Items where Division is "03 Faculty of Medicine > Departement Biomedizin > Division of Biochemistry and Genetics > Cancer- and Immunobiology (Wymann)"

2015

Botindari, Fabrizio. Targeting SHIP1 and PI3Ky for a synergistic inhibition of mast cell activation. 2015, Doctoral Thesis, University of Basel, Faculty of Science.

Cal, Ruben. Development of novel chemical inducers of dimerization to regulate proteins with high spatial and temporal precision. 2015, Doctoral Thesis, University of Basel, Faculty of Science.

Zimmermann, Mirjam Sarah. Novel photocleavable intracellular heterodimerizer to manipulate protein dynamics with high spatiotemporal precision. 2015, Doctoral Thesis, University of Basel, Faculty of Science.

2014

Melone, Anna. Endosomal docking of mTOR modulates mTORC1 activity. 2014, Doctoral Thesis, University of Basel, Faculty of Science.

Walser, Romy. Non-canonical activation of PI3Kγ by Ca²⁺/PKCβ in mast cells. 2014, Doctoral Thesis, University of Basel, Faculty of Science.

Zimmermann, Mirjam and Cal, Ruben and Janett, Elia and Hoffmann, Viktor and Bochet, Christian G. and Constable, Edwin and Beaufils, Florent and Wymann, Matthias P.. (2014) Cell-Permeant and Photocleavable Chemical Inducer of Dimerization. Angewandte Chemie International Edition, 53 (18). pp. 4717-4720.

2013

Barthwal, M. K. and Anzinger, J. J. and Xu, Q. and Bohnacker, T. and Wymann, M. P. and Kruth, H. S.. (2013) Fluid-phase pinocytosis of native low density lipoprotein promotes murine M-CSF differentiated macrophage foam cell formation. PLoS one, Vol. 8, H. 3 , e58054.

Collmann, E. and Bohnacker, T. and Marone, R. and Dawson, J. and Rehberg, M. and Stringer, R. and Krombach, F. and Burkhart, C. and Hirsch, E. and Hollingworth, G. J. and Thomas, M. and Wymann, M. P.. (2013) Transient targeting of phosphoinositide 3-kinase acts as a roadblock in mast cells' route to allergy. Journal of allergy and clinical immunology, Vol. 132, H. 4. pp. 959-968.

Erhart, D. and Zimmermann, M. and Jacques, O. and Wittwer, M. B. and Ernst, B. and Constable, E. and Zvelebil, M. and Beaufils, F. and Wymann, M. P.. (2013) Chemical development of intracellular protein heterodimerizers. Chemistry & Biology, 20 (4). pp. 549-557.

Schmidt, C. and Schneble, N. and Muller, J. P. and Bauer, R. and Perino, A. and Marone, R. and Rybalkin, S. D. and Wymann, M. P. and Hirsch, E. and Wetzker, R.. (2013) Phosphoinositide 3-kinase gamma mediates microglial phagocytosis via lipid kinase-independent control of cAMP. Neuroscience, Vol. 233. pp. 44-53.

Walser, R. and Burke, J. E. and Gogvadze, E. and Bohnacker, T. and Zhang, X. and Hess, D. and Kuenzi, P. and Leitges, M. and Hirsch, E. and Williams, R. L. and Laffargue, M. and Wymann, M. P.. (2013) PKCβ phosphorylates PI3Kγ to activate it and release it from GPCR control. PLoS Biology, Vol. 11, H. 6 , e1001587.

Wymann, M. P. and Simons, K.. (2013) Membrane dynamics in physiology and disease. The FEBS journal, Vol. 280, H. 12. p. 2729.

Wymann, M. P. and Solinas, G.. (2013) Inhibition of phosphoinositide 3-kinase γ attenuates inflammation, obesity, and cardiovascular risk factors. Annals of the New York Academy of Sciences, Vol. 1280. pp. 44-47.

Zotes, T. M. and Arias, C. F. and Fuster, J. J. and Spada, R. and Perez-Yague, S. and Hirsch, E. and Wymann, M. and Carrera, A. C. and Andres, V. and Barber, D. F.. (2013) PI3K p110γ deletion attenuates murine atherosclerosis by reducing macrophage proliferation but not polarization or apoptosis in lesions. PLoS one, Vol. 8, H. 8 , e72674.

2012

Anzinger, Joshua J. and Chang, Janet and Xu, Qing and Barthwal, Manoj K. and Bohnacker, Thomas and Wymann, Matthias P. and Kruth, Howard S.. (2012) Murine bone marrow-derived macrophages differentiated with GM-CSF become foam cells by PI3K?-dependent fluid-phase pinocytosis of native LDL. Journal of Lipid Research, 53 (1). pp. 34-42.

Erhart, Dominik. Control of cellular signals in time and space. 2012, Doctoral Thesis, University of Basel, Faculty of Science.

