Items where Division is "09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Parasite Chemotherapy (Mäser)"

2018

Cretton, Sylvian and Oyarzún, Alejandra and Righi, Davide and Sahib, Lamia and Kaiser, Marcel and Christen, Philippe and Fajardo, Victor. (2018) A new antifungal and antiprotozoal bibenzyl derivative from Gavilea lutea. Natural Product Research, 32 (6). pp. 695-701.

Farahat, Abdelbasset A. and Ismail, Mohamed A. and Kumar, Arvind and Wenzler, Tanja and Brun, Reto and Paul, Ananya and Wilson, W. David and Boykin, David W.. (2018) Indole and benzimidazole bichalcophenes: synthesis, DNA binding and antiparasitic activity. European journal of medicinal chemistry, 143. pp. 1590-1596.

Schies, C. and Seupel, R. and Feineis, D. and Gehrold, A. and Schraut, M. and Kaiser, M. and Brun, R. and Bringmann, G.. (2018) Biomimetic total synthesis of mbandakamine A and further antiplasmodial naphthylisoquinoline dimers. ChemistrySelect, 3. pp. 940-945.

Wiedemar, Natalie and Graf, Fabrice E. and Zwyer, Michaela and Ndomba, Emiliana and Kunz Renggli, Christina and Cal, Monica and Schmidt, Remo S. and Wenzler, Tanja and Mäser, Pascal. (2018) Beyond immune escape: a variant surface glycoprotein causes suramin resistance in Trypanosoma brucei. Molecular microbiology, 107 (1). pp. 57-67.

2017

Abla, Nada and Bashyam, Sridevi and Charman, Susan A. and Greco, Béatrice and Hewitt, Philip and Jiménez-Díaz, Maria Belén and Katneni, Kasiram and Kubas, Holger and Picard, Didier and Sambandan, Yuvaraj and Sanz, Laura and Smith, Dennis and Wang, Tai and Willis, Paul and Wittlin, Sergio and Spangenberg, Thomas. (2017) Long-lasting and fast-acting in vivo efficacious antiplasmodial azepanylcarbazole amino alcohol. ACS medicinal chemistry letters, 8 (12). pp. 1304-1308.

Akama, T. and Zhang, Y. K. and Freund, Y. R. and Berry, P. and Lee, J. and Easom, E. E. and Jacobs, R. T. and Plattner, J. J. and Witty, M. J. and Peter, R. and Rowan, T. G. and Gillingwater, K. and Brun, R. and Nare, B. and Mercer, L. and Xu, M. and Wang, J. and Liang, H.. (2017) Identification of a 4-fluorobenzyl L-valinate amide benzoxaborole (AN11736) as a potential development candidate for the treatment of Animal African Trypanosomiasis (AAT). Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, 28. pp. 6-10.

Althaus, Julia B. and Malyszek, Claudine and Kaiser, Marcel and Brun, Reto and Schmidt, Thomas J.. (2017) Alkamides from Anacyclus pyrethrum L. and their in vitro antiprotozoal activity. Molecules, 22 (5). p. 796.

Bapela, M. J. and Kaiser, M. and Meyer, J. J. M.. (2017) Antileishmanial activity of selected South African plant species. South African journal of botany, 108. pp. 342-345.

Bode, Edna and He, Yue and Vo, Tien Duy and Schultz, Roland and Kaiser, Marcel and Bode, Helge B.. (2017) Biosynthesis and function of simple amides in Xenorhabdus doucetiae. Environmental Microbiology, 19 (11). pp. 4564-4575.

Bringmann, Gerhard and Seupel, Raina and Feineis, Doris and Xu, Minjuan and Zhang, Guoliang and Kaiser, Marcel and Brun, Reto and Seo, Ean-Jeong and Efferth, Thomas. (2017) Antileukemic ancistrobenomine B and related 5,1'-coupled naphthylisoquinoline alkaloids from the Chinese liana Ancistrocladus tectorius. Fitoterapia, 121. pp. 76-85.

Bruno, Stefano and Uliassi, Elisa and Zaffagnini, Mirko and Prati, Federica and Bergamini, Christian and Amorati, Riccardo and Paredi, Gianluca and Margiotta, Marilena and Conti, Paola and Costi, Maria Paola and Kaiser, Marcel and Cavalli, Andrea and Fato, Romana and Bolognesi, Maria Laura. (2017) Molecular basis for covalent inhibition of glyceraldehyde-3-phosphate dehydrogenase by a 2-phenoxy-1,4-naphthoquinone small molecule. Chemical Biology and Drug Design, 90 (2). pp. 225-235.

Cadelis, Melissa M. and Bourguet-Kondracki, Marie-Lise and Dubois, Joëlle and Kaiser, Marcel and Brunel, Jean Michel and Barker, David and Copp, Brent R.. (2017) Structure-activity relationship studies on thiaplidiaquinones A and B as novel inhibitors of Plasmodium falciparum and farnesyltransferase. Bioorganic & medicinal chemistry, 25 (16). pp. 4433-4443.

Cai, Xiaofeng and Challinor, Victoria L. and Zhao, Lei and Reimer, Daniela and Adihou, Hélène and Grün, Peter and Kaiser, Marcel and Bode, Helge B.. (2017) Biosynthesis of the antibiotic nematophin and its elongated derivatives in entomopathogenic bacteria. Organic letters, 19 (4). pp. 806-809.

Cai, Xiaofeng and Nowak, Sarah and Wesche, Frank and Bischoff, Iris and Kaiser, Marcel and Fürst, Robert and Bode, Helge B.. (2017) Entomopathogenic bacteria use multiple mechanisms for bioactive peptide library design. Nature Chemistry, 9 (4). pp. 379-386.

Cai, Xiaofeng and Shi, Yi-Ming and Pöhlmann, Nicole and Revermann, Ole and Bahner, Isabel and Pidot, Sacha J. and Wesche, Frank and Lackner, Helmut and Büchel, Claudia and Kaiser, Marcel and Richter, Christian and Schwalbe, Harald and Stinear, Timothy P. and Zeeck, Axel and Bode, Helge B.. (2017) Structure and biosynthesis of isatropolones, bioactive amine-scavenging fluorescent natural products from streptomyces Go66. Angewandte Chemie International Edition, 56 (18). pp. 4945-4949.

Chianese, Giuseppina and Silber, Johanna and Luciano, Paolo and Merten, Christian and Erpenbeck, Dirk and Topaloglu, Bülent and Kaiser, Marcel and Tasdemir, Deniz. (2017) Antiprotozoal linear furanosesterterpenoids from the marine sponge Ircinia oros. Journal of natural products, 80 (9). pp. 2566-2571.

Dawidowski, M. and Emmanouilidis, L. and Kalel, V. C. and Tripsianes, K. and Schorpp, K. and Hadian, K. and Kaiser, M. and Mäser, P. and Kolonko, M. and Tanghe, S. and Rodriguez, A. and Schliebs, W. and Erdmann, R. and Sattler, M. and Popowicz, G. M.. (2017) Inhibitors of PEX14 disrupt protein import into glycosomes and kill Trypanosoma parasites. Science, 355 (6332). pp. 1416-1420.

De Mieri, M. and Smiesko, M. and Ismajili, I. and Kaiser, M. and Hamburger, M.. (2017) Acid-induced rearrangement of epoxygermacranolides: synthesis of furanoheliangolides and cadinanes from nobilin. Molecules, 22 (12). E2252.

De Mieri, Maria and Monteleone, Giannicola and Ismajili, Isidor and Kaiser, Marcel and Hamburger, Matthias. (2017) Antiprotozoal activity-based profiling of a dichloromethane extract from anthemis nobilis flowers. Journal of Natural Products, 80 (2). pp. 459-470.

Dong, Yuxiang and Wang, Xiaofang and Kamaraj, Sriraghavan and Bulbule, Vivek J. and Chiu, Francis C. K. and Chollet, Jacques and Dhanasekaran, Manickam and Hein, Christopher D. and Papastogiannidis, Petros and Morizzi, Julia and Shackleford, David M. and Barker, Helena and Ryan, Eileen and Scheurer, Christian and Tang, Yuanqing and Zhao, Qingjie and Zhou, Lin and White, Karen L. and Urwyler, Heinrich and Charman, William N. and Matile, Hugues and Wittlin, Sergio and Charman, Susan A. and Vennerstrom, Jonathan L.. (2017) Structure-activity relationship of the antimalarial ozonide artefenomel (OZ439). Journal of medicinal chemistry, 60 (7). pp. 2654-2668.

Espinoza-Moraga, Marlene and Singh, Kawaljit and Njoroge, Mathew and Kaur, Gurminder and Okombo, John and De Kock, Carmen and Smith, Peter J. and Wittlin, Sergio and Chibale, Kelly. (2017) Synthesis and biological characterisation of ester and amide derivatives of fusidic acid as antiplasmodial agents. Bioorganic & medicinal chemistry, 27 (3). pp. 658-661.

Faist, Johanna and Hinteregger, Clemens and Seebacher, Werner and Saf, Robert and Mäser, Pascal and Kaiser, Marcel and Weis, Robert. (2017) New derivatives of 7-chloroquinolin-4-amine with antiprotozoal activity. Bioorganic & medicinal chemistry, 25 (3). pp. 941-948.

Farahat, A. A. and Kumar, A. and Say, M. and Wenzler, T. and Brun, R. and Paul, A. and Wilson, D. W. and Boykin, D. W.. (2017) Exploration of DAPI analogues : synthesis, antitrypanosomal activity, DNA binding and fluorescence properties. European journal of medicinal chemistry, 128. pp. 70-78.

Gillingwater, Kirsten and Kunz, Christina and Braghiroli, Christiane and Boykin, David W. and Tidwell, Richard R. and Brun, Reto. (2017) In vitro, ex vivo and in vivo activity of diamidines against Trypanosoma congolense and Trypanosoma vivax. Antimicrobial agents and chemotherapy, 61 (5). e02356-16.

Greve, Hippolyt L. and Kaiser, Marcel and Brun, Reto and Schmidt, Thomas J.. (2017) Terpenoids from the oleo-gum-resin of Boswellia serrata and their antiplasmodial effects In Vitro. Planta medica, 83 (14-15). pp. 1214-1226.

Jeacock, Laura and Baker, Nicola and Wiedemar, Natalie and Mäser, Pascal and Horn, David. (2017) Aquaglyceroporin-null trypanosomes display glycerol transport defects and respiratory-inhibitor sensitivity. PLoS Pathogens, 13 (3). e1006307.

Krieg, Reimar and Jortzik, Esther and Goetz, Alice-Anne and Blandin, Stéphanie and Wittlin, Sergio and Elhabiri, Mourad and Rahbari, Mahsa and Nuryyeva, Selbi and Voigt, Kerstin and Dahse, Hans-Martin and Brakhage, Axel and Beckmann, Svenja and Quack, Thomas and Grevelding, Christoph G. and Pinkerton, Anthony B. and Schönecker, Bruno and Burrows, Jeremy and Davioud-Charvet, Elisabeth and Rahlfs, Stefan and Becker, Katja. (2017) Arylmethylamino steroids as antiparasitic agents. Nature communications, 8. p. 14478.

Leven, Michael and Knaab, Tanja C. and Held, Jana and Duffy, Sandra and Meister, Stephan and Fischli, Christoph and Meitzner, Diane and Lehmann, Ursula and Lungerich, Beate and Kuna, Krystina and Stahlke, Petra and Delves, Michael J. and Buchholz, Mirko and Winzeler, Elizabeth A. and Avery, Vicky M. and Mordmüller, Benjamin and Wittlin, Sergio and Kurz, Thomas. (2017) 3-hydroxy-N'-arylidenepropanehydrazonamides with halo-substituted phenanthrene scaffolds cure P. berghei infected mice when administered perorally. Journal of Medicinal Chemistry, 60 (14). pp. 6036-6044.

Li, Jun and Seupel, Raina and Feineis, Doris and Mudogo, Virima and Kaiser, Marcel and Brun, Reto and Brünnert, Daniela and Chatterjee, Manik and Seo, Ean-Jeong and Efferth, Thomas and Bringmann, Gerhard. (2017) Dioncophyllines C2, D2, and F and related naphthylisoquinoline alkaloids from the congolese liana Ancistrocladus ileboensis with potent activities against Plasmodium falciparum and against multiple myeloma and leukemia cell lines. Journal of natural products, 80 (2). pp. 443-458.

Lombe, Blaise Kimbadi and Bruhn, Torsten and Feineis, Doris and Mudogo, Virima and Brun, Reto and Bringmann, Gerhard. (2017) Antiprotozoal spirombandakamines A1 and A2, fused naphthylisoquinoline dimers from a congolese Ancistrocladus plant. Organic Letters, 19 (24). pp. 6740-6743.

Lombe, Blaise Kimbadi and Bruhn, Torsten and Feineis, Doris and Mudogo, Virima and Brun, Reto and Bringmann, Gerhard. (2017) Cyclombandakamines A1 and A2, oxygen-bridged naphthylisoquinoline dimers from a congolese Ancistrocladus liana. Organic letters, 19 (6). pp. 1342-1345.

Mathieu, Christoph and Macêdo, Juan P. and Hürlimann, Daniel and Wirdnam, Corina and Haindrich, Alexander C. and Suter Grotemeyer, Marianne and González-Salgado, Amaia and Schmidt, Remo S. and Inbar, Ehud and Mäser, Pascal and Bütikofer, Peter and Zilberstein, Dan and Rentsch, Doris. (2017) Arginine and lysine transporters are essential for Trypanosoma brucei. PLoS One, 12. e0168775.

Mohsin, N. U. A. and Seebacher, W. and Faist, J. and Hochegger, P. and Kaiser, M. and Mäser, P. and Saf, R. and Weis, R.. (2017) The antiplasmodial and antitrypanosomal activities of novel piperazine derivatives of 3-azabicyclo[3.2.2]nonanes. Monatshefte für Chemie, 149 (1). pp. 99-109.

Mohsin, Noor-Ul-Amin and Seebacher, Werner and Faist, Johanna and Hochegger, Patrick and Kaiser, Marcel and Mäser, Pascal and Belaj, Ferdinand and Saf, Robert and Kretschmer, Nadine and Alajlani, Muaaz and Turek, Ivana and Brantner, Adelheid and Bauer, Rudolf and Bucar, Franz and Weis, Robert. (2017) Synthesis of new 1-benzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities. European journal of medicinal chemistry, 143. pp. 97-106.

Mäser, Pascal. (2017) Cherchez l'electron. Molecular microbiology, 106 (2). pp. 183-185.

Ndjakou Lenta, B. and Ngatchou, J. and Frese, M. and Ladoh-Yemeda, F. and Nardella, F. and Michalek, C. and Wibberg, D. and Ngouela, S. and Tsamo, E. and Kaiser, M. and Kalinowski, J. and Sewald, N.. (2017) Purpureone, an antileishmanial ergochrome from the endophytic fungus Purpureocillium lilacinum. Zeitschrift für Naturforschung. Sect. B, Chemical sciences, 71 (11). pp. 1159-1167.

Nnadi, Charles Okeke and Nwodo, Ngozi Justina and Kaiser, Marcel and Brun, Reto and Schmidt, Thomas J.. (2017) Steroid Alkaloids from Holarrhena africana with Strong Activity against Trypanosoma brucei rhodesiense. Molecules, 22 (7). E1129.

Pagliero, Romina J. and Kaiser, Marcel and Brun, Reto and Nieto, Marcelo J. and Mazzieri, María R.. (2017) Lead selection of antiparasitic compounds from a focused library of benzenesulfonyl derivatives of heterocycles. Bioorganic & medicinal chemistry, 27 (17). pp. 3945-3949.

Papadopoulou, Maria V. and Bloomer, William D. and Rosenzweig, Howard S. and Kaiser, Marcel. (2017) The antitrypanosomal and antitubercular activity of some nitro(triazole/imidazole)-based aromatic amines. European Journal of Medicinal Chemistry, 138. pp. 1106-1113.

Paquet, Tanya and Le Manach, Claire and Cabrera, Diego González and Younis, Yassir and Henrich, Philipp P. and Abraham, Tara S. and Lee, Marcus C. S. and Basak, Rajshekhar and Ghidelli-Disse, Sonja and Lafuente-Monasterio, María José and Bantscheff, Marcus and Ruecker, Andrea and Blagborough, Andrew M. and Zakutansky, Sara E. and Zeeman, Anne-Marie and White, Karen L. and Shackleford, David M. and Mannila, Janne and Morizzi, Julia and Scheurer, Christian and Angulo-Barturen, Iñigo and Martínez, María Santos and Ferrer, Santiago and Sanz, Laura María and Gamo, Francisco Javier and Reader, Janette and Botha, Mariette and Dechering, Koen J. and Sauerwein, Robert W. and Tungtaeng, Anchalee and Vanachayangkul, Pattaraporn and Lim, Chek Shik and Burrows, Jeremy and Witty, Michael J. and Marsh, Kennan C. and Bodenreider, Christophe and Rochford, Rosemary and Solapure, Suresh M. and Jiménez-Díaz, María Belén and Wittlin, Sergio and Charman, Susan A. and Donini, Cristina and Campo, Brice and Birkholtz, Lyn-Marie and Hanson, Kirsten K. and Drewes, Gerard and Kocken, Clemens H. M. and Delves, Michael J. and Leroy, Didier and Fidock, David A. and Waterson, David and Street, Leslie J. and Chibale, Kelly. (2017) Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase. Science translational medicine, 9 (387). eaad9735.

Pavadai, E. and Kaur, G. and Wittlin, S. and Chibale, K.. (2017) Identification of steroid-like natural products as antiplasmodial agents by 2D and 3D similarity-based virtual screening. MedChemComm , 8 (6). pp. 1152-1157.

Pearce, A. Norrie and Kaiser, Marcel and Copp, Brent R.. (2017) Synthesis and antimalarial evaluation of artesunate-polyamine and trioxolane-polyamine conjugates. European journal of medicinal chemistry, 140. pp. 595-603.

Schwertz, Geoffrey and Witschel, Matthias C. and Rottmann, Matthias and Bonnert, Roger and Leartsakulpanich, Ubolsree and Chitnumsub, Penchit and Jaruwat, Aritsara and Ittarat, Wanwipa and Schäfer, Anja and Aponte, Raphael A. and Charman, Susan A. and White, Karen L. and Kundu, Abhijit and Sadhukhan, Surajit and Lloyd, Mel and Freiberg, Gail M. and Srikumaran, Myron and Siggel, Marc and Zwyssig, Adrian and Chaiyen, Pimchai and Diederich, François. (2017) Antimalarial inhibitors rargeting serine hydroxymethyltransferase (SHMT) with in vivo efficacy and analysis of their binding mode based on X-ray cocrystal structures. Journal of Medicinal Chemistry, 60 (12). pp. 4840-4860.

Scott, Fraser J. and Nichol, Ryan J. O. and Khalaf, Abedawn I. and Giordani, Federica and Gillingwater, Kirsten and Ramu, Soumya and Elliott, Alysha and Zuegg, Johannes and Duffy, Paula and Rosslee, Michael-Jon and Hlaka, Lerato and Kumar, Santosh and Ozturk, Mumin and Brombacher, Frank and Barrett, Michael and Guler, Reto and Suckling, Colin J.. (2017) An evaluation of minor groove binders as anti-fungal and anti-mycobacterial therapeutics. European Journal of Medicinal Chemistry, 136. pp. 561-572.

Seebacher, W. and Belaj, F. and Faist, J. and Saf, R. and Bucar, F. and Turek, I. and Branter, A. and Alajlani, M. and Kaiser, M. and Mäser, P. and Weis, R.. (2017) Synthesis of new pyrido-benzodiazepine salts and their antimicrobial activities. Monatshefte für Chemie, 148 (2). pp. 263-274.

Singh, Kawaljit and Okombo, John and Brunschwig, Christel and Ndubi, Ferdinand and Barnard, Linley and Wilkinson, Chad and Njogu, Peter M. and Njoroge, Mathew and Laing, Lizahn and Machado, Marta and Prudêncio, Miguel and Reader, Janette and Botha, Mariette and Nondaba, Sindisiwe and Birkholtz, Lyn-Marie and Lauterbach, Sonja and Churchyard, Alisje and Coetzer, Theresa L. and Burrows, Jeremy N. and Yeates, Clive and Denti, Paolo and Wiesner, Lubbe and Egan, Timothy J. and Wittlin, Sergio and Chibale, Kelly. (2017) Antimalarial pyrido[1,2-a]benzimidazoles : lead optimization, parasite life cycle stage profile, mechanistic evaluation, killing kinetics, and in vivo oral efficacy in a mouse model. Journal of medicinal chemistry, 60 (4). pp. 1432-1448.

Smyrniotopoulos, Vangelis and Merten, Christian and Kaiser, Marcel and Tasdemir, Deniz. (2017) Bifurcatriol, a new antiprotozoal acyclic diterpene from the brown alga Bifurcaria bifurcata. Marine drugs, 15 (8). p. 245.

Steinmann, Michael E. and Schmidt, Remo S. and Bütikofer, Peter and Mäser, Pascal and Sigel, Erwin. (2017) TbIRK is a signature sequence free potassium channel from Trypanosoma brucei locating to acidocalcisomes. Scientific Reports, 7 (1). p. 656.

Tallini, Luciana R. and Andrade, Jean Paulo de and Kaiser, Marcel and Viladomat, Francesc and Nair, Jerald J. and Zuanazzi, José Angelo S. and Bastida, Jaume. (2017) Alkaloid constituents of the amaryllidaceae plant amaryllis belladonna L. Molecules, 22 (9). p. 1437.

Tallini, Luciana R. and Osorio, Edison H. and Santos, Vanessa Dias Dos and Borges, Warley de Souza and Kaiser, Marcel and Viladomat, Francesc and Zuanazzi, José Angelo S. and Bastida, Jaume. (2017) Hippeastrum reticulatum (Amaryllidaceae): alkaloid profiling, biological activities and molecular docking. Molecules, 22 (12). E2191.

Tshitenge, Dieudonné Tshitenge and Feineis, Doris and Mudogo, Virima and Kaiser, Marcel and Brun, Reto and Bringmann, Gerhard. (2017) Antiplasmodial ealapasamines A-C,'mixed' naphthylisoquinoline dimers from the Central African liana Ancistrocladus ealaensis. Scientific Reports, 7. p. 5767.

Waldsö, I. and Hallén, D. and Jansoon, M. and Suurkuusk, J. and Wenzler, T. and Braissant, O.. (2017) A well-plate format isothermal multi-channel microcalorimeter for monitoring the activity of living cells and tissues. Thermochimica acta, 652. pp. 141-149.

Xu, Ze-Jun and Wittlin, Sergio and Wu, Yikang. (2017) Probing the peroxycarbenium [3+2] cycloaddition reactions with 1,2-disubstituted ethylenes: results and insights. Chemistry (Weinheim an der Bergstrasse, Germany), 23 (9). pp. 2031-2034.

2016

Ahmad, Sarfraz and Seebacher, Werner and Faist, Johanna and Kaiser, Marcel and Brun, Reto and Saf, Robert and Weis, Robert. (2016) The antiprotozoal potencies of newly prepared 3-azabicyclo[3.2.2]nonanes. Archives of pharmacal research, 39 (10). pp. 1391-1403.

Atay, Irem and Kirmizibekmez, Hasan and Kaiser, Marcel and Akaydin, Galip and Yesilada, Erdem and Tasdemir, Deniz. (2016) Evaluation of in vitro antiprotozoal activity of Ajuga laxmannii and its secondary metabolites. Pharmaceutical biology, 54 (9). pp. 1808-1814.

Boss, Christoph and Aissaoui, Hamed and Amaral, Nathalie and Bauer, Aude and Bazire, Stephanie and Binkert, Christoph and Brun, Reto and Bürki, Cédric and Ciana, Claire-Lise and Corminboeuf, Olivier and Delahaye, Stephane and Dollinger, Claire and Fischli, Christoph and Fischli, Walter and Flock, Alexandre and Frantz, Marie-Céline and Girault, Malory and Grisostomi, Corinna and Friedli, Astrid and Heidmann, Bibia and Hinder, Claire and Jacob, Gael and Le Bihan, Amelie and Malrieu, Sophie and Mamzed, Saskia and Merot, Aurelien and Meyer, Solange and Peixoto, Sabrina and Petit, Nolwenn and Siegrist, Romain and Trollux, Julien and Weller, Thomas and Wittlin, Sergio. (2016) Discovery and characterization of ACT-451840 : an antimalarial drug with a novel mechanism of action. ChemMedChem, 11 (18). pp. 1995-2014.

Cal, Monica and Ioset, Jean-Robert and Fügi, Matthia A. and Mäser, Pascal and Kaiser, Marcel. (2016) Assessing anti-T. cruzi candidates in vitro for sterile cidality. International journal for parasitology. Drugs and drug resistance, 6 (3). pp. 165-170.

Faist, J. and Seebacher, W. and Saf, R. and Brun, R. and Kaiser, M. and Weis, R.. (2016) New derivatives of bicyclic diamines with antiprotozoal activity. Monatshefte für Chemie, 147 (2). pp. 369-381.

Faist, Johanna and Seebacher, Werner and Saf, Robert and Brun, Reto and Kaiser, Marcel and Weis, Robert. (2016) Antiprotozoal activity of bicycles featuring a dimethylamino group at their bridgehead. Bioorganic & medicinal chemistry, 24 (16). pp. 3781-3789.

Farahat, Abdelbasset A. and Bennett-Vaughn, Cheree and Mineva, Ekaterina M. and Kumar, Arvind and Wenzler, Tanja and Brun, Reto and Liu, Yang and Wilson, W. David and Boykin, David W.. (2016) Synthesis, DNA binding and antitrypanosomal activity of benzimidazole analogues of DAPI. Bioorganic & medicinal chemistry letters, 26 (24). pp. 5907-5910.

Graf, Fabrice E. and Ludin, Philipp and Arquint, Christian and Schmidt, Remo S. and Schaub, Nadia and Kunz Renggli, Christina and Munday, Jane C. and Krezdorn, Jessica and Baker, Nicola and Horn, David and Balmer, Oliver and Caccone, Adalgisa and de Koning, Harry P. and Mäser, Pascal. (2016) Comparative genomics of drug resistance in Trypanosoma brucei rhodesiense. Cellular and molecular life sciences, 73 (17). pp. 3387-3400.

Hiltensperger, Georg and Hecht, Nina and Kaiser, Marcel and Rybak, Jens-Christoph and Hoerst, Alexander and Dannenbauer, Nicole and Müller-Buschbaum, Klaus and Bruhn, Heike and Esch, Harald and Lehmann, Leane and Meinel, Lorenz and Holzgrabe, Ulrike. (2016) Quinolone amides as anti-trypanosomal lead compounds with in vivo activity. Antimicrobial agents and chemotherapy, 60 (8). pp. 4442-4452.

Houël, Emeline and Nardella, Flore and Jullian, Valérie and Valentin, Alexis and Vonthron-Sénécheau, Catherine and Villa, Pascal and Obrecht, Adeline and Kaiser, Marcel and Bourreau, Eliane and Odonne, Guillaume and Fleury, Marie and Bourdy, Geneviève and Eparvier, Véronique and Deharo, Eric and Stien, Didier. (2016) Wayanin and guaijaverin, two active metabolites found in a Psidium acutangulum mart. ex DC (syn. P. persoonii McVaugh) (Myrtaceae) antimalarial decoction from the Wayana Amerindians. Journal of ethnopharmacology, 187. pp. 241-248.

Karaaslan, Cigdem and Kaiser, Marcel and Brun, Reto and Göker, Hakan. (2016) Synthesis and potent antiprotozoal activity of mono/di amidino 2-anilinobenz-imidazoles versus Plasmodium falciparum and Trypanosoma brucei rhodesiense. Bioorganic and Medicinal Chemistry, 24 (18). pp. 4038-4044.

