Items where Division is "09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Helminth Drug Development (Keiser)"

2017

Abla, Nada and Keiser, Jennifer and Vargas, Mireille and Reimers, Natalie and Haas, Helmut and Spangenberg, Thomas. (2017) Evaluation of the pharmacokinetic-pharmacodynamic relationship of praziquantel in the Schistosoma mansoni mouse model. PLoS neglected tropical diseases, 11 (9). e0005942.

Barbosa, Eder Alves and Oliveira, Ana and Plácido, Alexandra and Socodato, Renato and Portugal, Camila C. and Mafud, Ana Carolina and Ombredane, Alicia S. and Moreira, Daniel C. and Vale, Nuno and Bessa, Lucinda J. and Joanitti, Graziella A. and Alves, Cláudia and Gomes, Paula and Delerue-Matos, Cristina and Mascarenhas, Yvonne Primerano and Marani, Mariela M. and Relvas, João B. and Pintado, Manuela and Leite, José Roberto S. A.. (2017) Structure and function of a novel antioxidant peptide from the skin of tropical frogs. Free radical biology & medicine, 115. pp. 68-79.

Barda, Beatrice and Albonico, Marco and Buonfrate, Dora and Ame, Shaali M. and Ali, Said and Speich, Benjamin and Keiser, Jennifer. (2017) Side benefits of mass drug administration for lymphatic filariasis on Strongyloides stercoralis prevalence on Pemba Island, Tanzania. American journal of tropical medicine and hygiene, 97 (3). pp. 681-683.

Barda, Beatrice and Coulibaly, Jean T. and Hatz, Christoph and Keiser, Jennifer. (2017) Ultrasonographic evaluation of urinary tract morbidity in school-aged and preschool-aged children infected with Schistosoma haematobium and its evolution after praziquantel treatment : a randomized controlled trial. PLoS Neglected Tropical Diseases, 11 (2). e0005400.

Barda, Beatrice and Sayasone, Somphou and Phongluxa, Khampheng and Xayavong, Syda and Keoduangsy, Khonsavanh and Odermatt, Peter and Puchkov, Maxim and Huwyler, Jörg and Hattendorf, Jan and Keiser, Jennifer. (2017) Efficacy of moxidectin versus ivermectin against Strongyloides stercoralis infections: a randomized controlled non-inferiority trial. Clinical Infectious Diseases, 65 (2). pp. 276-281.

Coulibaly, Jean T. and Panic, Gordana and Silué, Kigbafori D. and Kovac, Jana and Hattendorf, Hattendorf and Keiser, Jennifer. (2017) Efficacy and safety of praziquantel in preschool-aged and school-aged children infected with Schistosoma mansoni: a randomised controlled, parallel-group, dose-ranging, phase 2 trial. Lancet Glob Health, 5 (7). e688-e698.

Cowan, Noemi and Meier, Charles and Neodo, Anna and Keiser, Jennifer. (2017) Exposure of Heligmosomoides polygyrus and Trichuris muris to albendazole, albendazole sulfoxide, mebendazole and oxantel pamoate in vitro and in vivo to elucidate the pathway of drug entry into these gastrointestinal nematodes. International journal for parasitology. Drugs and drug resistance, 7 (2). pp. 159-173.

Duthaler, U. and Berger, B. and Erb, S. and Battegay, M. and Letang, E. and Gaugler, S. and Krähenbühl, S. and Haschke, M.. (2017) Automated high throughput analysis of antiretroviral drugs in dried blood spots. Journal of Mass Spectrometry, 52 (8). pp. 534-542.

Gétaz, M. and Bühlmann, A. and Schneeberger, P. H. H. and Van Malderghem, C. and Duffy, B. and Maes, M. and Pothier, J. F. and Cottyn, B.. (2017) A diagnostic tool for improved detection of Xanthomonas fragariae using a rapid and highly specific LAMP assay designed with comparative genomics. Plant Pathology, 66 (7). pp. 1094-1102.

Hess, Jeannine and Panic, Gordana and Patra, Malay and Mastrobuoni, Luciano and Spingler, Bernhard and Roy, Saonli and Keiser, Jennifer and Gasser, Gilles. (2017) Ferrocenyl, ruthenocenyl, and benzyl oxamniquine derivatives with cross-species activity against Schistosoma mansoni and Schistosoma haematobium. ACS infectious diseases, 3 (9). pp. 645-652.

Keiser, J.. (2017) Jennifer Keiser - tackling drug resistance before it arises. Trends in parasitology, 33 (3). pp. 153-154.

Kovač, Jana and Vargas, Mireille and Keiser, Jennifer. (2017) In vitro and in vivo activity of R- and S- praziquantel enantiomers and the main human metabolite trans-4-hydroxy-praziquantel against Schistosoma haematobium. Parasites and vectors, 10. p. 365.

Moser, Wendelin and Labhardt, Niklaus Daniel and Cheleboi, Molisana and Muhairwe, Josephine and Keiser, Jennifer. (2017) Unexpected low soil-transmitted helminth prevalence in the Butha-Buthe district in Lesotho, results from a cross-sectional survey. Parasites and Vectors, 10. p. 72.

Moser, Wendelin and Schindler, Christian and Keiser, Jennifer. (2017) Efficacy of recommended drugs against soil transmitted helminths: systematic review and network meta-analysis. BMJ, 358. j4307.

Okombo, John and Singh, Kawaljit and Mayoka, Godfrey and Ndubi, Ferdinand and Barnard, Linley and Njogu, Peter M. and Njoroge, Mathew and Gibhard, Liezl and Brunschwig, Christel and Vargas, Mireille and Keiser, Jennifer and Egan, Timothy J. and Chibale, Kelly. (2017) Antischistosomal activity of pyrido[1,2-a]benzimidazole derivatives and correlation with inhibition of beta-hematin formation. ACS Infectious Diseases, 3 (6). pp. 411-420.

Panic, Gordana and Ruf, Marie-Thérèse and Keiser, Jennifer. (2017) Immunohistochemical investigations of treatment with Ro 13-3978, praziquantel, oxamniquine, and mefloquine in Schistosoma mansoni-infected mice. Antimicrobial agents and chemotherapy, 61 (12). e01142-17.

Perissutti, Beatrice and Passerini, Nadia and Trastullo, Ramona and Keiser, Jennifer and Zanolla, Debora and Zingone, Guglielmo and Voinovich, Dario and Albertini, Beatrice. (2017) An explorative analysis of process and formulation variables affecting comilling in a vibrational mill: the case of praziquantel. International journal of pharmaceutics, 533 (2). pp. 402-412.

Preston, Sarah and Jiao, Yaqing and Baell, Jonathan B. and Keiser, Jennifer and Crawford, Simon and Koehler, Anson V. and Wang, Tao and Simpson, Moana M. and Kaplan, Ray M. and Cowley, Karla J. and Simpson, Kaylene J. and Hofmann, Andreas and Jabbar, Abdul and Gasser, Robin B.. (2017) Screening of the 'Open Scaffolds' collection from Compounds Australia identifies a new chemical entity with anthelmintic activities against different developmental stages of the barber's pole worm and other parasitic nematodes. International Journal for Parasitology: Drugs and Drug Resistance, 7 (3). pp. 286-294.

Sayasone, Somphou and Meister, Isabel and Andrews, Jason R. and Odermatt, Peter and Vonghachack, Youthanavanh and Xayavong, Syda and Senggnam, Kanpaseuth and Phongluxa, Khampheng and Hattendorf, Jan and Bogoch, Isaac I. and Keiser, Jennifer. (2017) Efficacy and safety of praziquantel against light infections of Opisthorchis viverrini : a randomised parallel single blind dose-ranging trial. Clinical infectious diseases, 64 (4). pp. 451-458.

Tritten, Lucienne and Tam, Mifong and Vargas, Mireille and Jardim, Armando and Stevenson, Mary M. and Keiser, Jennifer and Geary, Timothy G.. (2017) Excretory/secretory products from the gastrointestinal nematode Trichuris muris. Experimental parasitology, 178. pp. 30-36.

Zhang, Qi and Ma, Cheng and Oberli, Alexander and Zinz, Astrid and Engels, Sonja and Przyborski, Jude M.. (2017) Proteomic analysis of exported chaperone/co-chaperone complexes of P. falciparum reveals an array of complex protein-protein interactions. Scientific Reports, 7. p. 42188.

2016

Albonico, Marco and Becker, Sören L. and Odermatt, Peter and Angheben, Andrea and Anselmi, Mariella and Amor, Arancha and Barda, Beatrice and Buonfrate, Dora and Cooper, Philip and Gétaz, Laurent and Keiser, Jennifer and Khieu, Virak and Montresor, Antonio and Muñoz, José and Requena-Méndez, Ana and Savioli, Lorenzo and Speare, Richard and Steinmann, Peter and van Lieshout, Lisette and Utzinger, Jürg and Bisoffi, Zeno. (2016) StrongNet: An International Network to Improve Diagnostics and Access to Treatment for Strongyloidiasis Control. PLoS Neglected Tropical Diseases, 10 (9). e0004898.