Fougerat, A. and Smirnova, N. F. and Gayral, S. and Malet, N. and Hirsch, E. and Wymann, M. P. and Perret, B. and Martinez, L. O. and Douillon, M. and Laffargue, M.. (2012) Key role of PI3Kgamma in monocyte chemotactic protein-1-mediated amplification of PDGF-induced aortic smooth muscle cell migration. British journal of pharmacology, Vol. 166, no. 5. pp. 1643-1653.

Harris, S. J. and Ciuclan, L. and Finan, P. M. and Wymann, M. P. and Walker, C. and Westwick, J. and Ward, S. G. and Thomas, M. J.. (2012) Genetic ablation of PI3Kgamma results in defective IL-17RA signalling in T lymphocytes and increased IL-17 levels. European journal of immunology, Vol. 42, H. 12. pp. 3394-3404.

Kohler, Reto. Functional characterization of human NDR kinases : novel regulatory mechanisms and a path towards direct substrates. 2012, Doctoral Thesis, University of Basel, Faculty of Science.

Reichel, C. A. and Puhr-Westerheide, D. and Zuchtriegel, G. and Uhl, B. and Berberich, N. and Zahler, S. and Wymann, M. P. and Luckow, B. and Krombach, F.. (2012) C-C motif chemokine CCL3 and canonical neutrophil attractants promote neutrophil extravasation through common and distinct mechanisms. Blood, Vol. 120, H. 4. pp. 880-890.

Restuccia, David. Protein kinase B : the beta version elucidating novel contributions of protein kinase B beta (PKBß/Akt2) to endocrine metabolism, PCOS and cancer. 2012, Doctoral Thesis, University of Basel, Faculty of Science.

Schaefer, T. and Zajonz, A. and Lorentz, P. and Bohnacker, T. and Wymann, M. P. and Schweighoffer, T.. (2012) Luminal decoration of blood vessels by activated perivasal mast cells in allergic rhinitis. Allergy, Vol. 67, H. 4. pp. 510-520.

Wymann, M. P. and Schultz, C.. (2012) The chemical biology of phosphoinositide 3-kinases. ChemBioChem, Vol. 13, H. 14. pp. 2022-2035.

Wymann, Matthias. (2012) PI3Ks-drug targets in inflammation and cancer. Subcellular biochemistry, Vol. 58. pp. 111-181.

2011

Becattini, Barbara and Marone, Romina and Zani, Fabio and Arsenijevic, Denis and Seydoux, Josiane and Montani, Jean-Pierre and Dulloo, Abdul G. and Thorens, Bernard and Preitner, Frédéric and Wymann, Matthias P. and Solinas, Giovanni. (2011) PI3Kγ within a nonhematopoietic cell type negatively regulates diet-induced thermogenesis and promotes obesity and insulin resistance. Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, H. 42 , E854-E863.

Mertz Biro, Ann Christine. Class III phosphoinositide 3-kinase in melanoma. 2011, Doctoral Thesis, University of Basel, Faculty of Science.

Perino, A. and Ghigo, A. and Ferrero, E. and Morello, F. and Santulli, G. and Baillie, G. S. and Damilano, F. and Dunlop, A. J. and Pawson, C. and Walser, R. and Levi, R. and Altruda, F. and Silengo, L. and Langeberg, L. K. and Neubauer, G. and Heymans, S. and Lembo, G. and Wymann, M. P. and Wetzker, R. and Houslay, M. D. and Iaccarino, G. and Scott, J. D. and Hirsch, E.. (2011) Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ. Molecular cell, Vol. 42, H. 1. pp. 84-95.

Reichel, C. A. and Lerchenberger, M. and Uhl, B. and Rehberg, M. and Berberich, N. and Zahler, S. and Wymann, M. P. and Krombach, F.. (2011) Plasmin inhibitors prevent leukocyte accumulation and remodeling events in the postischemic microvasculature. PLoS one, Vol. 6, H. 2 , e17229.

Wymann, Matthias P. and Wenk, Markus R.. (2011) Neutral not a loss : phosphoinositides beyond the head group. Nature methods, Vol. 8, H. 3. pp. 219-220.

2010

Ciraolo, Elisa and Morello, Fulvio and Hobbs, Robin M. and Wolf, Frieder and Marone, Romina and Iezzi, Manuela and Lu, Xiaoyun and Mengozzi, Giulio and Altruda, Fiorella and Sorba, Giovanni and Guan, Kaomei and Pandolfi, Pier Paolo and Wymann, Matthias P. and Hirsch, Emilio. (2010) Essential role of the p110beta subunit of phosphoinositide 3-OH kinase in male fertility. Molecular Biology of the Cell, 21 (5). pp. 704-711.

