition of human and zebrafish 11β-hydroxysteroid dehydrogenase 2 by thiram and organotins. Toxicology, Vol. 301, H. 1-3. pp. 72-78.

Nashev, Lyubomir G. and Vuorinen, Anna and Praxmarer, Lukas and Chantong, Boonrat and Cereghetti, Diego and Winiger, Rahel and Schuster, Daniela and Odermatt, Alex. (2012) Virtual screening as a strategy for the identification of xenobiotics disrupting corticosteroid action. PLoS one, Vol. 7, H. 10 , e46958.

Odermatt, Alex and Kratschmar, Denise V.. (2012) Tissue-specific modulation of mineralocorticoid receptor function by 11β-hydroxysteroid dehydrogenases : an overview. Molecular and cellular endocrinology, Vol. 350, H. 2. pp. 168-186.

Ramming, Thomas and Appenzeller-Herzog, Christian. (2012) The physiological functions of mammalian endoplasmic oxidoreductin 1: on disulfides and more. Antioxidants & redox signaling, Vol. 16, No. 10. pp. 1109-1118.

Vacchi-Suzzi, Caterina. MicroRNAs regulatory networks in cardiotoxicity. 2012, Doctoral Thesis, University of Basel, Faculty of Science.

Veyrat-Durebex, Christelle and Deblon, Nicolas and Caillon, Aurélie and Andrew, Ruth and Altirriba, Jordi and Odermatt, Alex and Rohner-Jeanrenaud, Françoise. (2012) Central glucocorticoid administration promotes weight gain and increased 11β-hydroxysteroid dehydrogenase type 1 expression in white adipose tissue. PLoS one, Vol. 7, H. 3 , e34002.

2011

Appenzeller-Herzog, Christian. (2011) Glutathione- and non-glutathione-based oxidant control in the endoplasmic reticulum. Journal of cell science, Vol. 124, H. 6. pp. 847-855.

Blumberg, Bruce and Iguchi, Taisen and Odermatt, Alex. (2011) Endocrine disrupting chemicals. The journal of steroid biochemistry and molecular biology, Vol. 127, H. 1/2. pp. 1-3.

Gaware, Rawindra and Khunt, Rupesh and Czollner, Laszlo and Stanetty, Christian and Da Cunha, Thierry and Kratschmar, Denise V. and Odermatt, Alex and Kosma, Paul and Jordis, Ulrich and Classen-Houben, Dirk. (2011) Synthesis of new glycyrrhetinic acid derived ring A azepanone, 29-urea and 29-hydroxamic acid derivatives as selective 11?-hydroxysteroid dehydrogenase 2 inhibitors. Bioorganic & medicinal chemistry, Vol. 19, H. 6. pp. 1866-1880.

Kratschmar, Denise V. and Vuorinen, Anna and Da Cunha, Thierry and Wolber, Gerhard and Classen-Houben, Dirk and Doblhoff, Otto and Schuster, Daniela and Odermatt, Alex. (2011) Characterization of activity and binding mode of glycyrrhetinic acid derivatives inhibiting 11?-hydroxysteroid dehydrogenase type 2. The journal of steroid biochemistry and molecular biology, Vol. 125, H. 1-2. pp. 129-142.

Odermatt, Alex. (2011) The Western-style diet : a major risk factor for impaired kidney function and chronic kidney disease. American journal of physiology. Renal Physiology, Vol. 301, H. 5 , F919-931.

Odermatt, Alex and Da Cunha, Thierry and Penno, Carlos A. and Chandsawangbhuwana, Charlie and Reichert, Christian and Wolf, Armin and Dong, Min and Baker, Michael E.. (2011) Hepatic reduction of the secondary bile acid 7-oxolithocholic acid is mediated by 11?-hydroxysteroid dehydrogenase 1. The Biochemical Journal, Vol. 436, H. 3. pp. 621-629.