Bogoch, Isaac I. and Sayasone, Somphou and Vonghachack, Youthanavanh and Meister, Isabel and Utzinger, Jürg and Odermatt, Peter and Andrews, Jason R. and Keiser, Jennifer. (2016) Diagnosis of Opisthorchis viverrini infection with handheld microscopy in Lao People's Democratic Republic. American journal of tropical medicine and hygiene, 94 (1). pp. 158-160.

Clède, Sylvain and Cowan, Noemi and Lambert, François and Bertrand, Hélène C. and Rubbiani, Riccardo and Patra, Malay and Hess, Jeannine and Sandt, Christophe and Trcera, Nicolas and Gasser, Gilles and Keiser, Jennifer and Policar, Clotilde. (2016) Bimodal x-ray and infrared imaging of an organometallic derivative of praziquantel in Schistosoma mansoni. ChemBioChem, 17 (11). pp. 1004-1007.

Cordey, S. and Brito, F. and Vu, D. L. and Turin, L. and Kilowoko, M. and Kyungu, E. and Genton, B. and Zdobnov, E. M. and D'Acremont, V. and Kaiser, L.. (2016) Astrovirus VA1 identified by next-generation sequencing in a nasopharyngeal specimen of a febrile Tanzanian child with acute respiratory disease of unknown etiology. Emerging microbes and infections, 5 (7). e67.

Coulibaly, Jean T. and Ouattara, Mamadou and Becker, Sören L. and Lo, Nathan C. and Keiser, Jennifer and N'Goran, Eliézer K. and Ianniello, Davide and Rinaldi, Laura and Cringoli, Giuseppe and Utzinger, Jürg. (2016) Comparison of sensitivity and faecal egg counts of Mini-FLOTAC using fixed stool samples and Kato-Katz technique for the diagnosis of Schistosoma mansoni and soil-transmitted helminths. Acta tropica, 164. pp. 107-116.

Coulibaly, Jean T. and Ouattara, Mamadou and D'Ambrosio, Michael V. and Fletcher, Daniel A. and Keiser, Jennifer and Utzinger, Jürg and N'Goran, Eliézer K. and Andrews, Jason R. and Bogoch, Isaac I.. (2016) Accuracy of Mobile Phone and Handheld Light Microscopy for the Diagnosis of Schistosomiasis and Intestinal Protozoa Infections in Côte d’Ivoire. PLoS Neglected Tropical Diseases, 10 (6). e0004768.

Coulibaly, Jean T. and Ouattara, Mamadou and Keiser, Jennifer and Bonfoh, Bassirou and N'Goran, Eliézer K. and Andrews, Jason R. and Bogoch, Isaac I.. (2016) Evaluation of malaria diagnoses using a handheld light microscope in a community-based setting in rural Côte d'Ivoire. American journal of tropical medicine and hygiene, 95 (4). pp. 831-834.

Cowan, Noemi and Raimondo, Alessia and Keiser, Jennifer. (2016) Approved oncology drugs lack in vivo activity against Trichuris muris despite in vitro activity. Parasitology research, 115 (11). pp. 4443-4446.

Cowan, Noemi and Vargas, Mireille and Keiser, Jennifer. (2016) In vitro and in vivo drug interaction Ssudy of two lead combinations, oxantel pamoate plus albendazole and albendazole plus mebendazole, for the treatment of soil-transmitted helminthiasis. Antimicrobial agents and chemotherapy, 60 (10). pp. 6127-6133.

Duthaler, Urs and Sayasone, Somphou and Vanobbergen, Fiona and Penny, Melissa A. and Odermatt, Peter and Huwyler, Jörg and Keiser, Jennifer. (2016) Single ascending dose pharmacokinetic study of tribendimidine in Opisthorchis viverrini-infected patients. Antimicrobial agents and chemotherapy, 60 (10). pp. 5705-5715.

Flores, Dayana and Panic, Gordana and Braissant, Olivier and Keiser, Jennifer. (2016) A novel isothermal microcalorimetry tool to assess drug effects on Ancylostoma ceylanicum and Necator americanus. Applied microbiology and biotechnology, 100 (2). pp. 837-846.

Keiser, Jennifer and Panic, Gordana and Adelfio, Roberto and Cowan, Noemi and Vargas, Mireille and Scandale, Ivan. (2016) Evaluation of an FDA approved library against laboratory models of human intestinal nematode infections. Parasites and Vectors, 9. p. 376.

Khan, M. O. Faruk and Keiser, Jennifer and Amoyaw, P. N. A. and Hossain, Mohammad F. and Vargas, Mireille and Le, Justin G. and Simpson, Natalie C. and Roewe, Kimberly D. and Freeman, TaRynn N. Carder and Hasley, Travis R. and Maples, Randall D. and Archibald, Stephen J. and Hubin, Timothy J.. (2016) Discovery of antischistosomal drug leads based on tetraazamacrocyclic derivatives and their metal complexes. Antimicrobial agents and chemotherapy, 60 (9). pp. 5331-5336.

Leonidova, Anna and Vargas, Mireille and Huwyler, Jörg and Keiser, Jennifer. (2016) Pharmacokinetics of the antischistosomal lead OZ418 in uninfected mice determined by LC-MS/MS. Antimicrobial agents and chemotherapy, 60 (12). pp. 7364-7371.

Lo, Nathan C. and Coulibaly, Jean T. and Bendavid, Eran and N'Goran, Eliézer K. and Utzinger, Jürg and Keiser, Jennifer and Bogoch, Isaac I. and Andrews, Jason R.. (2016) Evaluation of a urine pooling strategy for the rapid and cost-efficient prevalence classification of schistosomiasis. PLoS Neglected Tropical Diseases, 10 (8). e0004894.

Sayasone, Somphou and Odermatt, Peter and Vonghachack, Youthanavanh and Xayavong, Syda and Senggnam, Kanpaseuth and Duthaler, Urs and Akkhavong, Kongsap and Hattendorf, Jan and Keiser, Jennifer. (2016) Efficacy and safety of tribendimidine against Opisthorchis viverrini : two randomised, parallel-group, single-blind, dose-ranging, phase 2 trials. Lancet Infectious Diseases, 16 (10). pp. 1145-1453.

Speich, Benjamin and Moser, Wendelin and Ali, Said M. and Ame, Shaali M. and Albonico, Marco and Hattendorf, Jan and Keiser, Jennifer. (2016) Efficacy and reinfection with soil-transmitted helminths 18-weeks post-treatment with albendazole-ivermectin, albendazole-mebendazole, albendazole-oxantel pamoate and mebendazole. Parasites and Vectors, 9. p. 123.

