Items where Division is "03 Faculty of Medicine > Departement Biomedizin > Division of Biochemistry and Genetics > Molecular Genetics (Schär)"

2016

Manser, Melissa. Influence of extremely-low-frequency magnetic fields on epigenetic programming and cellular differentiation. 2016, Doctoral Thesis, University of Basel, Faculty of Science.

2015

Weber, Alain. The biochemistry of DNA Oxidation- and repair-mediated active DNA demethylation. 2015, Doctoral Thesis, University of Basel, Faculty of Science.

Weis, Stefan. Unravelling molecular mechanisms underlying genetic and epigenetic instabilities in colorectal cancer. 2015, Doctoral Thesis, University of Basel, Faculty of Science.

2014

Krawczyk, C. and Dion, V. and Schar, P. and Fritsch, O.. (2014) Reversible Top1 cleavage complexes are stabilized strand-specifically at the ribosomal replication fork barrier and contribute to ribosomal DNA stability. Nucleic Acids Research, 42 (8). pp. 4985-4995.

Krawczyk, Claudia. Novel functional aspects of topoisomerase Top1 and DNA Glycosylase Thp1 in the maintenance of genetic and epigenetic stability in Yeast. 2014, Doctoral Thesis, University of Basel, Faculty of Science.

Noreen, Faiza and Röösli, Martin and Gaj, Pawel and Pietrzak, Jakub and Weis, Stefan and Urfer, Patric and Regula, Jaroslaw and Schär, Primo and Truninger, Kaspar. (2014) Modulation of age- and cancer-associated DNA methylation change in the healthy colon by aspirin and lifestyle. Journal Of The National Cancer Institute, Vol. 106, Iss. 7 , dju161.

Pfaffeneder, T. and Spada, F. and Wagner, M. and Brandmayr, C. and Laube, S. K. and Eisen, D. and Truss, M. and Steinbacher, J. and Hackner, B. and Kotljarova, O. and Schuermann, D. and Michalakis, S. and Kosmatchev, O. and Schiesser, S. and Steigenberger, B. and Raddaoui, N. and Kashiwazaki, G. and Muller, U. and Spruijt, C. G. and Vermeulen, M. and Leonhardt, H. and Schar, P. and Muller, M. and Carell, T.. (2014) Tet oxidizes thymine to 5-hydroxymethyluracil in mouse embryonic stem cell DNA. Nature chemical biology, Vol. 10, H. 7. pp. 574-581.

Weber, A. R. and Schuermann, D. and Schar, P.. (2014) Versatile recombinant SUMOylation system for the production of SUMO-modified protein. PLoS one, Vol. 9, H. 7 , e102157.

Wirz, Annika. Linking active DNA demethylation by Thymine DNA Glycosylase with epigenetic regulation of gene expression. 2014, Doctoral Thesis, University of Basel, Faculty of Science.

2013

Capstick, M. and Schar, P. and Schuermann, D. and Romann, A. and Kuster, N.. (2013) ELF exposure system for live cell imaging. Bioelectromagnetics, Vol. 34, H. 3. pp. 231-239.

Jacobs, Angelika L.. A function of thymine DNA glycosylase-initiated DNA repair in maintaining epigenome stability. 2013, Doctoral Thesis, University of Basel, Faculty of Science.

Siegrist, Fredy. Transcriptional responses of tumor cell lines to interferon-alpha. 2013, Doctoral Thesis, University of Basel, Faculty of Science.

Talhaoui, I. and Couve, S. and Ishchenko, A. A. and Kunz, C. and Schar, P. and Saparbaev, M.. (2013) 7,8-Dihydro-8-oxoadenine, a highly mutagenic adduct, is repaired by Escherichia coli and human mismatch-specific uracil/thymine-DNA glycosylases. Nucleic Acids Research, 41 (2). pp. 912-923.

2012

Jacobs, A. L. and Schar, P.. (2012) DNA glycosylases: in DNA repair and beyond. Chromosoma, Vol. 121, H. 1. pp. 1-20.