Reichenbach, Stephan and Leunig, Michael and Werlen, Stefan and Nüesch, Eveline and Pfirrmann, Christian W. and Bonel, Harald and Odermatt, Alex and Hofstetter, Willy and Ganz, Reinhold and Jüni, Peter. (2011) Association between cam-type deformities and magnetic resonance imaging-detected structural hip damage : a cross-sectional study in young men. Arthritis and rheumatism, Vol. 63, H. 12. pp. 4023-4030.

Riemer, Jan and Hansen, Henning Gram and Appenzeller-Herzog, Christian and Johansson, Linda and Ellgaard, Lars. (2011) Identification of the PDI-family member ERp90 as an interaction partner of ERFAD. PLoS One, 6 (2). e17037.

Schuster, Daniela and Kowalik, Dorota and Kirchmair, Johannes and Laggner, Christian and Markt, Patrick and Aebischer-Gumy, Christel and Ströhle, Fabian and Möller, Gabriele and Wolber, Gerhard and Wilckens, Thomas and Langer, Thierry and Odermatt, Alex and Adamski, Jerzy. (2011) Identification of chemically diverse, novel inhibitors of 17?-hydroxysteroid dehydrogenase type 3 and 5 by pharmacophore-based virtual screening. The journal of steroid biochemistry and molecular biology, Vol. 125, H. 1-2. pp. 148-161.

2010

Appenzeller-Herzog, Christian and Riemer, Jan and Zito, Ester and Chin, King-Tung and Ron, David and Spiess, Martin and Ellgaard, Lars. (2010) Disulphide production by Ero1alpha-PDI relay is rapid and effectively regulated. The EMBO journal, Vol. 29, H. 19. pp. 3318-3329.

Beseda, Igor and Czollner, Laszlo and Shah, Priti S. and Khunt, Rupesh and Gaware, Rawindra and Kosma, Paul and Stanetty, Christian and Del Ruiz-Ruiz, Maria Carmen and Amer, Hassan and Mereiter, Kurt and Da Cunha, Thierry and Odermatt, Alex and Classen-Houben, Dirk and Jordis, Ulrich. (2010) Synthesis of glycyrrhetinic acid derivatives for the treatment of metabolic diseases. Bioorganic & medicinal chemistry, Vol. 18, H. 1. pp. 433-454.

Nashev, Lyubomir G. and Schuster, Daniela and Laggner, Christian and Sodha, Seloni and Langer, Thierry and Wolber, Gerhard and Odermatt, Alex. (2010) The UV-filter benzophenone-1 inhibits 17beta-hydroxysteroid dehydrogenase type 3 : virtual screening as a strategy to identify potential endocrine disrupting chemicals. Biochemical Pharmacology, Vol. 79, Issue 8. pp. 1189-1199.

Odermatt, Alex and Nashev, Lyubomir G.. (2010) The glucocorticoid-activating enzyme 11beta-hydroxysteroid dehydrogenase type 1 has broad substrate specificity: Physiological and toxicological considerations. The journal of steroid biochemistry and molecular biology, Vol. 119, H. 1-2. pp. 1-13.

Reichenbach, Stephan and Jüni, Peter and Werlen, Stefan and Nüesch, Eveline and Pfirrmann, Christian W. and Trelle, Sven and Odermatt, Alex and Hofstetter, Willy and Ganz, Reinhold and Leunig, Michael. (2010) Prevalence of cam-type deformity on hip magnetic resonance imaging in young males : a cross-sectional study. Arthritis care & research, Vol. 62, H. 9. pp. 1319-1327.

Rollinger, Judith M. and Kratschmar, Denise V. and Schuster, Daniela and Pfisterer, Petra H. and Gumy, Christel and Aubry, Evelyne M. and Brandstötter, Sarah and Stuppner, Hermann and Wolber, Gerhard and Odermatt, Alex. (2010) 11beta-Hydroxysteroid dehydrogenase 1 inhibiting constituents from Eriobotrya japonica revealed by bioactivity-guided isolation and computational approaches. Bioorganic & medicinal chemistry, Vol. 18, H. 4. pp. 1507-1515.