Spitzenberg, Volker and König, Christian and Ulm, Susanne and Marone, Romina and Röpke, Luise and Müller, Jörg P. and Grün, Michael and Bauer, Reinhard and Rubio, Ignacio and Wymann, Matthias Paul and Voigt, Astrid and Wetzker, Reinhard. (2010) Targeting PI3K in neuroblastoma. Journal of cancer research and clinical oncology, Vol. 136, H. 12. pp. 1881-1890.

2009

Barberis, Laura and Pasquali, Christian and Bertschy-Meier, Dominique and Cuccurullo, Alessandra and Costa, Carlotta and Ambrogio, Chiara and Vilbois, Francis and Chiarle, Roberto and Wymann, Matthias and Altruda, Fiorella and Rommel, Christian and Hirsch, Emilio. (2009) Leukocyte transmigration is modulated by chemokine-mediated PI3Kgamma-dependent phosphorylation of vimentin. European journal of immunology, Vol. 39. pp. 1136-1146.

Bohnacker, Thomas. PI3Kγ adapter subunits in mast cells. 2009, Doctoral Thesis, University of Basel, Faculty of Science.

Bohnacker, Thomas and Marone, Romina and Collmann, Emilie and Calvez, Ronan and Hirsch, Emilio and Wymann, Matthias P.. (2009) PI3Kgamma adaptor subunits define coupling to degranulation and cell motility by distinct PtdIns(3,4,5)P3 pools in mast cells. Science signaling : the signal transduction knowledge environment, Vol. 2 , ra27.

Kurig, Barbara and Shymanets, Aliaksei and Bohnacker, Thomas and Prajwal, and Brock, Carsten and Ahmadian, Mohammad Reza and Schaefer, Michael and Gohla, Antje and Harteneck, Christian and Wymann, Matthias P. and Jeanclos, Elisabeth and Nürnberg, Bernd. (2009) Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110gamma. Proceedings of the National Academy of Sciences of the United States of America, Vol. 106. pp. 20312-20317.

Marone, Romina and Erhart, Dominik and Mertz, Ann C. and Bohnacker, Thomas and Schnell, Christian and Cmiljanovic, Vladimir and Stauffer, Frédéric and Garcia-Echeverria, Carlos and Giese, Bernd and Maira, Sauveur-Michel and Wymann, Matthias P.. (2009) Targeting melanoma with dual phosphoinosite 3-kinase/mammalian target of rapamycin inhibitors. Molecular Cancer Research, Vol. 7. pp. 601-613.

Santos-Sierra, Sandra and Deshmukh, Sachin D. and Kalnitski, Julia and Küenzi, Peter and Wymann, Matthias P. and Golenbock, Douglas T. and Henneke, Philipp. (2009) Mal connects TLR2 to PI3Kinase activation and phagocyte polarization. The EMBO journal, Vol. 28. pp. 2018-2027.

Thomas, Matthew and Edwards, Matthew J. and Sawicka, Elzbieta and Duggan, Nicholas and Hirsch, Emilio and Wymann, Matthias P. and Owen, Charles and Trifilieff, Alexandre and Walker, Christoph and Westwick, John and Finan, Peter. (2009) Essential role of phosphoinositide 3-kinase gamma in eosinophil chemotaxis within acute pulmonary inflammation. Immunology : an official journal of the British Society for Immunology, Vol. 126. pp. 413-422.

2008

Ciraolo, E. and Iezzi, M. and Marone, R. and Marengo, S. and Curcio, C. and Costa, C. and Azzolino, O. and Gonella, C. and Rubinetto, C. and Wu, H. and Dastrù, W. and Martin, E. L. and Silengo, L. and Altruda, F. and Turco, E. and Lanzetti, L. and Musiani, P. and Rückle, T. and Rommel, C. and Backer, J. M. and Forni, G. and Wymann, M. P. and Hirsch, E.. (2008) Phosphoinositide 3-kinase p110beta activity : key role in metabolism and mammary gland cancer but not development. Science signaling, Vol. 1, H. 36 , ra3.

Fougerat, A. and Gayral, S. and Gourdy, P. and Schambourg, A. and Rückle, T. and Schwarz, M. K. and Rommel, C. and Hirsch, E. and Arnal, J. F. and Salles, J. P. and Perret, B. and Breton-Douillon, M. and Wymann, M. P. and Laffargue, M.. (2008) Genetic and pharmacological targeting of phosphoinositide 3-kinase-gamma reduces atherosclerosis and favors plaque stability by modulating inflammatory processes. Circulation, Vol. 117, H. 10. pp. 1310-1317.

Marone, R. and Cmiljanovic, V. and Giese, B. and Wymann, M. P.. (2008) Targeting phosphoinositide 3-kinase-Moving towards therapy. Biochimica et biophysica acta, Vol. 1784, H. 1. pp. 159-185.

Wymann, M. P. and Schneiter, R.. (2008) Lipid signalling in disease. Nature reviews. Molecular cell biology, Vol. 9, H. 2. pp. 162-176.