Kedzierska, Ewa and Orzelska, Jolanta and Perković, Ivana and Knežević, Danijel and Fidecka, Sylwia and Kaiser, Marcel and Zorc, Branka. (2016) Pharmacological effects of primaquine ureas and semicarbazides on the central nervous system in mice and antimalarial activity in vitro. Fundamental and clinical pharmacology, 30. pp. 58-69.

Le Bihan, Amélie and de Kanter, Ruben and Angulo-Barturen, Iñigo and Binkert, Christoph and Boss, Christoph and Brun, Reto and Brunner, Ralf and Buchmann, Stephan and Burrows, Jeremy and Dechering, Koen J. and Delves, Michael and Ewerling, Sonja and Ferrer, Santiago and Fischli, Christoph and Gamo-Benito, Francisco Javier and Gnädig, Nina F. and Heidmann, Bibia and Jiménez-Díaz, María Belén and Leroy, Didier and Martínez, Maria Santos and Meyer, Solange and Moehrle, Joerg J. and Ng, Caroline L. and Noviyanti, Rintis and Ruecker, Andrea and Sanz, Laura María and Sauerwein, Robert W. and Scheurer, Christian and Schleiferboeck, Sarah and Sinden, Robert and Snyder, Christopher and Straimer, Judith and Wirjanata, Grennady and Marfurt, Jutta and Price, Ric N. and Weller, Thomas and Fischli, Walter and Fidock, David A. and Clozel, Martine and Wittlin, Sergio. (2016) Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose–Efficacy Modeling. PLoS medicine, 13 (10). e1002138.

Le Manach, Claire and Nchinda, Aloysius T. and Paquet, Tanya and Gonzàlez Cabrera, Diego and Younis, Yassir and Han, Ze and Bashyam, Sridevi and Zabiulla, Mohammed and Taylor, Dale and Lawrence, Nina and White, Karen L. and Charman, Susan A. and Waterson, David and Witty, Michael J. and Wittlin, Sergio and Botha, Mariëtte E. and Nondaba, Sindisiswe H. and Reader, Janette and Birkholtz, Lyn-Marie and Jiménez-Díaz, María Belén and Martínez, María Santos and Ferrer, Santiago and Angulo-Barturen, Iñigo and Meister, Stephan and Antonova-Koch, Yevgeniya and Winzeler, Elizabeth A. and Street, Leslie J. and Chibale, Kelly. (2016) Identification of a potential antimalarial drug candidate from a series of 2-aminopyrazines by optimization of aqueous solubility and potency across the parasite life cycle. Journal of medicinal chemistry, 59 (21). pp. 9890-9905.

Mir Mohseni, M. and Hover, T. and Barra, L. and Kaiser, M. and Dorrestein, P. C. and Dickschat, J. S. and Schaberle, T. F.. (2016) Discovery of a mosaic-like biosynthetic assembly line with a decarboxylative off-loading mechanism through a combination of genome mining and imaging. Angewandte Chemie. International edition in English, 55 (43). pp. 13611-13614.

Ng, Caroline L. and Siciliano, Giulia and Lee, Marcus C. S. and de Almeida, Mariana J. and Corey, Victoria C. and Bopp, Selina E. and Bertuccini, Lucia and Wittlin, Sergio and Kasdin, Rachel G. and Le Bihan, Amélie and Clozel, Martine and Winzeler, Elizabeth A. and Alano, Pietro and Fidock, David A.. (2016) CRISPR-Cas9-modified pfmdr1 protects Plasmodium falciparum asexual blood stages and gametocytes against a class of piperazine-containing compounds but potentiates artemisinin-based combination therapy partner drugs. Molecular microbiology, 101 (3). pp. 381-393.

Nogueira, Mauro S. and Da Costa, Fernando B. and Brun, Reto and Kaiser, Marcel and Schmidt, Thomas J.. (2016) Ent-pimarane and ent-kaurane diterpenes from Aldama discolor (asteraceae) and their antiprotozoal activity. Molecules, 21 (9). p. 1237.

Norcross, Neil R. and Baragaña, Beatriz and Wilson, Caroline and Hallyburton, Irene and Osuna-Cabello, Maria and Norval, Suzanne and Riley, Jennifer and Stojanovski, Laste and Simeons, Frederick R. C. and Porzelle, Achim and Grimaldi, Raffaella and Wittlin, Sergio and Duffy, Sandra and Avery, Vicky M. and Meister, Stephan and Sanz, Laura and Jiménez-Díaz, Belén and Angulo-Barturen, Iñigo and Ferrer, Santiago and Martínez, María Santos and Gamo, Francisco Javier and Frearson, Julie A. and Gray, David W. and Fairlamb, Alan H. and Winzeler, Elizabeth A. and Waterson, David and Campbell, Simon F. and Willis, Paul and Read, Kevin D. and Gilbert, Ian H.. (2016) Trisubstituted Pyrimidines as Efficacious and Fast-Acting Antimalarials. Journal of Medicinal Chemistry, 59 (13). pp. 6101-6120.

Papadopoulou, Maria V. and Bloomer, William D. and Rosenzweig, Howard S. and Wilkinson, Shane R. and Szular, Joanna and Kaiser, Marcel. (2016) Antitrypanosomal activity of 5-nitro-2-aminothiazole-based compounds. European journal of medicinal chemistry, 117. pp. 179-186.

Papadopoulou, Maria V. and Bloomer, William D. and Rosenzweig, Howard S. and Wilkinson, Shane R. and Szular, Joanna and Kaiser, Marcel. (2016) Nitrotriazole-based acetamides and propanamides with broad spectrum antitrypanosomal activity. European journal of medicinal chemistry, 123. pp. 895-904.

Patrick, Donald A. and Wenzler, Tanja and Yang, Sihyung and Weiser, Patrick T. and Wang, Michael Zhuo and Brun, Reto and Tidwell, Richard R.. (2016) Synthesis of novel amide and urea derivatives of thiazol-2-ethylamines and their activity against Trypanosoma brucei rhodesiense. Bioorganic & medicinal chemistry, 24 (11). pp. 2451-2465.

Pavadai, Elumalai and El Mazouni, Farah and Wittlin, Sergio and de Kock, Carmen and Phillips, Margaret A. and Chibale, Kelly. (2016) Identification of new human malaria parasite Plasmodium falciparum dihydroorotate dehydrogenase inhibitors by pharmacophore and structure-based virtual screening. Journal of chemical information and modeling, 56 (3). pp. 548-562.

Pirttimaa, Minni and Nasereddin, Abedelmajeed and Kopelyanskiy, Dmitry and Kaiser, Marcel and Yli-Kauhaluoma, Jari and Oksman-Caldentey, Kirsi-Marja and Brun, Reto and Jaffe, Charles L. and Moreira, Vânia M. and Alakurtti, Sami. (2016) Abietane-type diterpenoid amides with highly potent and selective activity against Leishmania donovani and Trypanosoma cruzi. Journal of natural products, 79 (2). pp. 362-368.

Russell, Stephanie and Rahmani, Raphaël and Jones, Amy J. and Newson, Harriet L. and Neilde, Kevin and Cotillo, Ignacio and Rahmani Khajouei, Marzieh and Ferrins, Lori and Qureishi, Sana and Nguyen, Nghi and Martinez-Martinez, Maria S. and Weaver, Donald F. and Kaiser, Marcel and Riley, Jennifer and Thomas, John and De Rycker, Manu and Read, Kevin D. and Flematti, Gavin R. and Ryan, Eileen and Tanghe, Scott and Rodriguez, Ana and Charman, Susan A. and Kessler, Albane and Avery, Vicky M. and Baell, Jonathan B. and Piggott, Matthew J.. (2016) Hit-to-lead optimization of a novel class of potent, broad-spectrum trypanosomacides. Journal of Medicinal Chemistry, 59 (21). pp. 9686-9720.

Seupel, Raina and Hertlein-Amslinger, Barbara and Gulder, Tanja and Stawski, Philipp and Kaiser, Marcel and Brun, Reto and Bringmann, Gerhard. (2016) Directed synthesis of all four pure stereoisomers of the N,C-Coupled naphthylisoquinoline alkaloid ancistrocladinium A. Organic letters, 18 (24). pp. 6508-6511.

Silveira, Narjara and Saar, Julia and Santos, Alan Diego C. and Barison, Andersson and Sandjo, Louis P. and Kaiser, Marcel and Schmidt, Thomas J. and Biavatti, Maique W.. (2016) A new alkamide with an endoperoxide structure from acmella ciliata (asteraceae) and its in vitro antiplasmodial activity. Molecules, 21 (6). pp. 1-10.

Tasdemir, D. and Sen, R. and Bergonzi, M. C. and Demirci, B. and Bilia, A. R. and Baser, K. H. C. and Brun, R. and Chatterjee, M.. (2016) Rapid chemical analysis and antiprotozoal effect of the solvent extracts and the essential oil of Artemisia indica. Planta medica, 81 (16). pp. 1547-1548.

Vahermo, M. and Krogerus, S. and Nasereddin, A. and Kaiser, M. and Brun, R. and Jaffe, C. L. and Yli-Kauhaluoma, J. and Moreira, V. M.. (2016) Antiprotozoal activity of dehydroabietic acid derivatives against Leishmania denovani and Trypanosoma cruzi. MedChemComm, 7 (3). pp. 457-463.

Vanden Eynde, J. J. and Mayence, A. and Mottamal, M. and Bacchi, C. J. and Yarlett, N. and Kaiser, M. and Brun, R. and Huang, T. L.. (2016) Alkanediamide-linked bisbenzamidines are promising antiparasitic agents. Pharmaceuticals, 9 (2). pp. 1-11.

Wang, Tai and Mäser, Pascal and Picard, Didier. (2016) Inhibition of Plasmodium falciparum Hsp90 contributes to the antimalarial activities of aminoalcohol-carbazoles. Journal of Medicinal Chemistry, 59 (13). pp. 6344-6352.

Wenzler, Tanja and Schumann Burkard, Gabriela and S. Schmidt, Remo and Mäser, Pascal and Bergner, Andreas and Roditi, Isabel and Brun, Reto. (2016) A new approach to chemotherapy : drug-induced differentiation kills African trypanosomes. Scientific Reports, 6. p. 22451.

Williamson, Alice E. and Ylioja, Paul M. and Robertson, Murray N. and Antonova-Koch, Yevgeniya and Avery, Vicky and Baell, Jonathan B. and Batchu, Harikrishna and Batra, Sanjay and Burrows, Jeremy N. and Bhattacharyya, Soumya and Calderon, Felix and Charman, Susan A. and Clark, Julie and Crespo, Benigno and Dean, Matin and Debbert, Stefan L. and Delves, Michael and Dennis, Adelaide S. M. and Deroose, Frederik and Duffy, Sandra and Fletcher, Sabine and Giaever, Guri and Hallyburton, Irene and Gamo, Francisco-Javier and Gebbia, Marinella and Guy, R. Kiplin and Hungerford, Zoe and Kirk, Kiaran and Lafuente-Monasterio, Maria J. and Lee, Anna and Meister, Stephan and Nislow, Corey and Overington, John P. and Papadatos, George and Patiny, Luc and Pham, James and Ralph, Stuart A. and Ruecker, Andrea and Ryan, Eileen and Southan, Christopher and Srivastava, Kumkum and Swain, Chris and Tarnowski, Matthew J. and Thomson, Patrick and Turner, Peter and Wallace, Iain M. and Wells, Timothy N. C. and White, Karen and White, Laura and Willis, Paul and Winzeler, Elizabeth A. and Wittlin, Sergio and Todd, Matthew H.. (2016) Open source drug discovery : highly potent antimalarial compounds derived from the tres cantos arylpyrroles. ACS central science, 2 (10). pp. 687-701.

Wolkinger, V. and Ahmad, S. and Seebacher, W. and Faist, J. and Saf, R. and Kaiser, M. and Brun, R. and Weis, R.. (2016) New diaryl-substituted azabicyclo[3.2.2]nonanes and their antiprotozoal potencies. Monatshefte für Chemie, 147 (10). pp. 1721-1735.

Zheng, Zhaoyan and Tran, Huu-Anh and Manivannan, Srinivasan and Wen, Xianghui and Kaiser, Marcel and Brun, Reto and Snyder, Floyd F. and Back, Thomas G.. (2016) Novel nucleoside-based antimalarial compounds. Bioorganic & medicinal chemistry letters, 26 (12). pp. 2861-2865.

2015

Ahmad, Sarfraz and Seebacher, Werner and Wolkinger, Volker and Presser, Armin and Faist, Johanna and Kaiser, Marcel and Brun, Reto and Saf, Robert and Weis, Robert. (2015) Synthesis and antiprotozoal activities of new 3-azabicyclo[3.2.2]nonanes. Archives of pharmacal research, Vol. 38, H. 8. pp. 1455-1467.

Baragaña, Beatriz and Hallyburton, Irene and Lee, Marcus C. S. and Norcross, Neil R. and Grimaldi, Raffaella and Otto, Thomas D. and Proto, William R. and Blagborough, Andrew M. and Meister, Stephan and Wirjanata, Grennady and Ruecker, Andrea and Upton, Leanna M. and Abraham, Tara S. and Almeida, Mariana J. and Pradhan, Anupam and Porzelle, Achim and Martínez, María Santos and Bolscher, Judith M. and Woodland, Andrew and Norval, Suzanne and Zuccotto, Fabio and Thomas, John and Simeons, Frederick and Stojanovski, Laste and Osuna-Cabello, Maria and Brock, Paddy M. and Churcher, Tom S. and Sala, Katarzyna A. and Zakutansky, Sara E. and Jiménez-Díaz, María Belén and Sanz, Laura Maria and Riley, Jennifer and Basak, Rajshekhar and Campbell, Michael and Avery, Vicky M. and Sauerwein, Robert W. and Dechering, Koen J. and Noviyanti, Rintis and Campo, Brice and Frearson, Julie A. and Angulo-Barturen, Iñigo and Ferrer-Bazaga, Santiago and Gamo, Francisco Javier and Wyatt, Paul G. and Leroy, Didier and Siegl, Peter and Delves, Michael J. and Kyle, Dennis E. and Wittlin, Sergio and Marfurt, Jutta and Price, Ric N. and Sinden, Robert E. and Winzeler, Elizabeth A. and Charman, Susan A. and Bebrevska, Lidiya and Gray, David W. and Campbell, Simon and Fairlamb, Alan H. and Willis, Paul A. and Rayner, Julian C. and Fidock, David A. and Read, Kevin D. and Gilbert, Ian H.. (2015) A novel multiple-stage antimalarial agent that inhibits protein synthesis. Nature, Vol. 522, H. 7556. pp. 315-320.

Bode, Edna and Brachmann, Alexander O. and Kegler, Carsten and Simsek, Rukayye and Dauth, Christina and Zhou, Qiuqin and Kaiser, Marcel and Klemmt, Petra and Bode, Helge B.. (2015) Simple "on-demand" production of bioactive natural products. ChemBioChem, Vol. 16, H. 7. pp. 1115-1119.

Bode, Helge B. and Brachmann, Alexander O. and Jadhav, Kirtikumar B. and Seyfarth, Lydia and Dauth, Christina and Fuchs, Sebastian W. and Kaiser, Marcel and Waterfield, Nick R. and Sack, Holger and Heinemann, Stefan H. and Arndt, Hans-Dieter. (2015) Structure elucidation and activity of kolossin A, the D-/L-Pentadecapeptide product of a giant nonribosomal peptide synthetase. Angewandte Chemie, Jg. 54, Nr. 35. pp. 10352-10355.

Brücher, Karin and Gräwert, Tobias and Konzuch, Sarah and Held, Jana and Lienau, Claudia and Behrendt, Christoph and Illarionov, Boris and Maes, Louis and Bacher, Adelbert and Wittlin, Sergio and Mordmüller, Benjamin and Fischer, Markus and Kurz, Thomas. (2015) Prodrugs of reverse fosmidomycin analogues. Journal of medicinal chemistry, 58 (4). pp. 2025-2035.

Bürstner, Nathalie and Roggo, Silvio and Ostermann, Nils and Blank, Jutta and Delmas, Cecile and Freuler, Felix and Gerhartz, Bernd and Hinniger, Alexandra and Hoepfner, Dominic and Liechty, Brigitta and Mihalic, Manuel and Murphy, Jason and Pistorius, Dominik and Rottmann, Matthias and Thomas, Jason R. and Schirle, Markus and Schmitt, Esther K.. (2015) Gift from nature : cyclomarin s kills Mycobacteria and malaria parasites by distinct modes of action. ChemBioChem, 16 (17). pp. 2433-2436.

Cheikh-Ali, Zakaria and Glynou, Kyriaki and Ali, Tahir and Ploch, Sebastian and Kaiser, Marcel and Thines, Marco and Bode, Helge B. and Maciá-Vicente, Jose G.. (2015) Diversity of exophillic acid derivatives in strains of an endophytic Exophiala sp. Phytochemistry : an international journal of plant biochemistry, 118. pp. 83-93.

Chugh, Monika and Scheurer, Christian and Sax, Sibylle and Bilsland, Elizabeth and van Schalkwyk, Donelly A. and Wicht, Kathryn J. and Hofmann, Natalie and Sharma, Anil and Bashyam, Sridevi and Singh, Shivendra and Oliver, Stephen G. and Egan, Timothy J. and Malhotra, Pawan and Sutherland, Colin J. and Beck, Hans-Peter and Wittlin, Sergio and Spangenberg, Thomas and Ding, Xavier C.. (2015) Identification and deconvolution of cross-resistance signals from antimalarial compounds using multidrug-resistant Plasmodium falciparum strains. Antimicrobial agents and chemotherapy, Vol. 59, H. 2. pp. 1110-1118.

Cretton, Sylvian and Bréant, Lise and Pourrez, Lucie and Ambuehl, Chiara and Perozzo, Remo and Marcourt, Laurence and Kaiser, Marcel and Cuendet, Muriel and Christen, Philippe. (2015) Chemical constituents from Waltheria indica exert in vitro activity against Trypanosoma brucei and T. cruzi. Fitoterapia, 105. pp. 55-60.

Daeppen, Christophe and Kaiser, Marcel and Neuburger, Markus and Gademann, Karl. (2015) Preparation of antimalarial endoperoxides by a formal [2 + 2 + 2] cycloaddition. Organic letters, 17 (21). pp. 5420-5423.

De Mieri, M. and Kaiser, M. and Brun, R. and Thormann, U. and Imanidis, G. and Hamburger, M.. (2015) Anti-trypanosomal cadinanes synthesized by transannular cyclization of the natural sesquiterpene lactone nobilin. Bioorganic & medicinal chemistry, 23 (7). pp. 1521-1529.

Ellendorff, Therese and Brun, Reto and Kaiser, Marcel and Sendker, Jandirk and Schmidt, Thomas J.. (2015) PLS-prediction and confirmation of hydrojuglone glucoside as the antitrypanosomal constituent of "Juglans spp.". Molecules, Vol. 20, H. 6. pp. 10082-10094.

Gonzàlez Cabrera, Diego and Douelle, Frederic and Le Manach, Claire and Han, Ze and Paquet, Tanya and Taylor, Dale and Njoroge, Mathew and Lawrence, Nina and Wiesner, Lubbe and Waterson, David and Witty, Michael J. and Wittlin, Sergio and Street, Leslie J. and Chibale, Kelly. (2015) Structure-activity relationship studies of orally active antimalarial 2,4-diamino-thienopyrimidines. Journal of medicinal chemistry, 58 (18). pp. 7572-7579.

Graf, Fabrice. Drug resistance in Trypanosoma brucei : comparative genomics of melarsoprol-pentamidine cross-resistance and the role of aquaglyceroporin 2 in clinical resistance. 2015, Doctoral Thesis, University of Basel, Faculty of Science.

Graf, Fabrice E. and Baker, Nicola and Munday, Jane C. and de Koning, Harry P. and Horn, David and Mäser, Pascal. (2015) Chimerization at the AQP2-AQP3 locus is the genetic basis of melarsoprol-pentamidine cross-resistance in clinical Trypanosoma brucei gambiense isolates. International journal for parasitology. Drugs and drug resistance, Vol. 5, H. 2. pp. 65-68.

Hemberger, Yasmin and Zhang, Guoliang and Brun, Reto and Kaiser, Marcel and Bringmann, Gerhard. (2015) Highly antiplasmodial non-natural oxidative products of dioncophylline A: synthesis, absolute configuration, and conformational stability. Chemistry, a European journal, 21 (41). pp. 14507-14518.

Herrmann, Fabian C. and Lenz, Mairin and Jose, Joachim and Kaiser, Marcel and Brun, Reto and Schmidt, Thomas J.. (2015) In silico identification and in vitro activity of novel natural inhibitors of Trypanosoma brucei glyceraldehyde-3-phosphate-dehydrogenase. Molecules, Vol. 20, H. 9. pp. 16154-16169.

Inahashi, Yuki and Iwatsuki, Masato and Ishiyama, Aki and Matsumoto, Atsuko and Hirose, Tomoyasu and Oshita, Jun and Sunazuka, Toshiaki and Panbangred, Watanalai and Takahashi, Yoko and Kaiser, Marcel and Otoguro, Kazuhiko and O̅mura, Satoshi. (2015) Actinoallolides A-E, new anti-trypanosomal macrolides, produced by an endophytic actinomycete, actinoallomurus fulvus MK10-036. Organic letters, Vol. 17, H. 4. pp. 864-867.

Jones, Amy J. and Kaiser, Marcel and Avery, Vicky M.. (2015) Identification and characterization of FTY720 for the treatment of human African trypanosomiasis. Antimicrobial agents and chemotherapy, 60 (3). pp. 1859-1861.

Jortzik, Esther and Zocher, Kathleen and Isernhagen, Antje and Mailu, Boniface M. and Rahlfs, Stefan and Viola, Giampietro and Wittlin, Sergio and Hunt, Nicholas H. and Ihmels, Heiko and Becker, Katja. (2015) Benzo[b]quinolizinium derivatives have a strong antimalarial activity and inhibit indoleamine dioxygenase. Antimicrobial agents and chemotherapy, 60 (1). pp. 115-125.

Kaiser, Marcel and Maes, Louis and Tadoori, Leela Pavan and Spangenberg, Thomas and Ioset, Jean-Robert. (2015) Repurposing of the open access malaria box for kinetoplastid diseases identifies novel active scaffolds against trypanosomatids. Journal of biomolecular screening, Vol. 20, H. 5. pp. 634-645.

Kaiser, Marcel and Mäser, Pascal and Tadoori, Leela Pavan and Ioset, Jean-Robert and Brun, Reto. (2015) Antiprotozoal activity profiling of approved drugs : a starting point toward drug repositioning. PLoS one, Vol. 10, H. 8 , e0135556.

Kaur, G. and Singh, K. and Pavadai, E. and Njoroge, M. and Espinoza-Moraga, M. and de Kock, C. and Smith, P. J. and Wittlin, S. and Chibale, K.. (2015) Synthesis of fusidic acid bioisosteres as antiplasmodial agents and molecular docking studies in the binding site of elongation factor-G. MedChemComm, 6 (11). pp. 2023-2028.

Keller, Lena and Plaza, Alberto and Dubiella, Christian and Groll, Michael and Kaiser, Marcel and Müller, Rolf. (2015) Macyranones : structure, biosynthesis, and binding mode of an unprecedented epoxyketone that targets the 20S proteasome. The journal of the American Chemical Society, Vol. 137, H. 25. pp. 8121-8130.

Lakshminarayana, Suresh B. and Freymond, Céline and Fischli, Christoph and Yu, Jing and Weber, Sebastian and Goh, Anne and Yeung, Bryan K. S. and Ho, Paul C. and Dartois, Véronique and Diagana, Thierry T. and Rottmann, Matthias and Blasco, Francesca. (2015) Pharmacokinetic-pharmacodynamic analysis of spiroindolone analogs and KAE609 in a murine malaria model. Antimicrobial agents and chemotherapy, Vol. 59, H. 2. pp. 1200-1210.

Le Manach, Claire and Paquet, Tanya and Brunschwig, Christel and Njoroge, Mathew and Han, Ze and Gonzàlez Cabrera, Diego and Bashyam, Sridevi and Dhinakaran, Rajkumar and Taylor, Dale and Reader, Janette and Botha, Mariette and Churchyard, Alisje and Lauterbach, Sonja and Coetzer, Theresa L. and Birkholtz, Lyn-Marie and Meister, Stephan and Winzeler, Elizabeth A. and Waterson, David and Witty, Michael J. and Wittlin, Sergio and Jiménez-Díaz, María-Belén and Santos Martínez, María and Ferrer, Santiago and Angulo-Barturen, Iñigo and Street, Leslie J. and Chibale, Kelly. (2015) A novel pyrazolopyridine with in vivo activity in Plasmodium berghei- and Plasmodium falciparum-infected mouse models from structure-activity relationship studies around the core of recently identified antimalarial imidazopyridazines. Journal of medicinal chemistry, 58 (21). pp. 8713-8722.

Malmquist, Nicholas A. and Sundriyal, Sandeep and Caron, Joachim and Chen, Patty and Witkowski, Benoit and Menard, Didier and Suwanarusk, Rossarin and Renia, Laurent and Nosten, Francois and Jiménez-Díaz, María Belén and Angulo-Barturen, Iñigo and Martínez, María Santos and Ferrer, Santiago and Sanz, Laura M. and Gamo, Francisco-Javier and Wittlin, Sergio and Duffy, Sandra and Avery, Vicky M. and Ruecker, Andrea and Delves, Michael J. and Sinden, Robert E. and Fuchter, Matthew J. and Scherf, Artur. (2015) Histone methyltransferase inhibitors are orally bioavailable, fast-acting molecules with activity against different species causing malaria in humans. Antimicrobial agents and chemotherapy, Vol. 59, H. 2. pp. 950-959.

Manos-Turvey, A. and Watson, E. E. and Sykes, M. L. and Jones, A. J. and Baell, J. B. and Kaiser, M. and Avery, V. M. and Payne, R. J.. (2015) Synthesis and evaluation of phenoxymethylbenzamide analogues as anti-trypanosomal agents. MedChemComm, Vol. 6, H. 3. pp. 403-406.

Mital, Alka and Murugesan, Dinakaran and Kaiser, Marcel and Yeates, Clive and Gilbert, Ian H.. (2015) Discovery and optimisation studies of antimalarial phenotypic hits. European journal of medicinal chemistry, 103. pp. 530-538.

Montalvo-Quirós, Sandra and Taladriz-Sender, Andrea and Kaiser, Marcel and Dardonville, Christophe. (2015) Antiprotozoal activity and DNA binding of dicationic acridones. Journal of medicinal chemistry, 58 (4). pp. 1940-1949.

Montesino, Núria Llurba and Kaiser, Marcel and Brun, Reto and Schmidt, Thomas J.. (2015) Search for antiprotozoal activity in herbal medicinal preparations : new natural leads against neglected tropical diseases. Molecules, Vol. 20, H. 8. pp. 14118-14138.

Nollmann, Friederike I. and Dauth, Christina and Mulley, Geraldine and Kegler, Carsten and Kaiser, Marcel and Waterfield, Nick R. and Bode, Helge B.. (2015) Insect-specific production of new GameXPeptides in Photorhabdus luminescens TTO1, widespread natural products in entomopathogenic bacteria. ChemBioChem : a European journal of chemical biology, Vol. 16, H. 2. pp. 205-208.

Nollmann, Friederike I. and Heinrich, Antje K. and Brachmann, Alexander O. and Morisseau, Christophe and Mukherjee, Krishnendu and Casanova-Torres, Ángel M. and Strobl, Frederic and Kleinhans, David and Kinski, Sebastian and Schultz, Katharina and Beeton, Michael L. and Kaiser, Marcel and Chu, Ya-Yun and Phan Ke, Long and Thanwisai, Aunchalee and Bozhüyük, Kenan A. J. and Chantratita, Narisara and Götz, Friedrich and Waterfield, Nick R. and Vilcinskas, Andreas and Stelzer, Ernst H. K. and Goodrich-Blair, Heidi and Hammock, Bruce D. and Bode, Helge B.. (2015) A photorhabdus natural product inhibits insect juvenile hormone epoxide hydrolase. ChemBioChem, Vol. 16, H. 5. pp. 766-771.

