Paine, M. F. and Wang, M. Z. and Generaux, C. N. and Boykin, D. W. and Wilson, W. D. and de Koning H. P., and Olson, C. A. and Pohlig, G. and Burri, C. and Brun, R. and Murilla, G. A. and Thuita, J. K. and Barrett, M. P. and Tidwell, R. R.. (2010) Diamidines for human African trypanosomiasis. Current opinion in investigational drugs, Vol. 11, H. 8. pp. 876-883.
Full text not available from this repository.
Official URL: http://edoc.unibas.ch/dok/A5842866
Downloads: Statistics Overview
Abstract
Aromatic diamidines are potent trypanocides. Pentamidine, a diamidine, has been used for more than 60 years to treat human African trypanosomiasis (HAT); however, the drug must be administered parenterally and is active against first-stage HAT only, prior to the parasites causing neurological deterioration through invasion of the CNS. A major research effort to design novel diamidines has led to the development of orally active prodrugs and, remarkably, a new generation of compounds that can penetrate the CNS. In this review, progress in the development of diamidines for the treatment of HAT is discussed
| Faculties and Departments: | 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medicine (MED) 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medicine (MED) > Medicines Implementation Research (Burri) 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Parasite Chemotherapy (Mäser) |
|---|---|
| UniBasel Contributors: | Brun, Reto and Burri, Christian |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Biomed Central |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Related URLs: | |
| Identification Number: |
|
| Last Modified: | 14 Sep 2012 07:18 |
| Deposited On: | 14 Sep 2012 06:46 |
Repository Staff Only: item control page