Items where Division is "05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Structural Biology (Schirmer)"

2017

Stanger, Frédéric V. and de Beer, Tjaart A. P. and Dranow, David M. and Schirmer, Tilman and Phan, Isabelle and Dehio, Christoph. (2017) The BID Domain of Type IV Secretion Substrates Forms a Conserved Four-Helix Bundle Topped with a Hook. Structure , 25 (1). pp. 203-211.

2016

Dubey, Badri N. and Lori, Christian and Ozaki, Shogo and Fucile, Geoffrey and Plaza-Menacho, Ivan and Jenal, Urs and Schirmer, Tilman. (2016) Cyclic di-GMP mediates a histidine kinase/phosphatase switch by noncovalent domain cross-linking. Science Advances, 2 (9). e1600823.

Reinders, Alberto and Hee, Chee-Seng and Ozaki, Shogo and Mazur, Adam and Boehm, Alex and Schirmer, Tilman and Jenal, Urs. (2016) Expression and Genetic Activation of Cyclic Di-GMP-Specific Phosphodiesterases in Escherichia coli. Journal of Bacteriology, 198 (3). pp. 448-462.

Schirmer, Tilman. (2016) C-di-GMP Synthesis: Structural Aspects of Evolution, Catalysis and Regulation. Journal of molecular biology, 428 (19). pp. 3683-3701.

Stanger, Frédéric V. and Burmann, Björn M. and Harms, Alexander and Aragão, Hugo and Mazur, Adam and Sharpe, Timothy and Dehio, Christoph and Hiller, Sebastian and Schirmer, Tilman. (2016) Intrinsic regulation of FIC-domain AMP-transferases by oligomerization and automodification. Proceedings of the National Academy of Sciences of the United States of America, 113 (5). E529-E537.

Stanger, Frédéric V. and Harms, Alexander and Dehio, Christoph and Schirmer, Tilman. (2016) Crystal Structure of the Escherichia coli Fic Toxin-Like Protein in Complex with Its Cognate Antitoxin. PLoS One, 11 (9). e0163654.

September 2015

Harms, Alexander and Stanger, Frédéric Valentin and Scheu, Patrick Daniel and de Jong, Imke Greet and Goepfert, Arnaud and Glatter, Timo and Gerdes, Kenn and Schirmer, Tilman and Dehio, Christoph. (2015) Adenylylation of Gyrase and Topo IV by FicT Toxins Disrupts Bacterial DNA Topology. Cell reports, 12 (9). pp. 1497-1507.

2015

Bosshart, Andreas and Hee, Chee Seng and Bechtold, Matthias and Schirmer, Tilman and Panke, Sven. (2015) Directed Divergent Evolution of a Thermostable D-Tagatose Epimerase towards Improved Activity for Two Hexose Substrates. ChemBioChem, 16 (4). pp. 592-601.

Kauer, Stefanie L.. Structural and functional investigations of the Pseudomonas aeruginosa YfiBNR-system. 2015, Doctoral Thesis, University of Basel, Faculty of Science.

Lori, Christian and Ozaki, Shogo and Steiner, Samuel and Böhm, Raphael and Abel, Sören and Dubey, Badri N. and Schirmer, Tilman and Hiller, Sebastian and Jenal, Urs. (2015) Cyclic di-GMP acts as a cell cycle oscillator to drive chromosome replication. Nature, Vol. 523, H. 7559. pp. 236-239.

2014

Goepfert, Arnaud. Fic-mediated adenylylation : catalysis and regulation. 2014, Doctoral Thesis, University of Basel, Faculty of Science.

Hutter, C. A. J. and Lehner, R. and Wirth, Ch. and Condemine, G. and Peneff, C. and Schirmer, T.. (2014) Structure of the oligogalacturonate-specific KdgM porin. Acta Crystallographica Section D: Biological Crystallography, 70 (6). pp. 1770-1778.

Munoz-Robles, Victor and Dürrenberger, Marc and Tillmann, Heinisch and Lledos, Agustí and Schirmer, Tilman and Ward, Thomas R. and Maréchal, Jean-Didier. (2014) Structural, Kinetic, and Docking Studies of Artificial Imine Reductases Based on Biotin–Streptavidin Technology: An Induced Lock-and-Key Hypothesis. Journal of the American Chemical Society, 136 (44). pp. 15676-15683.

Ozaki, Shogo and Schalch-Moser, Annina and Zumthor, Ludwig and Manfredi, Pablo and Ebbensgaard, Anna and Schirmer, Tilman and Jenal, Urs. (2014) Activation and polar sequestration of PopA, a c-di-GMP effector protein involved in Caulobacter crescentus cell cycle control. Molecular Microbiology, 94 (3). pp. 580-594.