Van Voorhis, Wesley C. and Adams, John H. and Adelfio, Roberto and Ahyong, Vida and Akabas, Myles H. and Alano, Pietro and Alday, Aintzane and Alemán Resto, Yesmalie and Alsibaee, Aishah and Alzualde, Ainhoa and Andrews, Katherine T. and Avery, Simon V. and Avery, Vicky M. and Ayong, Lawrence and Baker, Mark and Baker, Stephen and Ben Mamoun, Choukri and Bhatia, Sangeeta and Bickle, Quentin and Bounaadja, Lotfi and Bowling, Tana and Bosch, Jürgen and Boucher, Lauren E. and Boyom, Fabrice F. and Brea, Jose and Brennan, Marian and Burton, Audrey and Caffrey, Conor R. and Camarda, Grazia and Carrasquilla, Manuela and Carter, Dee and Belen Cassera, Maria and Chih-Chien Cheng, Ken and Chindaudomsate, Worathad and Chubb, Anthony and Colon, Beatrice L. and Colón-López, Daisy D. and Corbett, Yolanda and Crowther, Gregory J. and Cowan, Noemi and D'Alessandro, Sarah and Le Dang, Na and Delves, Michael and DeRisi, Joseph L. and Du, Alan Y. and Duffy, Sandra and Abd El-Salam El-Sayed, Shimaa and Ferdig, Michael T. and Fernández Robledo, José A. and Fidock, David A. and Florent, Isabelle and Fokou, Patrick V. T. and Galstian, Ani and Gamo, Francisco Javier and Gokool, Suzanne and Gold, Ben and Golub, Todd and Goldgof, Gregory M. and Guha, Rajarshi and Guiguemde, W. Armand and Gural, Nil and Guy, R. Kiplin and Hansen, Michael A. E. and Hanson, Kirsten K. and Hemphill, Andrew and Hooft van Huijsduijnen, Rob and Horii, Takaaki and Horrocks, Paul and Hughes, Tyler B. and Huston, Christopher and Igarashi, Ikuo and Ingram-Sieber, Katrin and Itoe, Maurice A. and Jadhav, Ajit and Naranuntarat Jensen, Amornrat and Jensen, Laran T. and Jiang, Rays H. Y. and Kaiser, Annette and Keiser, Jennifer and Ketas, Thomas and Kicka, Sebastien and Kim, Sunyoung and Kirk, Kiaran and Kumar, Vidya P. and Kyle, Dennis E. and Lafuente, Maria Jose and Landfear, Scott and Lee, Nathan and Lee, Sukjun and Lehane, Adele M. and Li, Fengwu and Little, David and Liu, Liqiong and Llinás, Manuel and Loza, Maria I. and Lubar, Aristea and Lucantoni, Leonardo and Lucet, Isabelle and Maes, Louis and Mancama, Dalu and Mansour, Nuha R. and March, Sandra and McGowan, Sheena and Medina Vera, Iset and Meister, Stephan and Mercer, Luke and Mestres, Jordi and Mfopa, Alvine N. and Misra, Raj N. and Moon, Seunghyun and Moore, John P. and Morais Rodrigues da Costa, Francielly and Müller, Joachim and Muriana, Arantza and Nakazawa Hewitt, Stephen and Nare, Bakela and Nathan, Carl and Narraidoo, Nathalie and Nawaratna, Sujeevi and Ojo, Kayode K. and Ortiz, Diana and Panic, Gordana and Papadatos, George and Parapini, Silvia and Patra, Kailash and Pham, Ngoc and Prats, Sarah and Plouffe, David M. and Poulsen, Sally-Ann and Pradhan, Anupam and Quevedo, Celia and Quinn, Ronald J. and Rice, Christopher A. and Abdo Rizk, Mohamed and Ruecker, Andrea and St Onge, Robert and Salgado Ferreira, Rafaela and Samra, Jasmeet and Robinett, Natalie G. and Schlecht, Ulrich and Schmitt, Marjorie and Silva Villela, Filipe and Silvestrini, Francesco and Sinden, Robert and Smith, Dennis A. and Soldati, Thierry and Spitzmüller, Andreas and Stamm, Serge Maximilian and Sullivan, David J. and Sullivan, William and Suresh, Sundari and Suzuki, Brian M. and Suzuki, Yo and Swamidass, S. Joshua and Taramelli, Donatella and Tchokouaha, Lauve R. Y. and Theron, Anjo and Thomas, David and Tonissen, Kathryn F. and Townson, Simon and Tripathi, Abhai K. and Trofimov, Valentin and Udenze, Kenneth O. and Ullah, Imran and Vallieres, Cindy and Vigil, Edgar and Vinetz, Joseph M. and Voong Vinh, Phat and Vu, Hoan and Watanabe, Nao-Aki and Weatherby, Kate and White, Pamela M. and Wilks, Andrew F. and Winzeler, Elizabeth A. and Wojcik, Edward and Wree, Melanie and Wu, Wesley and Yokoyama, Naoaki and Zollo, Paul H. A. and Abla, Nada and Blasco, Benjamin and Burrows, Jeremy and Laleu, Benoît and Leroy, Didier and Spangenberg, Thomas and Wells, Timothy and Willis, Paul A.. (2016) Open source drug discovery with the malaria box compound collection for neglected diseases and beyond. PLoS Pathogens, 12 (7). e1005763.

Wang, Chunkai and Zhao, Qingjie and Vargas, Mireille and Jones, Jeremy O. and White, Karen L. and Shackleford, David M. and Chen, Gong and Saunders, Jessica and Ng, Alice C. F. and Chiu, Francis C. K. and Dong, Yuxiang and Charman, Susan A. and Keiser, Jennifer and Vennerstrom, Jonathan L.. (2016) Revisiting the SAR of the antischistosomal aryl hydantoin (Ro 13-3978). Journal of medicinal chemistry, 59 (23). pp. 10705-10718.

2015

Barda, B. D. and Keiser, J. and Albonico, M.. (2015) Human trichuriasis : diagnostics update. Current tropical medicine reports, 2. pp. 201-208.

Barda, Beatrice and Albonico, Marco and Ianniello, Davide and Ame, Shaali M. and Keiser, Jennifer and Speich, Benjamin and Rinaldi, Laura and Cringoli, Giuseppe and Burioni, Roberto and Montresor, Antonio and Utzinger, Jürg. (2015) How long can stool samples be fixed for an accurate diagnosis of soil-transmitted helminth infection using mini-FLOTAC? PLoS neglected tropical diseases, Vol. 9, H. 4 , e0003698.

Braissant, Olivier and Keiser, Jennifer and Meister, Isabel and Bachmann, Alexander and Wirz, Dieter and Göpfert, Beat and Bonkat, Gernot and Wadsö, Ingemar. (2015) Isothermal microcalorimetry accurately detects bacteria, tumorous microtissues, and parasitic worms in a label-free well-plate assay. Biotechnology journal, Vol. 10, H. 3. pp. 460-468.

Cowan, Noemi and Dätwyler, Philipp and Ernst, Beat and Wang, Chunkai and Vennerstrom, Jonathan L. and Spangenberg, Thomas and Keiser, Jennifer. (2015) Activities of N,N'-Diarylurea MMV665852 analogs against Schistosoma mansoni. Antimicrobial Agents and Chemotherapy, 59 (4). pp. 1935-1941.

Cowan, Noemi and Keiser, Jennifer. (2015) Repurposing of anticancer drugs: in vitro and in vivo activities against Schistosoma mansoni. Parasites and Vectors, 8. p. 417.

Cowan, Noemi and Yaremenko, Ivan A. and Krylov, Igor B. and Terent'ev, Alexander O. and Keiser, Jennifer. (2015) Elucidation of the in vitro and in vivo activities of bridged 1,2,4-trioxolanes, bridged 1,2,4,5-tetraoxanes, tricyclic monoperoxides, silyl peroxides, and hydroxylamine derivatives against Schistosoma mansoni. Bioorganic & medicinal chemistry, 23 (16). pp. 5175-5181.

Ephraim, Richard K. D. and Duah, Evans and Cybulski, James S. and Prakash, Manu and D'Ambrosio, Michael V. and Fletcher, Daniel A. and Keiser, Jennifer and Andrews, Jason R. and Bogoch, Isaac I.. (2015) Diagnosis of Schistosoma haematobium infection with a mobile phone-mounted foldscope and a reversed-lens CellScope in Ghana. American journal of tropical medicine and hygiene, Vol. 92, H. 6. pp. 1253-1256.

Hess, Jeannine and Keiser, Jennifer and Gasser, Gilles. (2015) Toward organometallic antischistosomal drug candidates. Future medicinal chemistry, Vol. 7, H. 6. pp. 821-830.

Keiser, Jenifer and [et al.], . (2015) Efficacy and safety of albendazole plus ivermectin, albendazole plus mebendazole, albendazole plus oxantel pamoate, and mebendazole alone against Trichuris trichiura and concomitant soil-transmitted helminth infection : a four-arm, randomised controlled trial. The Lancet infectious diseases, Vol. 15, H. 3. pp. 277-284.

Keiser, Jennifer. (2015) Is caenorhabditis elegans the magic bullet for anthelminthic drug discovery? Trends in parasitology, Vol. 31, H. 10. pp. 455-456.

Keiser, Jennifer and Panic, Gordana and Vargas, Mireille and Wang, Chunkai and Dong, Yuxiang and Gautam, Nagsen and Vennerstrom, Jonathan L.. (2015) Aryl hydantoin Ro 13-3978, a broad-spectrum antischistosomal. Journal of Antimicrobial Chemotherapy, Vol. 70, H. 6. pp. 1788-1797.

Meister, Isabel. Pharmacological and pharmacokinetic studies on trematocidal drugs : praziquantel and two synthetic peroxide lead candidates. 2015, Doctoral Thesis, University of Basel, Faculty of Science.

Moser, Wendelin and Ali, Said M. and Ame, Shaali M. and Speich, Benjamin and Puchkov, Maxim and Huwyler, Jörg and Albonico, Marco and Hattendorf, Jan and Keiser, Jennifer. (2015) Efficacy and safety of oxantel pamoate in school-aged children infected with Trichuris trichiura on Pemba Island, Tanzania: a parallel, randomised, controlled, dose-ranging study. The Lancet infectious diseases, 16 (1). pp. 53-60.

Ogorodova, Ludmila M. and Fedorova, Olga S. and Sripa, Banchob and Mordvinov, Viatcheslav A. and Katokhin, Aleksei V. and Keiser, Jennifer and Odermatt, Peter and Brindley, Paul J. and Mayboroda, Oleg A. and Velavan, Thirumalaisamy P. and Freidin, Maxim B. and Sazonov, Alexey E. and Saltykova, Irina V. and Pakharukova, Mariya Y. and Kovshirina, Yulia V. and Kaloulis, Kostas and Krylova, Olga Y. and Yazdanbakhsh, Maria and Topic Consortium, . (2015) Opisthorchiasis: an overlooked danger. PLoS neglected tropical diseases, Vol. 9, H. 4 , e0003563.