Piscuoglio, Salvatore. Identification of novel genetic and prognostic markers in hereditary and sporadic cancer: "two sides of the same coin". 2012, Doctoral Thesis, University of Basel, Faculty of Science.

Wilson, Gareth A. and Dhami, Pawandeep and Feber, Andrew and Cortázar, Daniel and Suzuki, Yuka and Schulz, Reiner and Schär, Primo and Beck, Stephan. (2012) Resources for methylome analysis suitable for gene knockout studies of potential epigenome modifiers. GigaScience, Vol. 1, H. 1 , 3.

2011

Cortázar, Daniel. Identification of a possible role of thymine DNA glycosylase (TDG) in epigenome maintenance. 2011, Doctoral Thesis, University of Basel, Faculty of Science.

Cortázar, Daniel and Kunz, Christophe and Selfridge, Jim and Lettieri, Teresa and Saito, Yusuke and MacDougall, Eilidh and Wirz, Annika and Schuermann, David and Jacobs, Angelika L. and Siegrist, Fredy and Steinacher, Roland and Jiricny, Josef and Bird, Adrian and Schär, Primo. (2011) Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability. Nature, Vol. 470, H. 7334. pp. 419-423.

Schär, Primo and Fritsch, Olivier. (2011) DNA repair and the control of DNA methylation. Progress in drug research, Vol. 67. pp. 51-68.

2010

Focke, F. and Schuermann, D. and Kuster, N. and Schär, P.. (2010) DNA fragmentation in human fibroblasts under extremely low frequency electromagnetic field exposure. Mutation research, Vol. 683, no. 1-2. pp. 74-83.

2009

Kunz, C. and Saito, Y. and Schär, P.. (2009) DNA Repair in mammalian cells: mismatched repair : variations on a theme. Cellular and molecular life sciences, Vol. 66, no. 6. pp. 1021-1038.

Kunz, Christophe and Focke, Frauke and Saito, Yusuke and Schuermann, David and Lettieri, Teresa and Selfridge, Jim and Schär, Primo. (2009) Base excision by thymine DNA glycosylase mediates DNA-directed cytotoxicity of 5-fluorouracil. PLoS Biology, Vol. 7, H. 4 , e91.

Menigatti, Mirco and Truninger, Kaspar and Gebbers, J.-O. and Marbet, Urs and Marra, Giancarlo and Schär, Primo. (2009) Normal colorectal mucosa exhibits sex- and segment-specific susceptibility to DNA methylation at the hMLH1 and MGMT promoters. Oncogene, Vol. 28, H. 6. pp. 899-909.

Messner, Simon and Schuermann, David and Altmeyer, Matthias and Kassner, Ingrid and Schmidt, Darja and Schär, Primo and Müller, Stefan and Hottiger, Michael O.. (2009) Sumoylation of poly(ADP-ribose) polymerase 1 inhibits its acetylation and restrains transcriptional coactivator function. The FASEB Journal, Vol. 23, H. 11. pp. 3978-3989.

2008

Focke, Frauke. Insights into genotoxic effects of electromagnetic fields. 2008, Doctoral Thesis, University of Basel, Faculty of Science.

2007

Cortázar, Daniel and Kunz, Christophe and Saito, Yusuke and Steinacher, Roland and Schär, Primo. (2007) The enigmatic thymine DNA glycosylase. DNA repair, Vol. 6, no. 4. pp. 489-504.

Hardeland, Ulrike and Kunz, Christophe and Focke, Frauke and Szadkowski, Marta and Schär, Primo. (2007) Cell cycle regulation as a mechanism for functional separation of the apparently redundant uracil DNA glycosylases TDG and UNG2. Nucleic Acids Research, 35 (11). pp. 3859-3867.

Herrmann, Gernot and Kais, Sanja and Hoffbauer, Jan and Shah-Hosseini, Kijwasch and Brüggenolte, Nicole and Schober, Heiko and Fäsi, Margaret and Schär, Primo. (2007) Conserved interactions of the splicing factor Ntr1/Spp382 with proteins involved in DNA double-strand break repair and telomere metabolism. Nucleic Acids Research, 35 (7). pp. 2321-2332.