Stanger, Frédéric V.. Tightly regulated FIC domain proteins modulate bacterial topoisomerases by adenylylation. 2014, Doctoral Thesis, University of Basel, Faculty of Science.

Stanger, Frédéric V. and Dehio, Christoph and Schirmer, Tilman. (2014) Structure of the N-terminal gyrase B fragment in complex with ADP⋅Pi reveals rigid-body motion induced by ATP hydrolysis. PloS one, Vol. 9, H. 9 , e107289.

Sundriyal, Amit and Massa, Claudia and Samoray, Dietrich and Zehender, Fabian and Sharpe, Timothy and Jenal, Urs and Schirmer, Tilman. (2014) Inherent regulation of EAL domain-catalyzed hydrolysis of second messenger c-di-GMP. Journal of Biological Chemistry, 289 (10). pp. 6978-6990.

2013

Goepfert, Arnaud and Harms, Alexander and Schirmer, Tilman and Dehio, Christoph. (2013) Type II Toxin-Antitoxin Loci: The fic Family. In: Prokaryotic Toxin-Antitoxins. Heidelberg, pp. 177-187.

Zimbron, Jeremy M. and Heinisch, Tillmann and Schmid, Maurus and Hamels, Didier and Nogueira, Elisa S. and Schirmer, Tilman and Ward, Thomas R.. (2013) A Dual Anchoring Strategy for the Localization and Activation of Artificial Metalloenzymes Based on the Biotin-Streptavidin Technology. Journal of the American Chemical Society, 135 (14). pp. 5384-5388.

Zähringer, Franziska. Structural and biochemical investigations into c-di-GMP signaling in "E.coli" : Zinc dependent regulation of the diguanylate cyclase YdeH and characterization of PgaA and PgaB, involved in c-di-GMP controlled exopolysaccharide synthesis. 2013, Doctoral Thesis, University of Basel, Faculty of Science.

2012

Engel, Philipp and Goepfert, Arnaud and Stanger, Frédéric V. and Harms, Alexander and Schmidt, Alexander and Schirmer, Tilman and Dehio, Christoph. (2012) Adenylylation control by intra- or intermolecular active-site obstruction in Fic proteins. Nature, 482 (7383). pp. 107-110.

Gentner, Martin and Allan, Martin G. and Zaehringer, Franziska and Schirmer, Tilman and Grzesiek, Stephan. (2012) Oligomer formation of the bacterial second messenger c-di-GMP : reaction rates and equilibrium constants indicate a monomeric state at physiological concentrations. The journal of the American Chemical Society, 134 (2). pp. 1019-1029.

Giri, Janhavi and Tang, John M. and Wirth, Christophe and Peneff, Caroline M. and Eisenberg, Bob. (2012) Single-channel measurements of an N-acetylneuraminic acid-inducible outer membrane channel in Escherichia coli. European biophysics journal, 41 (3). pp. 259-271.

Wirth, Christophe. Structural investigation on membrane proteins : the case of the KdgM porin family, OmpF and IIBCSUC. 2012, Doctoral Thesis, University of Basel, Faculty of Science.

2011

Abel, Sören and Chien, Peter and Wassmann, Paul and Schirmer, Tilman and Kaever, Volkhard and Laub, Michael T. and Baker, Tania A. and Jenal, Urs. (2011) Regulatory Cohesion of Cell Cycle and Cell Differentiation through Interlinked Phosphorylation and Second Messenger Networks. Molecular cell, Vol. 43, H. 4. pp. 550-560.

Borer, Aline S. and Wassmann, Paul and Schmidt, Margit and Hoffman, Donald R. and Zhou, Jing-Jiang and Wright, Christine and Schirmer, Tilman and Marković-Housley, Zora. (2011) Crystal structure of Sol i 2 : a major allergen from fire ant venom. Journal of molecular biology, Vol. 415, H. 4. pp. 635-648.

Köhler, Valentin and Mao, Jincheng and Heinisch, Tillmann and Pordea, Anca and Sardo, Alessia and Wilson, Yvonne M. and Knörr, Livia and Creus, Marc and Prost, Jean-Christophe and Schirmer, Tilman and Ward, Thomas R.. (2011) OsO4·streptavidin: a tunable hybrid catalyst for the enantioselective cis-dihydroxylation of olefins. Angewandte Chemie International Edition, 50 (46). pp. 10863-10866.