Senesi, Silvia and Legeza, Balázs and Balázs, Zoltán and Csala, Miklós and Marcolongo, Paola and Kereszturi, Eva and Szelényi, Péter and Egger, Christine and Fulceri, Rosella and Mandl, József and Giunti, Roberta and Odermatt, Alex and Bánhegyi, Gábor and Benedetti, Angelo. (2010) Contribution of fructose-6-phosphate to glucocorticoid activation in the endoplasmic reticulum : possible implication in the metabolic syndrome. Endocrinology, Vol. 151, H. 10. pp. 4830-4839.

Stanetty, Christian and Czollner, Laszlo and Koller, Iris and Shah, Priti and Gaware, Rawindra and Cunha, Thierry Da and Odermatt, Alex and Jordis, Ulrich and Kosma, Paul and Classen-Houben, Dirk. (2010) Synthesis of novel 3-amino and 29-hydroxamic acid derivatives of glycyrrhetinic acid as selective 11?-hydroxysteroid dehydrogenase 2 inhibitors. Bioorganic & medicinal chemistry, Vol. 18, H. 21. pp. 7522-7541.

2009

Aubry, E. M. and Odermatt, A.. (2009) Retinoic acid reduces glucocorticoid sensitivity in C2C12 myotubes by decreasing 11beta-hydroxysteroid dehydrogenase type 1 and glucocorticoid receptor activities. Endocrinology, Vol. 150, No. 6. pp. 2700-2708.

Balazs, Z. and Nashev, L. G. and Chandsawangbhuwana, C. and Baker, M. E. and Odermatt, A.. (2009) Hexose-6-phosphate dehydrogenase modulates the effect of inhibitors and alternative substrates of 11beta-hydroxysteroid dehydrogenase 1. Molecular and cellular endocrinology, Vol. 301, H. 1-2. pp. 117-122.

Classen-Houben, D. and Schuster, D. and Da Cunha, T. and Odermatt, A. and Wolber, G. and Jordis, U. and Kueenburg, B.. (2009) Selective inhibition of 11beta-hydroxysteroid dehydrogenase 1 by 18alpha-glycyrrhetinic acid but not 18beta-glycyrrhetinic acid. The journal of steroid biochemistry and molecular biology, Vol. 113, H. 3-5. pp. 248-252.

Dzyakanchuk, A. A. and Balazs, Z. and Nashev, L. G. and Amrein, K. E. and Odermatt, A.. (2009) 11beta-Hydroxysteroid dehydrogenase 1 reductase activity is dependent on a high ratio of NADPH/NADP(+) and is stimulated by extracellular glucose. Molecular and cellular endocrinology, Vol. 301, H. 1-2. pp. 137-141.

Gumy, C. and Thurnbichler, C. and Aubry, E. M. and Balazs, Z. and Pfisterer, P. and Baumgartner, L. and Stuppner, H. and Odermatt, A. and Rollinger, J. M.. (2009) Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 by plant extracts used as traditional antidiabetic medicines. Fitoterapia, Vol. 80, no.3. pp. 200-205.

Odermatt, A.. (2009) Diazepane-acetamide derivatives as selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitors. Expert opinion on therapeutic patents, Vol. 19, H. 10. pp. 1477-1483.

Odermatt, A. and Atanasov, A. G.. (2009) Mineralocorticoid receptors : Emerging complexity and functional diversity. Steroids, Vol. 74, H. 2. pp. 163-171.

Riemer, Jan and Appenzeller-Herzog, Christian and Johansson, Linda and Bodenmiller, Bernd and Hartmann-Petersen, Rasmus and Ellgaard, Lars. (2009) A luminal flavoprotein in endoplasmic reticulum-associated degradation. Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, H. 35. pp. 14831-14836.

2008

Appenzeller-Herzog, Christian and Ellgaard, Lars. (2008) In vivo reduction-oxidation state of protein disulfide isomerase: the two active sites independently occur in the reduced and oxidized forms. Antioxidants and Redox Signaling, 10 (1). pp. 55-64.