Olliaro, Piero L. and Vaillant, Michel and Diawara, Aïssatou and Coulibaly, Jean T. and Garba, Amadou and Keiser, Jennifer and King, Charles H. and Knopp, Stefanie and Landouré, Aly and N'Goran, Eliézer K. and Raso, Giovanna and Scherrer, Alexandra U. and Sousa-Figueiredo, José Carlos and Stete, Katarina and Zhou, Xiao-Nong and Utzinger, Jürg. (2015) Toward measuring Schistosoma response to praziquantel treatment with appropriate descriptors of egg excretion. PLoS neglected tropical diseases, Vol. 9, H. 6 , e0003821.

Panic, Gordana and Flores, Dayana and Ingram-Sieber, Katrin and Keiser, Jennifer. (2015) Fluorescence/luminescence-based markers for the assessment of Schistosoma mansoni schistosomula drug assays. Parasites and Vectors, 8. p. 624.

Panic, Gordana and Vargas, Mireille and Scandale, Ivan and Keiser, Jennifer. (2015) Activity profile of an FDA-approved compound library against Schistosoma mansoni. PLoS neglected tropical diseases, Vol. 9, H. 7 , e0003962.

Speich, Benjamin and Ali, Said M. and Ame, Shaali M. and Albonico, Marco and Utzinger, Jürg and Keiser, Jennifer. (2015) Quality control in the diagnosis of Trichuris trichiura and Ascaris lumbricoides using the Kato-Katz technique : experience from three randomised controlled trials. Parasites and Vectors, 8 (82).

Vejzagić, Nermina and Adelfio, Roberto and Keiser, Jennifer and Kringel, Helene and Thamsborg, Stig Milan and Kapel, Christian M. O.. (2015) Bacteria-induced egg hatching differs for Trichuris muris and Trichuris suis. Parasites and Vectors, 8 (371).

2014

Bogoch, Isaac I. and Andrews, Jason R. and Speich, Benjamin and Ame, Shaali M. and Ali, Said M. and Stothard, J. Russell and Utzinger, Jürg and Keiser, Jennifer. (2014) Quantitative evaluation of a handheld light microscope for field diagnosis of soil-transmitted helminth infection. American journal of tropical medicine and hygiene, Vol. 91, H. 6. pp. 1138-1141.

Bogoch, Isaac I. and Coulibaly, Jean T. and Andrews, Jason R. and Speich, Benjamin and Keiser, Jennifer and Stothard, J. Russell and N'goran, Eliézer K. and Utzinger, Jürg. (2014) Evaluation of portable microscopic devices for the diagnosis of Schistosoma and soil-transmitted helminth infection. Parasitology, Vol. 141, H. 14. pp. 1811-1818.

Ingram-Sieber, Katrin and Cowan, Noemi and Panic, Gordana and Vargas, Mireille and Mansour, Nuha R. and Bickle, Quentin D. and Wells, Timothy N. C. and Spangenberg, Thomas and Keiser, Jennifer. (2014) Orally active antischistosomal early leads identified from the open access malaria box. PLoS neglected tropical diseases, Vol. 8, H. 1 , e2610.

Ingram-Sieber, Katrin Jane. Accelerating antischistosomal drug discovery : preclinical studies of antimalarials, synthetic peroxides and praziquantel derivatives. 2014, Doctoral Thesis, University of Basel, Faculty of Science.

Keiser, J. and Speich, B. and Utzinger, J.. (2014) The authors reply : Yasukawa K. comment to "Oxantel pamoate-albendazole for Trichuris trichiura infection". The New England journal of medicine, Vol. 370, H. 20. p. 1953.

Keiser, Jennifer and Silué, Kigbafori D. and Adiossan, Lukas K. and N'Guessan, Nicaise A. and Monsan, N'Chou and Utzinger, Jürg and N'Goran, Eliézer K.. (2014) Praziquantel, mefloquine-praziquantel, and mefloquine-artesunate-praziquantel against Schistosoma haematobium : a randomized, exploratory, open-label trial. PLoS neglected tropical diseases, Vol. 8, H. 7 , e2975.

Keiser, Jennifer and Vargas, Mireille and Rubbiani, Riccardo and Gasser, Gilles and Biot, Christophe. (2014) In vitro and in vivo antischistosomal activity of ferroquine derivatives. Parasites and Vectors, 7 (424).

Kljun, J. and Scott, A. J. and Rizner, T. L. and Keiser, J. and Turel, I.. (2014) Synthesis and biological evaluation of organoruthenium complexes with azole antifungal agents : first crystal structure of a tioconazole metal complex. Organometallics, Vol. 33, H. 7. pp. 1594-1601.

Kulke, Daniel and von Samson-Himmelstjerna, Georg and Miltsch, Sandra M. and Wolstenholme, Adrian J. and Jex, Aaron R. and Gasser, Robin B. and Ballesteros, Cristina and Geary, Timothy G. and Keiser, Jennifer and Townson, Simon and Harder, Achim and Krücken, Jürgen. (2014) Characterization of the Ca2+-gated and voltage-dependent k+-channel slo-1 of nematodes and its interaction with emodepside. PLoS neglected tropical diseases, Vol. 8, H. 12 , e3401.

Küster, Tatiana and Kriegel, Nadja and Stadelmann, Britta and Wang, Xiaofang and Dong, Yuxiang and Vennerstrom, Jonathan L. and Keiser, Jennifer and Hemphill, Andrew. (2014) Amino ozonides exhibit in vitro activity against Echinococcus multilocularis metacestodes. International journal of antimicrobial agents, Vol. 43, H. 1. pp. 40-46.

Meister, Isabel and Ingram-Sieber, Katrin and Cowan, Noemi and Todd, Matthew and Robertson, Murray N. and Meli, Claudia and Patra, Malay and Gasser, Gilles and Keiser, Jennifer. (2014) Activity of praziquantel enantiomers and main metabolites against Schistosoma mansoni. Antimicrobial agents and chemotherapy, Vol. 58, H. 9. pp. 5466-5472.

Olliaro, Piero and Delgado-Romero, Petra and Keiser, Jennifer. (2014) The little we know about the pharmacokinetics and pharmacodynamics of praziquantel (racemate and R-enantiomer). Journal of Antimicrobial Chemotherapy, Vol. 69, H. 4. pp. 863-870.

Panic, Gordana and Duthaler, Urs and Speich, Benjamin and Keiser, Jennifer. (2014) Repurposing drugs for the treatment and control of helminth infections. International journal of parasitology : drugs and drug resistance, Vol. 4. pp. 185-200.

Speich, B. and Utzinger, J. and Marti, H. and Ame, S. M. and Ali, S. M. and Albonico, M. and Keiser, J.. (2014) Comparison of the Kato-Katz method and ether-concentration technique for the diagnosis of soil-transmitted helminth infections in the framework of a randomised controlled trial. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, Vol. 33, H. 5. pp. 815-822.

Speich, Benjamin. Novel tools for the control of soil-transmitted helminthiasis : drug combinations, diagnostics, and meta-analyses on the effect of sanitation facilities. 2014, Doctoral Thesis, University of Basel, Faculty of Science.

Speich, Benjamin and Ame, Shaali M. and Ali, Said M. and Alles, Rainer and Huwyler, Jörg and Hattendorf, Jan and Utzinger, Jürg and Albonico, Marco and Keiser, Jennifer. (2014) Oxantel pamoate-albendazole for Trichuris trichiura infection. The New England journal of medicine, Vol. 370, H. 7. pp. 610-620.

Spivak, Anna Yu and Keiser, Jennifer and Vargas, Mireille and Gubaidullin, Rinat R. and Nedopekina, Darya A. and Shakurova, Elvira R. and Khalitova, Rezeda R. and Odinokov, Victor N.. (2014) Synthesis and activity of new triphenylphosphonium derivatives of betulin and betulinic acid against Schistosoma mansoni in vitro and in vivo. Bioorganic & medicinal chemistry, 22 (21). pp. 6297-6304.

Tritten, Lucienne and Keiser, Jennifer and Karwa, Tasneem and Utzinger, Jürg and Holmes, Elaine and Saric, Jasmina. (2014) Comparing systemic metabolic responses in mice to single or dual infection with Plasmodium berghei and Heligmosomoides bakeri. Molecular biosystems, Vol. 10, H. 9. pp. 2358-2367.

Wang, Chunkai and Zhao, Qingjie and Min, Jaeki and Muniyan, Sakthivel and Vargas, Mireille and Wang, Xiaofang and Dong, Yuxiang and Guy, R. Kiplin and Lin, Ming-Fong and Keiser, Jennifer and Vennerstrom, Jonathan L.. (2014) Antischistosomal versus antiandrogenic properties of aryl hydantoin Ro 13-3978. American journal of tropical medicine and hygiene, Vol. 90, H. 6. pp. 1156-1158.

