Nwodo, Ngozi Justina and Okoye, Festus Basden C. and Lai, Daowan and Debbab, Abdessamad and Brun, Reto and Proksch, Peter. (2014) Two trypanocidal dipeptides from the roots of Zapoteca portoricensis (Fabaceae). Molecules, Vol. 19, H. 5. pp. 5470-5477.
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Official URL: http://edoc.unibas.ch/dok/A6348511
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Abstract
Zapoteca portoricensis (Jacq) HM Hernández is used with remarkable efficacy in ethnomedicinal management of tonsillitis in the Eastern part of Nigeria. Previous pharmacological studies have validated the antiinflammatory and antimicrobial activities of the crude extract. In this study, two dipeptides, saropeptate (aurantiamide acetate) and anabellamide, were isolated from the methanol root extract of Zapoteca portoricensis and their chemical structures deduced by one dimensional and two dimensional NMR and mass spectrometry. These compounds were isolated for the first time from this plant, and no report has been found on their previous isolation from the genus Zapoteca. Evaluation of their trypanocidal activity showed that compound 1 exhibited potent activity against Trypanosoma brucei rhodesiense with an IC50 value of 3.63 μM and selectivity index of 25.3.
| Faculties and Departments: | 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Parasite Chemotherapy (Mäser) |
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| UniBasel Contributors: | Brun, Reto |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | MDPI |
| ISSN: | 1420-3049 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
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| Last Modified: | 10 Apr 2015 09:12 |
| Deposited On: | 10 Apr 2015 09:12 |
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