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Synthesis and biological properties of a rhodacyanine derivative, Ssj-127, having high efficacy against malaria protozoa

Pudhom, K. and Ge, M. F. and Arai, C. and Yang, M. and Kaiser, M. and Wittlin, S. and Brun, R. and Itoh, I. and Ihara, M.. (2009) Synthesis and biological properties of a rhodacyanine derivative, Ssj-127, having high efficacy against malaria protozoa. Heterocycles : an international journal for reviews and communications in heterocyclic chemistry, Vol. 77, H. 1. pp. 207-210.

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Official URL: http://edoc.unibas.ch/dok/A5843342

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Abstract

One of rhodacyanine derivatives, SSJ-127 (1), showed a complete cure of a mouse model infected with Plasmodium berghei by subcutaneous administration. The synthesis, in vitro activities against several protozoa and in vivo antimalarial test and PK study of SSJ-127 (1) are reported
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Parasite Chemotherapy (Mäser)
UniBasel Contributors:Brun, Reto and Kaiser, Marcel and Wittlin, Sergio
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:0385-5414
Note:Publication type according to Uni Basel Research Database: Journal article
Last Modified:14 Sep 2012 07:17
Deposited On:14 Sep 2012 06:41

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