Appenzeller-Herzog, Christian and Ellgaard, Lars. (2008) The human PDI family: versatility packed into a single fold. Biochimica et Biophysica Acta, 1783 (4). pp. 535-548.

Appenzeller-Herzog, Christian and Riemer, Jan and Christensen, Brian and Sørensen, Esben S. and Ellgaard, Lars. (2008) A novel disulphide switch mechanism in Ero1alpha balances ER oxidation in human cells. The EMBO Journal, 27 (22). pp. 2977-2987.

Atanasov, Atanas G. and Nashev, Lyubomir G. and Gelman, Laurent and Legeza, Balazs and Sack, Ragna and Portmann, Reto and Odermatt, Alex. (2008) Direct protein-protein interaction of 11 beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase in the endoplasmic reticulum lumen. Biochimica et biophysica acta. Molecular cell research, Vol. 1783, Issue 8. pp. 1536-1543.

Balazs, Z. and Schweizer, R. A. and Frey, F. J. and Rohner-Jeanrenaud, F. and Odermatt, A.. (2008) DHEA induces 11beta-HSD2 by acting on CCAAT/enhancer-binding proteins. Journal of the American Society of Nephrology, Vol. 19, H. 1. pp. 92-101.

Gumy, C. and Chandsawangbhuwana, C. and Dzyakanchuk, A. A. and Kratschmar, D. V. and Baker, M. E. and Odermatt, A.. (2008) Dibutyltin disrupts glucocorticoid receptor function and impairs glucocorticoid-induced suppression of cytokine production. PLoS one, Vol. 3, H. 10 , e3545.

Kardon, Tamás and Senesi, Silvia and Marcolongo, Paola and Legeza, Balázs and Bánhegyi, Gábor and Mandl, József and Fulceri, Rosella and Benedetti, Angelo. (2008) Maintenance of luminal NADPH in the endoplasmic reticulum promotes the survival of human neutrophil granulocytes. FEBS letters, Vol. 582, H. 13. pp. 1809-1815.

Odermatt, Alex and Gumy, Christel. (2008) Disruption of glucocorticoid and mineralocorticoid receptor-mediated responses by environmental chemicals. Chimia, 62 (5). pp. 335-339.

Odermatt, Alex and Gumy, Christel. (2008) Glucocorticoid and mineralocorticoid action : Why should we consider influences by environmental chemicals? Biochemical Pharmacology, Volume 76, Issue 10. pp. 1184-1193.

Schuster, Daniela and Nashev, Lyubomir G. and Kirchmair, Johannes and Laggner, Christian and Wolber, Gerhard and Langer, Thierry and Odermatt, Alex. (2008) Discovery of nonsteroidal 17 beta-hydroxysteroid dehydrogenase 1 inhibitors by pharmacophore-based screening of virtual compound libraries. Journal of medicinal chemistry, Vol. 51, no. 14. pp. 4188-4199.

2007

Atanasov, A. G. and Ignatova, I. D. and Nashev, L. G. and Dick, B. and Ferrari, P. and Frey, F. J. and Odermatt, A.. (2007) Impaired protein stability of 11beta-hydroxysteroid dehydrogenase type : a novel mechanism of apparent mineralocorticoid excess. Journal of the American Society of Nephrology, Vol. 18, H. 4. pp. 1262-1270.

Nashev, L. G. and Chandsawangbhuwana, C. and Balazs, Z. and Atanasov, A. G. and Dick, B. and Frey, F. J. and Baker, M. E. and Odermatt, A.. (2007) Hexose-6-phosphate Dehydrogenase Modulates 11beta-Hydroxysteroid Dehydrogenase Type 1-Dependent Metabolism of 7-keto- and 7beta-hydroxy-neurosteroids. PLoS one, Vol. 2, H. 6 , e561.

2005

Appenzeller-Herzog, C. and Nyfeler, B. and Burkhard, P. and Santamaria, I. and Lopez-Otin, C. and Hauri, H. -P.. (2005) Carbohydrate- and conformation-dependent cargo capture for ER-exit. Molecular Biology of the Cell, 16 (3). pp. 1258-1267.