Monnard, Fabien W. and Heinisch, Tillmann and Nogueira, Elisa S. and Schirmer, Tilman and Ward, Thomas R.. (2011) Human Carbonic Anhydrase II as a host for piano-stool complexes bearing a sulfonamide anchor. Chemical Communications, 47 (29). pp. 8238-8240.

2010

Kim, D. and Hunt, J. F. and Schirmer, T.. (2010) Making, breaking, and sensing of cyclic Di-GMP : structural, thermodynamic, and evolutionary principles. In: The second messenger cyclic Di-GMP. Washington, D.C, pp. 76-95.

Mittermann, Irene and Zidarn, Mihaela and Silar, Mira and Markovic-Housley, Zora and Aberer, Werner and Korosec, Peter and Kosnik, Mitja and Valenta, Rudolf. (2010) Recombinant allergen-based IgE testing to distinguish bee and wasp allergy. The Journal of Allergy and Clinical Immunology, Vol. 125, H. 6 , S. 1300-1307.e3.

Zimbron, Jeremy M. and Sardo, Alessia and Heinisch, Tillmann and Wohlschlager, Therese and Gradinaru, Julieta and Massa, Claudia and Schirmer, Tilman and Creus, Marc and Ward, Thomas R.. (2010) Chemo-Genetic Optimization of DNA Recognition by Metallodrugs using a Presenter-Protein Strategy. Chemistry - A European Journal, 16 (43). pp. 12883-12889.

Zähringer, Franziska and Massa, Claudia and Schirmer, Tilman. (2010) Efficient Enzymatic Production of the Bacterial Second Messenger c-di-GMP by the Diguanylate Cyclase YdeH from E. coli. Applied biochemistry and biotechnology, Vol. 163, H. 1. p. 71.

2009

Abel, Sören. Analysis of the c-di-GMP mediated cell fate determination in Caulobacter crescentus. 2009, Doctoral Thesis, University of Basel, Faculty of Science.

Boehm, Alex and Steiner, Samuel and Zaehringer, Franziska and Casanova, Alain and Hamburger, Fabienne and Ritz, Daniel and Keck, Wolfgang and Ackermann, Martin and Schirmer, Tilman and Jenal, Urs. (2009) Second messenger signaling governs Escherichia coli biofilm induction upon ribosomal stress. Molecular microbiology, Vol. 72, H. 6. pp. 1500-1516.

Markovic-Housley, Zora and Basle, Arnaud and Padavattan, Sivaraman and Maderegger, Bernhard and Schirmer, Tilman and Hoffmann-Sommergruber, Karin. (2009) Structure of the major carrot allergen Dau c 1. Acta crystallographica. Section D, Biological crystallography, Vol. 65, Pt. 11. pp. 1206-1212.

Minasov, George and Padavattan, Sivaraman and Shuvalova, Ludmilla and Brunzelle, Joseph S. and Miller, Darcie J. and Baslé, Arnaud and Massa, Claudia and Collart, Frank R. and Schirmer, Tilman and Anderson, Wayne F.. (2009) Crystal Structures of YkuI and Its Complex with Second Messenger Cyclic Di-GMP Suggest Catalytic Mechanism of Phosphodiester Bond Cleavage by EAL Domains. Journal of biological chemistry, Vol. 284, H. 19. pp. 13174-13184.

Padavattan, Sivaraman and Flicker, Sabine and Schirmer, Tilman and Madritsch, Christoph and Randow, Stefanie and Reese, Gerald and Vieths, Stefan and Lupinek, Christian and Ebner, Christof and Valenta, Rudolf and Markovic-Housley, Zora. (2009) High-affinity IgE recognition of a conformational epitope of the major respiratory allergen Phl p 2 as revealed by X-ray crystallography. Journal of immunology, Vol. 182, H. 4. pp. 2141-2151.

Schirmer, Tilman and Jenal, Urs. (2009) Structural and mechanistic determinants of c-di-GMP signalling. Nature Reviews Microbiology, Vol. 7. pp. 724-735.

Wassmann, Paul. Elucidation of the regulatory mechanisms of the diguanylate cyclases PleD, DgcA and DgcB by structural and biophysical analysis. 2009, Doctoral Thesis, University of Basel, Faculty of Science.

Wirth, Christophe and Condemine, Guy and Boiteux, Céline and Bernèche, Simon and Schirmer, Tilman and Peneff, Caroline M.. (2009) NanC crystal structure, a model for outer-membrane channels of the acidic sugar-specific KdgM porin family. Journal of molecular biology, Vol. 394, H. 4. pp. 718-731.