Nwodo, Ngozi and Okoye, Festus and Lai, Daowan and Debbab, Abdesammed and Kaiser, Marcel and Brun, Reto and Proksch, Peter. (2015) Evaluation of the in vitro trypanocidal activity of methylated flavonoid constituents of Vitex simplicifolia leaves. BMC complementary and alternative medicine, Vol. 15 , 82.

Ongarora, Dennis S. B. and Strydom, Natasha and Wicht, Kathryn and Njoroge, Mathew and Wiesner, Lubbe and Egan, Timothy J. and Wittlin, Sergio and Jurva, Ulrik and Masimirembwa, Collen M. and Chibale, Kelly. (2015) Antimalarial benzoheterocyclic 4-aminoquinolines : structure-activity relationship, in vivo evaluation, mechanistic and bioactivation studies. Bioorganic & medicinal chemistry, 23 (17). pp. 5419-5432.

Papadopoulou, Maria V. and Bloomer, William D. and Lepesheva, Galina I. and Rosenzweig, Howard S. and Kaiser, Marcel and Aguilera-Venegas, Benjamín and Wilkinson, Shane R. and Chatelain, Eric and Ioset, Jean-Robert. (2015) Novel 3-nitrotriazole-based amides and carbinols as bifunctional antichagasic agents. Journal of medicinal chemistry, 58 (3). pp. 1307-1319.

Papadopoulou, Maria V. and Bloomer, William D. and Rosenzweig, Howard S. and O'Shea, Ivan P. and Wilkinson, Shane R. and Kaiser, Marcel. (2015) 3-Nitrotriazole-based piperazides as potent antitrypanosomal agents. European journal of medicinal chemistry, 103. pp. 325-334.

Papadopoulou, Maria V. and Bloomer, William D. and Rosenzweig, Howard S. and O'Shea, Ivan P. and Wilkinson, Shane R. and Kaiser, Marcel and Chatelain, Eric and Ioset, Jean-Robert. (2015) Discovery of potent nitrotriazole-based antitrypanosomal agents : in vitro and in vivo evaluation. Bioorganic & medicinal chemistry, 23 (19). pp. 6467-6476.

Phillips, Margaret A. and Lotharius, Julie and Marsh, Kennan and White, John and Dayan, Anthony and White, Karen L. and Njoroge, Jacqueline W. and El Mazouni, Farah and Lao, Yanbin and Kokkonda, Sreekanth and Tomchick, Diana R. and Deng, Xiaoyi and Laird, Trevor and Bhatia, Sangeeta N. and March, Sandra and Ng, Caroline L. and Fidock, David A. and Wittlin, Sergio and Lafuente-Monasterio, Maria and Benito, Francisco Javier Gamo and Alonso, Laura Maria Sanz and Martinez, Maria Santos and Jimenez-Diaz, Maria Belen and Bazaga, Santiago Ferrer and Angulo-Barturen, Iñigo and Haselden, John N. and Louttit, James and Cui, Yi and Sridhar, Arun and Zeeman, Anna-Marie and Kocken, Clemens and Sauerwein, Robert and Dechering, Koen and Avery, Vicky M. and Duffy, Sandra and Delves, Michael and Sinden, Robert and Ruecker, Andrea and Wickham, Kristina S. and Rochford, Rosemary and Gahagen, Janet and Iyer, Lalitha and Riccio, Ed and Mirsalis, Jon and Bathhurst, Ian and Rueckle, Thomas and Ding, Xavier and Campo, Brice and Leroy, Didier and Rogers, M. John and Rathod, Pradipsinh K. and Burrows, Jeremy N. and Charman, Susan A.. (2015) A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria. Science translational medicine, Vol. 7, H. 296 , 296ra111.

Prati, Federica and Bergamini, Christian and Molina, Maria Teresa and Falchi, Federico and Cavalli, Andrea and Kaiser, Marcel and Brun, Reto and Fato, Romana and Bolognesi, Maria Laura. (2015) 2-Phenoxy-1,4-naphthoquinones : from a multitarget antitrypanosomal to a potential antitumor profile. Journal of medicinal chemistry, 58 (16). pp. 6422-6434.

Rahmani, Raphaël and Ban, Kung and Jones, Amy J. and Ferrins, Lori and Ganame, Danny and Sykes, Melissa L. and Avery, Vicky M. and White, Karen L. and Ryan, Eileen and Kaiser, Marcel and Charman, Susan A. and Baell, Jonathan B.. (2015) 6-Arylpyrazine-2-carboxamides : a new core for Trypanosoma brucei inhibitors. Journal of medicinal chemistry, 58 (17). pp. 6753-6765.

Rodenko, Boris and Wanner, Martin J. and Alkhaldi, Abdulsalam A. M. and Ebiloma, Godwin U. and Barnes, Rebecca L. and Kaiser, Marcel and Brun, Reto and McCulloch, Richard and Koomen, Gerrit-Jan and de Koning, Harry P.. (2015) Targeting the parasite's DNA with methyltriazenyl purine analogs is a safe, selective, and efficacious antitrypanosomal strategy. Antimicrobial agents and chemotherapy, 59 (11). pp. 6708-6716.

Royo, Santiago and Rodríguez, Santiago and Schirmeister, Tanja and Kesselring, Jochen and Kaiser, Marcel and González, Florenci V.. (2015) Dipeptidyl enoates as potent rhodesain inhibitors that display a dual mode of action. ChemMedChem, 10 (9). pp. 1484-1487.

Rusman, Yudi and Held, Benjamin W. and Blanchette, Robert A. and Wittlin, Sergio and Salomon, Christine E.. (2015) Soudanones A-G : antifungal isochromanones from the ascomycetous fungus Cadophora sp. isolated from an iron mine. Journal of natural products, Vol. 78, H. 6. pp. 1456-1460.

Ríos Martínez, Carlos H. and Miller, Florence and Ganeshamoorthy, Kayathiri and Glacial, Fabienne and Kaiser, Marcel and de Koning, Harry P. and Eze, Anthonius A. and Lagartera, Laura and Herraiz, Tomás and Dardonville, Christophe. (2015) A new nonpolar n-hydroxy imidazoline lead compound with improved activity in a murine model of late-stage Trypanosoma brucei brucei infection is not cross-resistant with diamidines. Antimicrobial agents and chemotherapy, Vol. 59, H. 2. pp. 890-904.

Seebacher, W. and Faist, J. and Belaj, F. and Saf, R. and Kaiser, M. and Brun, R. and Weis, R.. (2015) Synthesis of new tetrahydropyridinylidene ammonium salts and their antprotozoal potency. Monatshefte für Chemie, 146 (8). pp. 1299-1308.

Seebacher, Werner and Wolkinger, Volker and Faist, Johanna and Kaiser, Marcel and Brun, Reto and Saf, Robert and Bucar, Franz and Gröblacher, Barbara and Brantner, Adelheid and Merino, Virginia and Kalia, Yogeshvar and Scapozza, Leonardo and Perozzo, Remo and Weis, Robert. (2015) Synthesis of 3-azabicyclo[3.2.2]nonanes and their antiprotozoal activities. Bioorganic & medicinal chemistry letters, Vol. 25, H. 7. pp. 1390-1393.

Shaban, E. and Wicht, K. J. and Wang, N. and Mei, Z. W. and Hayashi, I. and El Gokha, A. A. A. and Kaiser, M. and El Sayed, I. E. and Egan, T. J. and Inokuchi, T.. (2015) Synthesis and antimalarial activity of some neocryptolepine analogues carrying a multifunctional linear and branched carbon-side chains. Heterocycles, Vol. 89, H. 4. pp. 1055-1064.

Shameer, Sanu and Logan-Klumpler, Flora J. and Vinson, Florence and Cottret, Ludovic and Merlet, Benjamin and Achcar, Fiona and Boshart, Michael and Berriman, Matthew and Breitling, Rainer and Bringaud, Frédéric and Bütikofer, Peter and Cattanach, Amy M. and Bannerman-Chukualim, Bridget and Creek, Darren J. and Crouch, Kathryn and de Koning, Harry P. and Denise, Hubert and Ebikeme, Charles and Fairlamb, Alan H. and Ferguson, Michael A. J. and Ginger, Michael L. and Hertz-Fowler, Christiane and Kerkhoven, Eduard J. and Mäser, Pascal and Michels, Paul A. M. and Nayak, Archana and Nes, David W. and Nolan, Derek P. and Olsen, Christian and Silva-Franco, Fatima and Smith, Terry K. and Taylor, Martin C. and Tielens, Aloysius G. M. and Urbaniak, Michael D. and van Hellemond, Jaap J. and Vincent, Isabel M. and Wilkinson, Shane R. and Wyllie, Susan and Opperdoes, Fred R. and Barrett, Michael P. and Jourdan, Fabien. (2015) TrypanoCyc : a community-led biochemical pathways database for Trypanosoma brucei. Nucleic Acids Research, 43 (D1). D637-D644.

Steinmann, Michael E. and González-Salgado, Amaia and Bütikofer, Peter and Mäser, Pascal and Sigel, Erwin. (2015) A heteromeric potassium channel involved in the modulation of the plasma membrane potential is essential for the survival of African trypanosomes. The FASEB journal, Vol. 29, H. 8. pp. 3228-3237.

Tasdemir, Deniz and Tierney, Michelle and Sen, Rupashree and Bergonzi, Maria Camilla and Demirci, Betül and Bilia, Anna Rita and Baser, Kemal Hüsnü Can and Brun, Reto and Chatterjee, Mitali. (2015) Antiprotozoal effect of Artemisia indica extracts and essential oil. Planta medica, 81 (12-13). pp. 1029-1037.

Thao, Nguyen Phuong and Luyen, Bui Thi Thuy and Brun, Reto and Kaiser, Marcel and Van Kiem, Phan and Van Minh, Chau and Schmidt, Thomas J. and Kang, Jong Seong and Kim, Young Ho. (2015) Anti-protozoal activities of cembrane-type diterpenes from Vietnamese soft corals. Molecules, Vol. 20, H. 7. pp. 12459-12468.

Thuita, John K. and Wolf, Kristina K. and Murilla, Grace A. and Bridges, Arlene S. and Boykin, David W. and Mutuku, James N. and Liu, Qiang and Jones, Susan K. and Gem, Charles O. and Ching, Shelley and Tidwell, Richard R. and Wang, Michael Z. and Paine, Mary F. and Brun, Reto. (2015) Chemotherapy of second stage human African trypanosomiasis : comparison between the parenteral diamidine DB829 and its oral prodrug DB868 in vervet monkeys. PLoS neglected tropical diseases, Vol. 9, H. 2 , e3409.

Wang, X. and Dong, Y. and Cal, M. and Kasier, M. and Wittling, S. and Vennerstrom, J. L.. (2015) Antiprotozoal selectivity of diimidazoline N-phenylbenzamides. ACS infectious diseases, 1. pp. 135-139.

Witschel, Matthias C. and Rottmann, Matthias and Schwab, Anatol and Leartsakulpanich, Ubolsree and Chitnumsub, Penchit and Seet, Michael and Tonazzi, Sandro and Schwertz, Geoffrey and Stelzer, Frank and Mietzner, Thomas and McNamara, Case and Thater, Frank and Freymond, Céline and Jaruwat, Aritsara and Pinthong, Chatchadaporn and Riangrungroj, Pinpunya and Oufir, Mouhssin and Hamburger, Matthias and Mäser, Pascal and Sanz-Alonso, Laura M. and Charman, Susan and Wittlin, Sergio and Yuthavong, Yongyuth and Chaiyen, Pimchai and Diederich, François. (2015) Inhibitors of plasmodial serine hydroxymethyltransferase (SHMT) : co-crystal structures of pyrazolopyrans with potent blood-and liver-stage activities. Journal of Medicinal Chemistry, 58 (7). pp. 3117-3130.

de Macêdo, Juan P. and Schumann Burkard, Gabriela and Niemann, Moritz and Barrett, Michael P. and Vial, Henri and Mäser, Pascal and Roditi, Isabel and Schneider, André and Bütikofer, Peter. (2015) An atypical mitochondrial carrier that mediates drug action in Trypanosoma brucei. PLoS Pathogens, Vol. 11, H. 5 , e1004875.

2014

Althaus, Julia B. and Jerz, Gerold and Winterhalter, Peter and Kaiser, Marcel and Brun, Reto and Schmidt, Thomas J.. (2014) Antiprotozoal activity of Buxus sempervirens and activity-guided isolation of O-tigloylcyclovirobuxeine-B as the main constituent active against Plasmodium falciparum. Molecules : a journal of synthetic chemistry and natural product chemistry, Vol. 19, H. 5. pp. 6184-6201.

Althaus, Julia B. and Kaiser, Marcel and Brun, Reto and Schmidt, Thomas J.. (2014) Antiprotozoal activity of achillea ptarmica (Asteraceae) and its main alkamide constituents. Molecules : a journal of synthetic chemistry and natural product chemistry, Vol. 19, H. 5. pp. 6428-6438.

Bapela, M. Johanna and Meyer, J. J. Marion and Kaiser, Marcel. (2014) In vitro antiplasmodial screening of ethnopharmacologically selected South African plant species used for the treatment of malaria. Journal of ethnopharmacology : an interdisciplinary journal devoted to bioscientific research on indigenous drugs, Vol. 156. pp. 370-373.

Belluti, Federica and Uliassi, Elisa and Veronesi, Giacomo and Bergamini, Christian and Kaiser, Marcel and Brun, Reto and Viola, Angelo and Fato, Romana and Michels, Paul A. M. and Krauth-Siegel, R. Luise and Cavalli, Andrea and Bolognesi, Maria Laura. (2014) Toward the development of dual-targeted glyceraldehyde-3-phosphate dehydrogenase/trypanothione reductase inhibitors against Trypanosoma brucei and Trypanosoma cruzi. ChemMedChem : chemistry enabling drug discovery, Vol. 9, H. 2. pp. 371-382.

Burri, C. and Chappuis, F. and Brun, R.. (2014) Human African trypanosomiasis. In: Manson's Tropical Diseases. - 23rd ed.. [Edinburgh], pp. 606-621.

Carballeira, Néstor M. and Bwalya, Angela Gono and Itoe, Maurice Ayamba and Andricopulo, Adriano D. and Cordero-Maldonado, María Lorena and Kaiser, Marcel and Mota, Maria M. and Crawford, Alexander D. and Guido, Rafael V. C. and Tasdemir, Deniz. (2014) 2-Octadecynoic acid as a dual life stage inhibitor of Plasmodium infections and plasmodial FAS-II enzymes. Bioorganic & medicinal chemistry letters, Vol. 24, H. 17. pp. 4151-4157.

Carvalho, Samir Aquino and Kaiser, Marcel and Brun, Reto and Silva, Edson Ferreira da and Fraga, Carlos Alberto Manssour. (2014) Antiprotozoal activity of (e)-cinnamic N-acylhydrazone derivatives. Molecules, Vol. 19, H. 12. pp. 20374-20381.

Cretton, Sylvian and Breant, Lise and Pourrez, Lucie and Ambuehl, Chiara and Marcourt, Laurence and Ebrahimi, Samad Nejad and Hamburger, Matthias and Perozzo, Remo and Karimou, Soumana and Kaiser, Marcel and Cuendet, Muriel and Christen, Philippe. (2014) Antitrypanosomal quinoline alkaloids from the roots of Waltheria indica. Journal of natural products, Vol. 77, H. 10. pp. 2304-2311.

D. A. Silva, Cristiane França and Batista, Denise DA Gama Jaen and Batista, Marcos Meuser and Lionel, Jessica and Hammer, Erica Ripoll and Brun, Reto and Soeiro, Maria DE Nazaré Correia. (2014) In vitro and in vivo activity of the chloroaryl-substituted imidazole viniconazole against Trypanosoma cruzi. Parasitology, Vol. 141, H. 3. pp. 367-373.

Dandapani, S. and Germain, A. R. and Jewett, I. and Le Quement, S. and Marie, JC. and Muncipinto, G. and Duvall, J. R. and Carmody, L. C. and Perez, J. R. and Engel, J. C. and Gut, J. and Kellar, D. and Siqueira-Neto, J. L. and McKerrow, J. H. and Kaiser, M. and Rodriquez, A. and Palmer, M. A. and Foley, M. and Schreiber, S. L. and Munoz, B.. (2014) Diversity-oriented synthesis yields a new drug lead for treatment of Chagas disease. ACS medicinal chemistry letters, Vol. 5, H. 2. pp. 149-153.

Dong, Yuxiang and Wang, Xiaofang and Cal, Monica and Kaiser, Marcel and Vennerstrom, Jonathan L.. (2014) Activity of diimidazoline amides against African trypanosomiasis. Bioorganic & medicinal chemistry letters, Vol. 24, H. 3. pp. 944-948.

Ferrins, Lori and Gazdik, Michelle and Rahmani, Raphaël and Varghese, Swapna and Sykes, Melissa L. and Jones, Amy J. and Avery, Vicky M. and White, Karen L. and Ryan, Eileen and Charman, Susan A. and Kaiser, Marcel and Bergström, Christel A. S. and Baell, Jonathan B.. (2014) Pyridyl benzamides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei. Journal of medicinal chemistry, 57 (15). pp. 6393-6402.

Fuchs, Sebastian W. and Grundmann, Florian and Kurz, Michael and Kaiser, Marcel and Bode, Helge B.. (2014) Fabclavines : bioactive peptide-polyketide-polyamino hybrids from Xenorhabdus. ChemBioChem : a European journal of chemical biology, Vol. 15, H. 4. pp. 512-516.

Fügi, Matthias. Membrane therapy for chagas' disease. 2014, Doctoral Thesis, University of Basel, Faculty of Science.

Fügi, Matthias A. and Gunasekera, Kapila and Ochsenreiter, Torsten and Guan, Xueli and Wenk, Markus R. and Mäser, Pascal. (2014) Genome profiling of sterol synthesis shows convergent evolution in parasites and guides chemotherapeutic attack. Journal of Lipid Research, 55 (5). pp. 929-938.

Fügi, Matthias A. and Kaiser, Marcel and Tanner, Marcel and Schneiter, Roger and Mäser, Pascal and Guan, Xue Li. (2014) Match-making for posaconazole through systems thinking. Trends in parasitology, Vol. 31, H. 2. pp. 46-51.

Giordani, Federica and Buschini, Annamaria and Baliani, Alessandro and Kaiser, Marcel and Brun, Reto and Barrett, Michael P. and Pellacani, Claudia and Poli, Paola and Gilbert, Ian H.. (2014) Characterization of a melamino nitroheterocycle as a potential lead for the treatment of human african trypanosomiasis. Antimicrobial agents and chemotherapy, Vol. 58, H. 10. pp. 5747-5757.

González Cabrera, Diego and Le Manach, Claire and Douelle, Frederic and Younis, Yassir and Feng, Tzu-Shean and Paquet, Tanya and Nchinda, Aloysius T. and Street, Leslie J. and Taylor, Dale and de Kock, Carmen and Wiesner, Lubbe and Duffy, Sandra and White, Karen L. and Zabiulla, K. Mohammed and Sambandan, Yuvaraj and Bashyam, Sridevi and Waterson, David and Witty, Michael J. and Charman, Susan A. and Avery, Vicky M. and Wittlin, Sergio and Chibale, Kelly. (2014) 2,4-diaminothienopyrimidines as orally active antimalarial agents. Journal of medicinal chemistry, 57 (3). pp. 1014-1022.

Grundmann, Florian and Kaiser, Marcel and Schiell, Matthias and Batzer, Andreas and Kurz, Michael and Thanwisai, Aunchalee and Chantratita, Narisara and Bode, Helge B.. (2014) Antiparasitic chaiyaphumines from Entomopathogenic xenorhabdus sp. PB61.4. Journal of natural products, Vol. 77, H. 4. pp. 779-783.

Hanna, J. N. and Ntie-Kang, F. and Kaiser, M. and Brun, R. and Efange, S. M. N.. (2014) 1-Aryl-1,2,3,4-tetrahydroisoquinolines as potential antimalarials : synthesis, in vitro antiplasmodial activity and in silico pharmacokinetics evaluation. RSC advances, Vol. 4, H. 44 ,22856-22865.

Harms, Henrik and Rempel, Viktor and Kehraus, Stefan and Kaiser, Marcel and Hufendiek, Peter and Müller, Christa E. and König, Gabriele M.. (2014) Indoloditerpenes from a marine-derived fungal strain of Dichotomomyces cejpii with antagonistic activity at GPR18 and cannabinoid receptors. Journal of natural products, Vol. 77, H. 3. pp. 673-677.

Hata, Y. and De Mieri, M. and Ebrahimi, S. N. and Mokoka, T. and Fouche, G. and Kaiser, M. and Brun, R. and Potterat, O. and Hamburger, M.. (2014) Identification of two new phenathrenones and a saponin as antiprotozoal constituents of Drypetes gerrardii. Phytochemistry letters, Vol. 10. pp. 133-140.

Hata, Yoshie and Ebrahimi, Samad Nejad and De Mieri, Maria and Zimmermann, Stefanie and Mokoka, Tsholofelo and Naidoo, Dashnie and Fouche, Gerda and Maharaj, Vinesh and Kaiser, Marcel and Brun, Reto and Potterat, Olivier and Hamburger, Matthias. (2014) Antitrypanosomal isoflavan quinones from Abrus precatorius. Fitoterapia, Vol. 93. pp. 81-87.

Julianti, Tasqiah and De Mieri, Maria and Zimmermann, Stefanie and Ebrahimi, Samad N. and Kaiser, Marcel and Neuburger, Markus and Raith, Melanie and Brun, Reto and Hamburger, Matthias. (2014) HPLC-based activity profiling for antiplasmodial compounds in the traditional Indonesian medicinal plant Carica papaya L. Journal of ethnopharmacology, Vol. 155, H. 1. pp. 426-434.

Kronenwerth, M. and Dauth, C. and Kaiser, M. and Pemberton, I. and Bode, H. B.. (2014) Facile synthesis of cyclohexanediones and dialkylresorcinols : bioactive natural products from entomopathogenic bacteria. European journal of organic chemistry, H. 36. pp. 8026-8028.

Kronenwerth, Max and Bozhüyük, Kenan A. J. and Kahnt, Astrid S. and Steinhilber, Dieter and Gaudriault, Sophie and Kaiser, Marcel and Bode, Helge B.. (2014) Characterisation of taxlllaids A-G : natural products from Xenorhabdus indica. Chemistry : a European journal, Vol. 20, H. 52. pp. 17478-17487.

Kronenwerth, Max and Brachmann, Alexander O. and Kaiser, Marcel and Bode, Helge B.. (2014) Bioactive derivatives of isopropylstilbene from mutasynthesis and chemical synthesis. ChemBioChem : a European journal of chemical biology, Vol. 15, H. 18. pp. 2689-2691.

Kuhen, Kelli L. and Chatterjee, Arnab K. and Rottmann, Matthias and Gagaring, Kerstin and Borboa, Rachel and Buenviaje, Jennifer and Chen, Zhong and Francek, Carolyn and Wu, Tao and Nagle, Advait and Barnes, S. Whitney and Plouffe, David and Lee, Marcus C. S. and Fidock, David A. and Graumans, Wouter and van de Vegte-Bolmer, Marga and van Gemert, Geert J. and Wirjanata, Grennady and Sebayang, Boni and Marfurt, Jutta and Russell, Bruce and Suwanarusk, Rossarin and Price, Ric N. and Nosten, Francois and Tungtaeng, Anchalee and Gettayacamin, Montip and Sattabongkot, Jetsumon and Taylor, Jennifer and Walker, John R. and Tully, David and Patra, Kailash P. and Flannery, Erika L. and Vinetz, Joseph M. and Renia, Laurent and Sauerwein, Robert W. and Winzeler, Elizabeth A. and Glynne, Richard J. and Diagana, Thierry T.. (2014) KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment, and prevention of disease transmission. Antimicrobial agents and chemotherapy, Vol. 58, H. 9. pp. 5060-5067.

Kunfermann, Andrea and Witschel, Matthias and Illarionov, Boris and Martin, René and Rottmann, Matthias and Höffken, H. Wolfgang and Seet, Michael and Eisenreich, Wolfgang and Knölker, Hans-Joachim and Fischer, Markus and Bacher, Adelbert and Groll, Michael and Diederich, François. (2014) Pseudilins : halogenated, allosteric inhibitors of the non-mevalonate pathway enzyme IspD. Angewandte Chemie. International edition in English, Vol. 53, H. 8. pp. 2235-2239.

Le Manach, Claire and Gonzàlez Cabrera, Diego and Douelle, Frederic and Nchinda, Aloysius T. and Younis, Yassir and Taylor, Dale and Wiesner, Lubbe and White, Karen L. and Ryan, Eileen and March, Corinne and Duffy, Sandra and Avery, Vicky M. and Waterson, David and Witty, Michael J. and Wittlin, Sergio and Charman, Susan A. and Street, Leslie J. and Chibale, Kelly. (2014) Medicinal chemistry optimization of antiplasmodial imidazopyridazine hits from high throughput screening of a SoftFocus kinase library : part 1. Journal of medicinal chemistry, 57 (6). pp. 2789-2798.

Le Manach, Claire and Paquet, Tanya and Gonzàlez Cabrera, Diego and Younis, Yassir and Taylor, Dale and Wiesner, Lubbe and Lawrence, Nina and Schwager, Sylva and Waterson, David and Witty, Michael J. and Wittlin, Sergio and Street, Leslie J. and Chibale, Kelly. (2014) Medicinal chemistry optimization of antiplasmodial imidazopyridazine hits from high throughput screening of a softfocus kinase library : part 2. Journal of medicinal chemistry, 57 (21). pp. 8839-8848.

Leven, Michael and Held, Jana and Duffy, Sandra and Tschan, Serena and Sax, Sibylle and Kamber, Jolanda and Frank, Walter and Kuna, Krystina and Geffken, Detlef and Siethoff, Christoph and Barth, Stéphane and Avery, Vicky M. and Wittlin, Sergio and Mordmüller, Benjamin and Kurz, Thomas. (2014) Blood schizontocidal and gametocytocidal activity of 3-hydroxy-N'-arylidenepropanehydrazonamides. Journal of medicinal chemistry, 57 (19). pp. 7971-7976.

Liu, Zong-Ying and Wenzler, Tanja and Brun, Reto and Zhu, Xiaohua and Boykin, David W.. (2014) Synthesis and antiparasitic activity of new bis-arylimidamides : DB766 analogs modified in the terminal groups. European journal of medicinal chemistry, 83. pp. 167-173.

Lüscher, Alexandra and Lamprea-Burgunder, Estelle and Graf, Fabrice E. and de Koning, Harry P. and Mäser, Pascal. (2014) Trypanosoma brucei adenine-phosphoribosyltransferases mediate adenine salvage and aminopurinol susceptibility but not adenine toxicity. International journal for parasitology : drugs and drug resistance, Vol. 4, H. 1. pp. 55-63.

Mathieu, Christoph and Salgado, Amaia González and Wirdnam, Corina and Meier, Stefan and Grotemeyer, Marianne Suter and Inbar, Ehud and Mäser, Pascal and Zilberstein, Dan and Sigel, Erwin and Bütikofer, Peter and Rentsch, Doris. (2014) Trypanosoma brucei eflornithine transporter AAT6 is a low-affinity low-selective transporter for neutral amino acids. Biochemical journal, Vol. 463, Pt. 1. pp. 9-18.

Mizukawa, Yuki and Ge, Jian-Feng and Bakar Md, Abu and Itoh, Isamu and Scheurer, Christian and Wittlin, Sergio and Brun, Reto and Matsuoka, Hiroyuki and Ihara, Masataka. (2014) Novel synthetic route for antimalarial benzo[a]phenoxazine derivative SSJ-183 and two active metabolites. Bioorganic & medicinal chemistry, 22 (14). pp. 3749-3752.

