Liko, Dritan and Hall, Michael N.. (2015) mTOR in health and in sickness. Journal of Molecular Medicine, 93 (10). pp. 1061-1073.
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Official URL: http://edoc.unibas.ch/39652/
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Abstract
Target of rapamycin (TOR) is a highly conserved protein kinase that plays a key role in mediating cell growth and homeostasis. It is activated by nutrients, growth factors, and cellular energy levels to control a number of anabolic and catabolic processes. It is a validated drug target implicated in a variety of diseases. In this review, we describe the molecular mode of action of TOR in the context of cellular and organismal physiology. We focus on mammalian TOR (mTOR) signaling in cancer and neurological disease and discuss usage of TOR inhibitors in the clinic.
| Faculties and Departments: | 05 Faculty of Science > Departement Biozentrum > Growth & Development > Biochemistry (Hall) |
|---|---|
| UniBasel Contributors: | Hall, Michael N. |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Springer |
| ISSN: | 0946-2716 |
| e-ISSN: | 1432-1440 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Identification Number: |
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| Last Modified: | 09 Nov 2017 10:06 |
| Deposited On: | 23 May 2016 09:13 |
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