2008

Padavattan, S. and Schmidt, M. and Hoffman, D. R. and Markovic-Housley, Z.. (2008) Crystal structure of the major allergen from fire ant venom, Sol i 3. Journal of molecular biology, Vol. 383, H. 1. pp. 178-185.

2007

Padavattan, Sivaraman and Schirmer, Tilman and Schmidt, Margit and Akdis, Cezmi and Valenta, Rudolf and Mittermann, Irene and Soldatova, Lyudmila and Slater, Jay and Mueller, Ulrich and Markovic-Housley, Zora. (2007) Identification of a B-cell epitope of hyaluronidase, a major bee venom allergen, from its crystal structure in complex with a specific Fab. Journal of molecular biology, Vol. 368, H. 3. pp. 742-752.

Paul, Ralf and Abel, Sören and Wassmann, Paul and Beck, Andreas and Heerklotz, Heiko and Jenal, Urs. (2007) Activation of the diguanylate cyclase PleD by phosphorylation-mediated dimerization. Journal of biological chemistry, Vol. 282, H. 40. pp. 29170-29177.

Soldatova, Lyudmila N. and Tsai, Chaoming and Dobrovolskaia, Ekaterina and Marković-Housley, Zora and Slater, Jay E.. (2007) Characterization of the N-glycans of recombinant bee venom hyaluronidase (Api m 2) expressed in insect cells. Allergy and asthma proceedings, Vol. 28, no. 2. pp. 210-215.

Wassmann, P. and Chan, C. and Paul, R. and Beck, A. and Heerklotz, H. and Jenal, U. and Schirmer, T.. (2007) Structure of BeF3- -modified response regulator PleD: implications for diguanylate cyclase activation, catalysis, and feedback inhibition. Structure: with folding and design, Vol. 15, H. 8. pp. 915-927.

2006

Baslé, Arnaud and Rummel, Gabriele and Storici, Paola and Rosenbusch, Juerg P. and Schirmer, Tilman. (2006) Crystal structure of osmoporin OmpC from E. coli at 2.0 A. Journal of molecular biology, Vol. 362, H. 5. pp. 933-942.

Ma, Y. and Gadermaier, G. and Bohle, B. and Bolhaar, S. and Knulst, A. and Markovic-Housley, Z. and Breiteneder, H. and Briza, P. and Hoffmann-Sommergruber, K. and Ferreira, F.. (2006) Mutational analysis of amino acid positions crucial for IgE-binding epitopes of the major apple (Malus domestica) allergen, Mal d 1. International Archives of Allergy and Immunology, 139 (1). pp. 53-62.

Miedema, Henk and Vrouenraets, Maarten and Wierenga, Jenny and Eisenberg, Bob and Schirmer, Tilman and Baslé, Arnaud and Meijberg, Wim. (2006) Conductance and selectivity fluctuations in D127 mutants of the bacterial porin OmpF. European biophysics journal, Vol. 36, H. 1. pp. 13-22.

Padavattan, Sivaraman. Crystal structure determination of hyaluronidase : a major bee venom allergen, in complex with an IgG Fab fragment and purification and biophysical characterization of bovine testes hyaluronidase. 2006, Doctoral Thesis, University of Basel, Faculty of Science.

Palanivelu, D. V. and Kozono, D. E. and Engel, A. and Suda, K. and Lustig, A. and Agre, P. and Schirmer, T.. (2006) Co-axial association of recombinant eye lens aquaporin-0 observed in loosely packed 3D crystals. Journal of molecular biology, Vol. 355, H. 4. pp. 605-611.

Palanivelu, Dinesh Vellore. Structural investigation into recombinant eye lens aquaporin (AQP0) and the effector proteins (BEPS) from "Bartonella henselae". 2006, Doctoral Thesis, University of Basel, Faculty of Science.

2005

Hui, Kwok-Min and Orriss, George L. and Schirmer, Tilman and Magnadóttir, Bergljót and Schifferli, Jürg A. and Inal, Jameel M.. (2005) Expression of functional recombinant von Willebrand factor-A domain from human complement C2 : a potential binding site for C4 and CRIT. The Biochemical Journal, Vol. 389, Pt. 3. pp. 863-868.