2013

Alles, R. and Puchkov, M. and Jablonski, C. and Speich, B. and Keiser, J. and Huwyler, J.. (2013) Development of oxantel tablets for pediatric clinical studies : a technical note. Journal of drug delivery science and technology, Vol. 23, H. 6. pp. 623-625.

Bogoch, Isaac I. and Andrews, Jason R. and Speich, Benjamin and Utzinger, Jürg and Ame, Shaali M. and Ali, Said M. and Keiser, Jennifer. (2013) Mobile phone microscopy for the diagnosis of soil-transmitted helminth infections : a Proof-of-Concept Study. American journal of tropical medicine and hygiene, Vol. 88, H. 4. pp. 626-629.

Ingram, Katrin and Duthaler, Urs and Vargas, Mireille and Ellis, William and Keiser, Jennifer. (2013) Disposition of mefloquine and enpiroline is highly influenced by a chronic Schistosoma mansoni infection. Antimicrobial agents and chemotherapy, Vol. 57, H. 9. pp. 4506-4511.

Keiser, J. and Adelfio, R. and Vargas, M. and Odermatt, P. and Tesana, S.. (2013) Activity of tribendimidine and praziquantel combination therapy against the liver fluke Opisthorchis viverrini in vitro and in vivo. Journal of Helminthology, Vol. 87, H. 2. pp. 252-256.

Keiser, J. and Manneck, T. and Kirchhofer, C. and Braissant, O.. (2013) Isothermal microcalorimetry to study the activity of triclabendazole and its metabolites on juvenile and adult Fasciola hepatica. Experimental parasitology : EP, Vol. 133, H. 3. pp. 265-268.

Keiser, J. and Tritten, L. and Silbereisen, A. and Speich, B. and Adelfio, R. and Vargas, M.. (2013) Activity of oxantel pamoate monotherapy and combination chemotherapy against Trichuris muris and hookworms : revival of an old drug. PLoS neglected tropical diseases, Vol. 7, H. 3 , e2119.

Knopp, Stefanie and Becker, Sören L. and Ingram, Katrin J. and Keiser, Jennifer and Utzinger, Jürg. (2013) Diagnosis and treatment of schistosomiasis in children in the era of intensified control. Expert review of anti-infective therapy, Vol. 11, H. 11. pp. 1237-1258.

Panic, Gordana and Ingram, Katrin and Keiser, Jennifer. (2013) Development of an in vitro drug sensitivity assay based on newly excysted larvae of Echinostoma caproni. Parasites and Vectors, 6 (237).

Patra, M. and Ingram, K. and Pierroz, V. and Ferrari, S. and Spingler, B. and Gasser, R. B. and Keiser, J. and Gasser, G.. (2013) [(η(6) -praziquantel)Cr(CO)(3)] derivatives with remarkable in vitro anti-schistosomal activity. Chemistry : a European journal, Vol. 19, H. 7. pp. 2232-2235.

Patra, Malay and Ingram, Katrin and Leonidova, Anna and Pierroz, Vanessa and Ferrari, Stefano and Robertson, Murray N. and Todd, Matthew H. and Keiser, Jennifer and Gasser, Gilles. (2013) In vitro metabolic profile and in vivo antischistosomal activity studies of (η(6)-praziquantel)Cr(CO)3 derivatives. Journal of medicinal chemistry, 56 (22). pp. 9192-9198.

Patra, Malay and Joshi, Tanmaya and Pierroz, Vanessa and Ingram, Katrin and Kaiser, Marcel and Ferrari, Stefano and Spingler, Bernhard and Keiser, Jennifer and Gasser, Gilles. (2013) DMSO-mediated ligand dissociation : renaissance for biological activity of N-heterocyclic-[Ru(η(6) -arene)Cl2 ] drug candidates. Chemistry : a European journal, Vol. 19, H. 44. pp. 14768-14772.

Qian, M. B. and Yap, P. and Yang, Y. C. and Liang, H. and Jiang, Z. H. and Li, W. and Tan, Y. G. and Zhou, H. and Utzinger, J. and Zhou, X. N. and Keiser, J.. (2013) Efficacy and safety of tribendimidine against Clonorchis sinensis. Clinical Infectious Diseases, Vol. 56, H. 7 , e76-e82.

Qian, M. B. and Yap, P. and Yang, Y. C. and Liang, H. and Jiang, Z. H. and Li, W. and Utzinger, J. and Zhou, X. N. and Keiser, J.. (2013) Accuracy of the Kato-Katz method and formalin-ether concentration technique for the diagnosis of Clonorchis sinensis, and implication for assessing drug efficacy. Parasites and Vectors, 6 (314).

Schär, F. and Odermatt, P. and Khieu, V. and Panning, M. and Duong, S. and Muth, S. and Marti, H. and Kramme, S.. (2013) Evaluation of real-time PCR for Strongyloides stercoralis and hookworm as diagnostic tool in asymptomatic schoolchildren in Cambodia. Acta tropica : Zeitschrift für Tropenwissenschaften und Tropenmedizin, 126 (2). pp. 89-92.

Speich, B. and Marti, H. and Ame, S. M. and Ali, S. M. and Bogoch, I. I. and Utzinger, J. and Albonico, M. and Keiser, J.. (2013) Prevalence of intestinal protozoa infection among school-aged children on Pemba Island, Tanzania, and effect of single-dose albendazole, nitazoxanide and albendazole-nitazoxanide. Parasites and Vectors, 6 (3).

Tritten, Lucienne and Keiser, Jennifer and Godejohann, Markus and Utzinger, Jürg and Vargas, Mireille and Beckonert, Olaf and Holmes, Elaine and Saric, Jasmina. (2013) Metabolic profiling framework for discovery of candidate diagnostic markers of malaria. Scientific Reports, 3. p. 2769.

Tsang, A. S. and Ingram, K. and Keiser, J. and Hibbert, D. B. and Todd, M. H.. (2013) Enhancing the usefulness of cross dehydrogenative coupling reactions with a removable protecting group. Organic & biomolecular chemistry : an international journal of synthetic, physical and biomolecular organic chemistry, Vol. 11, H. 30. pp. 4921-4924.

Utzinger, Jürg and Keiser, Jennifer. (2013) Research and development for neglected diseases : more is still needed, and faster. Lancet global health, Vol. 1, H. 6 , e317-e318.

Vukcevic, M. and Zorzato, F. and Keck, S. and Tsakiris, D. A. and Keiser, J. and Maizels, R. M. and Treves, S.. (2013) Gain of function in the immune system caused by a ryanodine receptor 1 mutation. Journal of cell science, 126 (15). pp. 3485-3492.

Wimmersberger, David and Tritten, Lucienne and Keiser, Jennifer. (2013) Development of an in vitro drug sensitivity assay for Trichuris muris first-stage larvae. Parasites and Vectors, 6 (42).

Xiao, Shu-Hua and Utzinger, Jürg and Tanner, Marcel and Keiser, Jennifer and Xue, Jian. (2013) Advances with the Chinese anthelminthic drug tribendimidine in clinical trials and laboratory investigations. Acta tropica : Zeitschrift für Tropenwissenschaften und Tropenmedizin, 126 (2). pp. 115-126.

de Moraes, J. and Keiser, J. and Ingram, K. and Nascimento, C. and Yamaguchi, L. F. and Bittencourt, C. R. and Bemquerer, M. P. and Leite, J. R. and Kato, M. J. and Nakano, E.. (2013) In vitro synergistic interaction between amide piplartine and antimicrobial peptide dermaseptin against Schistosoma mansoni schistosomula and adult worms. Current medicinal chemistry, Vol. 20, H. 2. pp. 301-309.

2012

Caffrey, C. R. and Utzinger, J. and Keiser, J.. (2012) Drug discovery for trematodiases : challenges and progress. In: Parasitic helminths : targets, screens, drugs and vaccines. Weinheim, pp. 323-337.

Duthaler, U. and Huwyler, J. and Rinaldi, L. and Cringoli, G. and Keiser, J.. (2012) Evaluation of the pharmacokinetic profile of artesunate, artemether and their metabolites in sheep naturally infected with Fasciola hepatica. Veterinary parasitology, Vol. 186, H. 3-4. pp. 270-280.

Duthaler, Urs Philipp. Artemisinins for the treatment of fascioliasis : progress in preclinical and diagnostic research. 2012, Doctoral Thesis, University of Basel, Faculty of Science.

Fürst, T. and Duthaler, U. and Sripa, B. and Utzinger, J. and Keiser, J.. (2012) Trematode infections : liver and lung flukes. Infectious disease clinics of North America, Vol. 26, H. 2. pp. 399-419.