Mohsin, N. U. A. and Seebacher, W. and Faist, J. and Belaj, F. and Saf, R. and Kaiser, M. and Brun, R. and Weis, R.. (2014) Synthesis of antiprotozoal diamines by regioselective insertion of nitrogen into a bicyclic ring system. Monatshefte für Chemie, Vol. 145, H. 8. pp. 1319-1327.

Mokoka, Tsholofelo A. and Peter, Xolani K. and Fouche, Gerda and Moodley, Nivan and Adams, Michael and Hamburger, Matthias and Kaiser, Marcel and Brun, Reto and Maharaj, Vinesh and Koorbanally, Neil. (2014) Antileishmanial activity of 12-methoxycarnosic acid from Salvia repens Buch. ex Benth. (Lamiaceae). South African journal of botany, Vol. 90. pp. 93-95.

Munday, Jane C. and Eze, Anthonius A. and Baker, Nicola and Glover, Lucy and Clucas, Caroline and Aguinaga Andrés, David and Natto, Manal J. and Teka, Ibrahim A. and McDonald, Jennifer and Lee, Rebecca S. and Graf, Fabrice E. and Ludin, Philipp and Burchmore, Richard J. S. and Turner, C. Michael R. and Tait, Andy and MacLeod, Annette and Mäser, Pascal and Barrett, Michael P. and Horn, David and De Koning, Harry P.. (2014) Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs. Journal of Antimicrobial Chemotherapy, Vol. 69, H. 3. pp. 651-663.

Nwodo, Ngozi Justina and Okoye, Festus Basden C. and Lai, Daowan and Debbab, Abdessamad and Brun, Reto and Proksch, Peter. (2014) Two trypanocidal dipeptides from the roots of Zapoteca portoricensis (Fabaceae). Molecules, Vol. 19, H. 5. pp. 5470-5477.

Orhan, Ilkay Erdogan and Sener, Bilge and Kaiser, Marcel and Brun, Reto and Tasdemir, Deniz. (2014) Antiprotozoal activity and cytotoxicity of Lycopodium clavatum and Lycopodium complanatum subsp. chamaecyparissus extracts. Turkish journal of biochemistry, Vol. 38, H. 4. pp. 403-408.

Papadopoulou, Maria V. and Bloomer, William D. and Rosenzweig, Howard S. and Wilkinson, Shane R. and Kaiser, Marcel. (2014) Novel nitro(triazole/imidazole)-based heteroarylamides/sulfonamides as potential antitrypanosomal agents. European journal of medicinal chemistry, 87. pp. 79-88.

Patrick, Donald A. and Bakunov, Stanislav A. and Bakunova, Svetlana M. and Wenzler, Tanja and Brun, Reto and Tidwell, Richard R.. (2014) Antiprotozoal activity of dicationic 3,5-diphenylisoxazoles, their prodrugs and aza-analogues. Bioorganic & medicinal chemistry, 22 (1). pp. 559-576.

Persch, Elke and Bryson, Steve and Todoroff, Nickolay K. and Eberle, Christian and Thelemann, Jonas and Dirdjaja, Natalie and Kaiser, Marcel and Weber, Maria and Derbani, Hassan and Brun, Reto and Schneider, Gisbert and Pai, Emil F. and Krauth-Siegel, R. Luise and Diederich, François. (2014) Binding to large enzyme pockets : small-molecule inhibitors of trypanothione reductase. ChemMedChem, Vol. 9, H. 8. pp. 1880-1891.

Portmann, Cyril and Sieber, Simon and Wirthensohn, Silvan and Blom, Judith F. and Da Silva, Laeticia and Baudat, Emilie and Kaiser, Marcel and Brun, Reto and Gademann, Karl. (2014) Balgacyclamides, antiplasmodial heterocyclic peptides from Microcystis aeruguinosa EAWAG 251. Journal of natural products, Vol. 77, H. 3. pp. 557-562.

Reimer, Daniela and Nollmann, Friederike I. and Schultz, Katharina and Kaiser, Marcel and Bode, Helge B.. (2014) Xenortide biosynthesis by entomopathogenic xenorhabdus nematophila. Journal of natural products, 77 (8). pp. 1976-1980.

Reker, Daniel and Seet, Michael and Pillong, Max and Koch, Christian P. and Schneider, Petra and Witschel, Matthias C. and Rottmann, Matthias and Freymond, Céline and Brun, Reto and Schweizer, Bernd and Illarionov, Boris and Bacher, Adelbert and Fischer, Markus and Diederich, François and Schneider, Gisbert. (2014) Deorphaning pyrrolopyrazines as potent multi-target antimalarial agents. Angewandte Chemie, Jg. 53, Nr. 27. pp. 7079-7084.

Ríos Martínez, Carlos H. and Lagartera, Laura and Kaiser, Marcel and Dardonville, Christophe. (2014) Antiprotozoal activity and DNA binding of N-substituted N-phenylbenzamide and 1,3-diphenylurea bisguanidines. European journal of medicinal chemistry, 81. pp. 481-491.

Schmidt, Thomas J. and Da Costa, Fernando B. and Lopes, Norberto P. and Kaiser, Marcel and Brun, Reto. (2014) In Silico prediction and experimental evaluation of furanoheliangolide sesquiterpene lactones as potent agents against Trypanosoma brucei rhodesiense. Antimicrobial agents and chemotherapy, Vol. 58, H. 1. pp. 325-332.

Sistrom, Mark and Evans, Benjamin and Bjornson, Robert and Gibson, Wendy and Balmer, Oliver and Mäser, Pascal and Aksoy, Serap and Caccone, Adalgisa. (2014) Comparative genomics reveals multiple genetic backgrounds of human pathogenicity in the Trypanosoma brucei complex. Genome biology and evolution, Vol. 6, H. 10. pp. 2811-2819.

Tatipaka, Hari Babu and Gillespie, J. Robert and Chatterjee, Arnab K. and Norcross, Neil R. and Hulverson, Matthew A. and Ranade, Ranae M. and Nagendar, Pendem and Creason, Sharon A. and McQueen, Joshua and Duster, Nicole A. and Nagle, Advait and Supek, Frantisek and Molteni, Valentina and Wenzler, Tanja and Brun, Reto and Glynne, Richard and Buckner, Frederick S. and Gelb, Michael H.. (2014) Substituted 2-phenylimidazopyridines : a new class of drug leads for human African trypanosomiasis. Journal of medicinal chemistry, 57 (3). pp. 828-835.

Urbán, Patricia and Valle-Delgado, Juan José and Mauro, Nicolò and Marques, Joana and Manfredi, Amedea and Rottmann, Matthias and Ranucci, Elisabetta and Ferruti, Paolo and Fernàndez-Busquets, Xavier. (2014) Use of poly(amidoamine) drug conjugates for the delivery of antimalarials to Plasmodium. Journal of controlled release : official journal of the Controlled Release Society, Vol. 177. pp. 84-95.

Usuki, Toyonobu and Sato, Makiko and Hara, Shihori and Yoshimoto, Yukiko and Kondo, Ryosuke and Zimmermann, Stefanie and Kaiser, Marcel and Brun, Reto and Hamburger, Matthias and Adams, Michael. (2014) Antitrypanosomal structure-activity-relationship study of synthetic cynaropicrin derivatives. Bioorganic & medicinal chemistry letters, Vol. 24, H. 3. pp. 794-798.

Wang, Jiayi and Kaiser, Marcel and Copp, Brent R.. (2014) Investigation of indolglyoxamide and indolacetamide analogues of polyamines as antimalarial and antitrypanosomal agents. Marine drugs, Vol. 12, H. 6. pp. 3138-3160.

Wang, N. and Wicht, K. J. and Shaban, E. and Ngoc, T. A. and Wang, M. Q. and Hayashi, I. and Hossain, M. I. and Takemasa, Y. and Kaiser, M. and El Sayed, I. E. T. and Egan, T. J. and Inokuchi, T.. (2014) Synthesis and evaluation of artesunate-indoloquinoline hybrids as antimalarial drug candidates. MedChemComm : Medicinal chemistry communications, Vol. 5, H. 7. pp. 927-931.

Wang, Ning and Wicht, Kathryn J. and Imai, Kento and Wang, Ming-Qi and Anh Ngoc, Tran and Kiguchi, Ryo and Kaiser, Marcel and Egan, Timothy J. and Inokuchi, Tsutomu. (2014) Synthesis, β-haematin inhibition, and in vitro antimalarial testing of isocryptolepine analogues : SAR study of indolo[3,2-c]quinolines with various substituents at C2, C6, and N11. Bioorganic & medicinal chemistry, 22 (9). pp. 2629-2642.

Wang, Tai and Bisson, William H. and Mäser, Pascal and Scapozza, Leonardo and Picard, Didier. (2014) Differences in conformational dynamics between Plasmodium falciparum and human Hsp90 orthologues enable the structure-based discovery of pathogen-selective inhibitors. Journal of medicinal chemistry, 57 (6). pp. 2524-2535.

Weis, R. and Seebacher, W. and Brun, R. and Kaiser, M. and Saf, R. and Faist, J.. (2014) 4-Aminobicyclo[2.2.2]octan-2-yl 4-aminobutanoates with antiprotozoal activity. Monatshefte für Chemie, Vol. 145, H. 2. pp. 311-317.

Wenzler, Tanja and Yang, Sihyung and Patrick, Donald A. and Braissant, Olivier and Ismail, Mohamed A. and Tidwell, Richard R. and Boykin, David W. and Wang, Michael Zhuo and Brun, Reto. (2014) In vitro and In vivo evaluation of 28DAP010, a novel diamidine for treatment of second-stage African sleeping sickness. Antimicrobial agents and chemotherapy, Vol. 58, H. 8. pp. 4452-4463.

Wube, Abraham and Hüfner, Antje and Seebacher, Werner and Kaiser, Marcel and Brun, Reto and Bauer, Rudolf and Bucar, Franz. (2014) 1,2-substituted 4-(1H)-quinolones : synthesis, antimalarial and antitrypanosomal activities in vitro. Molecules, Vol. 19, H. 9. pp. 14204-14220.

Yang, Sihyung and Wenzler, Tanja and Miller, Patrik N. and Wu, Huali and Boykin, David W. and Brun, Reto and Wang, Michael Zhuo. (2014) Pharmacokinetic comparison to determine the mechanisms underlying the differential efficacies of cationic diamidines against first- and second-stage human African trypanosomiasis. Antimicrobial agents and chemotherapy, Vol. 58, H. 7. pp. 4064-4074.

Zimmermann, S. and Fouche, G. and de Mieri, M. and Yoshimoto, Y. and Usuki, R. and Nthambeleni, R. and van der Westhuyzen, C. and Kaiser, M. and Hamburger, M. and Adams, M.. (2014) Structure-activity relationship study of sesquiterpene lactones and their semi-synthetic amino derivatives as potential antitrypanosomal products. Molecules, 19 (3). pp. 3523-3538.

de Meijere, Armin and Kozhushkov, Sergei I. and Yufit, Dmitrii S. and Grosse, Christian and Kaiser, Marcel and Raev, Vitaly A.. (2014) (2R,1'S,2'R)- and (2S,1'S,2'R)-3-[2-Mono(di,tri)fluoromethylcyclopropyl]alanines and their incorporation into hormaomycin analogues. Beilstein journal of organic chemistry, Vol. 10. pp. 2844-2857.

2013

Abiodun, Oyindamola O. and Brun, Reto and Wittlin, Sergio. (2013) In vitro interaction of artemisinin derivatives or the fully synthetic peroxidic anti-malarial OZ277 with thapsigargin in Plasmodium falciparum strains. Malaria journal, Vol. 12 , 43.

Ali, J. A. M. and Creek, D. J. and Burgess, K. and Allison, H. C. and Field, M. C. and Mäser, P. and de Koning, H. P.. (2013) Pyrimidine salvage in Trypanosoma brucei bloodstream forms and the trypanocidal action of halogenated pyrimidines. Molecular pharmacology : an international journal, Vol. 83, H. 2. pp. 439-453.

Aureggi, V. and Ehmke, V. and Wieland, J. and Schweizer, W. B. and Bernet, B. and Bur, D. and Meyer, S. and Rottmann, M. and Freymond, C. and Brun, R. and Breit, B. and Diederich, F.. (2013) Potent inhibitors of malarial aspartic proteases, the plasmepsins, by hydroformylation of substituted 7-azanorbornenes. Chemistry : a European journal, Vol. 19, H. 1. pp. 155-164.

Baker, Nicola and de Koning, Harry P. and Mäser, Pascal and Horn, David. (2013) Drug resistance in African trypanosomiasis: the melarsoprol and pentamidine story. Trends in parasitology, Vol. 29, H. 3. pp. 110-118.

Balmer, Oliver and Pfiffner, Lukas and Schied, Johannes and Willareth, Martin and Leimgruber, Andrea and Luka, Henryk and Traugott, Michael. (2013) Noncrop flowering plants restore top-down herbivore control in agricultural fields. Ecology and Evolution, 3 (8). pp. 2634-2646.

Belluti, Federica and Perozzo, Remo and Lauciello, Leonardo and Colizzi, Francesco and Kostrewa, Dirk and Bisi, Alessandra and Gobbi, Silvia and Rampa, Angela and Bolognesi, Maria Laura and Recanatini, Maurizio and Brun, Reto and Scapozza, Leonardo and Cavalli, Andrea. (2013) Design, synthesis, and biological and crystallographic evaluation of novel inhibitors of Plasmodium falciparum enoyl-ACP-reductase (PfFabI). Journal of medicinal chemistry, 56 (19). pp. 7516-7526.

Belz, E. and Kölliker, M. and Balmer, O.. (2013) Olfactory attractiveness of flowering plants to the parasitoid Microplitis mediator : potential implications for biological control. BioControl : journal of the International Organization for Biological Control, Vol. 58, H. 2. pp. 163-173.

Bringmann, G. and Zhang, G. and Büttner, T. and Bauckmann, G. and Kupfer, T. and Braunschweig, H. and Brun, R. and Mudogo, V.. (2013) Jozimine A2 : the first dimeric dioncophyllaceae-type naphthylisoquinoline alkaloid, with three chiral axes and high antiplasmodial activity. Chemistry : a European journal, Vol. 19, H. 3. pp. 916-923.

Bringmann, Gerhard and Lombe, Blaise Kimbadi and Steinert, Claudia and Ioset, Karine Ndjoko and Brun, Reto and Turini, Florian and Heubl, Günther and Mudogo, Virima. (2013) Mbandakamines A and B, unsymmetrically coupled dimeric naphthylisoquinoline alkaloids, from a Congolese ancistrocladus species. Organic letters, Vol. 15, H. 11. pp. 2590-2593.

Bringmann, Gerhard and Zhang, Guoliang and Olschläger, Tobias and Stich, August and Wu, Jun and Chatterjee, Manik and Brun, Reto. (2013) Highly selective antiplasmodial naphthylisoquinoline alkaloids from Ancistrocladus tectorius. Phytochemistry : an international journal of plant biochemistry, Vol. 91. pp. 220-228.

Brunner, R. and Ng, C. L. and Aissaoui, H. and Akabas, M. H. and Boss, C. and Brun, R. and Callaghan, P. S. and Corminboeuf, O. and Fidock, D. A. and Frame, I. J. and Heidmann, B. and Le Bihan, A. and Jeno, P. and Mattheis, C. and Moes, S. and Muller, I. B. and Paguio, M. and Roepe, P. D. and Siegrist, R. and Voss, T. and Welford, R. W. and Wittlin, S. and Binkert, C.. (2013) UV-triggered affinity capture identifies interactions between the Plasmodium falciparum multidrug resistance protein 1 (PfMDR1) and antimalarial agents in live parasitized cells. Journal of biological chemistry, Vol. 288, H. 31. pp. 22576-22583.

Bruno, M. and Trucchi, B. and Monti, D. and Romeo, S. and Kaiser, M. and Verotta, L.. (2013) Synthesis of a potent antimalarial agent through natural products conjugation. ChemMedChem : chemistry enabling drug discovery, Vol. 8, H. 2. pp. 221-225.

Chianese, Giuseppina and Scala, Fernando and Calcinai, Barbara and Cerrano, Carlo and Dien, Henny A. and Kaiser, Marcel and Tasdemir, Deniz and Taglialatela-Scafati, Orazio. (2013) Natural and semisynthetic analogues of manadoperoxide B reveal new structural requirements for trypanocidal activity. Marine drugs, Vol. 11, H. 9. pp. 3297-3308.

Ciana, C. L. and Siegrist, R. and Aissaoui, H. and Marx, L. and Racine, S. and Meyer, S. and Binkert, C. and de Kanter, R. and Fischli, C. and Wittlin, S. and Boss, C.. (2013) Novel in vivo active anti-malarials based on a hydroxy-ethyl-amine scaffold. Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 23, H. 3. pp. 658-662.

Dürüst, Y. and Altug, C. and Kaiser, M. and Fronczek, F. R. and Tasdemir, D.. (2013) Synthesis, crystal structure, and in vitro antiprotozoal activity of some 5-phenyl(methyl)sulfonyl-substituted dihydroisoxazoles. Monatshefte für Chemie, Vol. 144, H. 5. pp. 707-716.

Ebrahimi, Samad N. and Zimmermann, Stefanie and Zaugg, Janine and Smiesko, Martin and Brun, Reto and Hamburger, Matthias. (2013) Abietane Diterpenoids from Salvia sahendica - Antiprotozoal Activity and Determination of Their Absolute Configurations. Planta medica, Vol. 79, H. 2. pp. 150-156.

Ehmke, Veronika and Winkler, Edwin and Banner, David W. and Haap, Wolfgang and Schweizer, W. Bernd and Rottmann, Matthias and Kaiser, Marcel and Freymond, Céline and Schirmeister, Tanja and Diederich, François. (2013) Optimization of triazine nitriles as rhodesain inhibitors : structure-activity relationships, bioisosteric imidazopyridine nitriles, and X-ray crystal structure analysis with human cathepsin L. ChemMedChem : chemistry enabling drug discovery, Vol. 8, H. 6. pp. 967-975.

Endeshaw, Molla and Zhu, Xiaohua and He, Shanshan and Pandharkar, Trupti and Cason, Emily and Mahasenan, Kiran V. and Agarwal, Hitesh and Li, Chenglong and Munde, Manoj and Wilson, W. David and Bahar, Mark and Doskotch, Raymond W. and Kinghorn, A. Douglas and Kaiser, Marcel and Brun, Reto and Drew, Mark E. and Werbovetz, Karl A.. (2013) 8,8-dialkyldihydroberberines with potent antiprotozoal activity. Journal of natural products, Vol. 76, H. 3. pp. 311-315.

Faist, Johanna and Seebacher, Werner and Kaiser, Marcel and Brun, Reto and Saf, Robert and Weis, Robert. (2013) Antiprotozoal activity of bicyclic diamines with a N-methylpiperazinyl group at the bridgehead atom. Bioorganic & medicinal chemistry : a Tetrahedron publication for the rapid dissemenination of full original research papers and critical reviews on biomolecular chemistry, medicinal chemistry and related disciplines, 21 (17). pp. 4988-4996.

Ferrins, Lori and Rahmani, Raphaël and Sykes, Melissa L. and Jones, Amy J. and Avery, Vicky M. and Teston, Eliott and Almohaywi, Basmah and Yin, Jiexiang and Smith, Jason and Hyland, Chris and White, Karen L. and Ryan, Eileen and Campbell, Michael and Charman, Susan A. and Kaiser, Marcel and Baell, Jonathan B.. (2013) 3-(Oxazolo[4,5-b]pyridin-2-yl)anilides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei, the causative agent for human African trypanosomiasis. European journal of medicinal chemistry, 66. pp. 450-465.

Friggeri, L. and Scipione, L. and Costi, R. and Kaiser, M. and Moraca, F. and Zamperini, C. and Botta, B. and Di Santo, R. and De Vita, D. and Brun, R. and Tortorella, S.. (2013) New promising compounds with in vitro nanomolar activity against Trypanosoma cruzi. ACS medicinal chemistry letters, Vol. 4, H. 6. pp. 538-541.

Gallé, Jean-Baptiste and Attioua, Barthélémy and Kaiser, Marcel and Rusig, Anne-Marie and Lobstein, Annelise and Vonthron-Sénécheau, Catherine. (2013) Eleganolone, a diterpene from the french marine alga Bifurcaria bifurcata inhibits growth of the human pathogens Trypanosoma brucei and Plasmodium falciparum. Marine drugs, Vol. 11, H. 3. pp. 599-610.

Graf, Fabrice E. and Ludin, Philipp and Wenzler, Tanja and Kaiser, Marcel and Brun, Reto and Pyana, Patient Pati and Büscher, Philippe and de Koning, Harry P. and Horn, David and Mäser, Pascal. (2013) Aquaporin 2 mutations in Trypanosoma brucei gambiense field isolates correlate with decreased susceptibility to pentamidine and melarsoprol. PLoS neglected tropical diseases, Vol. 7, H. 10 , e2475.

Greganova, Eva and Steinmann, Michael and Mäser, Pascal and Fankhauser, Niklaus. (2013) In silico ionomics segregates parasitic from free-living eukaryotes. Genome biology and evolution, Vol. 5, H. 10. pp. 1902-1909.

Grundmann, F. and Kaiser, M. and Kurz, M. and Schiell, M. and Batzer, A. and Bode, H. B.. (2013) Structure determination of the bioactive depsipeptide xenobactin from Xenorhabdus sp. PB30.3. RSC advances, Vol. 3, H. 44. pp. 22072-22077.

Géneau, Celine and Wäckers, Felix and Luka, Henryk and Balmer, Oliver. (2013) Effects of extrafloral and floral nectar of Centaurea cyanus on the parasitoid wasp Microplitis mediator : olfactory attractiveness and parasitization rates. Biological control, Vol. 66, H. 1. pp. 16-20.

Hampton, Shahienaz E. and Schipani, Alessandro and Bosch-Navarrete, Cristina and Recio, Eliseo and Kaiser, Marcel and Kahnberg, Pia and González-Pacanowska, Dolores and Johansson, Nils Gunnar and Gilbert, Ian H.. (2013) Investigation of acyclic uridine amide and 5'-amido nucleoside analogues as potential inhibitors of the Plasmodium falciparum dUTPase. Bioorganic & medicinal chemistry, 21 (18). pp. 5876-5885.

Hao, Hong-Dong and Wittlin, Sergio and Wu, Yikang. (2013) Potent antimalarial 1,2,4-trioxanes through perhydrolysis of epoxides. Chemistry : a European journal, Vol. 19, H. 23. pp. 7605-7619.

Harel, Dipak and Schepmann, Dirk and Brun, Reto and Schmidt, Thomas J. and Wünsch, Bernhard. (2013) Enantioselective synthesis of encecaline-derived potent antimalarial agents. Organic & biomolecular chemistry : an international journal of synthetic, physical and biomolecular organic chemistry, Vol. 11, H. 42. pp. 7342-7349.

Harel, Dipak and Schepmann, Dirk and Prinz, Helge and Brun, Reto and Schmidt, Thomas J. and Wünsch, Bernhard. (2013) Natural product derived antiprotozoal agents : synthesis, biological evaluation, and structure-activity relationships of novel chromene and chromane derivatives. Journal of medicinal chemistry, 56 (18). pp. 7442-7448.

Hata, Yoshie and Raith, Melanie and Ebrahimi, Samad Nejad and Zimmermann, Stefanie and Mokoka, Tsholofelo and Naidoo, Dashnie and Fouche, Gerda and Maharaj, Vinesh and Kaiser, Marcel and Brun, Reto and Hamburger, Matthias. (2013) Antiprotozoal Isoflavan Quinones from Abrus precatorius ssp. africanus. Planta Medica, 79 (6). pp. 492-498.

Hossain, Md Imran and Switalska, Marta and Peng, Wei and Takashima, Mariko and Wang, Ning and Kaiser, Marcel and Wietrzyk, Joanna and Dan, Shingo and Yamori, Takao and Inokuchi, Tsutomu. (2013) Design, synthesis, and in vitro cancer cell growth inhibition evaluation and antimalarial testing of trioxanes installed in cyclic 2-enoate substructures. European journal of medicinal chemistry, 69. pp. 294-309.

Hu, Laixing and Patel, Alpa and Bondada, Lavanya and Yang, Sihyung and Wang, Michael Zhuo and Munde, Manoj and Wilson, W. David and Wenzler, Tanja and Brun, Reto and Boykin, David W.. (2013) Synthesis and antiprotozoal activity of dicationic 2,6-diphenylpyrazines and aza-analogues. Bioorganic & medicinal chemistry, 21 (21). pp. 6732-6741.

Hwang, J. Y. and Smithson, S. C. and Zhu, F. and Holbrook, G. and Connelly, M. C. and Kaiser, M. and Brun, R. and Guy, R. K.. (2013) Optimization of chloronitrobenzamides (CNBs) as therapeutic leads for Human African Trypanosomiasis (HAT). Journal of medicinal chemistry, 56 (7). pp. 2850-2860.

Hwang, Jong Yeon and Smithson, David C. and Holbrook, Gloria and Zhu, Fangyi and Connelly, Michele C. and Kaiser, Marcel and Brun, Reto and Kiplin Guy, R.. (2013) Optimization of the electrophile of chloronitrobenzamide leads active against Trypanosoma brucei. Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 23, H. 14. pp. 4127-4131.

Kemp, Louise E. and Rusch, Marion and Adibekian, Alexander and Bullen, Hayley E. and Graindorge, Arnault and Freymond, Céline and Rottmann, Matthias and Braun-Breton, Catherine and Baumeister, Stefan and Porfetye, Arthur T. and Vetter, Ingrid R. and Hedberg, Christian and Soldati-Favre, Dominique. (2013) Characterization of a serine hydrolase targeted by acyl-protein thioesterase inhibitors in toxoplasma gondii. Journal of biological chemistry, Vol. 288, H. 38. pp. 27002-27018.

Lam, Cary F. C. and Pearce, A. Norrie and Tan, Shen H. and Kaiser, Marcel and Copp, Brent R.. (2013) Discovery and evaluation of thiazinoquinones as anti-protozoal agents. Marine drugs, Vol. 11, H. 9. pp. 3472-3499.

Liew, L. P. P. and Kaiser, M. and Copp, B. R.. (2013) Discovery and preliminary structure-activity relationship analysis of 1,14-sperminediphenylacetamides as potent and selective antimalarial lead compounds. Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 23, H. 2. pp. 452-454.

Liew, Lydia P. P. and Pearce, A. Norrie and Kaiser, Marcel and Copp, Brent R.. (2013) Synthesis and in vitro and in vivo evaluation of antimalarial polyamines. European journal of medicinal chemistry, 69. pp. 22-31.

Lu, Wen-Jie and Wicht, Kathryn J. and Wang, Li and Imai, Kento and Mei, Zhen-Wu and Kaiser, Marcel and El Sayed, Ibrahim El Tantawy and Egan, Timothy J. and Inokuchi, Tsutomu. (2013) Synthesis and antimalarial testing of neocryptolepine analogues : addition of ester function in SAR study of 2,11-disubstituted indolo[2,3-b]quinolines. European journal of medicinal chemistry, 64. pp. 498-511.

Lödige, Melanie and Lewis, Matthew D. and Paulsen, Eleonora S. and Esch, Harald L. and Pradel, Gabriele and Lehmann, Leane and Brun, Reto and Bringmann, Gerhard and Mueller, Ann-Kristin. (2013) A primaquine-chloroquine hybrid with dual activity against Plasmodium liver and blood stages. International journal of medical microbiology, Vol. 303, H. 8. pp. 539-547.

Macêdo, Juan P. and Schmidt, Remo S. and Mäser, Pascal and Rentsch, Doris and Vial, Henri J. and Sigel, Erwin and Bütikofer, Peter. (2013) Characterization of choline uptake in Trypanosoma brucei procyclic and bloodstream forms. Molecular & biochemical parasitology, Vol. 190, H. 1. pp. 16-22.