Karamloo, Fariba and Schmid-Grendelmeier, Peter and Kussebi, Fatimah and Akdis, Mübeccel and Salagianni, Maria and von Beust, Barbara R. and Reimers, Andrea and Zumkehr, Judith and Soldatova, Lyudmilla and Housley-Markovic, Zora and Müller, Ulrich and Kündig, Thomas and Kemeny, David M. and Spangfort, Michael D. and Blaser, Kurt and Akdis, Cezmi A.. (2005) Prevention of allergy by a recombinant multi-allergen vaccine with reduced IgE binding and preserved T cell epitopes. European Journal of Immunology, Vol. 35, H. 11. pp. 3268-3276.

Kussebi, F. and Karamloo, F. and Rhyner, C. and Schmid-Grendelmeier, P. and Salagianni, M. and Mannhart, C. and Akdis, M. and Soldatova, L. and Markovic-Housley, Z. and von Beust, B. R. and Kundig, T. and Kemeny, D. M. and Blaser, K. and Crameri, R. and Akdis, C. A.. (2005) A major allergen gene-fusion protein for potential usage in allergen-specific immunotherapy. The journal of allergy and clinical immunology, Vol. 115, H. 2. pp. 323-329.

Markova, Michaela and Peneff, Caroline and Hewlins, Michael J. E. and Schirmer, Tilman and John, Robert A.. (2005) Determinants of substrate specificity in omega-aminotransferases. Journal of Biological Chemistry, Vol. 280, H. 43. pp. 36409-36416.

Philippsen, Ansgar and Schirmer, Tilman and Stein, Martin A. and Giffhorn, Friedrich and Stetefeld, Jörg. (2005) Structure of zinc-independent sorbitol dehydrogenase from Rhodobacter sphaeroides at 2.4 A resolution. Acta Crystallographica. Section D, Biological Crystallography, Vol. 61, Pt. 4. pp. 374-379.

Schirmer, Tilman and Hoffimann-Sommergrube, Karin and Susani, Markus and Breiteneder, Heimo and Marković-Housley, Zora. (2005) Crystal structure of the major celery allergen Api g 1 : molecular analysis of cross-reactivity. Journal of molecular biology, Vol. 351, H. 5. pp. 1101-1109.

2004

Chan, C. and Paul, R. and Samoray, D. and Amiot, N. C. and Giese, B. and Jenal, U. and Schirmer, T.. (2004) Structural basis of activity and allosteric control of diguanylate cyclase. Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, H. 49. pp. 17084-17089.

Chan, Carmen. Structural elucidation of the multidomain response regulator PleD using X-ray crystallography. 2004, Doctoral Thesis, University of Basel, Faculty of Science.

Paul, R. and Weiser, S. and Amiot, N. C. and Chan, C. and Schirmer, T. and Giese, B. and Jenal, U.. (2004) Cell cycle-dependent dynamic localization of a bacterial response regulator with a novel di-guanylate cyclase output domain. Genes & development, Vol. 18, H. 6. pp. 715-727.

Storici, Paola and De Biase, Daniela and Bossa, Francesco and Bruno, Stefano and Mozzarelli, Andrea and Peneff, Caroline and Silverman, Richard B. and Schirmer, Tilman. (2004) Structures of gamma-aminobutyric acid (GABA) aminotransferase, a pyridoxal 5'-phosphate, and [2Fe-2S] cluster-containing enzyme, complexed with gamma-ethynyl-GABA and with the antiepilepsy drug vigabatrin. Journal of Biological Chemistry, Vol. 279, H. 1. pp. 363-373.

Storici, Paola and Qiu, Jian and Schirmer, Tilman and Silverman, Richard B.. (2004) Mechanistic crystallography. Mechanism of inactivation of gamma-aminobutyric acid aminotransferase by (1R,3S,4S)-3-amino-4-fluorocyclopentane-1-carboxylic acid as elucidated by crystallography. Biochemistry, Vol. 43, H. 44. pp. 14057-14063.

2003

Markovic-Housley, Z. and Degano, M. and Lamba, D. and von Roepenack-Lahaye, E. and Clemens, S. and Susani, M. and Ferreira, F. and Scheiner, O. and Breiteneder, H.. (2003) Crystal structure of a hypoallergenic isoform of the major birch pollen allergen Bet v 1 and its likely biological function as a plant steroid carrier. Journal of molecular biology, Vol. 325, H. 1. pp. 123-133.

Orriss, George L. and Erni, Bernhard and Schirmer, Tilman. (2003) Crystal structure of the IIB(Sor) domain of the sorbose permease from Klebsiella pneumoniae solved to 1.75A resolution. Journal of molecular biology, Vol. 327, H. 5. pp. 1111-1119.

