Pereira, Fernando Carvalho Rodrigues. Excess dopamine D2R activation accounts for PV+ basket cell and learning alterations in mouse model of schizophrenia. 2016, Doctoral Thesis, University of Basel, Faculty of Science.
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Official URL: http://edoc.unibas.ch/diss/DissB_12156
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Abstract
Schizophrenia is consistently associated with alterations in parvalbumin-positive basket cell functions, and with reduced gamma power of network activity, but causal relationships between PV dysfunctions and clinical manifestations of schizophrenia have remained unclear. Here I investigated LgDel+/- mice, a genetic model closely reproducing chromosomal deletions in 22q11 patients. I found that early-born PV interneurons are specifically affected in the LgDel+/- mice, suggesting a specific deficit in synaptic excitation of PV neurons. The PV alterations were associated with specific deficits in long-term memory consolidation and in top-down executive control. Delivery of the D2-receptor antagonist haloperidol to mutant mice rescued PV network alterations and long-term memory. My findings are consistent with the notion that PV network deregulation has an important role in cognitive deficits of schizophrenia model mice.
Advisors: | Caroni, Pico and Roska, Botond |
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Faculties and Departments: | 09 Associated Institutions > Friedrich Miescher Institut FMI > Neurobiology > Plasticity of neuronal connections (Caroni) |
UniBasel Contributors: | Roska, Botond |
Item Type: | Thesis |
Thesis Subtype: | Doctoral Thesis |
Thesis no: | 12156 |
Thesis status: | Complete |
Number of Pages: | 1 Online-Ressource (101 Blätter) |
Language: | English |
Identification Number: |
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edoc DOI: | |
Last Modified: | 02 Aug 2021 15:14 |
Deposited On: | 21 Jun 2017 14:14 |
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