Filipowicz, Magdalena and Bernsmeier, Christine and Terracciano, Luigi and Duong, Francois H. T. and Heim, Markus H.. (2010) S-adenosyl-methionine and betaine improve early virological response in chronic hepatitis C patients with previous nonresponse. PLoS one, Vol. 5, H. 11 , e15492.
Full text not available from this repository.
Official URL: http://edoc.unibas.ch/dok/A6006783
Downloads: Statistics Overview
Abstract
Treatment of chronic hepatitis C (CHC) with pegylated interferon (pegIFN ) and ribavirin results in a sustained response in approximately half of patients. Viral interference with IFN signal transduction through the Jak-STAT pathway might be an important factor underlying treatment failure. S-adenosyl-L-methionine (SAMe) and betaine potentiate IFN signaling in cultured cells that express hepatitis C virus (HCV) proteins, and enhance the inhibitory effect of IFN on HCV replicons. We have performed a clinical study with the aim to evaluate efficacy and safety of the addition of SAMe and betaine to treatment of CHC with pegIFN /ribavirin.
| Faculties and Departments: | 03 Faculty of Medicine > Bereich Querschnittsfächer (Klinik) > Pathologie USB > Molekulare Pathologie (Terracciano) 03 Faculty of Medicine > Departement Klinische Forschung > Bereich Querschnittsfächer (Klinik) > Pathologie USB > Molekulare Pathologie (Terracciano) 03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Hepatology Laboratory (Heim) |
|---|---|
| UniBasel Contributors: | Heim, Markus H. and Terracciano, Luigi M. |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | PubMed Central |
| ISSN: | 1932-6203 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Related URLs: | |
| Identification Number: |
|
| Last Modified: | 01 Feb 2013 08:46 |
| Deposited On: | 01 Feb 2013 08:43 |
Repository Staff Only: item control page