2002

Choi, Sun and Storici, Paola and Schirmer, Tilman and Silverman, Richard B.. (2002) Design of a conformationally restricted analogue of the antiepilepsy drug Vigabatrin that directs its mechanism of inactivation of gamma-aminobutyric acid aminotransferase. Journal of the American Chemical Society, Vol. 124, H. 8. pp. 1620-1624.

Dutzler, Raimund and Schirmer, Tilman and Karplus, Martin and Fischer, Stefan. (2002) Translocation mechanism of long sugar chains across the maltoporin membrane channel. Structure: with folding and design, Vol. 10, H. 9. pp. 1273-1284.

Markovic-Housley, Z. and Degano, M. and Lamba, D. and Susani, M. and Ferreira, F. and Scheiner, O. and Breiteneder, H.. (2002) Crystal structure of a hypoallergenic isoform of the major birch pollen allergen Bet v 1 and its biological function. Journal Of Allergy And Clinical Immunology, Vol. 109, H. 1, Suppl. S. p. 483.

Markovic-Housley, Z. and Schirmer, T.. (2002) Structural evidence for substrate assisted catalytic mechanism of bee venom hyaluronidase, a major allergen of bee venom. In: Carbohydrate bioengineering. Cambridge, UK, pp. 19-27.

Philippsen, A. and Im, W. and Engel, A. and Schirmer, T. and Roux, B. and Muller, D. J.. (2002) Imaging the electrostatic potential of transmembrane channels : atomic probe microscopy of OmpF porin. Biophysical journal, Vol. 82, H. 3. pp. 1667-1676.

Rodríguez-Marañón, María José and Bush, Robin M. and Peterson, Ellena M. and Schirmer, Tilman and de la Maza, Luis M.. (2002) Prediction of the membrane-spanning beta-strands of the major outer membrane protein of Chlamydia. Protein Science, Vol. 11, H. 7. pp. 1854-1861.

Sauer, Oliver and Roth, Michel and Schirmer, Tilman and Rummel, Gabriele and Kratky, Christoph. (2002) Low-resolution detergent tracing in protein crystals using xenon or krypton to enhance X-ray contrast. Acta Crystallographica. Section D, Biological Crystallography, Vol. 58, Pt. 1. pp. 60-69.

Van Gelder, Patrick and Dumas, Fabrice and Bartoldus, Ingrid and Saint, Nathalie and Prilipov, Alexei and Winterhalter, Mathias and Wang, Yanfei and Philippsen, Ansgar and Rosenbusch, Jürg P. and Schirmer, Tilman. (2002) Sugar transport through maltoporin of Escherichia coli : role of the greasy slide. Journal of bacteriology, Vol. 184, H. 11. pp. 2994-2999.

2001

Phale, P. S. and Philippsen, A. and Widmer, C. and Phale, V. P. and Rosenbusch, J. P. and Schirmer, T.. (2001) Role of charged residues at the OmpF porin channel constriction probed by mutagenesis and simulation. Biochemistry, Vol. 40, H. 21. pp. 6319-6325.

Schirmer, T.. (2001) Membrane proteins with beta-barrel fold. Chimia, 55. pp. 493-496.

Van Gelder, P. and Dutzler, R. and Dumas, F. and Koebnik, R. and Schirmer, T.. (2001) Sucrose transport through maltoporin mutants of Escherichia coli. Protein Engineering, Vol. 14, H. 11. pp. 943-948.

2000

Markovic-Housley, Z. and Miglierini, G. and Soldatova, L. and Rizkallah, P. J. and Muller, U. and Schirmer, T.. (2000) Crystal structure of hyaluronidase, a major allergen of bee venom. Structure: with folding and design, Vol. 8, H. 10. pp. 1025-1035.

1999

Dutzler, R. and Rummel, G. and Albertí, S. and Hernández-Allés, S. and Phale, P. and Rosenbusch, J. and Benedí, V. and Schirmer, T.. (1999) Crystal structure and functional characterization of OmpK36, the osmoporin of Klebsiella pneumoniae. Structure: with folding and design, Vol. 7, H. 4. pp. 425-434.

Schirmer, T. and Phale, P. S.. (1999) Brownian dynamics simulation of ion flow through porin channels. Journal of molecular biology, Vol. 294, H. 5. pp. 1159-1167.

Storici, P. and Capitani, G. and De Biase, D. and Moser, M. and John, R. A. and Jansonius, J. N. and Schirmer, T.. (1999) Crystal structure of GABA-aminotransferase, a target for antiepileptic drug therapy. Biochemistry, Vol. 38, H. 27. pp. 8628-8634.

