Munigunti, Ranjith and Becker, Katja and Brun, Reto and Calderón, Angela I.. (2013) Determination of antiplasmodial activity and binding affinity of selected natural products towards PfTrxR and PfGR. Natural product communications, Vol. 8, H. 8. pp. 1135-1136.
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Official URL: http://edoc.unibas.ch/dok/A6194559
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Abstract
In our study, the binding affinities of selected natural products towards PfTrxR, PfGR, human TrxR and human GR were determined using a mass spectrometry based ligand binding assay. The in vitro antimalarial activity and cytotoxicity of these ligands were also determined. Catharanthine, 11-(OH)-coronaridine, hernagine, vobasine and hispolone displayed antiplasmodial activity against PfK1 (IC50 = 0.996-3.63 microg/mL).
| Faculties and Departments: | 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Parasite Chemotherapy (Mäser) |
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| UniBasel Contributors: | Brun, Reto |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | NPC |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
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| Last Modified: | 04 Sep 2015 14:32 |
| Deposited On: | 31 Jan 2014 09:49 |
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