Fürst, T. and Keiser, J. and Utzinger, J.. (2012) Global burden of human food-borne trematodiasis : a systematic review and meta-analysis. The Lancet infectious diseases, Vol. 12, H. 3. pp. 210-221.

Ingram, K. and Ellis, W. and Keiser, J.. (2012) Antischistosomal activities of mefloquine-related arylmethanols. Antimicrobial agents and chemotherapy, Vol. 56, H. 6. pp. 3207-3215.

Ingram, K. and Schiaffo, C. E. and Sittiwong, W. and Benner, E. and Dussault, P. H. and Keiser, J.. (2012) In vitro and in vivo activity of 3-alkoxy-1,2-dioxolanes against Schistosoma mansoni. Journal of Antimicrobial Chemotherapy, Vol. 67, H. 8. pp. 1979-1986.

Ingram, K. and Yaremenko, I. A. and Krylov, I. and Hofer, L. and Terent'ev, A. O. and Keiser, J.. (2012) Identification of antischistosomal leads by evaluating peroxides of beta-dicarbonyl compounds and their heteroanalogs : bridged 1,2,4,5-tetraoxanes and alphaperoxides, and beta,delta-triketones: tricyclic monoperoxides. Journal of medicinal chemistry, 55 (20). pp. 8700-8711.

Keiser, J. and Ingram, K. and Vargas, M. and Chollet, J. and Wang, X. and Dong, Y. and Vennerstrom, J. L.. (2012) In vivo activity of aryl ozonides against Schistosoma species. Antimicrobial agents and chemotherapy, Vol. 56, H. 2. pp. 1090-1092.

Keiser, J. and Tritten, L. and Adelfio, R. and Vargas, M.. (2012) Effect of combinations of marketed human anthelmintic drugs against Trichuris muris in vitro and in vivo. Parasites and Vectors, 5 (292).

Keiser, J. and Vargas, M. and Winter, R.. (2012) Anthelminthic properties of mangostin and mangostin diacetate. Parasitology international, Vol. 61, H. 2. pp. 369-371.

Keiser, Jennifer and Utzinger, Jurg. (2012) Antimalarials in the treatment of schistosomiasis. Current pharmaceutical design, Vol. 18, H. 24. pp. 3531-3538.

Kirchhofer, C. and Vargas, M. and Huwyler, J. and Keiser, J.. (2012) Pharmacokinetics of the fasciocidal drug candidates MT04 and OZ78 in uninfected rats and in vitro pharmacodynamic studies. International journal for parasitology: drugs and drug resistance, Vol. 2. pp. 121-125.

Kirchhofer, Carla Martina. Elucidation of the activity, pharmacokinetics, and toxicity profiles of fasciocidal drug candidates 1,2,4-trioxolane OZ78 and 1,2,4,5-tetraoxane MT04. 2012, Doctoral Thesis, University of Basel, Faculty of Science.

Koné, W. M. and Vargas, M. and Keiser, J.. (2012) Anthelmintic activity of medicinal plants used in Côte d'Ivoire for treating parasitic diseases. Parasitology research : Organ der Deutschen Gesellschaft für Parasitologie, Vol. 110, H. 6. pp. 2351-2362.

Lochmatter, C. and Schneider, C. L. and Ingram, K. and Keiser, J. and Schifferli, J. A.. (2012) Schistosoma mansoni tetraspanning orphan receptor (SmTOR) : a new vaccine candidate against Schistosomiasis. Clinical and experimental immunology, Vol. 170, H. 3. pp. 342-357.

Manneck, T. and Keiser, J. and Müller, J.. (2012) Mefloquine interferes with glycolysis in schistosomula of Schistosoma mansoni via inhibition of enolase. Parasitology, Vol. 139, H. 4. pp. 497-505.

Manneck, Theresia. Antischistosomal properties of Mefloquine : from in vitro studies to drug target discovery. 2012, Doctoral Thesis, University of Basel, Faculty of Science.

Marxer, M. and Ingram, K. and Keiser, J.. (2012) Development of an in vitro drug screening assay using Schistosoma haematobium schistosomula. Parasites and Vectors, 5 (164).

Patra, M. and Ingram, K. and Pierroz, V. and Ferrari, S. and Spingler, B. and Keiser, J. and Gasser, G.. (2012) Ferrocenyl derivatives of the anthelmintic praziquantel : design, synthesis and biological evaluation. Journal of medicinal chemistry, 55 (20). pp. 8790-8798.

Saric, J. and Want, E. J. and Duthaler, U. and Lewis, M. and Keiser, J. and Schockcor, J. P. and Ross, G. A. and Nicholson, J. K. and Holmes, E. and Tavares, M. F.. (2012) Systematic evaluation of extraction methods for multi-platform based metabotyping : application to the Fasciola hepatica metabolome. Analytical chemistry, Vol. 84, H. 16. pp. 6963-6972.

Speich, B. and Ame, S. M. and Ali, S. M. and Alles, R. and Hattendorf, J. and Utzinger, J. and Albonico, M. and Keiser, J.. (2012) Efficacy and safety of nitazoxanide, albendazole, and nitazoxanide-albendazole against Trichuris trichiura infection : a randomized controlled trial. PLoS neglected tropical diseases, Vol. 6, H. 6 , e1685.

Thomsen, H. and Reider, K. and Franke, K. and Wessjohann, L. A. and Keiser, J. and Dagne, E. and Arnold, N.. (2012) Characterization of constituents and anthelmintic properties of Hagenia abyssinica. Scientia Pharmaceutica, 80 (2). pp. 433-446.

Toyang, N. J. and Ateh, E. N. and Keiser, J. and Vargas, M. and Bach, H. and Tane, P. and Sondengam, L. B. and Davis, H. and Bryant, J. and Verpoorte, R.. (2012) Toxicity, antimicrobial and anthelmintic activities of Vernonia guineensis Benth. (Asteraceae) crude extracts. Journal of ethnopharmacology : an interdisciplinary journal devoted to bioscientific research on indigenous drugs, Vol. 144, H. 3. pp. 700-704.

Tritten, L. and Braissant, O. and Keiser, J.. (2012) Comparison of novel and existing tools for studying drug sensitivity against the hookworm Ancylostoma ceylanicum in vitro. Parasitology, Vol. 139, H. 3. pp. 348-357.

Tritten, L. and Nwosu, U. and Vargas, M. and Keiser, J.. (2012) In vitro and in vivo efficacy of tribendimidine and its metabolites alone and in combination against the hookworms Heligmosomoides bakeri and Ancylostoma ceylanicum. Acta tropica : Zeitschrift für Tropenwissenschaften und Tropenmedizin, 122 (1). pp. 101-107.

Tritten, Lucienne. Investigations on potential drug candidates and metabonomics-based diagnostic biomarker discovery for human soil-transmitted helminthiases. 2012, Doctoral Thesis, University of Basel, Faculty of Science.

Tritten, Lucienne and Silbereisen, Angelika and Keiser, Jennifer. (2012) Nitazoxanide : in vitro and in vivo drug effects against Trichuris muris and Ancylostoma ceylanicum, alone or in combination. International journal for parasitology: drugs and drug resistance, Vol. 2. pp. 98-105.

Ziegelbauer, K. and Speich, B. and Mäusezahl, D. and Bos, R. and Keiser, J. and Utzinger, J.. (2012) Effect of sanitation on soil-transmitted helminth infection : systematic review and meta-analysis. PLoS medicine, Vol. 9, H. 1, e1001162.

Zumla, A. and Keiser, J.. (2012) Tropical diseases. Infectious disease clinics of North America, Vol. 26, H. 2 , xv-xvii.

2011

Duthaler, Urs and Keiser, Jennifer and Huwyler, Jörg. (2011) Development and validation of a liquid chromatography and ion spray tandem mass spectrometry method for the quantification of artesunate, artemether, and their major metabolites dihydroartemisinin and dihydroartemisininglucuronide in sheep plasma. Journal of Mass Spectrometry, 46 (2). pp. 172-181.

Ferreira, J. F. and Peaden, P. and Keiser, J.. (2011) In vitro trematocidal effects of crude alcoholic extracts of Artemisia annua, A. absinthium, Asimina triloba, and Fumaria officinalis : trematocidal plant alcoholic extracts. Parasitology research : Organ der Deutschen Gesellschaft für Parasitologie, Vol. 109, H. 6. pp. 1585-1592.

Jones, M. K. and Keiser, J. and McManus, D. P.. (2011) Trematodes. In: Manual of clinical microbiology, 2. Washington, pp. 2230-2242.

Keiser, J. and Ingram, K. and Vargas, M. and Chollet, J. and Wang, X. and Dong, Y. and Vennerstrom, J. L.. (2011) In vivo activity of next generation synthetic ozonides against Schistosoma species. Antimicrobial agents and chemotherapy, 56 (2). pp. 1090-1092.

