Lu, Y. T. and Arai, C. and Ge, J. F. and Ren, W. S. and Kaiser, M. and Wittlin, S. and Brun, R. and Lu, J. M. and Ihara, M.. (2011) Synthesis and in vitro antiprotozoal activities of water-soluble, inexpensive phenothiazinium chlorides. Dyes and pigments : an international journal, Vol. 89, H. 1. pp. 44-48.
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Official URL: http://edoc.unibas.ch/dok/A6002362
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Abstract
Tropical diseases are serious infectious diseases caused by protozoan parasites in tropical and subtropical regions Novel effective safe and inexpensive drugs are required to treat the parasites and contribute to the global goal of eradication A series of phenothiazinium chlorides were synthesized and evaluated for in vitro activities against Plasmodium falciparum Trypanosoma cruzi Trypanosoma brucei rhodesiense and Leishmania donovani Notably 3 7-bis(piperidinyl)phenothiazinium chloride showed IC50 of 0 097 mu mol L-1 against T cruzi and 3 7-bis(benzyl(methyl)amino)phenothiazinium chloride exhibited IC50 of 0 081 mu mol L-1 against L donovani although the cytotoxicities of these compounds against L-6 cells were observed at low concentration (C) 2010 Elsevier Ltd All rights reserved
| Faculties and Departments: | 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Parasite Chemotherapy (Mäser) |
|---|---|
| UniBasel Contributors: | Brun, Reto and Kaiser, Marcel and Wittlin, Sergio |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Elsevier Science |
| ISSN: | 0143-7208 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
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| Identification Number: | |
| Last Modified: | 11 Oct 2012 15:32 |
| Deposited On: | 11 Oct 2012 15:30 |
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