edoc-vmtest

Disruption of ribosome biogenesis triggers a p21/p53-mediated cell cycle checkpoint

Di Cara, Alessandro. Disruption of ribosome biogenesis triggers a p21/p53-mediated cell cycle checkpoint. 2006, Doctoral Thesis, University of Basel, Faculty of Science.

[img]
Preview
PDF
2205Kb

Official URL: http://edoc.unibas.ch/diss/DissB_7625

Downloads: Statistics Overview

Abstract

Cell cycle entry requires a dramatic increase in protein production. In order to cope with
this demand, the cell must upregulate ribosome biogenesis. Given that ribosome
biogenesis is the most energy-consuming anabolic process in a growing cell, and that
changes in cellular ribosome content can alter the genetic program, we hypothesized
that control mechanisms must exist to synchronize ribosome biogenesis and cell cycle
progression. Here I report on a novel cell cycle checkpoint which is activated on the
disruption of ribosome biogenesis and blocks cell cycle progression. Our studies, both
in vitro and in vivo, show p21 and p53 as key mediators of this response.
Advisors:Thomas, George
Committee Members:Hall, Michael N. and Amati, B
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development > Biochemistry (Hall)
UniBasel Contributors:Hall, Michael N.
Item Type:Thesis
Thesis Subtype:Doctoral Thesis
Thesis no:7625
Thesis status:Complete
Number of Pages:88
Language:English
Identification Number:
edoc DOI:
Last Modified:02 Aug 2021 15:05
Deposited On:13 Feb 2009 15:41

Repository Staff Only: item control page