Keiser, J. and Manneck, T. and Vargas, M.. (2011) Interactions of mefloquine with praziquantel in the Schistosoma mansoni mouse model and in vitro. Journal of Antimicrobial Chemotherapy, Vol. 66, H. 8. pp. 1791-1797.

Keiser, J. and Sayed, H. and El-Ghanam M., and Sabry, H. and Anani, S. and El-Wakeel A., and Hatz, C. and Utzinger, J. and El-Din S. S., and El-Maadawy W., and Botros, S.. (2011) Efficacy and safety of artemether in the treatment of chronic fascioliasis in Egypt: exploratory phase-2 trials. PLoS neglected tropical diseases, Vol. 5, H. 9 , e1285.

Keiser, Jennifer and Ingram, Katrin and Utzinger, Jürg. (2011) Antiparasitic drugs for paediatrics : systematic review, formulations, pharmacokinetics, safety, efficacy and implications for control. Parasitology, Vol. 138, H. 12. pp. 1620-1632.

Keiser, Jennifer and Utzinger, Jürg. (2011) Foodborne trematodiasis and schistosomiasis. In: Rudolph's Pediatrics. New York, pp. 1200-1203.

Kirchhofer, C. and Vargas, M. and Braissant, O. and Dong, Y. and Wang, X. and Vennerstrom, J. L. and Keiser, J.. (2011) Activity of OZ78 analogues against Fasciola hepatica and Echinostoma caproni. Acta tropica : Zeitschrift für Tropenwissenschaften und Tropenmedizin, 118 (1). pp. 56-62.

Küster, T. and Stadelmann, B. and Hermann, C. and Scholl, S. and Keiser, J. and Hemphill, A.. (2011) In vitro and in vivo efficacy of mefloquine-based treatment against alveolar echinococcosis. Antimicrobial agents and chemotherapy : AAC, Vol. 55, H. 2. pp. 713-721.

Li, J. V. and Saric, J. and Wang, Y. and Keiser, J. and Utzinger, J. and Holmes, E.. (2011) Chemometric analysis of biofluids from mice experimentally infected with Schistosoma mansoni. Parasites and Vectors, 4 (179).

Manneck, T. and Braissant, O. and Ellis, W. and Keiser, J.. (2011) Schistosoma mansoni: antischistosomal activity of the four optical isomers and the two racemates of mefloquine on schistosomula and adult worms in vitro and in vivo. Experimental parasitology : EP, Vol. 127, H. 1. pp. 260-269.

Manneck, T. and Braissant, O. and Haggenmüller, Y. and Keiser, J.. (2011) Isothermal microcalorimetry to study drugs against Schistosoma mansoni. Journal of clinical microbiology, Vol. 49, H. 4. pp. 1217-1225.

Nwosu, Uzoma and Vargas, Mireille and Harder, Achim and Keiser, Jennifer. (2011) Efficacy of the cyclooctadepsipeptide PF1022A against Heligmosomoides bakeri in vitro and in vivo. Parasitology, Vol. 138, H. 9. pp. 1193-1201.

Olliaro, P. and Seiler, J. and Kuesel, A. and Horton, J. and Clark, J. N. and Don, R. and Keiser, J.. (2011) Potential drug development candidates for human soil-transmitted helminthiases. PLoS neglected tropical diseases, Vol. 5, H. 6 , e1138.

Silbereisen, Angelika and Tritten, Lucienne and Keiser, Jennifer. (2011) Exploration of novel in vitro assays to study drugs against Trichuris spp. Journal of microbiological methods, Vol. 87, H. 2. pp. 169-175.

Soukhathammavong, P. and Odermatt, P. and Sayasone, S. and Vonghachack, Y. and Vounatsou, P. and Hatz, C. and Akkhavong, K. and Keiser, J.. (2011) Efficacy and safety of mefloquine, artesunate, mefloquine-artesunate, tribendimidine, and praziquantel in patients with Opisthorchis viverrini : a randomised, exploratory, open-label, phase 2 trial. The Lancet infectious diseases, 11 (2). pp. 110-118.

Tritten, Lucienne and Silbereisen, Angelika and Keiser, Jennifer. (2011) In vitro and in vivo efficacy of Monepantel (AAD 1566) against laboratory models of human intestinal nematode infections. PLoS neglected tropical diseases, Vol. 5, H. 12 , e1457.

Utzinger, J. and N'Goran E. K., and Caffrey, C. R. and Keiser, J.. (2011) From innovation to application: social-ecological context, diagnostics, drugs and integrated control of schistosomiasis. Acta tropica, 120 (1). S121-S137.

Wang, Xiaofang and Zhao, Qingjie and Vargas, Mireille and Dong, Yuxiang and Sriraghavan, Kamaraj and Keiser, Jennifer and Vennerstrom, Jonathan L.. (2011) The activity of dispiro peroxides against Fasciola hepatica. Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 21, H. 18. pp. 5320-5330.

2010

Dong, Y. and Chollet, J. and Vargas, M. and Mansour, N. R. and Bickle, Q. and Alnouti, Y. and Huang, J. and Keiser, J. and Vennerstrom, J. L.. (2010) Praziquantel analogs with activity against juvenile Schistosoma mansoni. Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 20, H. 8. pp. 2481-2484.

Duthaler, U. and Rinaldi, L. and Maurelli, M. P. and Vargas, M. and Utzinger, J. and Cringoli, G. and Keiser, J.. (2010) Fasciola hepatica: comparison of the sedimentation and FLOTAC techniques for the detection and quantification of faecal egg counts in rats. Experimental parasitology : EP, Vol. 126, H. 2. pp. 161-166.

Duthaler, U. and Smith, T. A. and Keiser, J.. (2010) In vivo and in vitro sensitivity of Fasciola hepatica to combinations of triclabendazole and artesunate, artemether or OZ78. Antimicrobial agents and chemotherapy : AAC, Vol. 54, H. 11. pp. 4596-4604.

Keiser, J. and N'Guessan N. A., and Adoubryn, K. D. and Silué, K. D. and Vounatsou, P. and Hatz, C. and Utzinger, J. and N'Goran E. K., . (2010) Efficacy and safety of mefloquine, artesunate, mefloquine-artesunate, and praziquantel against Schistosoma haematobium: randomized, exploratory open-label trial. Clinical Infectious Diseases, Vol. 50, H. 9. pp. 1205-1213.

Keiser, J. and Vargas, M. and Vennerstrom, J. L.. (2010) Activity of antiandrogens against juvenile and adult Schistosoma mansoni in mice. Journal of Antimicrobial Chemotherapy, Vol. 65, H. 9. pp. 1991-1995.

Keiser, Jennifer and Kirchhofer, Carla and Haschke, Manuel and Huwyler, Jörg and Dong, Yuxiang and Vennerstrom, Jonathan L. and Vanhoff, Kathleen and Kaminsky, Ronald and Malikides, Nick. (2010) Efficacy, safety and pharmacokinetics of 1,2,4-trioxolane OZ78 against an experimental infection with Fasciola hepatica in sheep. Veterinary parasitology, Vol. 173, H. 3-4. pp. 228-235.

Keiser, Jennifer and Vargas, Mireille. (2010) Effect of artemether, artesunate, OZ78, praziquantel, and tribendimidine alone or in combination chemotherapy on the tegument of Clonorchis sinensis. Parasitology international, Vol. 59, H. 3. pp. 472-476.

Keiser, Jennifer and Vargas, Mireille and Doenhoff, Michael J.. (2010) Activity of artemether and mefloquine against juvenile and adult Schistosoma mansoni in athymic and immunocompetent NMRI mice. American Journal of Tropical Medicine and Hygiene, Vol. 82, H. 1. pp. 112-114.

Keiser, Jennifer and Veneziano, Vincenzo and Rinaldi, Laura and Mezzino, Laura and Duthaler, Urs and Cringoli, Giuseppe. (2010) Anthelmintic activity of artesunate against Fasciola hepatica in naturally infected sheep. Research in Veterinary Science, Vol. 88, H. 1. pp. 107-110.

Kirchhofer, C. and Keiser, J. and Huwyler, J.. (2010) Development and validation of a liquid chromatography/mass spectrometry method for pharmacokinetic studies of OZ78, a fasciocidal drug candidate. Journal of chromatography B, Vol. 878, H. 28. pp. 2770-2774.

Manneck, T. and Haggenmüller, Y. and Keiser, J.. (2010) Morphological effects and tegumental alterations induced by mefloquine on schistosomula and adult flukes of Schistosoma mansoni. Parasitology, Vol. 137, H. 1. pp. 85-98.

Rufener, L. and Keiser, J. and Kaminsky, R. and Mäser, P. and Nilsson, D.. (2010) Phylogenomics of ligand-gated ion channels predicts monepantel effect. PLoS Pathogens, Vol. 6, H. 9 , e1001091.