Malebo, H. M. and Wenzler, T. and Cal, M. and Swaleh, S. M. and Omolo, M. O. and Hassanali, A. and Sequin, U. and Häussinger, D. and Dalsgaard, P. and Hamburger, M. and Brun, R. and Ndiege, I. O.. (2013) Anti-protozoal activity of aporphine and protoberberine alkaloids from Annickia kummeriae (Engl. & Diels) Setten & Maas (Annonaceae). BMC complementary and alternative medicine, Vol. 13 , 48.

Malebo, Hamisi M. and Wenzler, Tanja and Cal, Monical and Swaleh, Sauda M. and Hassanali, Ahmed and Sequin, Urs and Machocho, Alex K and Haeussinger, Daniel and Dalsgaard, Petur and Omolo, Maurice O. and Hamburger, Matthias and Brun, Reto and Ndiege, Isaiah O.. (2013) Anti-protozoal and structure-activity relationships of chemical constituents of Acridocarpus chloropterus Oliver (Malpighiaceae) from Tanzania. International Journal of Natural Products Research, 3 (4). pp. 74-81.

McKeever, C. and Kaiser, M. and Rozas, I.. (2013) Aminoalkyl derivatives of guanidine di-aromatic minor groove binders with antiprotozoal activity. Journal of medicinal chemistry, 56 (3). pp. 700-711.

McNamara, Case W. and Lee, Marcus C. S. and Lim, Chek Shik and Lim, Siau Hoi and Roland, Jason and Nagle, Advait and Simon, Oliver and Yeung, Bryan K. S. and Chatterjee, Arnab K. and McCormack, Susan L. and Manary, Micah J. and Zeeman, Anne-Marie and Dechering, Koen J. and Kumar, T. R. Santha and Henrich, Philipp P. and Gagaring, Kerstin and Ibanez, Maureen and Kato, Nobutaka and Kuhen, Kelli L. and Fischli, Christoph and Rottmann, Matthias and Plouffe, David M. and Bursulaya, Badry and Meister, Stephan and Rameh, Lucia and Trappe, Joerg and Haasen, Dorothea and Timmerman, Martijn and Sauerwein, Robert W. and Suwanarusk, Rossarin and Russell, Bruce and Renia, Laurent and Nosten, Francois and Tully, David C. and Kocken, Clemens H. M. and Glynne, Richard J. and Bodenreider, Christophe and Fidock, David A. and Diagana, Thierry T. and Winzeler, Elizabeth A.. (2013) Targeting Plasmodium PI(4)K to eliminate malaria. Nature, Vol. 504, H. 7479. pp. 248-253.

Mei, Zhen-Wu and Wang, Li and Lu, Wen-Jie and Pang, Cui-Qing and Maeda, Tsukasa and Peng, Wei and Kaiser, Marcel and El Sayed, Ibrahim and Inokuchi, Tsutomu. (2013) Synthesis and in vitro antimalarial testing of neocryptolepines : SAR study for improved activity by introduction and modifications of side chains at C2 and C11 on indolo[2,3-b]quinolines. Journal of medicinal chemistry, 56 (4). pp. 1431-1442.

Moehrle, J. J. and Duparc, S. and Siethoff, C. and van Giersbergen, P. L. and Craft, J. C. and Arbe-Barnes, S. and Charman, S. A. and Gutierrez, M. and Wittlin, S. and Vennerstrom, J. L.. (2013) First-in-man safety and pharmacokinetics of synthetic ozonide OZ439 demonstrates an improved exposure profile relative to other peroxide antimalarials. British journal of clinical pharmacology, Vol. 75, H. 2. pp. 535-548.

Mokoka, Tsholofelo A. and Xolani, Peter K. and Zimmermann, S. and Hata, Y. and Adams, M. and Kaiser, M. and Moodley, N. and Maharaj, Y. and Koorbanally, Neil A. and Hamburger, M. and Brun, R. and Fouche, G.. (2013) Antiprotozoal Screening of 60 South African Plants, and the Identification of the Antitrypanosomal Germacranolides Schkuhrin I and II. Planta medica, Vol. 79, H. 14. pp. 1380-1384.

Molette, J. and Routier, J. and Abla, N. and Besson, D. and Bombrun, A. and Brun, R. and Burt, H. and Georgi, K. and Kaiser, M. and Nwaka, S. and Muzerelle, M. and Scheer, A.. (2013) Identification and optimization of an aminoalcohol-carbazole series with antimalarial properties. ACS medicinal chemistry letters, Vol. 4, H. 11. pp. 1037-1041.

Moradi-Afrapoli, Fahimeh and Ebrahimi, Samad Nejad and Smiesko, Martin and Raith, Melanie and Zimmermann, Stefanie and Nadjafi, Farsad and Brun, Reto and Hamburger, Matthias. (2013) Bisabololoxide derivatives from Artemisia persica, and determination of their absolute configurations by ECD. Phytochemistry, Vol. 85. pp. 143-152.

Moridi Farimani, Mahdi and Nejad Ebrahimi, Samad and Salehi, Peyman and Bahadori, Mir Babak and Sonboli, Ali and Khavasi, Hamid Reza and Zimmermann, Stefanie and Kaiser, Marcel and Hamburger, Matthias. (2013) Antitrypanosomal triterpenoid with an ε-lactone e-ring from Salvia urmiensis. Journal of natural products, Vol. 76, H. 9. pp. 1806-1809.

Munigunti, Ranjith and Becker, Katja and Brun, Reto and Calderón, Angela I.. (2013) Determination of antiplasmodial activity and binding affinity of selected natural products towards PfTrxR and PfGR. Natural product communications, Vol. 8, H. 8. pp. 1135-1136.

Murugesan, D. and Mital, A. and Kaiser, M. and Shackleford, D. M. and Morizzi, J. and Katneni, K. and Campbell, M. and Hudson, A. and Charman, S. A. and Yeates, C. and Gilbert, I. H.. (2013) Discovery and structure-activity relationships of pyrrolone antimalarials. Journal of medicinal chemistry, 56 (7). pp. 2975-2990.

Murugesan, Dinakaran and Kaiser, Marcel and White, Karen L. and Norval, Suzanne and Riley, Jennifer and Wyatt, Paul G. and Charman, Susan A. and Read, Kevin D. and Yeates, Clive and Gilbert, Ian H.. (2013) Structure-activity relationship studies of pyrrolone antimalarial agents. ChemMedChem : chemistry enabling drug discovery, Vol. 8, H. 9. pp. 1537-1544.

Nsumiwa, Samkele and Kuter, David and Wittlin, Sergio and Chibale, Kelly and Egan, Timothy J.. (2013) Structure-activity relationships for ferriprotoporphyrin IX association and β-hematin inhibition by 4-aminoquinolines using experimental and ab initio methods. Bioorganic & medicinal chemistry, 21 (13). pp. 3738-3748.

Obbo, C. J. D. and Makanga, B. and Mulholland, D. A. and Coombes, P. H. and Brun, R.. (2013) Antiprotozoal activity of Khaya anthotheca, (Welv.) C.D.C. A plant used by chimpanzees for self medication. Journal of ethnopharmacology : an interdisciplinary journal devoted to bioscientific research on indigenous drugs, Vol. 147, H. 1. pp. 220-223.

Papadopoulou, Maria V. and Bloomer, William D. and Rosenzweig, Howard S. and Ashworth, Rachel and Wilkinson, Shane R. and Kaiser, Marcel and Andriani, Grasiella and Rodriguez, Ana. (2013) Novel 3-nitro-1H-1,2,4-triazole-based compounds as potential anti-Chagasic drugs : in vivo studies. Future medicinal chemistry, Vol. 5, H. 15. pp. 1763-1776.

Patra, Malay and Joshi, Tanmaya and Pierroz, Vanessa and Ingram, Katrin and Kaiser, Marcel and Ferrari, Stefano and Spingler, Bernhard and Keiser, Jennifer and Gasser, Gilles. (2013) DMSO-mediated ligand dissociation : renaissance for biological activity of N-heterocyclic-[Ru(η(6) -arene)Cl2 ] drug candidates. Chemistry : a European journal, Vol. 19, H. 44. pp. 14768-14772.

Patrick, Donald A. and Bakunov, Stanislav A. and Bakunova, Svetlana M. and Jones, Susan Kilgore and Wenzler, Tanja and Barszcz, Todd and Kumar, Arvind and Boykin, David W. and Werbovetz, Karl A. and Brun, Reto and Tidwell, Richard R.. (2013) Synthesis and antiprotozoal activities of benzyl phenyl ether diamidine derivatives. European journal of medicinal chemistry, 67. pp. 310-324.

Patrick, Donald A. and Ismail, Mohamed A. and Arafa, Reem K. and Wenzler, Tanja and Zhu, Xiaohua and Pandharkar, Trupti and Jones, Susan Kilgore and Werbovetz, Karl A. and Brun, Reto and Boykin, David W. and Tidwell, Richard R.. (2013) Synthesis and antiprotozoal activity of dicationic m-terphenyl and 1,3-dipyridylbenzene derivatives. Journal of medicinal chemistry, 56 (13). pp. 5473-5494.

Pieretti, Simone and Haanstra, Jurgen R. and Mazet, Muriel and Perozzo, Remo and Bergamini, Christian and Prati, Federica and Fato, Romana and Lenaz, Giorgio and Capranico, Giovanni and Brun, Reto and Bakker, Barbara M. and Michels, Paul A. M. and Scapozza, Leonardo and Bolognesi, Maria Laura and Cavalli, Andrea. (2013) Naphthoquinone derivatives exert their antitrypanosomal activity via a multi-target mechanism. PLoS neglected tropical diseases, Vol. 7 , e2012.

Reimer, Daniela and Cowles, Kimberly N. and Proschak, Anna and Nollmann, Friederike I. and Dowling, Andrea J. and Kaiser, Marcel and Constant, Richard Ffrench- and Goodrich-Blair, Heidi and Bode, Helge B.. (2013) Rhabdopeptides as insect-specific virulence factors from entomopathogenic bacteria. ChemBioChem : a European journal of chemical biology, Vol. 14, H. 15. pp. 1991-1997.

Rogé, S. and Van Reet, N. and Odiwuor, S. and Tran, T. and Schildermans, K. and Vandamme, S. and Vandenberghe, I. and Vervecken, W. and Gillingwater, K. and Claes, F. and Devreese, B. and Guisez, Y. and Büscher, P.. (2013) Recombinant expression of trypanosome surface glycoproteins in Pichia pastoris for the diagnosis of Trypanosoma evansi infection. Veterinary parasitology : an international scientific journal, Vol. 197, H. 3-4. pp. 571-579.

Schleiferböck, Sarah and Scheurer, Christian and Ihara, Masataka and Itoh, Isamu and Bathurst, Ian and Burrows, Jeremy N. and Fantauzzi, Pascal and Lotharius, Julie and Charman, Susan A. and Morizzi, Julia and Shackleford, David M. and White, Karen L. and Brun, Reto and Wittlin, Sergio. (2013) In vitro and in vivo characterization of the antimalarial lead compound SSJ-183 in Plasmodium models. Drug design, development and therapy, Vol. 7. pp. 1377-1384.

Spavieri, Jasmine and Allmendinger, Andrea and Kaiser, Marcel and Itoe, Maurice Ayamba and Blunden, Gerald and Mota, Maria M. and Tasdemir, Deniz. (2013) Assessment of dual life stage antiplasmodial activity of british seaweeds. Marine drugs, Vol. 11, H. 10. pp. 4019-4034.

Thuita, John K. and Wolf, Kristina K. and Murilla, Grace A. and Liu, Qiang and Mutuku, James N. and Chen, Yao and Bridges, Arlene S. and Mdachi, Raymond E. and Ismail, Mohamed A. and Ching, Shelley and Boykin, David W. and Hall, James Edwin and Tidwell, Richard R. and Paine, Mary F. and Brun, Reto and Wang, Michael Zhuo. (2013) Safety, pharmacokinetic, and efficacy studies of oral DB868 in a first stage vervet monkey model of human African trypanosomiasis. PLoS neglected tropical diseases, Vol. 7, H. 6 , e2230.

Wang, N. and Wicht, K. J. and Wang, L. and Lu, W. J. and Misumi, R. and Wang, M. Q. and El Gokha, A. A. and Kaiser, M. and El Sayed, T. and Egan, T. J. and Inokuchi, T.. (2013) Synthesis and in vitro testing of antimalarial activity of non-natural-type neocryptolepines : structure-activity relationship study of 2,11- and 9,11-disubstituted 6-methylindolo[2,3-b]quinolines. Chemical and pharmaceutical bulletin, Vol. 61, H. 12. pp. 1282-1290.

Wang, X. and Dong, Y. and Wittlin, S. and Charman, S. A. and Chiu, F. C. and Chollet, J. and Katneni, K. and Mannila, J. and Morizzi, J. and Ryan, E. and Scheurer, C. and Steuten, J. and Santo, Tomas J. and Snyder, C. and Vennerstrom, J. L.. (2013) Comparative antimalarial activities and ADME profiles of ozonides (1,2,4-trioxolanes) OZ277, OZ439, and their 1,2-dioxolane, 1,2,4-trioxane, and 1,2,4,5-tetraoxane isosteres. Journal of medicinal chemistry, 56 (6). pp. 2547-2555.

Wenzler, Tanja and Yang, Sihyung and Braissant, Olivier and Boykin, David W. and Brun, Reto and Wang, Michael Zhuo. (2013) Pharmacokinetics, Trypanosoma brucei gambiense efficacy, and time of drug action of DB829, a preclinical candidate for treatment of second-stage human African trypanosomiasis. Antimicrobial agents and chemotherapy, Vol. 57, H. 11. pp. 5330-5343.

Younis, Yassir and Douelle, Frederic and González Cabrera, Diego and Le Manach, Claire and Nchinda, Aloysius T. and Paquet, Tanya and Street, Leslie J. and White, Karen L. and Zabiulla, K. Mohammed and Joseph, Jayan T. and Bashyam, Sridevi and Waterson, David and Witty, Michael J. and Wittlin, Sergio and Charman, Susan A. and Chibale, Kelly. (2013) Structure-activity-relationship studies around the 2-amino group and pyridine core of antimalarial 3,5-diarylaminopyridines lead to a novel series of pyrazine analogues with oral in vivo activity. Journal of medicinal chemistry, 56 (21). pp. 8860-8871.

Zhou, Qiuqin and Grundmann, Florian and Kaiser, Marcel and Schiell, Matthias and Gaudriault, Sophie and Batzer, Andreas and Kurz, Michael and Bode, Helge B.. (2013) Structure and biosynthesis of xenoamicins from entomopathogenic xenorhabdus. Chemistry : a European journal, Vol. 19, H. 49. pp. 16772-16779.

Zimmermann, Stefanie and Oufir, Mouhssin and Leroux, Alejandro and Krauth-Siegel, R. Luise and Becker, Katja and Kaiser, Marcel and Brun, Reto and Hamburger, Matthias and Adams, Michael. (2013) Cynaropicrin targets the trypanothione redox system in Trypanosoma brucei. Bioorganic & Medicinal Chemistry, 21 (22). pp. 7202-7209.

da Silva, Cristiane Franca and Batista, Denise da Gama Jaen and Siciliano, Julianna Araujo and Batista, Marcos Meuser and Lionel, Jessica and de Souza, Elen Mello and Hammer, Erica Ripoll and da Silva, Patricia Bernardino and De Mieri, Maria and Adams, Michael and Zimmermann, Stefanie and Hamburger, Matthias and Brun, Reto and Schühly, Wolfgang and de Nazare, Maria Correia Soeiro. (2013) Activities of psilostachyin A and cynaropicrin against trypanosoma cruzi in vitro and in vivo. Antimicrobial Agents and Chemotherapy, 57 (11). pp. 5307-5314.

von Bargen, Katharina Walburga and Niehaus, Eva-Maria and Bergander, Klaus and Brun, Reto and Tudzynski, Bettina and Humpf, Hans-Ulrich. (2013) Structure elucidation and antimalarial activity of apicidin F : an apicidin-like compound produced by Fusarium fujikuroi. Journal of natural products, Vol. 76, H. 11. pp. 2136-2140.

2012

Abiodun, O. O. and Gbotosho, G. O. and Ajaiyeoba, E. O. and Brun, R. and Oduola, A. M.. (2012) Antitrypanosomal activity of some medicinal plants from Nigerian ethnomedicine. Parasitology research, Vol. 110, H. 2. pp. 521-526.

Ahmad, S. and Weis, R. and Faist, J. and Wolkinger, V. and Saf, R. and Belaj, F. and Brun, R. and Kaiser, M. and Seebacher, W.. (2012) Diarylcyclohexanones : synthons for new bicyclic compounds. Monatshefte für Chemie, Vol. 143, H. 1. pp. 145-152.

Arán, V. J. and Kaiser, M. and Dardonville, C.. (2012) Discovery of nitroheterocycles active against African trypanosomes : in vitro screening and preliminary SAR studies. Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 22, H. 14. pp. 4506-4516.

Attioua, B. and Yeo, D. and Lagnika, L. and Harisolo, R. and Antheaume, C. and Weniger, B. and Kaiser, M. and Lobstein, A. and Vonthron-Sénécheau, C.. (2012) In vitro antileishmanial, antiplasmodial and cytotoxic activities of a new ventiloquinone and five known triterpenes from Parinari excelsa. Pharmaceutical biology, Vol. 50, H. 7. pp. 801-806.

Banerjee, M. and Farahat, A. A. and Kumar, A. and Wenzler, T. and Brun, R. and Munde, M. M. and Wilson, W. D. and Zhu, X. and Werbovetz, K. A. and Boykin, D. W.. (2012) Synthesis, DNA binding and antileishmanial activity of low molecular weight bis-arylimidamides. European journal of medicinal chemistry, 55. pp. 449-454.

Brun, R. and Blum, J.. (2012) Human African trypanosomiasis. Infectious disease clinics of North America, Vol. 26, H. 2. pp. 261-273.

Brunner, R. and Aissaoui, H. and Boss, C. and Bozdech, Z. and Brun, R. and Corminboeuf, O. and Delahaye, S. and Fischli, C. and Heidmann, B. and Kaiser, M. and Kamber, J. and Meyer, S. and Papastogiannidis, P. and Siegrist, R. and Voss, T. and Welford, R. and Wittlin, S. and Binkert, C.. (2012) Identification of a new chemical class of antimalarials. The Journal of Infectious Diseases, Vol. 206, no. 5. pp. 735-743.

Carvalho, S. A. and Feitosa, L. O. and Soares, M. and Costa, T. E. and Henriques, M. G. and Salomao, K. and de Castro, S. L. and Kaiser, M. and Brun, R. and Wardell, J. L. and Wardell, S. M. and Trossini, G. H. and Andricopulo, A. D. and da Silva, E. F. and Fraga, C. A.. (2012) Design and synthesis of new (E)-cinnamic N-acylhydrazones as potent antitrypanosomal agents. European journal of medicinal chemistry, 54. pp. 512-521.

Chianese, G. and Fattorusso, E. and Scala, F. and Teta, R. and Calcinai, B. and Bavestrello, G. and Dien, H. A. and Kaiser, M. and Tasdemir, D. and Taglialatela-Scafati, O.. (2012) Manadoperoxides, a new class of potent antitrypanosomal agents of marine origin. Organic & biomolecular chemistry : an international journal of synthetic, physical and biomolecular organic chemistry, Vol. 10, H. 35. pp. 7197-7207.

Dastan, D. and Salehi, P. and Gohari, A. R. and Ebrahimi, S. N. and Zimmermann, S. and Kaiser, M. and Hamburger, M. and Khavasi, H. R.. (2012) Disesquiterpene and sesquiterpene coumarins from Ferula pseudalliacea, and determination of their absolute configurations. Phytochemistry, 78. pp. 170-178.

Delves, M. and Plouffe, D. and Scheurer, C. and Meister, S. and Wittlin, S. and Winzeler, E. A. and Sinden, R. E. and Leroy, D.. (2012) The activities of current antimalarial drugs on the life cycle stages of Plasmodium : a comparative study with human and rodent parasites. PLoS medicine, Vol. 9, H. 2 , e1001169.

Dürüst, Y. and Karakus, H. and Kaiser, M. and Tasdemir, D.. (2012) Synthesis and anti-protozoal activity of novel dihydropyrrolo[3,4-d][1,2,3]triazoles. European journal of medicinal chemistry, 48. pp. 296-304.

Edlin, C. D. and Morgans, G. and Winks, S. and Duffy, S. and Avery, V. M. and Wittlin, S. and Waterson, D. and Burrows, J. and Bryans, J.. (2012) Identification and in-vitro ADME assessment of a series of novel anti-malarial agents suitable for hit-to-lead chemistry. ACS medicinal chemistry letters, Vol. 3, H. 7. pp. 570-573.

Ehmke, V. and Quinsaat, J. E. and Rivera-Fuentes, P. and Heindl, C. and Freymond, C. and Rottmann, M. and Brun, R. and Schirmeister, T. and Diederich, F.. (2012) Tuning and predicting biological affinity : aryl nitriles as cysteine protease inhibitors. Organic & biomolecular chemistry, Vol. 10, H. 30. pp. 5764-5768.

Eltschinger, S. and Greganova, E. and Heller, M. and Bütikofer, P. and Altmann, M.. (2012) Eukaryotic translation elongation factor 1A (eEF1A) domain I from S. cerevisiae is required but not sufficient for inter-species complementation. PLoS one, Vol. 7, H. 7 , e42338.

Faist, J. and Seebacher, W. and Saf, R. and Brun, R. and Kaiser, M. and Weis, R.. (2012) New N-methylpiperazinyl derivatives of bicyclic antiprotozoal compounds. European journal of medicinal chemistry, 47 (1). pp. 510-519.

Farimani, M. M. and Taheri, S. and Ebrahimi, S. N. and Bahadori, M. B. and Khavasi, H. R. and Zimmermann, S. and Brun, R. and Hamburger, M.. (2012) Hydrangenone, a new Isoprenoid with an unprecedented skeleton from Salvia hydrangea. Organic Letters, 14 (1). pp. 166-169.

Ge, J. F. and Zhang, Q. Q. and Lu, J. M. and Kaiser, M. and Brun, R. and Ihara, M.. (2012) Synthesis of cyanine dyes and investigation of their in vitro antiprotozoal activities. MedChemComm, Vol. 3, H. 11. pp. 1435-1442.

Gemma, S. and Camodeca, C. and Sanna, Coccone and Joshi, B. P. and Bernetti, M. and Moretti, V. and Brogi, S. and Bonache, M. C. and Savini, L. and Taramelli, D. and Basilico, N. and Parapini, S. and Rottmann, M. and Brun, R. and Lamponi, S. and Caccia, S. and Guiso, G. and Summer, R. and Martin, R. and Saponara, S. and Gorelli, B. and Novellino, E. and Campiani, G. and Butini, S.. (2012) Optimization of 4-aminoquinoline/clotrimazole-based hybrid antimalarials : further structure-activity relationships, in vivo studies, and preliminary toxicity profiling. Journal of medicinal chemistry, 55 (15). pp. 6948-6967.

Geneau, Celine E. and Wackers, Felix L. and Luka, Henryk and Daniel, Claudia and Balmer, Oliver. (2012) Selective flowers to enhance biological control of cabbage pests by parasitoids. Basic and applied ecology, Vol. 13, H. 1 , S. 85–93.

Godel, C. and Kumar, S. and Koutsovoulos, G. and Ludin, P. and Nilsson, D. and Comandatore, F. and Wrobel, N. and Thompson, M. and Schmid, C. D. and Goto, S. and Bringaud, F. and Wolstenholme, A. and Bandi, C. and Epe, C. and Kaminsky, R. and Blaxter, M. and Mäser, P.. (2012) The genome of the heartworm, Dirofilaria immitis, reveals drug and vaccine targets. The FASEB Journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 26, H. 11. pp. 4650-4661.

Gonzalez-Salgado, A. and Steinmann, M. E. and Greganova, E. and Rauch, M. and Mäser, P. and Sigel, E. and Bütikofer, P.. (2012) myo-inositol uptake is essential for bulk inositol phospholipid but not glycosylphosphatidylinositol synthesis in Trypanosoma brucei. Journal of biological chemistry, Vol. 287, H. 16. pp. 13313-13323.

González, Cabrera and Douelle, F. and Younis, Y. E. and Feng, T. S. and Lemanach, C. and Nchinda, A. T. and Street, L. J. and Scheurer, C. and Kamber, J. and White, K. L. and Montagnat, O. D. and Ryan, E. and Katneni, K. and Zabiulla, K. M. and Joseph, J. T. and Bashyam, S. and Waterson, D. and Witty, M. J. and Charman, S. A. and Wittlin, S. and Chibale, K.. (2012) Structure-activity relationship studies of orally active antimalarial 3,5-substituted 2-aminopyridines. Journal of medicinal chemistry, 55 (24). pp. 11022-11030.

Greganova, Eva and Bütikofer, Peter. (2012) Ethanolamine phosphoglycerol attachment to eEF1A is not essential for normal growth of Trypanosoma brucei. Scientific Reports, 2 (254).

Gökbulut, A. and Kaiser, M. and Brun, R. and Sarer, E. and Schmidt, T. J.. (2012) 9β-hydroxyparthenolide esters from Inula montbretiana and their antiprotozoal activity. Planta medica, Vol. 78, H. 3. pp. 225-229.

Hiltensperger, G. and Jones, N. G. and Niedermeier, S. and Stich, A. and Kaiser, M. and Jung, J. and Puhl, S. and Damme, A. and Braunschweig, H. and Meinel, L. and Engstler, M. and Holzgrabe, U.. (2012) Synthesis and structure-activity relationships of new quinolone-type molecules against Trypanosoma brucei. Journal of medicinal chemistry, 55 (6). pp. 2538-2548.

Li, Y. and Hao, H. D. and Wittlin, S. and Wu, Y.. (2012) Simple analogues of Qinghaosu (Artemisinin). Chemistry : an Asian journal / an ACES journal, Vol. 7, H. 8. pp. 1881-1886.

Li, Y. and Wittlin, S. and Wu, Y.. (2012) Access to some UV chromophore-containing antimalarial trioxanes using hydrogen peroxide as source of the peroxy bonds. Heterocycles : an international journal for reviews and communications in heterocyclic chemistry, Vol. 84, H. 2. pp. 1217-1226.

Lizzi, F. and Veronesi, G. and Belluti, F. and Bergamini, C. and Lopez-Sanchez, A. and Kaiser, M. and Brun, R. and Krauth-Siegel, R. L. and Hall, D. and Rivas, L. and Bolognesi, M. L.. (2012) Conjugation of quinones with natural polyamines : towards an expanded anti-trypanosomatid profile. Journal of medicinal chemistry, 55 (23). pp. 10490-10500.

Ludin, Philipp and Woodcroft, Ben and Ralph, Stuart A. and Maeser, Pascal. (2012) In silicio prediction of antimalarial drug target candidates. International journal for parasitology: drugs and drug resistance, Vol. 2. pp. 191-199.

Marfurt, J. and Chalfein, F. and Prayoga, P. and Wabiser, F. and Wirjanata, G. and Sebayang, B. and Piera, K. A. and Wittlin, S. and Haynes, R. K. and Mohrle, J. J. and Anstey, N. M. and Kenangalem, E. and Price, R. N.. (2012) Comparative ex vivo activity of novel endoperoxides in multidrug-resistant Plasmodium falciparum and P. vivax. Antimicrobial agents and chemotherapy : AAC, Vol. 56, H. 10. pp. 5258-5263.

McCracken, S. T. and Kaiser, M. and Boshoff, H. I. and Boyd, P. D. and Copp, B. R.. (2012) Synthesis and antimalarial and antituberculosis activities of a series of natural and unnatural 4-methoxy-6-styryl-pyran-2-ones, dihydro analogues and photo-dimers. Bioorganic & medicinal chemistry : a Tetrahedron publication for the rapid dissemenination of full original research papers and critical reviews on biomolecular chemistry, medicinal chemistry and related disciplines, 20 (4). pp. 1482-1493.