Menigatti, Mirco and Pedroni, Monica and Verrone, Anna Maria and Borghi, Francesca and Scarselli, Alessandra and Benatti, Piero and Losi, Lorena and Di Gregorio, Carmela and Schär, Primo and Marra, Giancarlo and Ponz de Leon, Maurizio and Roncucci, Luca. (2007) O6-methylguanine-DNA methyltransferase promoter hypermethylation in colorectal carcinogenesis. Oncology reports, Vol. 17, no. 6. pp. 1421-1427.

2006

El-Andaloussi, Nazim and Valovka, Taras and Toueille, Magali and Steinacher, Roland and Focke, Frauke and Gehrig, Peter and Covic, Marcela and Hassa, Paul O. and Schär, Primo and Hübscher, Ulrich and Hottiger, Michael O.. (2006) Arginine methylation regulates DNA polymerase beta. Molecular cell, Vol. 22, H. 1. pp. 51-62.

2005

Borys-Brzywczy, Ewa and Arczewska, Katarzyna D. and Saparbaev, Murat and Hardeland, Ulrike and Schär, Primo and Kuzmierek, Jaroszaw T.. (2005) Mismatch dependent uracil/thymine-DNA glycosylases excise exocyclic hydroxyethano and hydroxypropano cytosine adducts. Acta biochimica Polonica, Vol. 52, Nr. 1. pp. 149-165.

Cejka, Petr and Mojas, Nina and Gillet, Ludovic and Schär, Primo and Jiricny, Josef. (2005) Homologous recombination rescues mismatch-repair-dependent cytotoxicity of S(N)1-type methylating agents in S. cerevisiae. Current biology, Vol. 15, H. 15. pp. 1395-1400.

Lucey, Marie J. and Chen, Dongsheng and Lopez-Garcia, Jorge and Hart, Stephen M. and Phoenix, Fladia and Al-Jehani, Rajai and Alao, John P. and White, Roger and Kindle, Karin B. and Losson, Régine and Chambon, Pierre and Parker, Malcolm G. and Schär, Primo and Heery, David M. and Buluwela, Lakjaya and Ali, Simak. (2005) T:G mismatch-specific thymine-DNA glycosylase (TDG) as a coregulator of transcription interacts with SRC1 family members through a novel tyrosine repeat motif. Nucleic Acids Research, 33 (19). pp. 6393-6404.

Steinacher, Roland and Schär, Primo. (2005) Functionality of human thymine DNA glycosylase requires SUMO-regulated changes in protein conformation. Current biology, Vol. 15, H. 7. pp. 616-623.

Truninger, Kaspar and Menigatti, Mirco and Luz, Judith and Russell, Anna and Haider, Ritva and Gebbers, Jan-Olaf and Bannwart, Fridolin and Yurtsever, Hueseyin and Neuweiler, Joerg and Riehle, Hans-Martin and Cattaruzza, Maria Sofia and Heinimann, Karl and Schär, Primo and Jiricny, Josef and Marra, Giancarlo. (2005) Immunohistochemical analysis reveals high frequency of PMS2 defects in colorectal cancer. Gastroenterology, Vol. 128, H. 5. pp. 1160-1171.

2004

Fleck, Oliver and Schär, Primo. (2004) Translesion DNA synthesis : little fingers teach tolerance. Current biology, Vol. 14, H. 10 , R389-391.

Kunz, Christophe and Schär, Primo. (2004) Meiotic recombination: sealing the partnership at the junction. Current Biology, Vol. 14, H. 22 , R962-4.

Schär, Primo and Fäsi, Margaret and Jessberger, Rolf. (2004) SMC1 coordinates DNA double-strand break repair pathways. Nucleic Acids Research, 32 (13). pp. 3921-3929.

Springer, Burkhard and Sander, Peter and Sedlacek, Ludwig and Hardt, Wolf-Dietrich and Mizrahi, Valerie and Schär, Primo and Böttger, Erik C.. (2004) Lack of mismatch correction facilitates genome evolution in mycobacteria. Molecular Microbiology, Vol. 53, H. 6. pp. 1601-1609.

