Hysek, C. M. and Simmler, L. D. and Ineichen, M. and Grouzmann, E. and Hoener, M. C. and Brenneisen, R. and Huwyler, J. and Liechti, M. E.. (2011) The Norepinephrine Transporter Inhibitor Reboxetine Reduces Stimulant Effects of MDMA ("Ecstasy") in Humans. Clinical pharmacology and therapeutics, Vol. 90, H. 2. pp. 246-255.
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Official URL: http://edoc.unibas.ch/dok/A5849089
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Abstract
This study assessed the pharmacodynamic and pharmacokinetic effects of the interaction between the selective norepinephrine (NE) transporter inhibitor reboxetine and 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") in 16 healthy subjects. The study used a double-blind, placebo-controlled crossover design. Reboxetine reduced the effects of MDMA including elevations in plasma levels of NE, increases in blood pressure and heart rate, subjective drug high, stimulation, and emotional excitation. These effects were evident despite an increase in the concentrations of MDMA and its active metabolite 3,4-methylenedioxyamphetamine (MDA) in plasma. The results demonstrate that transporter-mediated NE release has a critical role in the cardiovascular and stimulant-like effects of MDMA in humans.
| Faculties and Departments: | 05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Pharmaceutical Technology (Huwyler) |
|---|---|
| UniBasel Contributors: | Huwyler, Jörg and Simmler, Linda and Liechti, Matthias Emanuel |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Mosby |
| ISSN: | 0009-9236 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Last Modified: | 14 Sep 2012 07:17 |
| Deposited On: | 14 Sep 2012 06:40 |
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