Mombelli, P. and Witschel, M. C. and van Zijl, A. W. and Geist, J. G. and Rottmann, M. and Freymond, C. and Röhl, F. and Kaiser, M. and Illarionova, V. and Fischer, M. and Siepe, I. and Schweizer, W. B. and Brun, R. and Diederich, F.. (2012) Identification of 1,3-diiminoisoindoline carbohydrazides as potential antimalarial candidates. ChemMedChem, Vol. 7, H. 1. pp. 151-158.

Moradi-Afrapoli, Fahimeh and Yassa, Nargues and Zimmermann, Stefanie and Saeidnia, Soodabeh and Hadjiakhoondia, Abbas and Ebrahimi, Samad N. and Hamburger, Matthias. (2012) Cinnamoylphenethyl Amides from Polygonum hyrcanicum Possess Anti-Trypanosomal Activity. Natural Product Communications, 7 (6). pp. 753-755.

Mäser, P. and Wittlin, S. and Rottmann, M. and Wenzler, T. and Kaiser, M. and Brun, R.. (2012) Antiparasitic agents : new drugs on the horizon. Current opinion in pharmacology, Vol. 12, H. 5. pp. 562-566.

Nagle, A. and Wu, T. and Kuhen, K. and Gagaring, K. and Borboa, R. and Francek, C. and Chen, Z. and Plouffe, D. and Lin, X. and Caldwell, C. and Ek, J. and Skolnik, S. and Liu, F. and Wang, J. and Chang, J. and Li, C. and Liu, B. and Hollenbeck, T. and Tuntland, T. and Isbell, J. and Chuan, T. and Alper, P. B. and Fischli, C. and Brun, R. and Lakshminarayana, S. B. and Rottmann, M. and Diagana, T. T. and Winzeler, E. A. and Glynne, R. and Tully, D. C. and Chatterjee, A. K.. (2012) Imidazolopiperazines: lead optimization of the second-generation antimalarial agents. Journal of medicinal chemistry, 55 (9). pp. 4244-4273.

Nollmann, Friederike I. and Dowling, Andrea and Kaiser, Marcel and Deckmann, Klaus and Grösch, Sabine and Ffrench-Constant, Richard and Bode, Helge B.. (2012) Synthesis of szentiamide, a depsipeptide from entomopathogenic Xenorhabdus szentirmaii with activity against Plasmodium falciparum. Beilstein journal of organic chemistry, Vol. 8. pp. 528-533.

Oehring, S. C. and Woodcroft, B. J. and Moes, S. and Wetzel, J. and Dietz, O. and Pulfer, A. and Dekiwadia, C. and Maeser, P. and Flueck, C. and Witmer, K. and Brancucci, N. M. and Niederwieser, I. and Jenoe, P. and Ralph, S. A. and Voss, T. S.. (2012) Organellar proteomics reveals hundreds of novel nuclear proteins in the malaria parasite Plasmodium falciparum. Genome biology, Vol. 13, H. 11 , R108.

Schmidt, T. J. and Khalid, S. A. and Romanha, A. J. and Alves, T. Ma and Biavatti, M. W. and Brun, R. and Da Costa, F. B. and de Castro, S. L. and Ferreira, V. F. and de Lacerda, M. V. G. and Lago, J. H. G. and Leon, L. L. and Lopes, N. P. and das Neves Amorim, R. C. and Niehues, M. and Ogungbe, I. V. and Pohlit, A. M. and Scotti, M. T. and Setzer, W. N. and de N. C. Soeiro, M. and Steindel, M. and Tempone, A. G.. (2012) The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases : part I. Current medicinal chemistry, Vol. 19, H. 14. pp. 2128-2175.

Schmidt, T. J. and Khalid, S. A. and Romanha, A. J. and Alves, T. Ma and Biavatti, M. W. and Brun, R. and Da Costa, F. B. and de Castro, S. L. and Ferreira, V. F. and de Lacerda, M. V. G. and Lago, J. H. G. and Leon, L. L. and Lopes, N. P. and das Neves Amorim, R. C. and Niehues, M. and Ogungbe, I. V. and Pohlit, A. M. and Scotti, M. T. and Setzer, W. N. and de N. C. Soeiro, M. and Steindel, M. and Tempone, A. G.. (2012) The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases : part II. Current medicinal chemistry, Vol. 19, H. 14. pp. 2176-2228.

Schmidt, T. J. and Rzeppa, S. and Kaiser, M. and Brun, R.. (2012) Larrea tridentata - absolute configuration of its epoxylignans and investigations on its antiprotozoal activity. Phytochemistry letters, Vol. 5, H. 3. pp. 632-637.

Stec, J. and Huang, Q. and Pieroni, M. and Kaiser, M. and Fomovska, A. and Mui, E. and Witola, W. H. and Bettis, S. and McLeod, R. and Brun, R. and Kozikowski, A. P.. (2012) Synthesis, biological evaluation and structure-activity relationships of N-benzoyl-2-hydroxybenzamides as agents active against P. falciparum (K1 strain), Trypanosomes, and Leishmania. Journal of medicinal chemistry, 55 (7). pp. 3088-3100.

Sykes, M. L. and Baell, J. B. and Kaiser, M. and Chatelain, E. and Moawad, S. R. and Ganame, D. and Ioset, J. R. and Avery, V. M.. (2012) Identification of compounds with anti-proliferative activity against Trypanosoma brucei brucei strain 427 by a whole cell viability based HTS campaign. PLoS neglected tropical diseases, Vol. 6, H. 11 , e1896.

Symula, R. E. and Beadell, J. S. and Sistrom, M. and Agbebakun, K. and Balmer, O. and Gibson, W. and Aksoy, S. and Caccone, A.. (2012) Trypanosoma brucei gambiense group 1 is distinguished by a unique amino acid substitution in the HpHb receptor implicated in human serum resistance. PLoS neglected tropical diseases, Vol. 6, H. 7 , e1728.

Taladriz, A. and Healy, A. and Flores, Perez and Herrero, Garcia and Rios, Martinez and Alkhaldi, A. A. and Eze, A. A. and Kaiser, M. and de Koning, H. P. and Chana, A. and Dardonville, C.. (2012) Synthesis and structure-activity analysis of new phosphonium salts with potent activity against African trypanosomes. Journal of medicinal chemistry, 55 (6). pp. 2606-2622.

Thuita, J. K. and Wang, M. Z. and Kagira, J. M. and Denton, C. L. and Paine, M. F. and Mdachi, R. E. and Murilla, G. A. and Ching, S. and Boykin, D. W. and Tidwell, R. R. and Hall, J. E. and Brun, R.. (2012) Pharmacology of DB844, an orally active aza analogue of pafuramidine, in a monkey model of second stage human African trypanosomiasis. PLoS neglected tropical diseases, Vol. 6, H. 7 , e1734.

Wenzler, T. and Steinhuber, A. and Wittlin, S. and Scheurer, C. and Brun, R. and Trampuz, A.. (2012) Isothermal microcalorimetry, a new tool to monitor drug action against Trypanosoma brucei and Plasmodium falciparum. PLoS neglected tropical diseases, Vol. 6, H. 6 , e1668.

Witschel, M. and Rottmann, M. and Kaiser, M. and Brun, R.. (2012) Agrochemicals against malaria, sleeping sickness, leishmaniasis and Chagas disease. PLoS neglected tropical diseases, Vol. 6, H. 10 , e1805.

Wittlin, S. and Ekland, E. and Craft, J. C. and Lotharius, J. and Bathurst, I. and Fidock, D. A. and Fernandes, P.. (2012) In vitro and in vivo activity of Solithromycin (CEM-101) against Plasmodium species. Antimicrobial agents and chemotherapy : AAC, Vol. 56, H. 2. pp. 703-707.

Younis, Y. and Douelle, F. and Feng, T. S. and Cabrera, D. G. and Manach, C. L. and Nchinda, A. T. and Duffy, S. and White, K. L. and Shackleford, D. M. and Morizzi, J. and Mannila, J. and Katneni, K. and Bhamidipati, R. and Zabiulla, K. M. and Joseph, J. T. and Bashyam, S. and Waterson, D. and Witty, M. J. and Hardick, D. and Wittlin, S. and Avery, V. and Charman, S. A. and Chibale, K.. (2012) 3,5-Diaryl-2-aminopyridines as a novel class of orally active antimalarials demonstrating single dose cure in mice and clinical candidate potential. Journal of medicinal chemistry, 55 (7). pp. 3479-3487.

Zimmermann, S. and Kaiser, M. and Brun, R. and Hamburger, M. and Adams, M.. (2012) Cynaropicrin : the first natural product with in vivo activity against Trypanosoma bruce rhodesiense. Planta medica, Vol. 78, H. 6. pp. 553-556.

Zimmermann, S. and Thomi, S. and Kaiser, M. and Hamburger, M. and Adams, M.. (2012) Screening and HPLC-based activity profiling for new antiprotozoal leads from European plants. Scientia Pharmaceutica, 80 (1). pp. 205-213.

van Pelt-Koops, J. C. and Pett, H. E. and Graumans, W. and Vegte-Bolmer, Mv and van Gemert, G. J. and Rottmann, M. and Yeung, B. K. and Diagana, T. T. and Sauerwein, R. W.. (2012) The spiroindolone drug candidate NITD609 potently inhibits gametocytogenesis and blocks Plasmodium falciparum transmission to Anopheles mosquito vector. Antimicrobial agents and chemotherapy, Vol. 56, H. 7. pp. 3544-3548.

2011

Arafa, R. K. and Wenzler, T. and Brun, R. and Chai, Y. and Wilson, D.. (2011) Molecular modeling study and synthesis of novel dicationic flexible triaryl guanidines and imidamides as antiprotozoal agents. European journal of medicinal chemistry, 46 (12). pp. 5852-5860.

Attioua, B. and Lagnika, L. and Yeo, D. and Antheaume, C. and Kaiser, M. and Weniger, B. and Lobstein, A. and Vonthron-Sénécheau C., . (2011) In vitro antiplasmodial and antileishmanial activities of flavonoids form Anogeissus leiocarpus (Combretaceae). International journal of pharmaceutical sciences review and research, Vol. 11, H. 2 , 001.

Bakunov, S. A. and Bakunova, S. M. and Wenzler, T. and Ghebru, M. and Werbovetz, K. A. and Brun, R. and Tidwell, R. R.. (2011) Correction to synthesis and antiprotozoal activity of cationic1,4-diphenyl-1H-1,2,3-triazoles. Journal of medicinal chemistry, 54 (12). p. 4281.

Balmer, O. and Beadell, J. S. and Gibson, W. and Caccone, A.. (2011) Phylogeography and taxonomy of Trypanosoma brucei. PLoS neglected tropical diseases, Vol. 5, H. 2 , e961.

Balmer, O. and Tanner, M.. (2011) Prevalence and implications of multiple-strain infections. The Lancet infectious diseases, Vol. 11, H. 11. pp. 868-878.

Baragana, B. and McCarthy, O. and Sanchez, P. and Bosch-Navarrete C., and Kaiser, M. and Brun, R. and Whittingham, J. L. and Roberts, S. M. and Zhou, X. X. and Wilson, K. S. and Johansson, N. G. and Gonzalez-Pacanowska D., and Gilbert, I. H.. (2011) Beta-Branched acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase. Bioorganic & medicinal chemistry : a Tetrahedron publication for the rapid dissemenination of full original research papers and critical reviews on biomolecular chemistry, medicinal chemistry and related disciplines, 19 (7). pp. 2378-2391.

Barker, R. H. Jr. and Urgaonkar, S. and Mazitschek, R. and Celatka, C. and Skerlj, R. and Cortese, J. F. and Tyndall, E. and Liu, H. and Cromwell, M. and Sidhu, A. B. and Guerrero-Bravo, J. E. and Crespo-Llado, K. N. and Serrano, A. E. and Lin, J. W. and Janse, C. J. and Khan, S. M. and Duraisingh, M. and Coleman, B. I. and Angulo-Barturen, I. and Jimenez-Diaz, M. B. and Magan, N. and Gomez, V. and Ferrer, S. and Martinez, M. S. and Wittlin, S. and Papastogiannidis, P. and O'Shea, T. and Klinger, J. D. and Bree, M. and Lee, E. and Levine, M. and Wiegand, R. C. and Munoz, B. and Wirth, D. F. and Clardy, J. and Bathurst, I. and Sybertz, E.. (2011) Aminoindoles, a novel scaffold with potent activity against Plasmodium falciparum. Antimicrobial agents and chemotherapy, 55 (6). pp. 2612-2622.

Baschong, Werner and Wittlin, Sergio and Inglis, Kirstine A. and Fairlamb, Alan H. and Croft, Simon L. and Kumar, T. R. Santha and Fidock, David A. and Brun, Reto. (2011) Triclosan is minimally effective in rodent malaria models. Nature medicine, Vol. 17. pp. 33-34.

Bouchikhi, F. and Anizon, F. and Brun, R. and Moreau, P.. (2011) Biological evaluation of glycosyl-isoindigo derivatives against the pathogenic agents of tropical diseases (malaria, Chagas disease, leishmaniasis and human African trypanosomiasis). Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 21, H. 21. pp. 6319-6321.

Bourdin Trunz B., and Jedrysiak, R. and Tweats, D. and Brun, R. and Kaiser, M. and Suwinski, J. and Torreele, E.. (2011) 1-aryl-4-nitro-1H-imidazoles, a new promising series for the treatment of human African trypanosomiasis. European journal of medicinal chemistry, 46 (5). pp. 1524-1535.

Bringmann, G. and Hertlein-Amslinger B., and Kajahn, I. and Dreyer, M. and Brun, R. and Moll, H. and Stich, A. and Ioset, K. N. and Schmitz, W. and Ngoc, L. H.. (2011) Phenolic analogs of the N,C-coupled naphthylisoquinoline alkaloid ancistrocladinium A, from Ancistrocladus cochinchinensis (Ancistrocladaceae), with improved antiprotozoal activities. Phytochemistry : an international journal of plant biochemistry, Vol. 72, H. 1. pp. 89-93.

Broniatowska, B. and Allmendinger, A. and Kaiser, M. and Montamat-Sicotte D., and Hingley-Wilson S., and Lalvani, A. and Guiry, M. and Blunden, G. and Tasdemir, D.. (2011) Antiprotozoal, antitubercular and cytotoxic potential of cyanobacterial (blue-green algal) extracts from Ireland. Natural product communications, Vol. 6, H. 5. pp. 689-694.

Brun, R. and Don, R. and Jacobs, R. T. and Wang, M. Z. and Barrett, M. P.. (2011) Development of novel drugs for human African trypanosomiasis. Future microbiology, Vol. 6. pp. 677-691.

Brunner, Ralf Oskar. A novel antimalarial lead compound: in vitro properties and mode of action studies. 2011, Doctoral Thesis, University of Basel, Faculty of Science.

Chadwick, J. and Amewu, R. K. and Marti, F. and Bousejra-El Garah F., and Sharma, R. and Berry, N. G. and Stocks, P. A. and Burrell-Saward H., and Wittlin, S. and Rottmann, M. and Brun, R. and Taramelli, D. and Parapini, S. and Ward, S. A. and O'Neill P. M., . (2011) Antimalarial mannoxanes : hybrid antimalarial drugs with outstanding oral activity profiles and a potential dual mechanism of action. ChemMedChem : chemistry enabling drug discovery, Vol. 6, H. 8. pp. 1357-1361.

Chan, S. T. and Pearce, A. N. and Januario, A. H. and Page, M. J. and Kaiser, M. and McLaughlin, R. J. and Harper, J. L. and Webb, V. L. and Barker, D. and Copp, B. R.. (2011) Anti-inflammatory and antimalarial meroterpenoids from the New Zealand ascidian Aplidium scabellum. The journal of organic chemistry, Vol. 76, H. 21. pp. 9151-9160.

Chan, S. T. and Pearce, A. N. and Page, M. J. and Kaiser, M. and Copp, B. R.. (2011) Antimalarial beta-carbolines from the New Zealand ascidian Pseudodistoma opacum. Journal of natural products, Vol. 74, H. 9. pp. 1972-1979.

Charman, S. A. and Arbe-Barnes S., and Bathurst, I. C. and Brun, R. and Campbell, M. and Charman, W. N. and Chiu, F. C. and Chollet, J. and Craft, J. C. and Creek, D. J. and Dong, Y. and Matile, H. and Maurer, M. and Morizzi, J. and Nguyen, T. and Papastogiannidis, P. and Scheurer, C. and Shackleford, D. M. and Sriraghavan, K. and Stingelin, L. and Tang, Y. and Urwyler, H. and Wang, X. and White, K. L. and Wittlin, S. and Zhou, L. and Vennerstrom, J. L.. (2011) Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria. Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, H. 11. pp. 4400-4405.

Dua, V. K. and Verma, G. and Agarwal, D. D. and Kaiser, M. and Brun, R.. (2011) Antiprotozoal activities of traditional medicinal plants from the Garhwal region of North West Himalaya, India. Journal of ethnopharmacology : an interdisciplinary journal devoted to bioscientific research on indigenous drugs, Vol. 136, H. 1. pp. 123-128.

Eberle, C. and Lauber, B. S. and Fankhauser, D. and Kaiser, M. and Brun, R. and Krauth-Siegel R. L., and Diederich, F.. (2011) Improved inhibitors of trypanothione reductase by combination of motifs : synthesis, inhibitory potency, binding mode, and antiprotozoal activities. ChemMedChem : chemistry enabling drug discovery, Vol. 6, H. 2. pp. 292-301.

Ehmke, V. and Heindl, C. and Rottmann, M. and Freymond, C. and Schweizer, W. B. and Brun, R. and Stich, A. and Schirmeister, T. and Diederich, F.. (2011) Potent and selective inhibition of cysteine proteases from Plasmodium falciparum and Trypanosoma brucei. ChemMedChem : chemistry enabling drug discovery, Vol. 6, H. 2. pp. 273-278.

Farahat, A. A. and Paliakov, E. and Kumar, A. and Barghash, A. E. and Goda, F. E. and Eisa, H. M. and Wenzler, T. and Brun, R. and Liu, Y. and Wilson, W. D. and Boykin, D. W.. (2011) Exploration of larger central ring linkers in furamidine analogues : synthesis and evaluation of their DNA binding, antiparasitic and fluorescence properties. Bioorganic & medicinal chemistry : a Tetrahedron publication for the rapid dissemenination of full original research papers and critical reviews on biomolecular chemistry, medicinal chemistry and related disciplines, 19 (7). pp. 2156-2167.

Finlayson, R. and Pearce, A. N. and Page, M. J. and Kaiser, M. and Bourguet-Kondracki, M. L. and Harper, J. L. and Webb, V. L. and Copp, B. R.. (2011) Didemnidines A and B, indole spermidine alkaloids from the New Zealand ascidian Didemnum sp. Journal of Natural Products, 74 (4). pp. 888-892.

Gachet, M. S. and Kunert, O. and Kaiser, M. and Brun, R. and Zehl, M. and Keller, W. and Munoz, R. A. and Bauer, R. and Schuehly, W.. (2011) Antiparasitic compounds from Cupania cinerea with activities against Plasmodium falciparum and Trypanosoma brucei rhodesiense. Journal of Natural Products, 74 (4). pp. 559-566.

Gillingwater, K. and Gutierrez, C. and Bridges, A. and Wu, H. and Deborggraeve, S. and Ali Ekangu R., and Kumar, A. and Ismail, M. and Boykin, D. and Brun, R.. (2011) Efficacy study of novel diamidine compounds in a Trypanosoma evansi goat model. PLoS one, Vol. 6, H. 6 , e20836.

González Cabrera D., and Douelle, F. and Feng, T. S. and Nchinda, A. T. and Younis, Y. and White, K. L. and Wu, Q. and Ryan, E. and Burrows, J. N. and Waterson, D. and Witty, M. J. and Wittlin, S. and Charman, S. A. and Chibale, K.. (2011) Novel orally active antimalarial thiazoles. Journal of medicinal chemistry, 54 (21). pp. 7713-7719.

Greganova, E. and Altmann, M. and Bütikofer, P.. (2011) Unique modifications of translation elongation factors. The FEBS journal, Vol. 278, H. 15. pp. 2613-2624.

Hampton, S. E. and Baragana, B. and Schipani, A. and Bosch-Navarrete C., and Musso-Buendia J. A., and Recio, E. and Kaiser, M. and Whittingham, J. L. and Roberts, S. M. and Shevtsov, M. and Brannigan, J. A. and Kahnberg, P. and Brun, R. and Wilson, K. S. and Gonzalez-Pacanowska D., and Johansson, N. G. and Gilbert, I. H.. (2011) Design, synthesis, and evaluation of 5'-diphenyl nucleoside analogues as inhibitors of the Plasmodium falciparum dUTPase. ChemMedChem : chemistry enabling drug discovery, Vol. 6, H. 10. pp. 1816-1831.

Harel, D. and Khalid, S. A. and Kaiser, M. and Brun, R. and Wunsch, B. and Schmidt, T. J.. (2011) Encecalol angelate, an unstable chromene from Ageratum conyzoides L. : total synthesis and investigation of its antiprotozoal activity. Journal of ethnopharmacology : an interdisciplinary journal devoted to bioscientific research on indigenous drugs, Vol. 137, H. 1. pp. 620-650.

Hata, Y. and Zimmermann, S. and Quitschau, M. and Kaiser, M. and Brun, R. and Hamburger, M. and Adams, M.. (2011) Antiplasmodial and antitrypanosomal activity of pyrethrins and pyrethroids. Journal of agricultural and food chemistry, Vol. 59, H. 17. pp. 9172-9176.

Hobbie, S. N. and Kaiser, M. and Schmidt, S. and Shcherbakov, D. and Janusic, T. and Brun, R. and Böttger, E. C.. (2011) Genetic reconstruction of protozoan rRNA decoding sites provides a rationale for paromomycin activity against Leishmania and Trypanosoma. PLoS neglected tropical diseases, Vol. 5, H. 5 , e1161.

Ismail, M. A. and Bialy, S. A. and Brun, R. and Wenzler, T. and Nanjunda, R. and Wilson, W. D. and Boykin, D. W.. (2011) Dicationic phenyl-2,2'-bichalcophenes and analogues as antiprotozoal agents. Bioorganic & medicinal chemistry : a Tetrahedron publication for the rapid dissemenination of full original research papers and critical reviews on biomolecular chemistry, medicinal chemistry and related disciplines, 19 (2). pp. 978-984.

Jacobs, R. T. and Naré, B. and Wring, S. A. and Orr, M. D. and Chen, D. and Sligar, J. M. and Jenks, M. X. and Noe, R. A. and Bowling, T. S. and Mercer, L. T. and Rewerts, C. and Gaukel, E. and Owens, J. and Parham, R. and Randolph, R. and Beaudet, B. and Bacchi, C. J. and Yarlett, N. and Plattner, J. J. and Freund, Y. and Ding, C. and Akama, T. and Zhang, Y. K. and Brun, R. and Kaiser, M. and Scandale, I. and Don, R.. (2011) SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 Human African trypanosomiasis. PLoS neglected tropical diseases, Vol. 5, H. 6 , e1151.

Julianti, Tasqiah and Hata Uribe, Yoshie and Zimmermann, Stefanie and Kaiser, Marcel and Hamburger, Matthias and Adams, Michael. (2011) Antitrypanosomal sesquiterpene lactones from Saussurea costus. Fitoterapia, 82 (7). pp. 955-959.

Kaiser, M. and Bray, M. A. and Cal, M. and Trunz, B. B. and Torreele, E. and Brun, R.. (2011) Anti-trypanosomal activity of Fexinidazole: a new oral nitroimidazole drug candidate for the treatment of sleeping sickness. Antimicrobial agents and chemotherapy : AAC, Vol. 55, H. 12. pp. 5602-5608.

Kaya, G. I. and Sarikaya, B. and Onur, M. A. and Somer, N. U. and Viladomat, F. and Codina, C. and Bastida, J. and Lauinger, I. L. and Kaiser, M. and Tasdemir, D.. (2011) Antiprotozoal alkaloids from Galanthus trojanus. Phytochemistry letters, Vol. 4, H. 3. pp. 301-305.

Kirmizibekmez, H. and Atay, I. and Kaiser, M. and Brun, R. and Cartagena, M. M. and Carballeira, N. M. and Yesilada, E. and Tasdemir, D.. (2011) Antiprotozoal activity of Melampyrum arvense and its metabolites. Phytotherapy research : an international journal devoted to pharmacological and toxocological evaluation of natural product derivatives, Vol. 25, H. 1. pp. 142-146.

Kirmizibekmez, H. and Atay, I. and Kaiser, M. and Yesilada, E. and Tasdemir, D.. (2011) In vitro antiprotozoal activity of extracts of five Turkish Lamiaceae species. Natural Product Communications , 6 (11). pp. 1697-1700.

Kuhn-Nentwig, L. and Willems, J. and Seebeck, T. and Shalaby, T. and Kaiser, M. and Nentwig, W.. (2011) Cupiennin 1a exhibits a remarkably broad, non-stereospecific cytolytic activity on bacteria, protozoan parasites, insects, and human cancer cells. Amino Acids, 40 (1). pp. 69-76.

Lamprea-Burgunder, E. and Ludin, P. and Mäser, P.. (2011) Species-specific typing of DNA based on palindrome frequency patterns. DNA research, 18 (2). pp. 117-124.

Li, J. V. and Saric, J. and Wang, Y. and Utzinger, J. and Holmes, E. and Balmer, O.. (2011) Metabonomic investigation of single and multiple strain Trypanosoma brucei brucei infections. American journal of tropical medicine and hygiene, Vol. 84, H. 1. pp. 91-98.

Liu, L. and Bruhn, T. and Guo, L. and Gotz, D. C. and Brun, R. and Stich, A. and Che, Y. and Bringmann, G.. (2011) Chloropupukeanolides C-E : cytotoxic pupukeanane chlorides with a spiroketal skeleton from Pestalotiopsis fici. Chemistry : an Asian journal / an ACES journal, Vol. 17, H. 9. pp. 2604-2613.

Lu, Y. T. and Arai, C. and Ge, J. F. and Ren, W. S. and Kaiser, M. and Wittlin, S. and Brun, R. and Lu, J. M. and Ihara, M.. (2011) Synthesis and in vitro antiprotozoal activities of water-soluble, inexpensive phenothiazinium chlorides. Dyes and pigments : an international journal, Vol. 89, H. 1. pp. 44-48.

Ludin, P. and Nilsson, D. and Mäser, P.. (2011) Genome-wide identification of molecular mimicry candidates in parasites. PLoS one, 6 (3). e17546.

Maas, M. and Hensel, A. and Batista da Costa F., and Brun, R. and Kaiser, M. and Schmidt, T. J.. (2011) An unusual dimeric guaianolide with antiprotozoal activity and further sesquiterpene lactones from Eupatorium perfoliatum. Phytochemistry : an international journal of plant biochemistry, Vol. 72, H. 7. pp. 635-644.

Mayence, A. and Vanden Eynde J. J., and Kaiser, M. and Brun, R. and Yarlett, N. and Huang, T. L.. (2011) Bis(oxyphenylene)benzimidazoles: a novel class of anti-Plasmodium falciparum agents. Bioorganic & medicinal chemistry : a Tetrahedron publication for the rapid dissemenination of full original research papers and critical reviews on biomolecular chemistry, medicinal chemistry and related disciplines, 19 (24). pp. 7493-7500.

Meister, S. and Plouffe, D. M. and Kuhen, K. L. and Bonamy, G. M. and Wu, T. and Barnes, S. W. and Bopp, S. E. and Borboa, R. and Bright, A. T. and Che, J. and Cohen, S. and Dharia, N. V. and Gagaring, K. and Gettayacamin, M. and Gordon, P. and Groessl, T. and Kato, N. and Lee, M. C. and McNamara, C. W. and Fidock, D. A. and Nagle, A. and Nam, T. G. and Richmond, W. and Roland, J. and Rottmann, M. and Zhou, B. and Froissard, P. and Glynne, R. J. and Mazier, D. and Sattabongkot, J. and Schultz, P. G. and Tuntland, T. and Walker, J. R. and Zhou, Y. and Chatterjee, A. and Diagana, T. T. and Winzeler, E. A.. (2011) Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery. Science, Vol. 334, H. 6061. pp. 1372-1377.