2003

Chen, Dongsheng and Lucey, Marie J. and Phoenix, Fladia and Lopez-Garcia, Jorge and Hart, Stephen M. and Losson, Régine and Buluwela, Lakjaya and Coombes, R. Charles and Chambon, Pierre and Schär, Primo and Ali, Simak. (2003) T:G mismatch-specific thymine-DNA glycosylase potentiates transcription of estrogen-regulated genes through direct interaction with estrogen receptor alpha. Journal of biological chemistry, Vol. 278, H. 40. pp. 38586-38592.

Hardeland, Ulrike and Bentele, Marc and Jiricny, Josef and Schär, Primo. (2003) The versatile thymine DNA-glycosylase: a comparative characterization of the human, Drosophila and fission yeast orthologs. Nucleic Acids Research, 31 (9). pp. 2261-2271.

Wellinger, Ralf Erik and Schär, Primo and Sogo, Jose M.. (2003) Rad52-independent accumulation of joint circular minichromosomes during S phase in Saccharomyces cerevisiae. Molecular and cellular biology, Vol. 23, H. 18. pp. 6363-6372.

2002

Hardeland, Ulrike and Steinacher, Roland and Jiricny, Josef and Schär, Primo. (2002) Modification of the human thymine-DNA glycosylase by ubiquitin-like proteins facilitates enzymatic turnover. The EMBO Journal, Vol. 21, H. 6. pp. 1456-1464.

Hasan, Sameez and El-Andaloussi, Nazim and Hardeland, Ulrike and Hassa, Paul O. and Bürki, Christine and Imhof, Ralph and Schär, Primo and Hottiger, Michael O.. (2002) Acetylation regulates the DNA end-trimming activity of DNA polymerase beta. Molecular cell, Vol. 10, H. 5. pp. 1213-1222.

2001

Hardeland, U. and Bentele, M. and Lettieri, T. and Steinacher, R. and Jiricny, J. and Schär, P.. (2001) Thymine DNA glycosylase. Progress in nucleic acid research and molecular biology, Vol. 68. pp. 235-253.

Sartori, A. A. and Schär, P. and Fitz-Gibbon, S. and Miller, J. H. and Jiricny, J.. (2001) Biochemical characterization of uracil processing activities in the hyperthermophilic archaeon Pyrobaculum aerophilum. Journal of biological chemistry, Vol. 276, H. 32. pp. 29979-29986.

Schär, Primo. (2001) Spontaneous DNA damage, genome instability, and cancer - when DNA replication escapes control. Cell, Vol. 104, H. 3. pp. 329-332.

Valencia, Maia and Bentele, Marc and Vaze, M. B. and Herrmann, Gernot and Lee, S. E. and Schär, Primo* and Haber, James E*. (2001) NEJ1 controls non-homologous end joining in Saccharomyces cerevisiae. Nature, Vol. 414, H. 6864. pp. 666-699.

2000

Hardeland, Ulrike and Bentele, Marc and Jiricny, Josef and Schär, Primo. (2000) Separating substrate recognition from base hydrolysis in human thymine DNA glycosylase by mutational analysis. Journal of biological chemistry, Vol. 275, H. 43. pp. 33449-33456.

1999

Fleck, Oliver and Lehmann, Elisabeth and Schär, Primo and Kohli, Jürg. (1999) Involvement of nucleotide-excision repair in msh2 pms1-independent mismatch repair. Nature genetics, Vol. 21, H. 3. pp. 314-317.

Marra, Giancaro and Schär, Primo. (1999) Recognition of DNA alterations by the mismatch repair system. The biochemical journal, Vol. 338, Pt. 1. pp. 1-13.

Räschle, M. and Marra, G. and Nyström-Lahti, M. and Schär, P. and Jiricny, J.. (1999) Identification of hMutLbeta, a heterodimer of hMLH1 and hPMS1. Journal of biological chemistry, Vol. 274, H. 45. pp. 32368-32375.