Storici, P. and Capitani, G. and Müller, R. and Schirmer, T. and Jansonius, J. N.. (1999) Crystal structure of human ornithine aminotransferase complexed with the highly specific and potent inhibitor 5-fluoromethylornithine. Journal of molecular biology, Vol. 285, H. 1. pp. 297-309.

1998

Penel, S. and Pebay-Peyroula, E. and Rosenbusch, J. and Rummel, G. and Schirmer, T. and Timmins, P. A.. (1998) Detergent binding in trigonal crystals of OmpF porin from Escherichia coli. Biochimie, Vol. 80, H. 5-6. pp. 543-551.

Phale, P. S. and Philippsen, A. and Kiefhaber, T. and Koebnik, R. and Phale, V. P. and Schirmer, T. and Rosenbusch, J. P.. (1998) Stability of trimeric OmpF porin : the contributions of the latching loop L2. Biochemistry, Vol. 37, H. 45. pp. 15663-15670.

Schauder, S. and Nunn, R. S. and Lanz, R. and Erni, B. and Schirmer, T.. (1998) Crystal structure of the IIB subunit of a fructose permease (IIBLev) from Bacillus subtilis. Journal of molecular biology, Vol. 276, H. 3. pp. 591-602.

Schirmer, T.. (1998) General and specific porins from bacterial outer membranes. Journal of Structural Biology, Vol. 121, H. 2. pp. 101-109.

Shen, B. W. and Hennig, M. and Hohenester, E. and Jansonius, J. N. and Schirmer, T.. (1998) Crystal structure of human recombinant ornithine aminotransferase. Journal of molecular biology, Vol. 277, H. 1. pp. 81-102.

1997

Phale, P. S. and Schirmer, T. and Prilipov, A. and Lou, K. L. and Hardmeyer, A. and Rosenbusch, J. P.. (1997) Voltage gating of Escherichia coli porin channels : role of the constriction loop. Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, H. 13. pp. 6741-6745.

Wang, Y. F. and Dutzler, R. and Rizkallah, P. J. and Rosenbusch, J. P. and Schirmer, T.. (1997) Channel specificity : structural basis for sugar discrimination and differential flux rates in maltoporin. Journal of molecular biology, Vol. 272, H. 1. pp. 56-63.

1996

Chan, W. C. and Schirmer, T. and Ferenci, T.. (1996) Combinatorial mutagenesis analysis of residues in the channel constriction loop L3 and neighbouring beta-strands in the LamB glycoporin of Escherichia coli. Molecular Membrane Biology, Vol. 13, H. 1. pp. 41-48.

Dutzler, R. and Wang, Y. F. and Rizkallah, P. and Rosenbusch, J. P. and Schirmer, T.. (1996) Crystal structures of various maltooligosaccharides bound to maltoporin reveal a specific sugar translocation pathway. Structure, Vol. 4, H. 2. pp. 127-134.

Lou, K. L. and Saint, N. and Prilipov, A. and Rummel, G. and Benson, S. A. and Rosenbusch, J. P. and Schirmer, T.. (1996) Structural and functional characterization of OmpF porin mutants selected for larger pore size. I.. Crystallographic analysis. Journal of Biological Chemistry, Vol. 271, H. 34. pp. 20669-20675.

Marković-Housley, Z. and Schirmer, T. and Hohenester, E. and Khomutov, A. R. and Khomutov, R. M. and Karpeisky, M. Y. and Sandmeier, E. and Christen, P. and Jansonius, J. N.. (1996) Crystal structures and solution studies of oxime adducts of mitochondrial aspartate aminotransferase. European journal of biochemistry, Vol. 236, H. 3. pp. 1025-1032.

Nunn, R. S. and Marković-Housley, Z. and Génovésio-Taverne, J. C. and Flükiger, K. and Rizkallah, P. J. and Jansonius, J. N. and Schirmer, T. and Erni, B.. (1996) Structure of the IIA domain of the mannose transporter from Escherichia coli at 1.7 angstroms resolution. Journal of molecular biology, Vol. 259, H. 3. pp. 502-511.

Saint, N. and Lou, K. L. and Widmer, C. and Luckey, M. and Schirmer, T. and Rosenbusch, J. P.. (1996) Structural and functional characterization of OmpF porin mutants selected for larger pore size. II.. Functional characterization. Journal of Biological Chemistry, Vol. 271, H. 34. pp. 20676-20680.