Mokoka, Tsholofelo A. and Zimmermann, Stefanie and Julianti, Tasqiah and Hata, Yoshie and Moodley, Nivan and Cal, Monica and Adams, Michael and Kaiser, Marcel and Brun, Reto and Koorbanally, Neil and Hamburger, Matthias. (2011) In vitro Screening of Traditional South African Malaria Remedies against Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Leishmania donovani, and Plasmodium falciparum. Planta medica, Vol. 77, H. 14. pp. 1663-1667.

Moridi Farimani M., and Bahadori, M. B. and Taheri, S. and Ebrahimi, S. N. and Zimmermann, S. and Brun, R. and Amin, G. and Hamburger, M.. (2011) Triterpenoids with rare carbon skeletons from Salvia hydrangea : antiprotozoal activity and absolute configurations. Journal of Natural Products, Vol. 74, H. 10. pp. 2200-2205.

Munigunti, R. and Nelson, N. and Mulabagal, V. and Gupta, M. P. and Brun, R. and Calderón, A. I.. (2011) Identification of oleamide in Guatteria recurvisepala by LC/MS-Based Plasmodium falciparum thioredoxin reductase ligand binding method. Planta medica : Zeitschrift für Arzneipflanzenforschung : official organ of the Society for Medicinal Plant Research, Vol. 77, H. 15. pp. 1749-1753.

Nehrbass-Stuedli A., and Boykin, D. and Tidwell, R. R. and Brun, R.. (2011) Novel diamidines with activity against Babesia divergens in Vitro and Babesia microti in Vivo. Antimicrobial agents and chemotherapy : AAC, Vol. 55, H. 7. pp. 3439-3445.

Nieto, L. and Mascaraque, A. and Miller, F. and Glacial, F. and Rios Martinez C., and Kaiser, M. and Brun, R. and Dardonville, C.. (2011) Synthesis and antiprotozoal activity of N-alkoxy analogues of the trypanocidal lead compound 4,4'-bis(imidazolinylamino)diphenylamine with improved human blood-brain barrier permeability. Journal of medicinal chemistry, 54 (2). pp. 485-494.

Oberle, Michael. Crosstalk between Trypanosoma brucei and the tsetse fly. 2011, Doctoral Thesis, University of Basel, Faculty of Science.

Papadopoulou, M. V. and Bourdin, B. and Bloomer, W. D. and McKenzie, C. and Wilkinson, S. R. and Prasittichai, C. and Brun, R. and Kaiser, M. and Torreele, E.. (2011) Novel 3-nitro-1H-1,2,4-triazole-based aliphatic and aromatic amines as anti-chagasic agents. Journal of medicinal chemistry, 54 (23). pp. 8214-8223.

Pyana, P. P. and Ngay Lukusa, I. and Mumba Ngoyi, D. and Van Reet, N. and Kaiser, M. and Karhemere Bin Shamamba, S. and Buscher, P.. (2011) Isolation of Trypanosoma brucei gambiense from cured and relapsed sleeping sickness patients and adaptation to laboratory mice. PLoS Neglected Tropical Diseases, 5 (4). e1025.

Regalado, E. L. and Turk, T. and Tasdemir, D. and Gorjanc, M. and Kaiser, M. and Thomas, O. P. and Fernandez, R. and Amade, P.. (2011) Cytotoxic and haemolytic steroidal glycosides from the Caribbean sponge Pandaros acanthifolium. Steroids : an international journal, Vol. 76, H. 12. pp. 1389-1396.

Reid, C. S. and Patrick, D. A. and He, S. and Fotie, J. and Premalatha, K. and Tidwell, R. R. and Wang, M. Z. and Liu, Q. and Gershkovich, P. and Wasan, K. M. and Wenzler, T. and Brun, R. and Werbovetz, K. A.. (2011) Synthesis and antitrypanosomal evaluation of derivatives of N-benzyl-1,2-dihydroquinolin-6-ols : effect of core substitutions and salt formation. Bioorganic & medicinal chemistry : a Tetrahedron publication for the rapid dissemenination of full original research papers and critical reviews on biomolecular chemistry, medicinal chemistry and related disciplines, 19 (1). pp. 513-523.

Ruda, G. F. and Nguyen, C. and Ziemkowski, P. and Felczak, K. and Kasinathan, G. and Musso-Buendia A., and Sund, C. and Zhou, X. X. and Kaiser, M. and Ruiz-Perez L. M., and Brun, R. and Kulikowski, T. and Johansson, N. G. and Gonzalez-Pacanowska D., and Gilbert, I. H.. (2011) Modified 5'-trityl nucleosides as inhibitors of Plasmodium falciparum dUTPase. ChemMedChem : chemistry enabling drug discovery, Vol. 6, H. 2. pp. 309-320.

Ruf, M. T. and Sopoh, G. E. and Brun, L. V. and Dossou, A. D. and Barogui, Y. T. and Johnson, R. C. and Pluschke, G.. (2011) Histopathological changes and clinical responses of Buruli ulcer plaque lesions during chemotherapy : a role for surgical removal of necrotic tissue? PLoS neglected tropical diseases, Vol. 5, H. 9 , e1334.

Schiaffo, C. E. and Rottmann, M. and Wittlin, S. and Dussault, P. H.. (2011) 3-alkoxy-1,2-dioxolanes : synthesis and evaluation as potential antimalarial agents. ACS medicinal chemistry letters, Vol. 2, H. 4. pp. 316-319.

Schmidt, T. J. and Kaiser, M. and Brun, R.. (2011) Complete structural assignment of serratol, a cembrane-type diterpene from Boswellia serrata and evaluation of its antiprotozoal activity. Planta medica, 77 (8). pp. 849-850.

Shi, X. L. and Ge, J. F. and Liu, B. Q. and Kaiser, M. and Wittlin, S. and Brun, R. and Ihara, M.. (2011) Synthesis and in vitro antiprotozoal activities of 5-phenyliminobenzo[a]phenoxazine derivatives. Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 21, H. 19. pp. 5804-5807.

Skerlj, R. T. and Bastos, C. M. and Booker, M. L. and Kramer, M. L. and Barker, R. H. and Celatka, C. A. and O'Shea T. J., and Munoz, B. and Sidhu, A. B. and Cortese, J. F. and Wittlin, S. and Papastogiannidis, P. and Angulo-Barturen I., and Jimenez-Diaz M. B., and Sybertz, E.. (2011) Optimization of potent inhibitors of P. falciparum dihydroorotate dehydrogenase for the treatment of malaria. ACS medicinal chemistry letters, Vol. 2, H. 9. pp. 708-713.

Teka, I. A. and Kazibwe, A. J. N. and El-Sabbagh N., and Al-Salabi M. I., and Ward, C. P. and Eze, A. A. and Munday, J. C. and Mäser, P. and Matovu, E. and Barrett, M. P. and de Koning H. P., . (2011) The diamidine diminazene aceturate is a substrate for the high-affinity pentamidine transporter: implications for the development of high resistance levels in trypanosomes. Molecular pharmacology : an international journal, Vol. 80, H. 1. pp. 110-116.

Tripathi, A. and Puddick, J. and Prinsep, M. R. and Rottmann, M. and Chan, K. P. and Chen, D. Y. and Tan, L. T.. (2011) Lagunamide C, a cytotoxic cyclodepsipeptide from the marine cyanobacterium Lyngbya majuscula. Phytochemistry : an international journal of plant biochemistry, Vol. 72, H. 18. pp. 2369-2375.

Vargas, S. and Ndjoko Ioset K., and Hay, A. E. and Ioset, J. R. and Wittlin, S. and Hostettmann, K.. (2011) Screening medicinal plants for the detection of novel antimalarial products applying the inhibition of beta-hematin formation. Journal of pharmaceutical and biomedical analysis, Vol. 56, H. 5. pp. 880-886.

Vonthron-Sénécheau, C. and Kaiser, M. and Devambez, I. and Vastel, A. and Mussio, I. and Rusig, A. M.. (2011) Antiprotozoal activities of organic extracts from French marine seaweeds. Marine drugs , 9 (6). pp. 922-933.

Wu, T. and Nagle, A. and Kuhen, K. and Gagaring, K. and Borboa, R. and Francek, C. and Chen, Z. and Plouffe, D. and Goh, A. and Lakshminarayana, S. B. and Wu, J. and Ang, H. Q. and Zeng, P. and Kang, M. L. and Tan, W. and Tan, M. and Ye, N. and Lin, X. and Caldwell, C. and Ek, J. and Skolnik, S. and Liu, F. and Wang, J. and Chang, J. and Li, C. and Hollenbeck, T. and Tuntland, T. and Isbell, J. and Fischli, C. and Brun, R. and Rottmann, M. and Dartois, V. and Keller, T. and Diagana, T. and Winzeler, E. and Glynne, R. and Tully, D. C. and Chatterjee, A. K.. (2011) Imidazolopiperazines: hit to lead optimization of new antimalarial agents. Journal of medicinal chemistry, 54 (14). pp. 5116-5130.

2010

Abiodun, O. O. and Gbotosho, G. O. and Ajaiyeoba, E. O. and Happi, C. T. and Hofer, S. and Wittlin, S. and Sowunmi, A. and Brun, R. and Oduola, A. M. J.. (2010) Comparison of SYBR Green I-, PicoGreen-, and [H-3]-hypoxanthine-based assays for in vitro antimalarial screening of plants from Nigerian ethnomedicine. Parasitology research : Organ der Deutschen Gesellschaft für Parasitologie, Vol. 106, H. 4. pp. 933-939.

Adams, M. and Christen, M. and Plitzko, I. and Zimmermann, S. and Brun, R. and Hamburger, M.. (2010) Antiplasmodial lanostanes from the Ganoderma lucidum mushroom. Journal of Natural Products, Vol. 73, H. 5. pp. 897-900.

Allmendinger, A. and Spavieri, J. and Kaiser, M. and Casey, R. and Hingley-Wilson S., and Lalvani, A. and Guiry, M. and Blunden, G. and Tasdemir, D.. (2010) Antiprotozoal, antimycobacterial and cytotoxic potential of twenty-three British and Irish red algae. Phytotherapy research : an international journal devoted to pharmacological and toxocological evaluation of natural product derivatives, Vol. 24, H. 7. pp. 1099-1103.

Athri, P. and Wenzler, T. and Tidwell, R. and Bakunova, S. M. and Wilson, W. D.. (2010) Pharmacophore model for pentamidine analogs active against Plasmodium falciparum. European Journal of Medicinal Chemistry, 45 (12). pp. 6147-6151.

Bakunov, S. A. and Bakunova, S. M. and Wenzler, T. and Ghebru, M. and Werbovetz, K. A. and Brun, R. and Tidwell, R. R.. (2010) Synthesis and antiprotozoal activity of cationic 1,4-diphenyl-1H-1,2,3-triazoles. Journal of Medicinal Chemistry, 53 (1). pp. 254-272.

Bonazzi, S. and Barbaras, D. and Patiny, L. and Scopelliti, R. and Schneider, P. and Cole, S. T. and Kaiser, M. and Brun, R. and Gademann, K.. (2010) Antimalarial and antitubercular nostocarboline and eudistomin derivatives: Synthesis, in vitro and in vivo biological evaluation. Bioorganic and Medicinal Chemistry, 18 (4). pp. 1464-1476.

Booker, M. L. and Bastos, C. M. and Kramer, M. L. and Barker, R. H. and Skerlj, R. and Sidhu, A. B. and Deng, X. and Celatka, C. and Cortese, J. F. and Guerrero Bravo J. E., and Crespo Llado K. N., and Serrano, A. E. and Angulo-Barturen I., and Jimenez-Diaz M. B., and Viera, S. and Garuti, H. and Wittlin, S. and Papastogiannidis, P. and Lin, J. W. and Janse, C. J. and Khan, S. M. and Duraisingh, M. and Coleman, B. and Goldsmith, E. J. and Phillips, M. A. and Munoz, B. and Wirth, D. F. and Klinger, J. D. and Wiegand, R. and Sybertz, E.. (2010) Novel inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with anti-malarial activity in the mouse model. Journal of Biological Chemistry, Vol. 285, H. 43. pp. 33054-33064.

Branowska, D. and Farahat, A. A. and Kumar, A. and Wenzler, T. and Brun, R. and Liu, Y. and Wilson, W. D. and Boykin, D. W.. (2010) Synthesis and antiprotozoal activity of 2,5-bis[amidinoaryl]thiazoles. Bioorganic & Medicinal Chemistry, 18 (10). pp. 3551-3558.

Bringmann, G. and Bischof, S. K. and Müller, S. and Gulder, T. and Winter, C. and Stich, A. and Moll, H. and Kaiser, M. and Brun, R. and Dreher, J. and Baumann, K.. (2010) QSAR guided synthesis of simplified antiplasmodial analogs of naphthylisoquinoline alkaloids. European journal of medicinal chemistry, 45 (11). pp. 5370-5383.

Brun, R. and Blum, J. and Chappuis, F. and Burri, C.. (2010) Human African trypanosomiasis. Lancet, Vol. 375, no. 9709. pp. 148-159.

Brun, R. and Stich, A.. (2010) Afrikanische Trypanosomiasis oder Schlafkrankheit. In: Tropenmedizin in Klinik und Praxis : mit Reise- und Migrationsmedizin. Stuttgart, pp. 617-629.

Burgess, S. J. and Kelly, J. X. and Shomloo, S. and Wittlin, S. and Brun, R. and Liebmann, K. and Peyton, D. H.. (2010) Synthesis, structure-activity relationship, and mode-of-action studies of antimalarial reversed chloroquine compounds. Journal of medicinal chemistry, 53 (17). pp. 6477-6489.

Dong, Y. and McCullough, K. J. and Wittlin, S. and Chollet, J. and Vennerstrom, J. L.. (2010) The structure and antimalarial activity of dispiro-1,2,4,5-tetraoxanes derived from (+)-dihydrocarvone. Bioorganic and Medicinal Chemistry Letters, Vol. 20, H. 22. pp. 6359-6361.

Dong, Y. and Wittlin, S. and Sriraghavan, K. and Chollet, J. and Charman, S. A. and Charman, W. N. and Scheurer, C. and Urwyler, H. and Santo, T. J. and Snyder, C. and Creek, D. J. and Morizzi, J. and Koltun, M. and Matile, H. and Wang, X. and Padmanilayam, M. and Tang, Y. and Dorn, A. and Brun, R. and Vennerstrom, J. L.. (2010) The structure-activity relationship of the antimalarial ozonide arterolane (OZ277). Journal of Medicinal Chemistry, 53 (1). pp. 481-491.

Faist, J. and Seebacher, W. and Kaiser, M. and Brun, R. and Saf, R. and Weis, R.. (2010) Alkyl and dialkylaminoethyl derivatives of 5-amino-2-azabicyclo[3.2.2]nonanes and their antiplasmodial and antitrypanosomal activities. European Journal of Medicinal Chemistry, 45 (1). pp. 179-185.

Faist, J. and Seebacher, W. and Kaiser, M. and Brun, R. and Saf, R. and Weis, R.. (2010) Dialkylaminoalkyl derivatives of bicyclic compounds with antiplasmodial activity. Bioorganic & medicinal chemistry : a Tetrahedron publication for the rapid dissemenination of full original research papers and critical reviews on biomolecular chemistry, medicinal chemistry and related disciplines, 18 (18). pp. 6796-6804.

Farahat, A. A. and Kumar, A. and Say, M. and Barghash Aedm, and Goda, F. E. and Eisa, H. M. and Wenzler, T. and Brun, R. and Liu, Y. and Mickelson, L. and Wilson, W. D. and Boykin, D. W.. (2010) Synthesis, DNA binding, fluorescence measurements and antiparasitic activity of DAPI related diamidines. Bioorganic & Medicinal Chemistry, 18 (2). pp. 557-566.

Fotie, J. and Kaiser, M. and Delfin, D. A. and Manley, J. and Reid, C. S. and Paris, J. M. and Wenzler, T. and Maes, L. and Mahasenan, K. V. and Li, C. and Werbovetz, K. A.. (2010) Antitrypanosomal activity of 1,2-dihydroquinolin-6-ols and their ester derivatives. Journal of medicinal chemistry, 53 (3). pp. 966-982.

Gachet, M. S. and Kunert, O. and Kaiser, M. and Brun, R. and Munoz, R. A. and Bauer, R. and Schuhly, W.. (2010) Jacaranone-derived glucosidic esters from Jacaranda glabra and their activity against Plasmodium falciparum. Journal of Natural Products, Vol. 73, H. 4. pp. 553-556.

Gachet, M. S. and Lecaro, J. S. and Kaiser, M. and Brun, R. and Navarrete, H. and Munoz, R. A. and Bauer, R. and Schuhly, W.. (2010) Assessment of anti-protozoal activity of plants traditionally used in Ecuador in the treatment of leishmaniasis. Journal of ethnopharmacology : an interdisciplinary journal devoted to bioscientific research on indigenous drugs, Vol. 128, H. 1. pp. 184-197.

Ge, J. F. and Arai, C. and Yang, M. and Bakar, M. A. and Lu, J. and Ismail, N. S. M. and Wittlin, S. and Kaiser, M. and Brun, R. and Charman, S. A. and Nguyen, T. and Morizzi, J. and Itoh, I. and Ihara, M.. (2010) Discovery of novel benzo[a]phenoxazine SSJ-183 as a drug candidate for malaria. ACS medicinal chemistry letters, Vol. 1, H. 7. pp. 360-364.

Gigante, F. and Kaiser, M. and Brun, R. and Gilbert, I. H.. (2010) Design and preparation of sterol mimetics as potential antiparasitics. Bioorganic & medicinal chemistry : a Tetrahedron publication for the rapid dissemenination of full original research papers and critical reviews on biomolecular chemistry, medicinal chemistry and related disciplines, 18 (20). pp. 7291-7301.

Gillingwater, K. and Kumar, A. and Ismail, M. A. and Arafa, R. K. and Stephens, C. E. and Boykin, D. W. and Tidwell, R. R. and Brun, R.. (2010) In vitro activity and preliminary toxicity of various diamidine compounds against Trypanosoma evansi. Veterinary parasitology : an international scientific journal, Vol. 169. pp. 264-272.

Link, Andreas and Heidler, Philipp and Kaiser, Marcel and Brun, Reto. (2010) Parallel synthesis of a series of non-functional ATP/NAD analogs with activity against trypanosomatid parasites. Molecular Diversity, 14 (2). pp. 215-224.

Mallari, J. P. and Zhu, F. and Lemoff, A. and Kaiser, M. and Lu, M. and Brun, R. and Guy, R. K.. (2010) Optimization of purine-nitrile TbcatB inhibitors for use in vivo and evaluation of efficacy in murine models. Bioorganic & medicinal chemistry : a Tetrahedron publication for the rapid dissemenination of full original research papers and critical reviews on biomolecular chemistry, medicinal chemistry and related disciplines, 18 (23). pp. 8302-8309.

Mosimann, M. and Goshima, S. and Wenzler, T. and Luscher, A. and Uozumi, N. and Mäser, P.. (2010) A Trk/HKT-type K+ transporter from Trypanosoma brucei. Eukaryotic Cell, Vol. 9, H. 4. pp. 539-546.

Nare, B. and Wring, S. and Bacchi, C. and Beaudet, B. and Bowling, T. and Brun, R. and Chen, D. and Ding, C. and Freund, Y. and Gaukel, E. and Hussain, A. and Jarnagin, K. and Jenks, M. and Kaiser, M. and Mercer, L. and Mejia, E. and Noe, A. and Orr, M. and Parham, R. and Plattner, J. and Randolph, R. and Rattendi, D. and Rewerts, C. and Sligar, J. and Yarlett, N. and Don, R. and Jacobs, R.. (2010) Discovery of novel orally bioavailable oxaborole 6-carboxamides that demonstrate cure in a murine model of late stage central nervous system African Trypanosomiasis. Antimicrobial agents and chemotherapy : AAC, Vol. 54, H. 10. pp. 4379-4388.

Nerima, B. and Nilsson, D. and Mäser, P.. (2010) Comparative genomics of metabolic networks of free-living and parasitic eukaryotes. BMC Genomics, Vol. 11 , 217.

Nour, A. M. and Khalid, S. A. and Kaiser, M. and Brun, R. and Abdalla, W. E. and Schmidt, T. J.. (2010) The antiprotozoal activity of methylated flavonoids from Ageratum conyzoides L. Journal of Ethnopharmacology, Vol. 129, H. 1. pp. 127-130.

Nzila, A. and Rottmann, M. and Chitnumsub, P. and Kiara, S. M. and Kamchonwongpaisan, S. and Maneeruttanarungroj, C. and Taweechai, S. and Yeung, B. K. and Goh, A. and Lakshminarayana, S. B. and Zou, B. and Wong, J. and Ma, N. L. and Weaver, M. and Keller, T. H. and Dartois, V. and Wittlin, S. and Brun, R. and Yuthavong, Y. and Diagana, T. T.. (2010) Preclinical evaluation of the antifolate QN254, 5-chloro- N'6'-(2,5-dimethoxy-benzyl)-quinazoline-2,4,6-triamine, as an antimalarial drug candidate. Antimicrobial agents and chemotherapy : AAC, Vol. 54, H. 6. pp. 2603-2610.

O'Neill P. M., and Amewu, R. K. and Nixon, G. L. and Bousejra, E. F. and Mungthin, M. and Chadwick, J. and Shone, A. E. and Vivas, L. and Lander, H. and Barton, V. and Muangnoicharoen, S. and Bray, P. G. and Davies, J. and Park, B. K. and Wittlin, S. and Brun, R. and Preschel, M. and Zhang, K. and Ward, S. A.. (2010) Identification of a 1,2,4,5-tetraoxane antimalarial drug-development candidate (RKA 182) with superior properties to the semisynthetic artemisinins. Angewandte Chemie. International edition in English, Vol. 49, H. 33. pp. 5693-5697.

Oberle, M. and Balmer, O. and Brun, R. and Roditi, I.. (2010) Bottlenecks and the maintenance of minor genotypes during the life cycle of Trypanosoma brucei. PLoS Pathogens, Vol. 6, H. 7 , e1001023.

Orhan, Ilkay and Sener, Bilge and Kaiser, Marcel and Brun, Reto and Tasdemir, Deniz. (2010) Inhibitory activity of marine sponge-derived natural products against parasitic protozoa. Marine drugs, Vol. 8, H. 1. pp. 47-58.

Pacorel, B. and Leung, S. C. and Stachulski, A. V. and Davies, J. and Vivas, L. and Lander, H. and Ward, S. A. and Kaiser, M. and Brun, R. and O'Neill P. M., . (2010) Modular synthesis and in vitro and in vivo antimalarial assessment of C-10 pyrrole mannich base derivatives of artemisinin. Journal of medicinal chemistry, 53 (2). pp. 633-640.

Pagliero, R. J. and Lusvarghi, S. and Pierini, A. B. and Brun, R. and Mazzieri, M. R.. (2010) Synthesis, stereoelectronic characterization and antiparasitic activity of new 1-benzenesulfonyl-2-methyl-1,2,3,4-tetrahydroquinolines. Bioorganic & Medicinal Chemistry, 18 (1). pp. 142-150.

Paine, M. F. and Wang, M. Z. and Generaux, C. N. and Boykin, D. W. and Wilson, W. D. and de Koning H. P., and Olson, C. A. and Pohlig, G. and Burri, C. and Brun, R. and Murilla, G. A. and Thuita, J. K. and Barrett, M. P. and Tidwell, R. R.. (2010) Diamidines for human African trypanosomiasis. Current opinion in investigational drugs, Vol. 11, H. 8. pp. 876-883.

Regalado, E. L. and Tasdemir, D. and Kaiser, M. and Cachet, N. and Amade, P. and Thomas, O. P.. (2010) Antiprotozoal steroidal saponins from the marine sponge Pandaros acanthifolium. Journal of natural products, Vol. 73, H. 8. pp. 1404-1410.

Rottmann, M. and McNamara, C. and Yeung, B. K. and Lee, M. C. and Zou, B. and Russell, B. and Seitz, P. and Plouffe, D. M. and Dharia, N. V. and Tan, J. and Cohen, S. B. and Spencer, K. R. and Gonzalez-Paez G. E., and Lakshminarayana, S. B. and Goh, A. and Suwanarusk, R. and Jegla, T. and Schmitt, E. K. and Beck, H. P. and Brun, R. and Nosten, F. and Renia, L. and Dartois, V. and Keller, T. H. and Fidock, D. A. and Winzeler, E. A. and Diagana, T. T.. (2010) Spiroindolones, a potent compound class for the treatment of malaria. Science, Vol. 329, no. 5996. pp. 1175-1180.

Rufener, L. and Baur, R. and Kaminsky, R. and Mäser, P. and Sigel, E.. (2010) Monepantel allosterically activates DEG-3/DES-2 channels of the gastrointestinal nematode Haemonchus contortus. Molecular pharmacology : an international journal, Vol. 78, H. 5. pp. 895-902.

Rufener, L. and Keiser, J. and Kaminsky, R. and Mäser, P. and Nilsson, D.. (2010) Phylogenomics of ligand-gated ion channels predicts monepantel effect. PLoS Pathogens, Vol. 6, H. 9 , e1001091.

Scala, F. and Fattorusso, E. and Menna, M. and Taglialatela-Scafati O., and Tierney, M. and Kaiser, M. and Tasdemir, D.. (2010) Bromopyrrole alkaloids as lead compounds against protozoan parasites. Marine drugs, Vol. 8, H. 7. pp. 2162-2174.

Spavieri, J. and Allmendinger, A. and Kaiser, M. and Casey, R. and Hingley-Wilson S., and Lalvani, A. and Guiry, M. D. and Blunden, G. and Tasdemir, D.. (2010) Antimycobacterial, antiprotozoal and cytotoxic potential of twenty-one brown algae (Phaeophyceae) from British and Irish waters. Phytotherapy research : an international journal devoted to pharmacological and toxocological evaluation of natural product derivatives, Vol. 24, H. 11. pp. 1724-1729.

Spavieri, J. and Kaiser, M. and Casey, R. and Hingley-Wilson S., and Lalvani, A. and Blunden, G. and Tasdemir, D.. (2010) Antiprotozoal, antimycobacterial and cytotoxic potential of some british green algae. Phytotherapy research : an international journal devoted to pharmacological and toxocological evaluation of natural product derivatives, Vol. 24, H. 7. pp. 1095-1098.

Tang, Y. and Wittlin, S. and Charman, S. A. and Chollet, J. and Chiu, F. C. and Morizzi, J. and Johnson, L. M. and Tomas, J. S. and Scheurer, C. and Snyder, C. and Zhou, L. and Dong, Y. and Charman, W. N. and Matile, H. and Urwyler, H. and Dorn, A. and Vennerstrom, J. L.. (2010) The comparative antimalarial properties of weak base and neutral synthetic ozonides. Bioorganic and Medicinal Chemistry Letters, Vol. 20, H. 2. pp. 563-566.

Tasdemir, D. and Sanabria, D. and Lauinger, I. L. and Tarun, A. and Herman, R. and Perozzo, R. and Zloh, M. and Kappe, S. H. and Brun, R. and Carballeira, N. M.. (2010) 2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage Plasmodium infections. Bioorganic and Medicinal Chemistry, 18 (21). pp. 7475-7485.

Torreele, E. and BourdinTrunz, B. and Tweats, D. and Kaiser, M. and Brun, R. and Mazue, G. and Bray, M. A. and Pecoul, B.. (2010) Fexinidazole: a new oral nitroimidazole drug candidate entering clinical development for the treatment of sleeping sickness. PLoS neglected tropical diseases, Vol. 4, H. 12 , e923.