Saric, Jasmina and Li, Jia V. and Utzinger, Jürg and Wang, Yulan and Keiser, Jennifer and Dirnhofer, Stephan and Beckonert, Olaf and Sharabiani, Mansour T. A. and Fonville, Judith M. and Nicholson, Jeremy K. and Holmes, Elaine. (2010) Systems parasitology: effects of Fasciola hepatica on the neurochemical profile in the rat brain. Molecular systems biology, Vol. 6 , 396.

Utzinger, J. and Keiser, J. and Albonico, M.. (2010) This wormy world : here and there and everywhere. Parassitologia : organo ufficiale della Società Italiana di Parassitologia, Vol. 52. pp. 47-50.

Utzinger, J. and Steinmann, P. and Keiser, J. and Bos, R.. (2010) Impacts santaires du développement des larges réserves d'eau, barrages et irrigation. In: Écologie de la santé et biodiversité : cours. Bruxelles, pp. 116-125.

Utzinger, Jürg and Tanner, Marcel and Keiser, Jennifer. (2010) ACTs for schistosomiasis: do they act? The Lancet infectious diseases, Vol. 10, H. 9. pp. 579-581.

Wang, Y. and Li, J. V. and Saric, J. and Keiser, J. and Wu, J. and Utzinger, J. and Holmes, E.. (2010) Advances in metabolic profiling of experimental nematode and trematode infections. Advances in parasitology, Vol. 73. pp. 373-404.

Xiao, S. H. and Keiser, J. and Chen, M. G. and Tanner, M. and Utzinger, J.. (2010) Research and development of antischistosomal drugs in the People's Republic of China a 60-year review. Advances in parasitology, Vol. 73. pp. 231-295.

Zhao, Qingjie and Vargas, Mireille and Dong, Yuxiang and Zhou, Lin and Wang, Xiaofang and Sriraghavan, Kamaraj and Keiser, Jennifer and Vennerstrom, Jonathan L.. (2010) Structure-activity relationship of an ozonide carboxylic acid (OZ78) against Fasciola hepatica. Journal of medicinal chemistry, 53 (10). pp. 4223-4233.

2009

Erlanger, T. E. and Weiss, S. and Keiser, J. and Utzinger, J. and Wiedenmayer, K.. (2009) Past, present, and future of Japanese encephalitis. Emerging Infectious Diseases, Vol. 15, no. 1 , 7 S..

Halferty, L. and O'Neill, J. F. and Brennan, G. P. and Keiser, J. and Fairweather, I.. (2009) Electron microscopical study to assess the in vitro effects of the synthetic trioxolane OZ78 against the liver fluke, Fasciola hepatica. Parasitology, Vol. 136, H. 11. pp. 1325-1337.

Hodel, E. M. and Zanolari, B. and Mercier, T. and Biollaz, J. and Keiser, J. and Olliaro, P. and Genton, B. and Decosterd, L. A.. (2009) A single LC-tandem mass spectrometry method for the simultaneous determination of 14 antimalarial drugs and their metabolites in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, Vol. 877, H. 10. pp. 867-886.

Keiser, J. and Chollet, J. and Xiao, S. H. and Mei, J. Y. and Jiao, P. Y. and Utzinger, J. and Tanner, M.. (2009) Mefloquine - an aminoalcohol with promising antischistosomal properties in mice. PLoS neglected tropical diseases, Vol. 3, H. 1 , e350.

Keiser, J. and Odermatt, P. and Tesana, S.. (2009) Dose-response relationships and tegumental surface alterations in Opisthorchis viverrini following treatment with mefloquine in vivo and in vitro. Parasitology research : Organ der Deutschen Gesellschaft für Parasitologie, Vol. 105, H. 1. pp. 261-266.

Keiser, J. and Utzinger, J.. (2009) Food-borne trematodiases. Clinical microbiology reviews, Vol. 22. pp. 466-483.

Keiser, Jennifer and Gruyer, Marie-Stella and Perrottet, Nancy and Zanolari, Boris and Mercier, Thomas and Decosterd, Laurent. (2009) Pharmacokinetic parameters of artesunate and dihydroartemisinin in rats infected with Fasciola hepatica. Journal of Antimicrobial Chemotherapy, Vol. 63, H. 3. pp. 543-549.

Keiser, Jennifer and Xiao, Shu-Hua and Smith, Thomas A. and Utzinger, Jürg. (2009) Combination chemotherapy against Clonorchis sinensis : experiments with artemether, artesunate, OZ78, praziquantel, and tribendimidine in the rat model. Antimicrobial agents and chemotherapy, Vol. 53, H. 9. pp. 3770-3776.

Kim, T. I. and Yoo, W. G. and Li, S. and Hong, S. T. and Keiser, J. and Hong, S. J.. (2009) Efficacy of artesunate and artemether against Clonorchis sinensis in rabbits. Parasitology research : Organ der Deutschen Gesellschaft für Parasitologie, Vol. 106. pp. 153-160.

Koudou, Benjamin G. and Tano, Yao and Keiser, Jennifer and Vounatsou, Penelope and Girardin, Olivier and Klero, Kouassi and Koné, Mamadou and N'goran, Eliézer K. and Cissé, Guéladio and Tanner, Marcel and Utzinger, Jürg. (2009) Effect of agricultural activities on prevalence rates, and clinical and presumptive malaria episodes in central Côte d'Ivoire. Acta tropica : Zeitschrift für Tropenwissenschaften und Tropenmedizin = revue des sciences tropicales et de médecine tropicale = review of tropical science and tropical medicine, 111 (3). pp. 268-274.

Li, Jia V. and Holmes, Elaine and Saric, Jasmina and Keiser, Jennifer and Dirnhofer, Stephan and Utzinger, Jürg and Wang, Yulan. (2009) Metabolic profiling of a Schistosoma mansoni infection in mouse tissues using magic angle spinning-nuclear magnetic resonance spectroscopy. International journal for parasitology, Vol. 39. pp. 547-558.

Lovis, L. and Mak, T. K. and Phongluxa, K. and Soukhathammavong, P. and Sayasone, S. and Akkhavong, K. and Odermatt, P. and Keiser, J. and Felger, I.. (2009) PCR diagnosis of Opisthorchis viverrini and Haplorchis taichui infections in a Lao community in an area of endemicity and comparison of diagnostic methods for parasitological field surveys. Journal of Clinical Microbiology, Vol. 47, H. 5. pp. 1517-1523.

O'Neill J. F., and Johnston, R. C. and Halferty, L. and Brennan, G. P. and Keiser, J. and Fairweather, I.. (2009) Adult triclabendazole-resistant Fasciola hepatica: morphological changes in the tegument and gut following in vivo treatment with artemether in the rat model. Journal of Helminthology, Vol. 83, H. 2. pp. 151-163.

Saric, J. and Li, J. V. and Wang, Y. and Keiser, J. and Veselkov, K. A. and Dirnhofer, S. and Yap, I. K. and Nicholson, J. K. and Holmes, E. and Utzinger, J.. (2009) Panorganismal metabolic response modelling of an experimental Echinostoma caproni infection in the mouse. Journal of Proteome Research, Vol. 8, H. 8. pp. 3899-3911.

Tchicaya, E. S. and Koudou, B. G. and Keiser, J. and Adja, A. M. and Cissé, G. and Tanner, M. and Tano, Y. and Utzinger, J.. (2009) Effect of repeated application of microbial larvicides on malaria transmission in central Côte d'Ivoire. Journal of the American mosquito control association : mosquito news, Vol. 25, H. 3. pp. 382-385.

Tritten, L. and Matile, H. and Brun, R. and Wittlin, S.. (2009) A new double-antibody sandwich ELISA targeting Plasmodium falciparum aldolase to evaluate anti-malarial drug sensitivity. Malaria Journal, Vol. 8 , 226.

Xiao, Shu-Hua and Chollet, Jacques and Utzinger, Jürg and Mei, Jin-Yan and Jiao, Pei-Yin and Keiser, Jennifer and Tanner, Marcel. (2009) Effect of single-dose oral mefloquine on the morphology of adult Schistosoma japonicum in mice. Parasitology research : Organ der Deutschen Gesellschaft für Parasitologie, Vol. 105, H. 3. pp. 853-861.

Xiao, Shu-Hua and Keiser, Jennifer and Xue, Jian and Tanner, Marcel and Morson, Gianni and Utzinger, Jürg. (2009) Effect of single-dose oral artemether and tribendimidine on the tegument of adult Clonorchis sinensis in rats. Parasitology research : Organ der Deutschen Gesellschaft für Parasitologie, Vol. 104, H. 3. pp. 533-541.

Zhang, Chao-Wei and Xiao, Shu-Hua and Utzinger, Jürg and Chollet, Jacques and Keiser, Jennifer and Tanner, Marcel. (2009) Histopathological changes in adult Schistosoma japonicum harbored in mice treated with a single dose of mefloquine. Parasitology research : Organ der Deutschen Gesellschaft für Parasitologie, Vol. 104, H. 6. pp. 1407-1416.