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Antiprotozoal spirombandakamines A1 and A2, fused naphthylisoquinoline dimers from a congolese Ancistrocladus plant

Lombe, Blaise Kimbadi and Bruhn, Torsten and Feineis, Doris and Mudogo, Virima and Brun, Reto and Bringmann, Gerhard. (2017) Antiprotozoal spirombandakamines A1 and A2, fused naphthylisoquinoline dimers from a congolese Ancistrocladus plant. Organic Letters, 19 (24). pp. 6740-6743.

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Official URL: http://edoc.unibas.ch/58352/

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Abstract

From the leaves of a yet undescribed Congolese Ancistrocladus species, two novel naphthylisoquinoline dimers, spirombandakamines A1 (1) and A2 (2), were isolated, together with a new, but "classical" dimer, mbandakamine B2 (3). The cage-like stereostructures of 1 and 2 were established by combining spectroscopic, chemical, and chiroptical methods with quantum-chemical ECD calculations. Their unique molecular frameworks may originate from "open-chain" dimers, such as 3, by an oxidation-induced cascade of reactions. They possess strong antiprotozoal properties.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Parasite Chemotherapy (Mäser)
UniBasel Contributors:Brun, Reto
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Chemical Society
ISSN:1523-7060
e-ISSN:1523-7052
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:02 Feb 2018 10:21
Deposited On:02 Feb 2018 10:21

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