Saint, N. and Prilipov, A. and Hardmeyer, A. and Lou, K. L. and Schirmer, T. and Rosenbusch, J. P.. (1996) Replacement of the sole histidinyl residue in OmpF porin from E. coli by threonine (H21T) does not affect channel structure and function. Biochemical and Biophysical Research Communications, Vol. 223, H. 1. pp. 118-122.

1995

Albertí, S. and Rodríquez-Quiñones, F. and Schirmer, T. and Rummel, G. and Tomás, J. M. and Rosenbusch, J. P. and Benedí, V. J.. (1995) A porin from Klebsiella pneumoniae : sequence homology, three-dimensional model, and complement binding. Infection and immunity, Vol. 63, H. 3. pp. 903-910.

Cowan, S. W. and Garavito, R. M. and Jansonius, J. N. and Jenkins, J. A. and Karlsson, R. and König, N. and Pai, E. F. and Pauptit, R. A. and Rizkallah, P. J. and Rosenbusch, J. P.. (1995) The structure of OmpF porin in a tetragonal crystal form. Structure, Vol. 3, H. 10. pp. 1041-1050.

Schirmer, T. and Keller, T. A. and Wang, Y. F. and Rosenbusch, J. P.. (1995) Structural basis for sugar translocation through maltoporin channels at 3.1 A resolution. Science, Vol. 267, no. 5197. pp. 512-514.

1994

Cowan, S. W. and Schirmer, T.. (1994) Structures of non-specific diffusion pores from E.coli. New comprehensive biochemistry, Vol. 27. pp. 353-361.

Jeanteur, D. and Schirmer, T. and Fourel, D. and Simonet, V. and Rummel, G. and Widmer, C. and Rosenbusch, J. P. and Pattus, F. and Pagès, J. M.. (1994) Structural and functional alterations of a colicin-resistant mutant of OmpF porin from Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, H. 22. pp. 10675-10679.

Karshikoff, A. and Spassov, V. and Cowan, S. W. and Ladenstein, R. and Schirmer, T.. (1994) Electrostatic properties of two porin channels from Escherichia coli. Journal of molecular biology, Vol. 240, H. 4. pp. 372-384.

1993

Pflügl, G. and Kallen, J. and Schirmer, T. and Jansonius, J. N. and Zurini, M. G. and Walkinshaw, M. D.. (1993) X-ray structure of a decameric cyclophilin-cyclosporin crystal complex. Nature, Vol. 361. pp. 91-94.

Schirmer, T. and Cowan, S. W.. (1993) Prediction of membrane-spanning beta-strands and its application to maltoporin. Protein Science, Vol. 2, H. 8. pp. 1361-1363.

1992

Cowan, S. W. and Schirmer, T. and Rummel, G. and Steiert, M. and Ghosh, R. and Pauptit, R. A. and Jansonius, J. N. and Rosenbusch, J. P.. (1992) Crystal structures explain functional properties of two E. coli porins. Nature, Vol. 358. pp. 727-733.

1991

Schirmer, T. and Roschenbusch, J. P.. (1991) Prokaryotic and eukaryotic porins. Current Opinion in Structural Biology, Vol. 1, H. 4. pp. 539-545.

1990

Schirmer, T. and Evans, P. R.. (1990) Structural basis of the allosteric behaviour of phosphofructokinase. Nature, Vol. 343. pp. 140-145.

1987

Schirmer, T. and Bode, W. and Huber, R.. (1987) Refined three-dimensional structures of two cyanobacterial C-phycocyanins at 2.1 and 2.5 A resolution : a common principle of phycobilin-protein interaction. Journal of molecular biology, Vol. 196, H. 3. pp. 677-695.

Schirmer, T. and Vincent, M. G.. (1987) Polarized absorption and fluorescence spectra of single crystals of C-phycocyanin. Biochimica et biophysica acta, Vol. 893, H. 3. pp. 379-385.

1986

Schirmer, T. and Huber, R. and Schneider, M. and Bode, W. and Miller, M. and Hackert, M. L.. (1986) Crystal structure analysis and refinement at 2.5 A of hexameric C-phycocyanin from the cyanobacterium Agmenellum quadruplicatum : the molecular model and its implications for light-harvesting. Journal of molecular biology, Vol. 188, H. 4. pp. 651-676.

1985

Schirmer, T. and Bode, W. and Huber, R. and Sidler, W. and Zuber, H.. (1985) X-ray crystallographic structure of the light-harvesting biliprotein C-phycocyanin from the thermophilic cyanobacterium Mastigocladus laminosus and its resemblance to globin structures. Journal of molecular biology, Vol. 184, H. 2. pp. 257-277.