Tripathi, A. and Puddick, J. and Prinsep, M. R. and Rottmann, M. and Tan, L. T.. (2010) Lagunamides A and B : cytotoxic and antimalarial cyclodepsipeptides from the marine cyanobacterium Lyngbya majuscula. Journal of natural products, Vol. 73, H. 11. pp. 1810-1814.

Wenzel, N. I. and Chavain, N. and Wang, Y. and Friebolin, W. and Maes, L. and Pradines, B. and Lanzer, M. and Yardley, V. and Brun, R. and Herold-Mende C., and Biot, C. and Toth, K. and Davioud-Charvet E., . (2010) Antimalarial versus cytotoxic properties of dual drugs derived from 4-aminoquinolines and Mannich bases: interaction with DNA. Journal of Medicinal Chemistry, 53 (8). pp. 3214-3226.

Wright, C. W. and Linley, P. A. and Brun, R. and Wittlin, S. and Hsu, E.. (2010) Ancient Chinese methods are remarkably effective for the preparation of artemisinin-rich extracts of Qing Hao with potent antimalarial activity. Molecules, Vol. 15, H. 2. pp. 804-812.

Xu, M. and Bruhn, T. and Hertlein, B. and Brun, R. and Stich, A. and Wu, J. and Bringmann, G.. (2010) Shuangancistrotectorines A-E, dimeric naphthylisoquinoline alkaloids with three chiral biaryl axes from the Chinese plant Ancistrocladus tectorius. Chemistry : a European journal, Vol. 16, H. 14. pp. 4206-4216.

Yang, M. and Arai, C. and Bakar, M. A. and Lu, J. and Ge, J. F. and Pudhom, K. and Takasu, K. and Kasai, K. and Kaiser, M. and Brun, R. and Yardley, V. and Itoh, I. and Ihara, M.. (2010) Fluorinated rhodacyanine (SJL-01) possessing high efficacy for visceral leishmaniasis (VL). Journal of medicinal chemistry, 53 (1). pp. 368-373.

Yeung, B. K. and Zou, B. and Rottmann, M. and Lakshminarayana, S. B. and Ang, S. H. and Leong, S. Y. and Tan, J. and Wong, J. and Keller-Maerki S., and Fischli, C. and Goh, A. and Schmitt, E. K. and Krastel, P. and Francotte, E. and Kuhen, K. and Plouffe, D. and Henson, K. and Wagner, T. and Winzeler, E. A. and Petersen, F. and Brun, R. and Dartois, V. and Diagana, T. T. and Keller, T. H.. (2010) Spirotetrahydro beta-carbolines (spiroindolones) : a new class of potent and orally efficacious compounds for the treatment of malaria. Journal of Medicinal Chemistry, 53 (14). pp. 5155-5164.

Zohrabi-Kalantari, V. and Heidler, P. and Kaiser, M. and Brun, R. and Kamper, C. and Link, A.. (2010) Inhibitors of adenosine consuming parasites through polymer-assisted N-acylation of N(6)-substituted 5 (`)-amino-5 (`)-deoxyadenosines. Molecular Diversity, 14 (2). pp. 307-320.

Zohrabi-Kalantari, V. and Heidler, P. and Kaiser, M. and Brun, R. and Kamper, C. and Link, A.. (2010) Inhibitors of adenosine consuming parasites through polymer-assisted N-acylation of N6-substituted 5'-amino-5'-deoxyadenosines. Molecular Diversity, 14 (2). pp. 307-320.

2009

Adams, M. and Plitzko, I. and Kaiser, M. and Brun, R. and Hamburger, M.. (2009) HPLC-profiling for antiplasmodial compounds-3-methoxycarpachromene from Pistacia atlantica. Planta medica : Zeitschrift für Arzneipflanzenforschung : official organ of the Society for Medicinal Plant Research, Vol. 75, H. 9. p. 948.

Alp, M. and Göker, H. and Brun, R. and Yildiz, S.. (2009) Synthesis and antiparasitic and antifungal evaluation of 2'-arylsubstituted-1H,1'H-[2,5']bisbenzimidazolyl-5-carboxamidines. European Journal of Medicinal Chemistry, 44 (5). pp. 2002-2008.

Bakunov, S. A. and Bakunova, S. M. and Bridges, A. S. and Wenzler, T. and Barszcz, T. and Werbovetz, K. A. and Brun, R. and Tidwell, R. R.. (2009) Synthesis and antiprotozoal properties of pentamidine congeners bearing the benzofuran motif. Journal of Medicinal Chemistry, 52 (18). pp. 5763-5767.

Bakunova, S. M. and Bakunov, S. A. and Patrick, D. A. and Kumar, E. V. and Ohemeng, K. A. and Bridges, A. S. and Wenzler, T. and Barszcz, T. and Jones, S. K. and Werbovetz, K. A. and Brun, R. and Tidwell, R. R.. (2009) Structure-activity study of pentamidine analogues as antiprotozoal agents. Journal of Medicinal Chemistry, 52 (7). pp. 2016-2035.

Bakunova, S. M. and Bakunov, S. A. and Wenzler, T. and Barszcz, T. and Werbovetz, K. A. and Brun, R. and Tidwell, R. R.. (2009) Synthesis and antiprotozoal activity of pyridyl analogues of pentamidine. Journal of Medicinal Chemistry, 52 (15). pp. 4657-4667.

Baliani, A. and Peal, V. and Gros, L. and Brun, R. and Kaiser, M. and Barrett, M. P. and Gilbert, I. H.. (2009) Novel functionalized melamine-based nitroheterocycles: synthesis and activity against trypanosomatid parasites. Organic & biomolecular chemistry : an international journal of synthetic, physical and biomolecular organic chemistry, Vol. 7, H. 6. pp. 1154-1166.

Balmer, O. and Stearns, S. C. and Schotzau, A. and Brun, R.. (2009) Intraspecific competition between co-infecting parasite strains enhances host survival in African trypanosomes. Ecology : a publication of the Ecological Society of America, Vol. 90, Nr. 12. pp. 3367-3378.

Barker, R. H. and Liu, H. and Hirth, B. and Celatka, C. A. and Fitzpatrick, R. and Xiang, Y. and Willert, E. K. and Phillips, M. A. and Kaiser, M. and Bacchi, C. J. and Rodriguez, A. and Yarlett, N. and Klinger, J. D. and Sybertz, E.. (2009) Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis. Antimicrobial agents and chemotherapy : AAC, Vol. 53, H. 5. pp. 2052-2058.

Berger, H. and Seebacher, W. and Kaiser, M. and Brun, R. and Saf, R. and Weis, R.. (2009) SARs of the antiprotozoal action of 6,7-diaryl-bicyclo[2.2.2]octan-2-ols. Monatshefte für Chemie = Chemical monthly : an international journal of chemistry, Vol. 140, H. 5. pp. 495-502.

Cavalli, A. and Lizzi, F. and Bongarzone, S. and Brun, R. and Luise Krauth-Siegel R., and Bolognesi, M. L.. (2009) Privileged structure-guided synthesis of quinazoline derivatives as inhibitors of trypanothione reductase. Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 19, H. 11. pp. 3031-3035.

Chavain, N. and Davioud-Charvet E., and Trivelli, X. and Mbeki, L. and Rottmann, M. and Brun, R. and Biot, C.. (2009) Antimalarial activities of ferroquine conjugates with either glutathione reductase inhibitors or glutathione depletors via a hydrolyzable amide linker. Bioorganic & medicinal chemistry : a Tetrahedron publication for the rapid dissemenination of full original research papers and critical reviews on biomolecular chemistry, medicinal chemistry and related disciplines, 17 (23). pp. 8048-8059.

Christen, M. and Adams, M. and Zimmermann, S. and Brun, R. and Hamburger, M.. (2009) HPLC based activity profiling of Ganoderma lucidum extract for antiplasmodial activity and isolation of new active lanostane triterpenoids. Planta medica : Zeitschrift für Arzneipflanzenforschung : official organ of the Society for Medicinal Plant Research, Vol. 75, H. 9. p. 948.

Dardonville, C. and Fernandez-Fernandez C., and Gibbons, S. L. and Jagerovic, N. and Nieto, L. and Ryan, G. and Kaiser, M. and Brun, R.. (2009) Antiprotozoal activity of 1-phenethyl-4-aminopiperidine derivatives. Antimicrobial agents and chemotherapy : AAC, Vol. 53, H. 9. pp. 3815-3821.

Eberle, C. and Burkhard, J. A. and Stump, B. and Kaiser, M. and Brun, R. and Krauth-Siegel R. L., and Diederich, F.. (2009) Synthesis, inhibition potency, binding mode, and antiprotozoal activities of fluorescent inhibitors of trypanothione reductase based on mepacrine-conjugated diaryl sulfide scaffolds. ChemMedChem : chemistry enabling drug discovery, Vol. 4, H. 12. pp. 2034-2044.

Efange, S. M. and Brun, R. and Wittlin, S. and Connolly, J. D. and Hoye, T. R. and McAkam, T. and Makolo, F. L. and Mbah, J. A. and Nelson, D. P. and Nyongbela, K. D. and Wirmum, C. K.. (2009) Okundoperoxide, a bicyclic cyclofarnesylsesquiterpene endoperoxide from Scleria striatinux with antiplasmodial activity. Journal of Natural Products, Vol. 72, H. 2. pp. 280-283.

Faist, J. and Seebacher, W. and Kaiser, M. and Brun, R. and Saf, R. and Weis, R.. (2009) Bicyclic amido compounds with antiprotozoal activity. Monatshefte für Chemie = Chemical monthly : an international journal of chemistry, Vol. 140, H. 10. pp. 1261-1268.

Faist, J. and Seebacher, W. and Schlapper, C. and Kaiser, M. and Brun, R. and Saf, R. and Weis, R.. (2009) Antiplasmodial and antitrypanosomal activity of bicyclic amides and esters of dialkylamino acids. Bioorganic & medicinal chemistry : a Tetrahedron publication for the rapid dissemenination of full original research papers and critical reviews on biomolecular chemistry, medicinal chemistry and related disciplines, 17 (10). pp. 3595-3603.

Gachet, M. S. and Schuhly, W. and Kunert, O. and Kaiser, M. and Brun, R. and Munoz, R. A. and Bauer, R.. (2009) Jacaranone derived glucosidic esters from Jacaranda glabra. Planta medica : Zeitschrift für Arzneipflanzenforschung : official organ of the Society for Medicinal Plant Research, Vol. 75, H. 9. pp. 901-902.

Ganapaty, S. and Srilakshmi, G. V. and Pannakal, S. T. and Rahman, H. and Laatsch, H. and Brun, R.. (2009) Cytotoxic benzil and coumestan derivatives from Tephrosia calophylla. Phytochemistry : an international journal of plant biochemistry, Vol. 70, H. 1. pp. 95-99.

Gemma, S. and Campiani, G. and Butini, S. and Joshi, B. P. and Kukreja, G. and Coccone, S. S. and Bernetti, M. and Persico, M. and Nacci, V. and Fiorini, I. and Novellino, E. and Taramelli, D. and Basilico, N. and Parapini, S. and Yardley, V. and Croft, S. and Keller-Maerki S., and Rottmann, M. and Brun, R. and Coletta, M. and Marini, S. and Guiso, G. and Caccia, S. and Fattorusso, C.. (2009) Combining 4-aminoquinoline- and clotrimazole-based pharmacophores toward innovative and potent hybrid antimalarials. Journal of Medicinal Chemistry, 52 (2). pp. 502-513.

Gigante, F. and Kaiser, M. and Brun, R. and Gilbert, I. H.. (2009) SAR studies on azasterols as potential anti-trypanosomal and anti-leishmanial agents. Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 17, H. 16. pp. 5950-5961.

Gillingwater, K. and Kumar, A. and Anbazhagan, M. and Boykin, D. W. and Tidwell, R. R. and Brun, R.. (2009) In vivo investigations of selected diamidine compounds against Trypanosoma evansi using a mouse model. Antimicrobial agents and chemotherapy : AAC, Vol. 53, H. 12. pp. 5074-5079.

Heidler, P. and Zohrabi-Kalantari V., and Kaiser, M. and Brun, R. and Emmrich, T. and Link, A.. (2009) Inhibitors of adenosine consuming parasites through polymer-assisted solution phase synthesis of lipophilic 5'-amido-5'-deoxyadenosine derivatives. Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 17, H. 4. pp. 1428-1436.

Holloway, G. A. and Charman, W. N. and Fairlamb, A. H. and Brun, R. and Kaiser, M. and Kostewicz, E. and Novello, P. M. and Parisot, J. P. and Richardson, J. and Street, I. P. and Watson, K. G. and Baell, J. B.. (2009) Trypanothione reductase high-throughput screening campaign identifies novel classes of inhibitors with anti-parasitic activity. Antimicrobial agents and chemotherapy : AAC, Vol. 53, H. 7. pp. 2824-2833.

Hu, L. and Arafa, R. K. and Ismail, M. A. and Patel, A. and Munde, M. and Wilson, W. D. and Wenzler, T. and Brun, R. and Boykin, D. W.. (2009) Synthesis and activity of azaterphenyl diamidines against Trypanosoma brucei rhodesiense and Plasmodium falciparum. Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 17, H. 18. pp. 6651-6658.

Huang, Q. and Mao, J. and Wan, B. and Wang, Y. and Brun, R. and Franzblau, S. G. and Kozikowski, A. P.. (2009) Searching for new cures for tuberculosis: design, synthesis, and biological evaluation of 2-methylbenzothiazoles. Journal of Medicinal Chemistry, 52 (21). pp. 6757-6767.

Irungu, B. and Kiboi, D. and Langat, B. and Rukunga, G. and Wittlin, S. and Nzila, A.. (2009) Methotrexate and aminopterin lack in vivo antimalarial activity against murine malaria species. Experimental parasitology : EP, Vol. 123, H. 2. pp. 118-121.

Karioti, A. and Skaltsa, H. and Kaiser, M. and Tasdemir, D.. (2009) Trypanocidal, leishmanicidal and cytotoxic effects of anthecotulide-type linear sesquiterpene lactones from Anthemis auriculata. Phytomedicine : international journal of phytotherapy and phytopharmacology, Vol. 16, H. 8. pp. 783-787.

Keiser, J. and Chollet, J. and Xiao, S. H. and Mei, J. Y. and Jiao, P. Y. and Utzinger, J. and Tanner, M.. (2009) Mefloquine - an aminoalcohol with promising antischistosomal properties in mice. PLoS neglected tropical diseases, Vol. 3, H. 1 , e350.

Kelly, J. X. and Smilkstein, M. J. and Brun, R. and Wittlin, S. and Cooper, R. A. and Lane, K. D. and Janowsky, A. and Johnson, R. A. and Dodean, R. A. and Winter, R. and Hinrichs, D. J. and Riscoe, M. K.. (2009) Discovery of dual function acridones as a new antimalarial chemotype. Nature, Vol. 459, H. 7244. pp. 270-273.

Kiboi, D. M. and Irungu, B. N. and Langat, B. and Wittlin, S. and Brun, R. and Chollet, J. and Abiodun, O. and Nganga, J. K. and Nyambati, V. C. and Rukunga, G. M. and Bell, A. and Nzila, A.. (2009) Plasmodium berghei ANKA: selection of resistance to piperaquine and lumefantrine in a mouse model. Experimental parasitology : EP, Vol. 122, H. 3. pp. 196-202.

Kuettel, S. and Mosimann, M. and Mäser, P. and Kaiser, M. and Brun, R. and Scapozza, L. and Perozzo, R.. (2009) Adenosine kinase of T. b. Rhodesiense identified as the putative target of 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine using chemical proteomics. PLoS Neglected Tropical Diseases, Vol. 3, H. 8 , e506.

Link, A. and Heidler, P. and Kaiser, M. and Brun, R.. (2009) Synthesis of a series of N(6)-substituted adenosines with activity against trypanosomatid parasites. European Journal of Medicinal Chemistry, 44 (9). pp. 3665-3671.

Ma, X. and Zhou, W. and Brun, R.. (2009) Synthesis, in vitro antitrypanosomal and antibacterial activity of phenoxy, phenylthio or benzyloxy substituted quinolones. Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 19, H. 3. pp. 986-989.

Malebo, H. M. and Wenzler, T. and Cal, M. and Swaleh, S. A. and Omolo, M. O. and Hassanali, A. and Sequin, U. and Hamburger, M. and Brun, R. and Ndiege, I. O.. (2009) Antiplasmodial, anti-trypanosomal, anti-leishmanial and cytotoxicity activity of selected Tanzanian medicinal plants. Tanzania journal of health research, Vol. 11, H. 4. pp. 226-234.

McCarthy, O. and Musso-Buendia A., and Kaiser, M. and Brun, R. and Ruiz-Perez L. M., and Johansson, N. G. and Pacanowska, D. G. and Gilbert, I. H.. (2009) Design, synthesis and evaluation of novel uracil acetamide derivatives as potential inhibitors of Plasmodium falciparum dUTP nucleotidohydrolase. European journal of medicinal chemistry, 44 (2). pp. 678-688.

Mdachi, R. E. and Thuita, J. K. and Kagira, J. M. and Ngotho, J. M. and Murilla, G. A. and Ndung'u J. M., and Tidwell, R. R. and Hall, J. E. and Brun, R.. (2009) Efficacy of the novel diamidine compound 2,5-Bis(4-amidinophenyl)- furan-bis-O-Methlylamidoxime (Pafuramidine, DB289) against Trypanosoma brucei rhodesiense infection in vervet monkeys after oral administration. Antimicrobial agents and chemotherapy : AAC, Vol. 53, H. 3. pp. 953-957.

Musonda, C. C. and Whitlock, G. A. and Witty, M. J. and Brun, R. and Kaiser, M.. (2009) Chloroquine-astemizole hybrids with potent in vitro and in vivo antiplasmodial activity. Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 19, H. 2. pp. 481-484.

Musonda, C. C. and Whitlock, G. A. and Witty, M. J. and Brun, R. and Kaiser, M.. (2009) Synthesis and evaluation of 2-pyridyl pyrimidines with in vitro antiplasmodial and antileishmanial activity. Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 19, H. 2. pp. 401-405.

Nour, A. M. and Khalid, S. A. and Kaiser, M. and Brun, R. and Abdallah, W. E. and Schmidt, T. J.. (2009) The antiprotozoal activity of sixteen asteraceae species native to Sudan and bioactivity-guided isolation of xanthanolides from Xanthium brasilicum. Planta medica : Zeitschrift für Arzneipflanzenforschung : official organ of the Society for Medicinal Plant Research, Vol. 75, H. 2. pp. 1363-1368.

Nwaka, S. and Ramirez, B. and Brun, R. and Maes, L. and Douglas, F. and Ridley, R.. (2009) Advancing drug innovation for neglected diseases-criteria for lead progression. PLoS Neglected Tropical Diseases, Vol. 3, H. 8 , e440.

Nwodo, N. J. and Omeje, E. O. and Brun, R.. (2009) In vitro-in vivo studies on anti-trypanosomal potentials of Zapoteca portoricensis. Asian pacific journal of tropical medicine, Vol. 2, H. 1. pp. 25-29.

Nyongbela, Kennedy and Ndjoko, Karine Ioset and Brun, Reto and Wittlin, Sergio and Mbah, James and Makolo, Felix and Akam, Marc and Wirmum, Claire and Efange, Simon and Hostettmann, Kurt. (2009) Occurrence of sesquiterpene derivatives in Scleria striatonux de wild (Cyperaceae). Natural product communications : NPC, Vol. 4, H. 1. pp. 5-8.

Patrick, D. A. and Bakunov, S. A. and Bakunova, S. M. and Suresh Kumar E. V., and Chen, H. and Jones, S. K. and Wenzler, T. and Barzcz, T. and Werbovetz, K. A. and Brun, R. and Tidwell, R. R.. (2009) Synthesis and antiprotozoal activities of dicationic bis(phenoxymethyl)benzenes, bis(phenoxymethyl)naphthalenes, and bis(benzyloxy)naphthalenes. European Journal of Medicinal Chemistry, 44 (9). pp. 3543-3551.

Portmann, C. and Blom, J. F. and Kaiser, M. and Brun, R. and Juttner, F. and Gademann, K.. (2009) New antiplasmodial natural products from cyanobacteria: linking their ecological role to their therapeutic potential. Planta medica : Zeitschrift für Arzneipflanzenforschung : official organ of the Society for Medicinal Plant Research, Vol. 75, H. 9. p. 886.

Pudhom, K. and Ge, M. F. and Arai, C. and Yang, M. and Kaiser, M. and Wittlin, S. and Brun, R. and Itoh, I. and Ihara, M.. (2009) Synthesis and biological properties of a rhodacyanine derivative, Ssj-127, having high efficacy against malaria protozoa. Heterocycles : an international journal for reviews and communications in heterocyclic chemistry, Vol. 77, H. 1. pp. 207-210.

Riente, R. R. and Souza, V. P. and Carvalho, S. A. and Kaiser, M. and Brun, R. and da Silva E. F., . (2009) Leishmanicidal activity of new megazol derivatives. Medicinal chemistry, Vol. 5, H. 4. pp. 392-397.

Schlapper, C. and Seebacher, W. and Faist, J. and Kaiser, M. and Brun, R. and Saf, R. and Weis, R.. (2009) Antiplasmodial and antitrypanosomal activities of aminobicyclo[2.2.2]octyl omega-aminoalkanoates. European journal of medicinal chemistry, 44 (2). pp. 736-744.

Schmidt, T. J. and Nour, A. M. and Khalid, S. A. and Kaiser, M. and Brun, R.. (2009) Quantitative structure--antiprotozoal activity relationships of sesquiterpene lactones. Molecules : a journal of synthetic chemistry and natural product chemistry, Vol. 14, H. 6. pp. 2062-2076.

Stump, B. and Eberle, C. and Schweizer, W. B. and Kaiser, M. and Brun, R. and Krauth-Siegel R. L., and Lentz, D. and Diederich, F.. (2009) Pentafluorosulfanyl as a novel building block for enzyme inhibitors: trypanothione reductase inhibition and antiprotozoal activities of diarylamines. ChemBioChem : a European journal of chemical biology, Vol. 10, H. 1. pp. 79-83.

Sturm, N. and Hu, Y. and Zimmermann, H. and Fritz-Wolf K., and Wittlin, S. and Rahlfs, S. and Becker, K.. (2009) Compounds structurally related to ellagic acid show improved antiplasmodial activity. Antimicrobial agents and chemotherapy : AAC, Vol. 53, H. 2. pp. 622-630.

Tritten, L. and Matile, H. and Brun, R. and Wittlin, S.. (2009) A new double-antibody sandwich ELISA targeting Plasmodium falciparum aldolase to evaluate anti-malarial drug sensitivity. Malaria Journal, Vol. 8 , 226.

Van Baelen G., and Hostyn, S. and Dhooghe, L. and Tapolcsanyi, P. and Matyus, P. and Lemiere, G. and Dommisse, R. and Kaiser, M. and Brun, R. and Cos, P. and Maes, L. and Hajos, G. and Riedl, Z. and Nagy, I. and Maes, B. U. and Pieters, L.. (2009) Structure-activity relationship of antiparasitic and cytotoxic indoloquinoline alkaloids, and their tricyclic and bicyclic analogues. Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 17, H. 20. pp. 7209-7217.

Vassella, E. and Oberle, M. and Urwyler, S. and Renggli, C. K. and Studer, E. and Hemphill, A. and Fragoso, C. and Butikofer, P. and Brun, R. and Roditi, I.. (2009) Major surface glycoproteins of insect forms of Trypanosoma brucei are not essential for cyclical transmission by tsetse. PLoS One, Vol. 4, H. 2 , e4493.

Wang, X. and Creek, D. J. and Schiaffo, C. E. and Dong, Y. and Chollet, J. and Scheurer, C. and Wittlin, S. and Charman, S. A. and Dussault, P. H. and Wood, J. K. and Vennerstrom, J. L.. (2009) Spiroadamantyl 1,2,4-trioxolane, 1,2,4-trioxane, and 1,2,4-trioxepane pairs : relationship between peroxide bond iron(II) reactivity, heme alkylation efficiency, and antimalarial activity. Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 19, H. 16. pp. 4542-4545.

Wenzler, T. and Boykin, D. W. and Ismail, M. A. and Hall, J. E. and Tidwell, R. R. and Brun, R.. (2009) New treatment option for second stage African sleeping sickness: In vitro and in vivo efficacy of aza analogs of DB289. Antimicrobial agents and chemotherapy : AAC, Vol. 53, H. 10. pp. 4185-4192.

Wolkinger, V. and Weis, R. and Belaj, F. and Kaiser, M. and Brun, R. and Saf, R. and Seebacher, W.. (2009) Synthesis of novel diazabicycles and their antiprotozoal activities. Australian journal of chemistry, Vol. 62, H. 9. pp. 1166-1172.

2008

Balmer, Oliver and Caccone, Adalgisa. (2008) Multiple-strain infections of Trypanosoma brucei across Africa. Acta tropica : Zeitschrift für Tropenwissenschaften und Tropenmedizin, 107 (3). pp. 275-279.

Portmann, C. and Blom, J. F. and Kaiser, M. and Brun, R. and Juttner, F. and Gademann, K.. (2008) Isolation of aerucyclamides C and D and structure revision of microcyclamide 7806A: heterocyclic ribosomal peptides from Microcystis aeruginosa PCC 7806 and their antiparasite evaluation. Journal of natural products, Vol. 71, H. 11. pp. 1891-1896.

2007

Bernhard, Sonja C. and Nerima, Barbara and Mäser, Pascal and Brun, Reto. (2007) Melarsoprol- and pentamidine-resistant Trypanosoma brucei rhodesiense populations and their cross-resistance. International journal for parasitology, Vol. 37, H. 13. pp. 1443-1448.

Gillingwater, Kirsten. Discovery of novel active diamidines as clinical candidates against "Trypanosoma evansi" infection. 2007, Doctoral Thesis, University of Basel, Faculty of Science.

Maina, Naomi and Maina, Kagira Joseph and Mäser, Pascal and Brun, Reto. (2007) Genotypic and phenotypic characterization of Trypanosoma brucei gambiense isolates from Ibba, South Sudan, an area of high melarsoprol treatment failure rate. Acta tropica : Zeitschrift für Tropenwissenschaften und Tropenmedizin = revue des sciences tropicales et de médecine tropicale = review of tropical science and tropical medicine, 104 (2-3). pp. 84-90.

2006

Balmer, Oliver and Tostado, Cristóbal. (2006) New fluorescence markers to distinguish co-infecting Trypanosoma brucei strains in experimental multiple infections. Acta tropica : Zeitschrift für Tropenwissenschaften und Tropenmedizin, 97 (1). pp. 94-101.

Brun, Reto and Balmer, Oliver. (2006) New developments in human African trypanosomiasis. Current opinion in infectious diseases, Vol. 19, H. 5. pp. 415-420.

2002

Mäser, Pascal and Grether-Bühler, Yvonne and Kaminsky, Ronald and Brun, Reto. (2002) An anti-contamination cocktail for the in vitro isolation and cultivation of parasitic protozoa. Parasitology research : Organ der Deutschen Gesellschaft für Parasitologie, Vol. 88, H. 2. pp. 172-174.

2000

Balmer, O. and Erhardt, A.. (2000) Gesteigerte Tagfalterdiversität durch 10-jährige Verbrachung von Magerweiden im Nordwestschweizer Jura. Mitteilungen der Deutschen Gesellschaft für allgemeine und angewandte Entomologie, Bd. 12. pp. 259-262.

Balmer, Oliver and Erhardt, Andreas. (2000) Consequences of succession on extensively grazed grasslands for Central European butterfly communities : rethinking conservation practices. Conservation biology, 14 (3). pp. 746-757.

1999

Balmer, Oliver. (1999) Butterfly fauna of different successional stages of extensively grazed calcareous grasslands in the Jura mountains. Mitteilungen der Schweizerischen Entomologischen Gesellschaft, Vol. 72, H. 3-4. pp. 303-314.